ZRdb KZFP & Repeats
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Human_ZNF891

  • Protein
    Zinc finger protein 891
  • Length
    544
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    A8MT65
  • NCBI_ID
    101060200
Sequence:
MAVMDLSSPWALTKQDSACFHLRNAEEERMIAVFLTTWLQEPMTFKDVAVEFTQEEWMMLDSAQRSLYRDVMLENYRNLTSVEYQLYRLTVISPLDQEEIRNMKKRIPQAICPDQKIQPKTKESTVQKILWEEPSNAVKMIKLTMHNWSSTLREDWECHKIRKQHKIPGGHWRQMIYAPKKTVPQELFRDYHELEENSKLGSKLIFSQSIFTSKHCQKCYSEIGCLKHNSIINNYVKNSISEKLYESHECDTTLWHFQRNQTVQKEYTYSKHGMHFTHNMFPVPNNLHMAQNACECNKDETLCHQSSLKKQGQTHTEKKHECNQCGKAFKRISNLTLYKKSHMGEKQYECKECGKVFNDSSTLRRHVRTHTGEKPYECNQCGKAFSQKTSLKAHMRTHTGEKPYECNQCGKSFGTSSYLIVHKRIHTGEKLYECSECGKAFNTSSHLKVHKKIHTGENVYECSDCGKVFSGVSSLRMHIRTHTGEKPYECKECRKAFSVSSSLRRHVRIHTGEKPYECIQCGKAFSQSSSLIIHKRIHTERETL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 43..113
2 dec2h2 320..342
3 C2h2 348..370
4 C2h2 376..398
5 C2h2 404..426
6 C2h2 432..454
7 C2h2 460..482
8 C2h2 488..510
9 C2h2 516..538
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR33B 11 **** 99.0 Highly correlated
2 AluJb 5 n.s 74.0 Weakly correlated
3 LTR10A 4 **** 28.9 Weakly correlated
4 L1P3 4 **** 74.0 Weakly correlated
5 LTR10F 3 **** 28.9 Weakly correlated
6 L1PA2 3 * 15.2 Weakly correlated
7 MIRb 2 n.s 99.0 Highly correlated
8 LTR14B 2 **** 28.9 Weakly correlated
9 L2c 2 n.s 99.0 Highly correlated
10 L2a 2 n.s 99.0 Highly correlated
11 MIR3 2 n.s 99.0 Highly correlated
12 MLT1B 2 * 99.0 Highly correlated
13 MLT1C 2 * 94.0 Weakly correlated
14 AluY 2 n.s 74.0 Weakly correlated
15 AluSx 2 n.s 74.0 Weakly correlated
16 MER52D 1 ** 74.0 Weakly correlated
17 THE1D-int 1 * 28.9 Weakly correlated
18 LTR67B 1 ** 99.0 Highly correlated
19 MSTD 1 * 74.0 Weakly correlated
20 LTR8B 1 ** 43.0 Weakly correlated
21 MLT1L 1 * 99.0 Highly correlated
22 MLT1H 1 * 99.0 Highly correlated
23 MLT1F 1 * 99.0 Highly correlated
24 MLT1A1 1 * 87.0 Weakly correlated
25 MER66B 1 ** 43.0 Weakly correlated
26 MIR 1 n.s 99.0 Highly correlated
27 LTR10B1 1 **** 28.9 Weakly correlated
28 MLT1A 1 * 99.0 Highly correlated
29 L1P4 1 * 74.0 Weakly correlated
30 AluJr 1 n.s 74.0 Weakly correlated
31 AluSc5 1 * 74.0 Weakly correlated
32 AluSg 1 n.s 74.0 Weakly correlated
33 AluSz 1 n.s 74.0 Weakly correlated
34 AluSz6 1 n.s 74.0 Weakly correlated
35 HAL1 1 n.s 99.0 Highly correlated
36 HAL1b 1 * 99.0 Highly correlated
37 L1M4 1 n.s 99.0 Highly correlated
38 LTR2C 1 **** 19.6 Weakly correlated
39 L1PA5 1 n.s 19.6 Weakly correlated
40 L1PA8 1 n.s 74.0 Weakly correlated
41 L1PB1 1 n.s 74.0 Weakly correlated
42 L2 1 n.s 99.0 Highly correlated
43 L2b 1 n.s 99.0 Highly correlated
44 LTR13 1 ** 19.6 Weakly correlated
45 LTR2 1 *** 28.9 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 4 **** 74.0 Weakly correlated
2 L1P4 1 * 74.0 Weakly correlated
3 LTR67B 1 ** 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP