ZRdb KZFP & Repeats
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LTR_HERVK14

  • Name
    HERVK14
  • Repbase
    HERV-K14I
  • Type
    LTR
  • Emergence
    28.9 Mya
  • Dfam Id
    DF0000192
Description :

Human HERV-K14 and its variants were examined carefully by Flockerzi etal . HERVK14 is found both with and without an env gene. This modellacks an env. In the rare variants that do, env would start aroundposition 5144. Long terminal repeats associated with HERVK14 are LTR14Aand LTR14B. Features in the consensus from ref : lysine PBS (~9-28),gag (~125-1798), protease (~1657-2604), pol (~2535-5183), polypyrimidinetract (~6078-6095).
Consensus sequence The consensus sequences obtained from Dfam are derived from the seed alignment using a specialized caller. :
ttcctggcgcccaacgtggggcgacgaagaccccggtgaaggaacgctagagcgtgtgaaagcggaggacgcatcgtcaaaggacacccgaggacgtctaaaagaagctcggcgggaaagctgagcgctcggaagaaccagggtaacaatgggacaaagtgaaagcagacattctgcttatttaaatttcttaaggcatttattacgaagagggggagtgaaagttagtactcagaatttgttatcactctttagtacagtaaagcagttttgcccatggttcccggaacaagggactatggagttggatgaatgggagagaattggnagagattttaaaaaggcgtataaagatggagcaaaaattccagtttccgtttggtcaatgtgggcgctaataaaggcagctcttgagccatttcaaacagatgatgaggcagattcagatgaggaagaggaggacgagtgtaaaaaactaacttcagattctgagtgtgaggaacagnnaccggaggagattaaagaaaagaaagggaaactgaaaaaagtatgttttactagcccgtcggctccacctgctgaattaagtgaatggccacctcctctctctccccttaatgggcgagaaaatgaattagctgnaaaacttactgctcctgtagttgcaacattaaaacctggagcaattggtggtgctatacaaaattctattcaaaaggctagagccgagggagaccttgaagcatggcaatttcccgttactataatccagcaaggaggacagaatatagctaattgggccgcttttccttttaagttactaaaggaatttaagcaagccattagtcaatatggaccgaactctccttttgtgcaaactttattaaaaaatgtggctcttgataatagattaataccatatgattgggatactttgacaaaatctgttctcactccatctcagtacttgcagtttaaaacctggtgggctgatgaagctcaaactcaggcaagggaaaacacacaagcgcagccacctgtgcctgtttcctttgaacagttaatgggagttggccctaattggggtcgattagagaatcaagcagtaatggaggatgttgccattgttcagctgcgctccgtgtgcttacgggcatgggaaaggataaatgttacaggggaaaaatatccttctttcagttctgtccgacaaggacctaaagaaccatatattgattttattgctcggctccaagaggctgtgtataaagccataactgataaaacagctcaggatgttgtaatacagcttcttgcatacgataatgctaatgcagagtgtcaaactgctattagacccctgagagggaaggctcatttagctgaatatattaaggcttgcgatggcattggaggtaacttacataaggctactcttttagctcaggctatggctggattaagagtaggaaagaatatgccccatttctcaggctcttgctttaattgtgggcaatttggacacacaagaaaggaatgtagaaaaggaaatcaaaaggcaaaaactactaccatcaatcaacagaaaagtcccggtgtatgtccccggtgtaagaaaggcaatcactgggcaagtcagtgtcattctaaatttagcaaagatggacaacctctttcgggaaacgggaagaggggcccgcctcgagcccctcaacaaaccgaggcatacccggcacagccagtgcccttacaaacgtacaacaattgtcccccgccncagcaggcagtgctgccgtagacctctgcagcacaattcccgtctccttacttcctggggagccaccaaagaaggtccccacgggagttaggggacccttaccctcaggaacagtcggtctattacttggaaggtctagtctaaatttaaaaggtgtcactgtgcatacgggaataattgactctgattataccggagaaattcaattagttattagttcctcgactccgtggtctgcctccccaggagaaagaattgctcagttgttgctgttaccttacataaaactaggaagcagcacagtgaaaagaacaggaggctttggtagtactaatccagcaggaaaggctgtatattgggttaatcaagtgtctgacaaaagacctatttgcacagtaactattcagggaaaagattttgaaggactagtagatactggagctgatgtctctattattgctntaaatcaatggccccggcactggcctaagcaaaaggcatccattggtattgttggagtaggagctgcctcggaagtttttcaaagttccttgattttaccatgtcaagggccggatggccaggaagggacaattcagcctatcattacacctattcctgtcaatttatggggtagagacttattgcaacaatgggatgctgaaatatctattcctatggatcaatatagtaataatagtagacaaatgatgaaaaatatgggatatcgcccgggaaaaggactaggaaaagataaaaatggccaatcagaacctttagaattaaaagggcaaacagatcggaccggattggggtgtcatttttaggagcggccattgttgagcctccggctcccattcctcttgtttggctaactgccaaaccggtttgggtggagcaatggccgctgaaacaggaaaaactggaggctttaaaagaactggtgcaggaacaattgcaaaagggacatatagagcctactttctccccttggaattctcctgtatttgtcattaagaaaaaatcagggaaatggagaatgttaacagatttaagggctgttaatgctgtgattcaacccatgggtgcactgcaaccagggctgccctccccaacaatgatcccaaaatactggcctctcatagtgatagatctaaaggattgcttttttaccattcctttagctgcccaagattatgaaaaatttgcttttactgttcccgccataaataataaagaaccagcggacagataccattggaaagtactaccacaaggcatgctaaatagcccgactatttgtcaaacttatgtcgggaaagctattaagccagttagagaacagtttaaaaaatgttatattatccattacatggatgatattctgtgtgcagctgaaactagggaagaattgatgttgtgctacaaacagttagaaaaggctgtaaatgcggcagggttaattatagcccccgataaaatccaaacttctactccctttcaatatctaggaatgaaggtagaacaaagtgctattaagcctcaaaaggttcaaattcgaagagataatttaaaaaccttaaatgatttccaaaaattattaggagacattaattggattcgtccaactttaggcattcctacctatgctatgtctcacctcttttctactttacgaggtgattctaaccttaacagtaaacgctccctgtccaaagaagcattggaggaacttcaattaattgaggaaaaaattcagcaagcacaagtggaacgaattaacccgatgcagccattacagtttttagtttttcctactaagcattcgcctacaggagttatngttcaacaggatgatctggttgagtggctttttctacctcacaatacaaccaaaacgctcactctgtacttagatcaaattgctgtgctagtaggacaagcgaggctgcgcacaacaaagttaatgggatatgatccaaatcagattatagttccattaaccaaacaacaaattcaacaagcctatattaattcccaggaatggcaagttaatttggcnggttttgttggcattcttgataatcattatcctaaatctaaaatattccagtttctaaaattaacatcctggatattgccttccattactcaaaaagcccctattgaaggggccattactgtttttactgatggatctagtaatggaaaagcctcatttgcgggacctcaacagcaagtttttcaaactgactttgcttctgctcaaagggctgaacttatggctgtgataacagtgttaaaaacttttaaacagccagtaaacattgtttctgattcagcctatgtagtgcaagccacgcaaaatattgaatgtgccttaattcgaaatgtgactgatgaacaacttaatcttttatttcattctttacagcaagcagtacaacaaaggcattcccctttctatatcactcatatgagagcacatactaacctccctggccctttaactaaacttaatcaaagggcggatgcattggtgtctgcagcctttgctgatgcacaaacattccattctttaacccatcttaatgccgcaggccttagaaaaagatatggtctatcatggaaacaagctaaagaaattgtgcaacactgttctgcctgccaagtcctgcatctgccacatcaaggaacaggagttaaccctagaggtttatctccaaattccatctggcagatggatgtaacacatattcctgcttttggaaaattgtcctttgttcatgtttcagtagatacctattcacattttatctgggccacatgtcaaacaggggaagctacagctcatgttaaaagacatcttttatcttgcttttcagttatgggaatcccagaaaaaatcaaaactgataacggcccaggatactgtagtaaagccatggctacattttttcaacaatggaatattacccatactacgggtattccatataactcacaaggacaggcaatagtggaaagagctaatcgtactttaaaaactcaaatacaaaagcaaaagggaggggaccaggaatataagacaccgcatatgcaattgcatttagctttattaacattaaattttttaaatttacaaaaagatcaacccatgactgcagctgaacaacacctgacaggacaaaaggaaaataaaaaggctggacaagatatatggtggagggatgcacatacaaagagctgggaaaaaggaaagataattntatggggaagaggatttgcttgtgtctctccaggtgacaatcaggtgcctgtgtgggtgcccaccaaacatctgaagatctatcatgagccacagcatctagtggacccacctgtacagtgcgaattgaaggtttgaggattgcttttttgctnnnncgncgnacgngaagganaagcctcgatttgctttctctgtgccttctgttanncagaaggggcctgtttctcattatcagtggtaagttttaccccgcggtaattaaccaaagaggcagaagctgagttacaaatgcttcagcaatggcangcctcccggctacagccacaaaagtttttgcttctgtttcagtagatttactaacgtgggggtgagggtatgcttgtgtttttgcaggagatgaacgaaccgtgtggatgccctcaagatgtgtacgaccatggaacgggagactggagggacccatggatcccaaccatggaccgggttcccccagtacgagccatgagccagttgaatctgaatgcgaagatggaacgaggaccgaccggagtcactgctgacatcaacccccataacatggggacagatcaagaaaaccgcacaggaagctgagaaactgctggagcgccagggttttacctnttgccggnantcagagnnacaatagatgcttaacggaccaatgctttctgactcagctcctctctaccctgaatacaagagaccctaatagttaggcaggaatatcatcgcccctattcagcatgaagaagttacagaagacggaccttcatccttctgcaacccctaggattaagggtcctcttgtaaaangggaaaggggagatatgtgggaagcattcaaaccagagtgactccantntgaatnanggctannaanaatgaagctggatcaccaaccggcaattaagggctgcacagcctgcaattgccttgctcaattaaaaagaggccaccttatgctagtaataatgatagctngtaataatgatacgtggtctcttttacaaaaaagagaaggggggca
Repeats structure For certain families, there exists a curated collection of TE-derived proteins, which constitutes a non-redundant set. As a results, several families may lack an associated coding sequences directly linked to them. The annotation for these families is obtained from Dfam. :
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequence on the genome. :
# KZFP name Record number KZFP age(Mya) Time correlation with Repeats
1 ZNF320 75 28.9 Highly correlated
2 ZNF723 19 15.2 Moderately correlated
3 ZNF534 16 19.6 Moderately correlated
4 ZNF28 14 28.9 Highly correlated
5 ZNF485 13 94.0 Weakly correlated
6 ZNF766 12 43.0 Weakly correlated
7 ZNF737 11 28.9 Highly correlated
8 ZFP57 9 87.0 Weakly correlated
9 ZNF317 9 99.0 Weakly correlated
10 ZNF175 8 94.0 Weakly correlated
11 ZNF587 7 28.9 Highly correlated
12 ZNF382 7 99.0 Weakly correlated
13 ZNF417 6 28.9 Highly correlated
14 ZNF679 6 28.9 Highly correlated
15 ZNF92 6 28.9 Highly correlated
16 ZNF816 5 28.9 Highly correlated
