ZRdb KZFP & Repeats
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Human_ZNF93

  • Protein
    Zinc finger protein 93
  • Length
    620
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    8.6 Mya
  • Uniprot_ID
    P35789
  • NCBI_ID
    81931
Sequence:
MGPLQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLGIVVSKPDLIAHLEQGKKPLTMKRHEMVANPSVICSHFAQDLWPEQNIKDSFQKVILRRYEKRGHGNLQLIKRCESVDECKVHTGGYNGLNQCSTTTQSKVFQCDKYGKVFHKFSNSNRHNIRHTEKKPFKCIECGKAFNQFSTLITHKKIHTGEKPYICEECGKAFKYSSALNTHKRIHTGEKPYKCDKCDKAFIASSTLSKHEIIHTGKKPYKCEECGKAFNQSSTLTKHKKIHTGEKPYKCEECGKAFNQSSTLTKHKKIHTGEKPYVCEECGKAFKYSRILTTHKRIHTGEKPYKCNKCGKAFIASSTLSRHEFIHMGKKHYKCEECGKAFIWSSVLTRHKRVHTGEKPYKCEECGKAFKYSSTLSSHKRSHTGEKPYKCEECGKAFVASSTLSKHEIIHTGKKPYKCEECGKAFNQSSSLTKHKKIHTGEKPYKCEECGKAFNQSSSLTKHKKIHTGEKPYKCEECGKAFNQSSTLIKHKKIHTREKPYKCEECGKAFHLSTHLTTHKILHTGEKPYRCRECGKAFNHSATLSSHKKIHSGEKPYECDKCGKAFISPSSLSRHEIIHTGEKP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..75
2 dec2h2 145..167
3 C2h2 173..195
4 C2h2 201..223
5 C2h2 229..251
6 C2h2 257..279
7 C2h2 285..307
8 C2h2 313..335
9 C2h2 341..363
10 C2h2 369..391
11 C2h2 397..419
12 C2h2 425..447
13 C2h2 453..475
14 C2h2 481..503
15 C2h2 509..531
16 C2h2 537..559
17 C2h2 565..587
18 C2h2 593..615
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Molecular Function zinc ion binding
6 Biological Process negative regulation of DNA-templated transcription
7 Biological Process negative regulation of transposon integration
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA4 796 **** 19.6 Moderately correlated
2 L1PA3 462 **** 19.6 Moderately correlated
3 L1PA5 342 **** 19.6 Moderately correlated
4 L1PA6 273 **** 28.9 Weakly correlated
5 L1P1 155 **** 19.6 Moderately correlated
6 L1PA7 106 **** 74.0 Weakly correlated
7 L1P2 81 **** 28.9 Weakly correlated
8 MIRb 31 n.s 99.0 Weakly correlated
9 L1P3 29 **** 74.0 Weakly correlated
10 L2a 26 n.s 99.0 Weakly correlated
11 L1PA8 25 *** 74.0 Weakly correlated
12 L1PA2 24 * 15.2 Moderately correlated
13 MIR 24 n.s 99.0 Weakly correlated
14 L2b 19 n.s 99.0 Weakly correlated
15 L2c 19 n.s 99.0 Weakly correlated
16 AluJb 15 n.s 74.0 Weakly correlated
17 AluSx 13 n.s 74.0 Weakly correlated
18 AluSz 11 n.s 74.0 Weakly correlated
19 AluSp 10 n.s 74.0 Weakly correlated
20 AluSx1 10 n.s 74.0 Weakly correlated
21 MIRc 10 n.s 99.0 Weakly correlated
22 L1HS 9 n.s 8.6 Highly correlated
23 LTR13 9 **** 19.6 Moderately correlated
24 MLT1N2 9 **** 99.0 Weakly correlated
25 AluJo 8 n.s 74.0 Weakly correlated
26 AluJr 8 n.s 74.0 Weakly correlated
27 AluSq2 8 n.s 74.0 Weakly correlated
28 AluY 8 n.s 74.0 Weakly correlated
29 AluSc 7 n.s 74.0 Weakly correlated
30 AluSg 7 n.s 74.0 Weakly correlated
31 HAL1 7 n.s 99.0 Weakly correlated
32 L1MB3 7 n.s 99.0 Weakly correlated
33 L1MC4 7 n.s 99.0 Weakly correlated
34 L1PA10 7 n.s 74.0 Weakly correlated
35 L3 7 n.s 99.0 Weakly correlated
36 L3b 7 ** 99.0 Weakly correlated
37 LTR16A 7 ** 99.0 Weakly correlated
38 MIR3 7 n.s 99.0 Weakly correlated
39 MLT1D 7 n.s 99.0 Weakly correlated
40 MamRTE1 7 ** 99.0 Weakly correlated
41 AluSz6 6 n.s 74.0 Weakly correlated
42 MLT1H 6 n.s 99.0 Weakly correlated
43 L1MB8 5 n.s 99.0 Weakly correlated
44 L1ME1 5 n.s 99.0 Weakly correlated
45 L2 5 n.s 99.0 Weakly correlated
46 MLT1F 5 * 99.0 Weakly correlated
47 AluSx3 4 n.s 74.0 Weakly correlated
48 FRAM 4 * 74.0 Weakly correlated
49 HERVE-int 4 ** 19.6 Moderately correlated
50 L1M4c 4 n.s 99.0 Weakly correlated
51 L1MC5a 4 n.s 99.0 Weakly correlated
52 L1ME3Cz 4 n.s 99.0 Weakly correlated
53 L1PA17 4 n.s 74.0 Weakly correlated
54 MLT1C 4 n.s 94.0 Weakly correlated
55 MLT1G 4 * 99.0 Weakly correlated
56 MLT1J 4 n.s 99.0 Weakly correlated
57 MLT1J2 4 n.s 99.0 Weakly correlated
58 MSTA 4 n.s 43.0 Weakly correlated
59 AluJr4 3 n.s 74.0 Weakly correlated
60 AluSc8 3 n.s 74.0 Weakly correlated
61 AluSq 3 n.s 74.0 Weakly correlated
62 AluSx4 3 n.s 74.0 Weakly correlated
63 AluYa5 3 n.s 15.2 Moderately correlated
64 ERVL-E-int 3 n.s 99.0 Weakly correlated
65 HERVK-int 3 * 28.9 Weakly correlated
66 L1M5 3 n.s 99.0 Weakly correlated
67 L1MB7 3 n.s 99.0 Weakly correlated
68 L1MD 3 n.s 99.0 Weakly correlated
69 L1MD1 3 n.s 99.0 Weakly correlated
70 L1MD2 3 n.s 99.0 Weakly correlated
71 L1ME2z 3 n.s 99.0 Weakly correlated
72 L1ME3A 3 n.s 99.0 Weakly correlated
73 L1MEc 3 n.s 99.0 Weakly correlated
74 L1MEf 3 n.s 99.0 Weakly correlated
75 L1MEg 3 n.s 99.0 Weakly correlated
76 L1PA13 3 n.s 74.0 Weakly correlated
77 L1PREC2 3 n.s 43.0 Weakly correlated
78 LTR10A 3 *** 28.9 Weakly correlated
79 LTR12C 3 n.s 19.6 Moderately correlated
80 LTR16A2 3 * 99.0 Weakly correlated
81 LTR16B2 3 * 99.0 Weakly correlated
82 LTR33B 3 ** 99.0 Weakly correlated
83 LTR50 3 * 99.0 Weakly correlated
84 LTR67B 3 * 99.0 Weakly correlated
85 LTR79 3 * 99.0 Weakly correlated
86 MLT1A0 3 n.s 99.0 Weakly correlated
87 MLT1B 3 n.s 99.0 Weakly correlated
88 MLT1F1 3 n.s 99.0 Weakly correlated
89 MLT1I 3 n.s 99.0 Weakly correlated
90 MLT1K 3 n.s 99.0 Weakly correlated
91 MLT2F 3 * 99.0 Weakly correlated
92 THE1B 3 n.s 43.0 Weakly correlated
93 AluSg7 2 n.s 74.0 Weakly correlated
94 AluYj4 2 n.s 0.0 Weakly correlated
95 AluYm1 2 n.s 19.6 Moderately correlated
96 FAM 2 n.s 87.0 Weakly correlated
97 L1M1 2 n.s 74.0 Weakly correlated
98 L1M2 2 n.s 99.0 Weakly correlated
99 L1M4a2 2 n.s 99.0 Weakly correlated
100 L1MA4 2 n.s 87.0 Weakly correlated
101 L1MA9 2 n.s 99.0 Weakly correlated
102 L1MC1 2 n.s 99.0 Weakly correlated
103 L1MDa 2 n.s 99.0 Weakly correlated
104 L1ME3 2 n.s 99.0 Weakly correlated
105 L1ME3D 2 n.s 99.0 Weakly correlated
106 L1ME3G 2 n.s 99.0 Weakly correlated
107 L1ME4a 2 n.s 99.0 Weakly correlated
108 L1ME4b 2 n.s 99.0 Weakly correlated
109 L1MEd 2 n.s 99.0 Weakly correlated
110 L1PA11 2 n.s 74.0 Weakly correlated
111 L1PA14 2 n.s 74.0 Weakly correlated
112 L1PB1 2 n.s 74.0 Weakly correlated
113 LTR10E 2 ** 28.9 Weakly correlated
114 LTR13A 2 ** 28.9 Weakly correlated
115 LTR16A1 2 n.s 99.0 Weakly correlated
116 LTR16B1 2 * 99.0 Weakly correlated
117 LTR33 2 n.s 99.0 Weakly correlated
118 LTR33A 2 n.s 99.0 Weakly correlated
119 LTR41 2 * 99.0 Weakly correlated
120 LTR55 2 ** 99.0 Weakly correlated
121 LTR78 2 n.s 99.0 Weakly correlated
122 LTR78B 2 n.s 99.0 Weakly correlated
123 MER31A 2 * 87.0 Weakly correlated
124 MER52C 2 * 74.0 Weakly correlated
125 MER52D 2 n.s 74.0 Weakly correlated
126 MER54A 2 * 87.0 Weakly correlated
127 MER61-int 2 n.s 43.0 Weakly correlated
128 MER65C 2 ** 74.0 Weakly correlated
129 MER74A 2 n.s 99.0 Weakly correlated
130 MER89 2 * 99.0 Weakly correlated
131 MLT1E3 2 n.s 99.0 Weakly correlated
132 MLT1G3 2 n.s 99.0 Weakly correlated
133 MLT1L 2 n.s 99.0 Weakly correlated
134 MLT2B4 2 n.s 99.0 Weakly correlated
135 MSTB 2 n.s 43.0 Weakly correlated
136 MSTB1 2 n.s 74.0 Weakly correlated
137 MamSINE1 2 n.s 99.0 Weakly correlated
138 Plat_L3 2 n.s 99.0 Weakly correlated
139 AluSc5 1 n.s 74.0 Weakly correlated
140 AluSg4 1 n.s 74.0 Weakly correlated
141 AluYb8 1 n.s 15.2 Moderately correlated
142 AluYh3a3 1 ** 15.2 Moderately correlated
143 AluYh9 1 *** 15.2 Moderately correlated
144 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
145 FLAM_A 1 n.s 74.0 Weakly correlated
146 FLAM_C 1 n.s 74.0 Weakly correlated
147 HAL1M8 1 n.s 99.0 Weakly correlated
148 HERVK13-int 1 ** 19.6 Moderately correlated
149 HERVL40-int 1 n.s 99.0 Weakly correlated
