ZRdb KZFP & Repeats
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Human_ZNF91

  • Protein
    Zinc finger protein 91
  • Length
    1191
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    6.0 Mya
  • Uniprot_ID
    Q05481
  • NCBI_ID
    7644
Sequence:
MPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWNMKQHEMVDEPTGICPHFPQDFWPEQSMEDSFQKVLLRKYEKCGHENLQLRKGCKSVDECKVHKEGYNKLNQCLTTAQSKVFQCGKYLKVFYKFLNSNRHTIRHTGKKCFKCKKCVKSFCIRLHKTQHKCVYITEKSCKCKECEKTFHWSSTLTNHKEIHTEDKPYKCEECGKAFKQLSTLTTHKIICAKEKIYKCEECGKAFLWSSTLTRHKRIHTGEKPYKCEECGKAFSHSSTLAKHKRIHTGEKPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKAFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRFHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTGEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKAFKQFSTLTTHKIIHAGKKLYKCEECGKAFNHSSSLSTHKIIHTGEKSYKCEECGKAFLWSSTLRRHKRIHTGEKPYKCEECGKAFSHSSALAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKTFKRLSTLTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKCEECGKAFNWSSSLTKHKRIHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTGEKPYKCKECGKAFKHSSALAKHKIIHAGEKLYKCEECGKAFNQSSNLTTHKIIHTKEKPSKSEECDKAFIWSSTLTEHKRIHTREKTYKCEECGKAFSQPSHLTTHKRMHTGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKPYKCEECGKAFRKSSTLTEHKIIHTGEKPYKCEECGKAFSQSSTLTRHTRMHTGEKPYKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHKRIHTREKPYKCEECGKAFSQSSTLTRHKRLHTGEKPYKCGECGKAFKESSALTKHKIIHTGEKPYKCEKCGKAFNQSSILTNHKKIHTITPVIPLLWEAEAGGSRGQEMETILANTVKPLLY
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 13..84
2 dec2h2 154..176
3 C2h2 179..200
4 C2h2 208..232
5 C2h2 238..260
6 C2h2 266..288
7 C2h2 294..316
8 C2h2 322..344
9 C2h2 350..372
10 C2h2 378..400
11 C2h2 406..428
12 C2h2 434..456
13 C2h2 462..484
14 C2h2 490..512
15 dec2h2 518..540
16 C2h2 546..568
17 C2h2 574..596
18 C2h2 602..624
19 C2h2 630..652
20 C2h2 658..680
21 C2h2 686..708
22 C2h2 714..736
23 C2h2 742..764
24 C2h2 770..792
25 C2h2 798..820
26 C2h2 826..848
27 C2h2 854..876
28 dec2h2 885..904
29 C2h2 910..932
30 C2h2 938..960
31 C2h2 966..988
32 C2h2 994..1016
33 C2h2 1022..1044
34 C2h2 1050..1072
35 C2h2 1078..1100
36 C2h2 1106..1128
37 C2h2 1134..1156
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription factor activity
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Molecular Function zinc ion binding
6 Biological Process negative regulation of DNA-templated transcription
7 Biological Process negative regulation of transposon integration
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_D 1418 **** 15.2 Moderately correlated
2 SVA_F 489 **** 0.0 Weakly correlated
3 SVA_B 428 **** 15.2 Moderately correlated
4 SVA_C 339 **** 15.2 Moderately correlated
5 SVA_A 249 **** 19.6 Moderately correlated
6 SVA_E 102 **** 0.0 Weakly correlated
7 LTR22A 73 **** 43.0 Weakly correlated
8 AluJb 39 n.s 74.0 Weakly correlated
9 AluSx 34 n.s 74.0 Weakly correlated
10 L2a 31 n.s 99.0 Weakly correlated
11 MIRb 26 n.s 99.0 Weakly correlated
12 L1PA2 25 * 15.2 Moderately correlated
13 AluSx1 20 n.s 74.0 Weakly correlated
14 L1MC4 19 n.s 99.0 Weakly correlated
15 MLT1C 19 ** 94.0 Weakly correlated
16 AluSz 18 n.s 74.0 Weakly correlated
17 L1PA3 18 n.s 19.6 Moderately correlated
18 L2b 18 n.s 99.0 Weakly correlated
19 L2c 18 n.s 99.0 Weakly correlated
20 LTR22B1 18 **** 28.9 Weakly correlated
21 MIR 16 n.s 99.0 Weakly correlated
22 MIR3 16 n.s 99.0 Weakly correlated
23 AluJr 14 n.s 74.0 Weakly correlated
24 L2 13 n.s 99.0 Weakly correlated
25 AluY 12 n.s 74.0 Weakly correlated
26 LTR22E 12 **** 28.9 Weakly correlated
27 AluJo 11 n.s 74.0 Weakly correlated
28 AluYa5 11 **** 15.2 Moderately correlated
29 HAL1 11 n.s 99.0 Weakly correlated
30 AluSz6 10 n.s 74.0 Weakly correlated
31 L1PA7 10 n.s 74.0 Weakly correlated
32 MIRc 10 n.s 99.0 Weakly correlated
33 L1ME1 9 n.s 99.0 Weakly correlated
34 AluSc 8 n.s 74.0 Weakly correlated
35 AluSx3 8 n.s 74.0 Weakly correlated
36 L1HS 8 n.s 8.6 Moderately correlated
37 L1MB3 8 n.s 99.0 Weakly correlated
38 AluSc8 7 n.s 74.0 Weakly correlated
39 HERVK22-int 7 **** 43.0 Weakly correlated
40 L1M5 7 n.s 99.0 Weakly correlated
41 L1MB8 7 n.s 99.0 Weakly correlated
42 LTR22C2 7 **** 28.9 Weakly correlated
43 AluSg 6 n.s 74.0 Weakly correlated
44 AluSq2 5 n.s 74.0 Weakly correlated
45 AluYj4 5 ** 0.0 Weakly correlated
46 FLAM_C 5 n.s 74.0 Weakly correlated
47 L1MC3 5 n.s 99.0 Weakly correlated
48 LTR16A 5 * 99.0 Weakly correlated
49 LTR22B 5 **** 28.9 Weakly correlated
50 LTR22C0 5 **** 28.9 Weakly correlated
51 MLT1A0 5 n.s 99.0 Weakly correlated
52 MLT1B 5 n.s 99.0 Weakly correlated
53 L1M2 4 n.s 99.0 Weakly correlated
54 L1MB2 4 n.s 99.0 Weakly correlated
55 L1MB7 4 n.s 99.0 Weakly correlated
56 L1MD2 4 n.s 99.0 Weakly correlated
57 L1MEd 4 n.s 99.0 Weakly correlated
58 L1PA10 4 n.s 74.0 Weakly correlated
59 L1PB1 4 n.s 74.0 Weakly correlated
60 MLT1K 4 n.s 99.0 Weakly correlated
61 MamRTE1 4 n.s 99.0 Weakly correlated
62 AluSg7 3 n.s 74.0 Weakly correlated
63 AluSp 3 n.s 74.0 Weakly correlated
64 FLAM_A 3 n.s 74.0 Weakly correlated
65 L1M1 3 n.s 74.0 Weakly correlated
66 L1M4 3 n.s 99.0 Weakly correlated
67 L1MA4A 3 n.s 87.0 Weakly correlated
68 L1MB5 3 n.s 99.0 Weakly correlated
69 L1MC1 3 n.s 99.0 Weakly correlated
70 L1ME4a 3 n.s 99.0 Weakly correlated
71 L1PA4 3 n.s 19.6 Moderately correlated
72 L1PA8 3 n.s 74.0 Weakly correlated