17 ZNF701 5 28.9 Highly correlated
18 ZNF589 5 28.9 Highly correlated
19 ZIM3 5 87.0 Weakly correlated
20 ZNF394 5 99.0 Weakly correlated
21 ZNF584 4 99.0 Weakly correlated
22 ZNF197 3 99.0 Weakly correlated
23 ZNF75D 2 94.0 Weakly correlated
24 ZNF486 2 8.6 Weakly correlated
25 ZNF786 2 99.0 Weakly correlated
26 ZNF251 2 94.0 Weakly correlated
27 ZNF680 2 28.9 Highly correlated
28 ZNF789 2 99.0 Weakly correlated
29 ZNF765 1 8.6 Weakly correlated
30 ZNF793 1 99.0 Weakly correlated
31 ZNF84 1 99.0 Weakly correlated
32 ZNF878 1 43.0 Weakly correlated
33 ZNF705D 1 28.9 Highly correlated
34 ZNF519 1 19.6 Moderately correlated
35 ZNF705B 1 28.9 Highly correlated
36 ZNF677 1 99.0 Weakly correlated
37 ZNF674 1 99.0 Weakly correlated
38 ZNF597 1 94.0 Weakly correlated
39 ZNF563 1 28.9 Highly correlated
40 ZNF506 1 28.9 Highly correlated
41 ZNF479 1 6.4 Weakly correlated
42 ZNF44 1 43.0 Weakly correlated
43 ZNF441 1 43.0 Weakly correlated
44 ZNF429 1 28.9 Highly correlated
45 ZNF302 1 43.0 Weakly correlated
46 ZNF273 1 28.9 Highly correlated
47 ZNF17 1 69.0 Weakly correlated
48 ZNF169 1 94.0 Weakly correlated
49 ZNF101 1 43.0 Weakly correlated
50 ZKSCAN8 1 160.0 Weakly correlated
51 ZFP69B 1 99.0 Weakly correlated
KZFPs Motif in Repeats The motif of KZFPs found by the meme-chip appears in the repeats sequence. :
# KZFP name Record number KZFP age(Mya) Time correlation with Repeats
1 ZNF723 18 15.2 Moderately correlated
2 ZNF534 13 19.6 Moderately correlated
3 ZNF485 8 94.0 Weakly correlated
4 ZNF587 7 28.9 Highly correlated
5 ZNF417 6 28.9 Highly correlated
6 ZNF766 5 43.0 Weakly correlated
7 ZIM3 4 87.0 Weakly correlated
8 ZFP57 3 87.0 Weakly correlated
9 ZNF789 2 99.0 Weakly correlated
10 ZNF317 2 99.0 Weakly correlated
11 ZNF320 2 28.9 Highly correlated
12 ZNF816 1 28.9 Highly correlated
13 ZNF44 1 43.0 Weakly correlated
14 ZNF701 1 28.9 Highly correlated
15 ZNF680 1 28.9 Highly correlated
16 ZNF506 1 28.9 Highly correlated
17 ZNF28 1 28.9 Highly correlated
18 ZNF677 1 99.0 Weakly correlated
19 ZNF674 1 99.0 Weakly correlated
20 ZNF589 1 28.9 Highly correlated
21 ZNF479 1 6.4 Weakly correlated
22 ZNF382 1 99.0 Weakly correlated
23 ZNF197 1 99.0 Weakly correlated
24 ZNF75D 1 94.0 Weakly correlated
25 ZNF584 1 99.0 Weakly correlated
26 ZNF175 1 94.0 Weakly correlated
27 ZNF429 1 28.9 Highly correlated
28 ZNF765 1 8.6 Weakly correlated
KZFPs Motif in Repeats Consensus The motif of KZFPs found by the meme-chip can find the corresponding region on the consensus sequence of repeats. :
# KZFP name KZFP age(Mya) Time correlation with Repeats
1 ZNF587 28.9 Highly correlated
2 ZNF723 15.2 Moderately correlated