150 HERVS71-int 1 n.s 28.9 Weakly correlated
151 Harlequin-int 1 n.s 74.0 Weakly correlated
152 L1M4a1 1 n.s 99.0 Weakly correlated
153 L1M8 1 n.s 99.0 Weakly correlated
154 L1MA4A 1 n.s 87.0 Weakly correlated
155 L1MA6 1 n.s 87.0 Weakly correlated
156 L1MB5 1 n.s 99.0 Weakly correlated
157 L1MC 1 n.s 99.0 Weakly correlated
158 L1MC3 1 n.s 99.0 Weakly correlated
159 L1MC5 1 n.s 99.0 Weakly correlated
160 L1MCb 1 n.s 99.0 Weakly correlated
161 L1ME2 1 n.s 99.0 Weakly correlated
162 L1ME3B 1 n.s 99.0 Weakly correlated
163 L1ME3E 1 n.s 99.0 Weakly correlated
164 L1ME3F 1 n.s 99.0 Weakly correlated
165 L1MEh 1 n.s 99.0 Weakly correlated
166 L1P4 1 n.s 74.0 Weakly correlated
167 L1P4d 1 * 74.0 Weakly correlated
168 L1PA15 1 n.s 74.0 Weakly correlated
169 L1PB2 1 n.s 74.0 Weakly correlated
170 L1PB4 1 n.s 99.0 Weakly correlated
171 L1PBa1 1 n.s 74.0 Weakly correlated
172 L1PBb 1 n.s 74.0 Weakly correlated
173 L4_A_Mam 1 n.s 99.0 Weakly correlated
174 LTR1 1 * 43.0 Weakly correlated
175 LTR10B2 1 ** 28.9 Weakly correlated
176 LTR10F 1 * 28.9 Weakly correlated
177 LTR15 1 * 28.9 Weakly correlated
178 LTR16 1 n.s 99.0 Weakly correlated
179 LTR16E1 1 n.s 99.0 Weakly correlated
180 LTR17 1 n.s 28.9 Weakly correlated
181 LTR18B 1 * 43.0 Weakly correlated
182 LTR1A2 1 n.s 43.0 Weakly correlated
183 LTR1D 1 n.s 43.0 Weakly correlated
184 LTR2 1 n.s 28.9 Weakly correlated
185 LTR21A 1 ** 28.9 Weakly correlated
186 LTR22B1 1 ** 28.9 Weakly correlated
187 LTR33C 1 n.s 99.0 Weakly correlated
188 LTR37A 1 n.s 99.0 Weakly correlated
189 LTR38-int 1 ** 74.0 Weakly correlated
190 LTR40b 1 n.s 99.0 Weakly correlated
191 LTR41B 1 n.s 99.0 Weakly correlated
192 LTR41C 1 * 99.0 Weakly correlated
193 LTR46 1 ** 43.0 Weakly correlated
194 LTR48B 1 n.s 74.0 Weakly correlated
195 LTR52 1 n.s 99.0 Weakly correlated
196 LTR52-int 1 ** 99.0 Weakly correlated
197 LTR6A 1 * 28.9 Weakly correlated
198 LTR71B 1 * 43.0 Weakly correlated
199 LTR75B 1 ** 99.0 Weakly correlated
200 LTR80B 1 * 99.0 Weakly correlated
201 LTR85a 1 n.s 99.0 Weakly correlated
202 LTR85b 1 n.s 99.0 Weakly correlated
203 LTR85c 1 n.s 99.0 Weakly correlated
204 LTR88c 1 * 99.0 Weakly correlated
205 MER110A 1 * 99.0 Weakly correlated
206 MER11A 1 n.s 28.9 Weakly correlated
207 MER21B 1 n.s 99.0 Weakly correlated
208 MER21C 1 n.s 99.0 Weakly correlated
209 MER39B 1 n.s 74.0 Weakly correlated
210 MER48 1 ** 28.9 Weakly correlated
211 MER50 1 n.s 43.0 Weakly correlated
212 MER51B 1 n.s 43.0 Weakly correlated