73 L1PBa 3 n.s 74.0 Weakly correlated
74 L1PBa1 3 * 74.0 Weakly correlated
75 LTR16A1 3 * 99.0 Weakly correlated
76 LTR16C 3 n.s 99.0 Weakly correlated
77 LTR7B 3 ** 28.9 Weakly correlated
78 MER52A 3 n.s 74.0 Weakly correlated
79 MER52C 3 ** 74.0 Weakly correlated
80 MLT1D 3 n.s 99.0 Weakly correlated
81 MLT1L 3 n.s 99.0 Weakly correlated
82 Alu 2 * 74.0 Weakly correlated
83 AluSg4 2 n.s 74.0 Weakly correlated
84 AluSq 2 n.s 74.0 Weakly correlated
85 AluSx4 2 n.s 74.0 Weakly correlated
86 AluYk11 2 *** 15.2 Moderately correlated
87 AmnSINE1 2 * 319.0 Weakly correlated
88 FAM 2 n.s 87.0 Weakly correlated
89 FRAM 2 n.s 74.0 Weakly correlated
90 HAL1ME 2 n.s 99.0 Weakly correlated
91 L1M3f 2 n.s 87.0 Weakly correlated
92 L1M4b 2 n.s 99.0 Weakly correlated
93 L1MA10 2 n.s 99.0 Weakly correlated
94 L1MA7 2 n.s 87.0 Weakly correlated
95 L1MB1 2 n.s 99.0 Weakly correlated
96 L1MC 2 n.s 99.0 Weakly correlated
97 L1MC5a 2 n.s 99.0 Weakly correlated
98 L1MEg 2 n.s 99.0 Weakly correlated
99 L1MEg2 2 ** 99.0 Weakly correlated
100 L1P3 2 n.s 74.0 Weakly correlated
101 L1PA14 2 n.s 74.0 Weakly correlated
102 L3 2 n.s 99.0 Weakly correlated
103 LTR22C 2 **** 28.9 Weakly correlated
104 LTR33C 2 ** 99.0 Weakly correlated
105 LTR75 2 *** 99.0 Weakly correlated
106 LTR8 2 n.s 43.0 Weakly correlated
107 MER66C 2 ** 43.0 Weakly correlated
108 MLT1F 2 n.s 99.0 Weakly correlated
109 MLT1F1 2 n.s 99.0 Weakly correlated
110 MLT1F2 2 n.s 99.0 Weakly correlated
111 MLT1H 2 n.s 99.0 Weakly correlated
112 MLT1J 2 n.s 99.0 Weakly correlated
113 AluJr4 1 n.s 74.0 Weakly correlated
114 AluSq10 1 n.s 74.0 Weakly correlated
115 AluYa8 1 ** 15.2 Moderately correlated
116 AluYc 1 n.s 74.0 Weakly correlated
117 AluYc3 1 * 74.0 Weakly correlated
118 AluYf1 1 n.s 19.6 Moderately correlated
119 AluYh3 1 n.s 15.2 Moderately correlated
120 AluYi6 1 * 15.2 Moderately correlated
121 AluYm1 1 n.s 19.6 Moderately correlated
122 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
123 ERV3-16A3_LTR 1 n.s 99.0 Weakly correlated
124 HERV16-int 1 n.s 99.0 Weakly correlated
125 HERVH-int 1 n.s 28.9 Weakly correlated
126 HERVL74-int 1 * 99.0 Weakly correlated
127 HUERS-P3b-int 1 n.s 43.0 Weakly correlated
128 L1M3 1 n.s 99.0 Weakly correlated
129 L1M4a1 1 n.s 99.0 Weakly correlated
130 L1M4a2 1 n.s 99.0 Weakly correlated
131 L1M4c 1 n.s 99.0 Weakly correlated
132 L1M7 1 n.s 99.0 Weakly correlated
133 L1MA3 1 n.s 74.0 Weakly correlated
134 L1MA5A 1 n.s 87.0 Weakly correlated
135 L1MA6 1 n.s 87.0 Weakly correlated
136 L1MA8 1 n.s 87.0 Weakly correlated
137 L1MA9 1 n.s 99.0 Weakly correlated
138 L1MB4 1 n.s 99.0 Weakly correlated
139 L1MC2 1 n.s 99.0 Weakly correlated
140 L1MCb 1 n.s 99.0 Weakly correlated
141 L1MDa 1 n.s 99.0 Weakly correlated
142 L1ME2 1 n.s 99.0 Weakly correlated
143 L1ME2z 1 n.s 99.0 Weakly correlated
144 L1ME3 1 n.s 99.0 Weakly correlated
145 L1ME3A 1 n.s 99.0 Weakly correlated
146 L1ME3Cz 1 n.s 99.0 Weakly correlated
147 L1ME3E 1 n.s 99.0 Weakly correlated
148 L1ME3G 1 n.s 99.0 Weakly correlated
149 L1MEc 1 n.s 99.0 Weakly correlated
150 L1MEg1 1 n.s 99.0 Weakly correlated
151 L1MEj 1 n.s 99.0 Weakly correlated
152 L1P1 1 n.s 19.6 Moderately correlated
153 L1P2 1 n.s 28.9 Weakly correlated
154 L1P3b 1 ** 43.0 Weakly correlated
155 L1P4 1 n.s 74.0 Weakly correlated
156 L1PA11 1 n.s 74.0 Weakly correlated
157 L1PA15 1 n.s 74.0 Weakly correlated
158 L1PA16 1 n.s 74.0 Weakly correlated
159 L1PA5 1 n.s 19.6 Moderately correlated
160 L1PB2 1 n.s 74.0 Weakly correlated
161 L1PB3 1 n.s 74.0 Weakly correlated
162 L1PB4 1 n.s 99.0 Weakly correlated
163 L1PREC2 1 n.s 43.0 Weakly correlated
164 L4_C_Mam 1 n.s 99.0 Weakly correlated
165 LTR10B1 1 ** 28.9 Weakly correlated
166 LTR10C 1 n.s 28.9 Weakly correlated
167 LTR13 1 n.s 19.6 Moderately correlated
168 LTR16 1 n.s 99.0 Weakly correlated
169 LTR16A2 1 n.s 99.0 Weakly correlated
170 LTR18B 1 * 43.0 Weakly correlated
171 LTR1C3 1 *** 43.0 Weakly correlated
172 LTR25-int 1 n.s 43.0 Weakly correlated
173 LTR26E 1 ** 74.0 Weakly correlated
174 LTR30 1 * 28.9 Weakly correlated
175 LTR33 1 n.s 99.0 Weakly correlated
176 LTR35A 1 ** 43.0 Weakly correlated
177 LTR38 1 * 74.0 Weakly correlated
178 LTR40a 1 n.s 99.0 Weakly correlated
179 LTR42 1 * 74.0 Weakly correlated
180 LTR48 1 n.s 74.0 Weakly correlated
181 LTR52 1 n.s 99.0 Weakly correlated
182 LTR53B 1 ** 99.0 Weakly correlated
183 LTR56 1 n.s 74.0 Weakly correlated
184 LTR5_Hs 1 n.s 0.0 Weakly correlated
185 LTR71A 1 ** 43.0 Weakly correlated
186 LTR73 1 * 99.0 Weakly correlated
187 LTR78 1 n.s 99.0 Weakly correlated
188 LTR79 1 n.s 99.0 Weakly correlated
189 LTR81AB 1 ** 99.0 Weakly correlated
190 LTR81C 1 * 99.0 Weakly correlated
191 LTR8A 1 n.s 43.0 Weakly correlated
192 LTR9B 1 n.s 43.0 Weakly correlated
193 MER21C 1 n.s 99.0 Weakly correlated
194 MER31-int 1 n.s 99.0 Weakly correlated
195 MER39 1 n.s 74.0 Weakly correlated
196 MER41-int 1 n.s 74.0 Weakly correlated
197 MER41B 1 n.s 74.0 Weakly correlated
198 MER49 1 n.s 43.0 Weakly correlated
199 MER4B 1 n.s 74.0 Weakly correlated
200 MER50 1 n.s 43.0 Weakly correlated
201 MER52D 1 n.s 74.0 Weakly correlated
202 MER54A 1 n.s 87.0 Weakly correlated
203 MER57B1 1 n.s 43.0 Weakly correlated
204 MER61-int 1 n.s 43.0 Weakly correlated
205 MER65-int 1 n.s 87.0 Weakly correlated
206 MER74A 1 n.s 99.0 Weakly correlated