213 MER52A 1 n.s 74.0 Weakly correlated
214 MER65A 1 n.s 74.0 Weakly correlated
215 MER65B 1 ** 74.0 Weakly correlated
216 MER66A 1 * 43.0 Weakly correlated
217 MER66B 1 n.s 43.0 Weakly correlated
218 MER66C 1 * 43.0 Weakly correlated
219 MER66D 1 ** 43.0 Weakly correlated
220 MER68 1 n.s 99.0 Weakly correlated
221 MER74B 1 n.s 99.0 Weakly correlated
222 MER9a1 1 * 19.6 Moderately correlated
223 MLT1A 1 n.s 99.0 Weakly correlated
224 MLT1A1 1 n.s 87.0 Weakly correlated
225 MLT1E1 1 n.s 99.0 Weakly correlated
226 MLT1E2 1 n.s 99.0 Weakly correlated
227 MLT1G-int 1 ** 99.0 Weakly correlated
228 MLT1G1 1 n.s 99.0 Weakly correlated
229 MLT1H1 1 n.s 99.0 Weakly correlated
230 MLT1H2 1 n.s 99.0 Weakly correlated
231 MLT1J1 1 n.s 99.0 Weakly correlated
232 MLT2C1 1 n.s 99.0 Weakly correlated
233 MLT2D 1 n.s 99.0 Weakly correlated
234 MSTB1-int 1 * 74.0 Weakly correlated
235 MSTD 1 n.s 74.0 Weakly correlated
236 SVA_E 1 n.s 0.0 Weakly correlated
237 THE1D 1 n.s 43.0 Weakly correlated
238 UCON51 1 **** 319.0 Weakly correlated
239 X7C_LINE 1 ** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA4 772 **** 19.6 Moderately correlated
2 L1PA3 414 **** 19.6 Moderately correlated
3 L1PA5 324 **** 19.6 Moderately correlated
4 L1PA6 258 **** 28.9 Weakly correlated
5 L1P1 138 **** 19.6 Moderately correlated
6 L1PA7 98 **** 74.0 Weakly correlated
7 L1P2 78 **** 28.9 Weakly correlated
8 L1P3 26 **** 74.0 Weakly correlated
9 L1PA8 20 * 74.0 Weakly correlated
10 L1PA2 8 n.s 15.2 Moderately correlated
11 L1HS 7 n.s 8.6 Highly correlated
12 L1PA10 4 n.s 74.0 Weakly correlated
13 L2c 3 n.s 99.0 Weakly correlated
14 AluJo 1 n.s 74.0 Weakly correlated
15 MLT2F 1 n.s 99.0 Weakly correlated
16 L2b 1 n.s 99.0 Weakly correlated
17 L1MD 1 n.s 99.0 Weakly correlated
18 MER110A 1 * 99.0 Weakly correlated
19 L1MC5a 1 n.s 99.0 Weakly correlated
20 MER68 1 n.s 99.0 Weakly correlated
21 L1MEh 1 n.s 99.0 Weakly correlated
22 MLT1J2 1 n.s 99.0 Weakly correlated
23 L1PA14 1 n.s 74.0 Weakly correlated
24 AluSp 1 n.s 74.0 Weakly correlated
25 MIR 1 n.s 99.0 Weakly correlated
26 LTR80B 1 * 99.0 Weakly correlated
27 L1MC1 1 n.s 99.0 Weakly correlated
28 L1M4a2 1 n.s 99.0 Weakly correlated
29 MLT1H2 1 n.s 99.0 Weakly correlated
30 L1PA15 1 n.s 74.0 Weakly correlated
31 L1PA13 1 n.s 74.0 Weakly correlated
32 L1P4d 1 * 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1P1 19.6 Moderately correlated
2 L1P2 28.9 Weakly correlated
3 L1P3 74.0 Weakly correlated