207 MER76 1 n.s 99.0 Weakly correlated
208 MER77B 1 n.s 99.0 Weakly correlated
209 MER83C 1 ** 43.0 Weakly correlated
210 MER89 1 n.s 99.0 Weakly correlated
211 MIR1_Amn 1 n.s 319.0 Weakly correlated
212 MLT1E2-int 1 ** 99.0 Weakly correlated
213 MLT1F2-int 1 * 99.0 Weakly correlated
214 MLT1I 1 n.s 99.0 Weakly correlated
215 MLT1J-int 1 n.s 99.0 Weakly correlated
216 MLT1J1 1 n.s 99.0 Weakly correlated
217 MLT1O 1 n.s 99.0 Weakly correlated
218 MLT2D 1 n.s 99.0 Weakly correlated
219 MLT2E 1 * 99.0 Weakly correlated
220 MLT2F 1 n.s 99.0 Weakly correlated
221 MSTA 1 n.s 43.0 Weakly correlated
222 MSTB 1 n.s 43.0 Weakly correlated
223 MSTB-int 1 n.s 43.0 Weakly correlated
224 MSTB1 1 n.s 74.0 Weakly correlated
225 MSTC 1 n.s 74.0 Weakly correlated
226 MamGypLTR1d 1 * 99.0 Weakly correlated
227 MamGypLTR3a 1 n.s 99.0 Weakly correlated
228 PABL_A-int 1 n.s 74.0 Weakly correlated
229 PABL_B-int 1 * 74.0 Weakly correlated
230 Plat_L3 1 n.s 99.0 Weakly correlated
231 THE1A-int 1 n.s 43.0 Weakly correlated
232 THE1B 1 n.s 43.0 Weakly correlated
233 THE1D-int 1 n.s 28.9 Weakly correlated
234 X7B_LINE 1 * 319.0 Weakly correlated
235 X7C_LINE 1 ** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_D 1077 **** 15.2 Moderately correlated
2 SVA_F 405 **** 0.0 Weakly correlated
3 SVA_B 358 **** 15.2 Moderately correlated
4 SVA_C 271 **** 15.2 Moderately correlated
5 SVA_A 210 **** 19.6 Moderately correlated
6 SVA_E 91 **** 0.0 Weakly correlated
7 L1PA2 12 n.s 15.2 Moderately correlated
8 L1PA3 11 n.s 19.6 Moderately correlated
9 L1HS 8 n.s 8.6 Moderately correlated
10 AluYa5 4 n.s 15.2 Moderately correlated
11 AluSc 3 n.s 74.0 Weakly correlated
12 L2c 2 n.s 99.0 Weakly correlated
13 L2a 2 n.s 99.0 Weakly correlated
14 AluJo 1 n.s 74.0 Weakly correlated
15 LTR48 1 n.s 74.0 Weakly correlated
16 LTR78 1 n.s 99.0 Weakly correlated
17 MER52C 1 n.s 74.0 Weakly correlated
18 L1MC1 1 n.s 99.0 Weakly correlated
19 L1PB2 1 n.s 74.0 Weakly correlated
20 L2 1 n.s 99.0 Weakly correlated
21 L2b 1 n.s 99.0 Weakly correlated
22 MLT1A0 1 n.s 99.0 Weakly correlated
23 MLT1E2-int 1 ** 99.0 Weakly correlated
24 AluYk11 1 * 15.2 Moderately correlated
25 AluSq2 1 n.s 74.0 Weakly correlated
26 MLT1C 1 n.s 94.0 Weakly correlated
27 LTR22B1 1 ** 28.9 Weakly correlated
28 L1P1 1 n.s 19.6 Moderately correlated
29 AluJr 1 n.s 74.0 Weakly correlated
30 LTR16A 1 n.s 99.0 Weakly correlated
31 MIRb 1 n.s 99.0 Weakly correlated
32 MLT1F1 1 n.s 99.0 Weakly correlated
33 L1PA7 1 n.s 74.0 Weakly correlated
34 L1PA5 1 n.s 19.6 Moderately correlated
35 L1MB2 1 n.s 99.0 Weakly correlated
36 AluYf1 1 n.s 19.6 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP