ZRdb KZFP & Repeats
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Human_ZNF878

  • Protein
    Zinc finger protein 878
  • Length
    531
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    C9JN71
  • NCBI_ID
    729747
Sequence:
MDSVAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIGKKWNNQYIEDEHQNPRRNLRRLIGERLSESKESHQHGEVLTQVPDDTLKKKTPGVQSYESSVCGEIGIGLSSLNRHLRAFSYSSSLAIHGRTHTGEKPYECKECGKAFRFPSSVRRHERIHSAKKPYECKQCGKAFSFPSSVRRHERIHSAKKPYECKQCGKALSYLVSFQTHMRMHTGERPHKCNICGKAFFSPSSLKRHEKSHTGEKRYKCKQCDKAFNCPSSFQYHERTHSGEKPYECTQCRKAFRSVKYLRVHERKHTGEKPYECKLCGKGFISSTSFRYHEKTHTGEKPYECKKCVKAFSFVKDLRIHERTHTGEKPFECKQCGKTFTSSNSFHYHERTHTGEKPYECKQCGKAFRSASVLQKHIRTHTGEKPYGCKQCGKVFRVASQLKMHERTHTGEKPYECKQCGKAFISSNSIRYHKRTHTGEKPYKCKQCGKAFISSNSFLYHERIHTGEKPYECKQCGKAFRSASILQKHVRTHAG
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 4..90
2 dec2h2 122..137
3 C2h2 143..165
4 C2h2 171..193
5 C2h2 199..221
6 C2h2 227..249
7 C2h2 255..277
8 C2h2 283..305
9 C2h2 311..333
10 C2h2 339..361
11 C2h2 367..389
12 C2h2 395..417
13 C2h2 423..445
14 C2h2 451..473
15 C2h2 479..501
16 C2h2 507..529
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_F 40 **** 0.0 Weakly correlated
2 AluJb 32 n.s 74.0 Weakly correlated
3 AluSx 26 n.s 74.0 Weakly correlated
4 AluSx1 24 n.s 74.0 Weakly correlated
5 AluY 24 n.s 74.0 Weakly correlated
6 L2c 23 n.s 99.0 Weakly correlated
7 L2a 21 n.s 99.0 Weakly correlated
8 AluSp 18 n.s 74.0 Weakly correlated
9 AluSc8 16 *** 74.0 Weakly correlated
10 AluSz 15 n.s 74.0 Weakly correlated
11 MIRb 15 n.s 99.0 Weakly correlated
12 MER66C 14 **** 43.0 Highly correlated
13 LTR12C 13 **** 19.6 Weakly correlated
14 MIR 13 n.s 99.0 Weakly correlated
15 SVA_D 13 **** 15.2 Weakly correlated
16 AluJo 11 n.s 74.0 Weakly correlated
17 AluJr 11 n.s 74.0 Weakly correlated
18 LTR8 11 **** 43.0 Highly correlated
19 MIRc 11 n.s 99.0 Weakly correlated
20 AluSc 10 n.s 74.0 Weakly correlated
21 L1P3 10 *** 74.0 Weakly correlated
22 MER11A 10 **** 28.9 Weakly correlated
23 MER4A 10 **** 74.0 Weakly correlated
24 SVA_E 10 **** 0.0 Weakly correlated
25 L1PB1 9 n.s 74.0 Weakly correlated
26 L3 9 n.s 99.0 Weakly correlated
27 MIR3 9 n.s 99.0 Weakly correlated
28 AluSx3 8 n.s 74.0 Weakly correlated
29 AluSz6 8 n.s 74.0 Weakly correlated
30 L1MC4 7 n.s 99.0 Weakly correlated
31 L1ME1 7 n.s 99.0 Weakly correlated
32 L2 7 n.s 99.0 Weakly correlated
33 MER57A-int 7 **** 43.0 Highly correlated
34 AluYj4 6 **** 0.0 Weakly correlated
35 L2b 6 n.s 99.0 Weakly correlated
36 AluSg 5 n.s 74.0 Weakly correlated
37 L1M5 5 n.s 99.0 Weakly correlated
38 L1MA4A 5 n.s 87.0 Weakly correlated
39 L1MC5 5 n.s 99.0 Weakly correlated
40 L1MEf 5 n.s 99.0 Weakly correlated
41 MER21B 5 ** 99.0 Weakly correlated
42 AluSq 4 n.s 74.0 Weakly correlated
43 AluYc 4 ** 74.0 Weakly correlated
44 HAL1 4 n.s 99.0 Weakly correlated
45 HAL1ME 4 n.s 99.0 Weakly correlated
46 L1M4 4 n.s 99.0 Weakly correlated
47 L1MB8 4 n.s 99.0 Weakly correlated
48 L1MCa 4 n.s 99.0 Weakly correlated
49 L1ME4a 4 n.s 99.0 Weakly correlated
50 L1PA7 4 n.s 74.0 Weakly correlated
51 LTR10A 4 **** 28.9 Weakly correlated
52 LTR33 4 n.s 99.0 Weakly correlated
53 MLT1L 4 n.s 99.0 Weakly correlated
54 MLT2A2 4 * 74.0 Weakly correlated
55 MLT2B1 4 * 99.0 Weakly correlated
56 AluSg4 3 n.s 74.0 Weakly correlated
57 AluSq2 3 n.s 74.0 Weakly correlated
58 FRAM 3 * 74.0 Weakly correlated
59 L1MA7 3 n.s 87.0 Weakly correlated
60 L1MB4 3 n.s 99.0 Weakly correlated
61 L1MC5a 3 n.s 99.0 Weakly correlated
62 L1MD1 3 n.s 99.0 Weakly correlated
63 L1MDa 3 n.s 99.0 Weakly correlated
64 L1MEc 3 n.s 99.0 Weakly correlated
65 L1MEg 3 n.s 99.0 Weakly correlated
66 L1PA5 3 n.s 19.6 Weakly correlated
67 L1PA8 3 n.s 74.0 Weakly correlated
68 L4_A_Mam 3 n.s 99.0 Weakly correlated
69 LTR10F 3 **** 28.9 Weakly correlated
70 LTR37B 3 ** 99.0 Weakly correlated
71 LTR41 3 *** 99.0 Weakly correlated
72 MER4-int 3 n.s 74.0 Weakly correlated
73 MLT1K 3 n.s 99.0 Weakly correlated
74 THE1D 3 n.s 43.0 Highly correlated
75 FLAM_C 2 n.s 74.0 Weakly correlated
76 HERV9-int 2 n.s 28.9 Weakly correlated
77 L1HS 2 n.s 8.6 Weakly correlated
78 L1M4b 2 n.s 99.0 Weakly correlated
79 L1M6 2 n.s 99.0 Weakly correlated
80 L1MA2 2 n.s 74.0 Weakly correlated
81 L1MA6 2 n.s 87.0 Weakly correlated
82 L1MA9 2 n.s 99.0 Weakly correlated
83 L1MB5 2 n.s 99.0 Weakly correlated
84 L1MB7 2 n.s 99.0 Weakly correlated
85 L1MC1 2 n.s 99.0 Weakly correlated
86 L1MD2 2 n.s 99.0 Weakly correlated
87 L1ME2 2 n.s 99.0 Weakly correlated
88 L1ME3A 2 n.s 99.0 Weakly correlated
89 L1MEd 2 n.s 99.0 Weakly correlated
90 L1P4 2 n.s 74.0 Weakly correlated
91 L1PA13 2 n.s 74.0 Weakly correlated
92 L1PA2 2 n.s 15.2 Weakly correlated
93 L1PA4 2 n.s 19.6 Weakly correlated
94 LOR1-int 2 * 74.0 Weakly correlated
95 LTR24B 2 *** 74.0 Weakly correlated
96 MER49 2 * 43.0 Highly correlated
97 MER4B-int 2 * 99.0 Weakly correlated
98 MER52A 2 n.s 74.0 Weakly correlated
99 MER65-int 2 * 87.0 Weakly correlated
100 MER66-int 2 * 43.0 Highly correlated
101 MER83A-int 2 **** 99.0 Weakly correlated
102 MIR1_Amn 2 n.s 319.0 Weakly correlated
103 MLT1A0 2 n.s 99.0 Weakly correlated
104 MLT1A1 2 n.s 87.0 Weakly correlated
105 MLT1C 2 n.s 94.0 Weakly correlated
106 MLT1D 2 n.s 99.0 Weakly correlated
107 MLT1E1A 2 n.s 99.0 Weakly correlated
108 MLT1J 2 n.s 99.0 Weakly correlated
109 MLT2B3 2 n.s 99.0 Weakly correlated
110 MSTB 2 n.s 43.0 Highly correlated
111 MamGypLTR1d 2 *** 99.0 Weakly correlated
112 THE1B 2 n.s 43.0 Highly correlated
113 Alu 1 * 74.0 Weakly correlated
114 AluJr4 1 n.s 74.0 Weakly correlated
115 AluSc5 1 n.s 74.0 Weakly correlated
116 AluSq10 1 n.s 74.0 Weakly correlated
117 AluSx4 1 n.s 74.0 Weakly correlated
118 AluYa5 1 n.s 15.2 Weakly correlated
119 AluYa8 1 ** 15.2 Weakly correlated
120 AluYb8 1 n.s 15.2 Weakly correlated
121 AluYg6 1 * 15.2 Weakly correlated
122 AluYh3 1 n.s 15.2 Weakly correlated
123 AluYh9 1 **** 15.2 Weakly correlated
124 AluYk4 1 * 15.2 Weakly correlated
125 AluYm1 1 n.s 19.6 Weakly correlated
126 AmnSINE1 1 * 319.0 Weakly correlated
127 ERVL-B4-int 1 n.s 99.0 Weakly correlated
128 HERV15-int 1 * 28.9 Weakly correlated
129 HERVK14-int 1 * 28.9 Weakly correlated
130 L1M2 1 n.s 99.0 Weakly correlated
131 L1M3 1 n.s 99.0 Weakly correlated
132 L1M3f 1 n.s 87.0 Weakly correlated
133 L1M4a1 1 n.s 99.0 Weakly correlated
134 L1M4a2 1 n.s 99.0 Weakly correlated
135 L1M7 1 n.s 99.0 Weakly correlated
136 L1M8 1 n.s 99.0 Weakly correlated
137 L1MA3 1 n.s 74.0 Weakly correlated
138 L1MA8 1 n.s 87.0 Weakly correlated
139 L1MB3 1 n.s 99.0 Weakly correlated
140 L1MC3 1 n.s 99.0 Weakly correlated
141 L1MC4a 1 n.s 99.0 Weakly correlated
142 L1MD 1 n.s 99.0 Weakly correlated
143 L1MD3 1 n.s 99.0 Weakly correlated
144 L1MDb 1 n.s 99.0 Weakly correlated
145 L1ME2z 1 n.s 99.0 Weakly correlated
146 L1ME3B 1 n.s 99.0 Weakly correlated
147 L1ME3Cz 1 n.s 99.0 Weakly correlated
148 L1ME3D 1 n.s 99.0 Weakly correlated
149 L1ME3F 1 n.s 99.0 Weakly correlated
150 L1ME4b 1 n.s 99.0 Weakly correlated
151 L1ME4c 1 n.s 99.0 Weakly correlated
152 L1MEb 1 n.s 99.0 Weakly correlated
153 L1MEg2 1 * 99.0 Weakly correlated
154 L1P1 1 n.s 19.6 Weakly correlated
155 L1PA11 1 n.s 74.0 Weakly correlated
156 L1PA15 1 n.s 74.0 Weakly correlated
157 L1PA15-16 1 n.s 74.0 Weakly correlated
158 L1PA6 1 n.s 28.9 Weakly correlated
159 L1PB 1 n.s 74.0 Weakly correlated
160 L1PB3 1 n.s 74.0 Weakly correlated
161 L1PREC2 1 n.s 43.0 Highly correlated
162 L3b 1 n.s 99.0 Weakly correlated
163 LTR103_Mam 1 ** 99.0 Weakly correlated
164 LTR105_Mam 1 * 99.0 Weakly correlated
165 LTR10B1 1 ** 28.9 Weakly correlated
166 LTR13 1 n.s 19.6 Weakly correlated
167 LTR14B 1 * 28.9 Weakly correlated
168 LTR16A1 1 n.s 99.0 Weakly correlated
169 LTR1A1 1 * 43.0 Highly correlated
170 LTR1B 1 * 43.0 Highly correlated
171 LTR1F2 1 ** 43.0 Highly correlated
172 LTR21B 1 *** 28.9 Weakly correlated
173 LTR25-int 1 n.s 43.0 Highly correlated
174 LTR27C 1 ** 43.0 Highly correlated
175 LTR27E 1 * 43.0 Highly correlated
176 LTR2B 1 * 19.6 Weakly correlated
177 LTR30 1 ** 28.9 Weakly correlated
178 LTR40a 1 n.s 99.0 Weakly correlated
179 LTR41C 1 * 99.0 Weakly correlated
180 LTR45C 1 * 99.0 Weakly correlated
181 LTR52 1 * 99.0 Weakly correlated
182 LTR52-int 1 ** 99.0 Weakly correlated
183 LTR5_Hs 1 n.s 0.0 Weakly correlated
184 LTR75 1 ** 99.0 Weakly correlated
185 LTR78 1 n.s 99.0 Weakly correlated
186 LTR81A 1 * 99.0 Weakly correlated
187 LTR85c 1 * 99.0 Weakly correlated
188 LTR86A1 1 ** 99.0 Weakly correlated
189 LTR86B1 1 ** 99.0 Weakly correlated
190 LTR87 1 * 99.0 Weakly correlated
191 LTR8A 1 n.s 43.0 Highly correlated
192 MER110A 1 * 99.0 Weakly correlated
193 MER11B 1 n.s 19.6 Weakly correlated
194 MER21C 1 n.s 99.0 Weakly correlated
195 MER34-int 1 * 99.0 Weakly correlated
196 MER34C_ 1 * 87.0 Weakly correlated
197 MER39 1 n.s 74.0 Weakly correlated
198 MER39B 1 n.s 74.0 Weakly correlated
199 MER41A 1 n.s 74.0 Weakly correlated
200 MER4A1 1 n.s 74.0 Weakly correlated
201 MER4B 1 n.s 74.0 Weakly correlated
202 MER4CL34 1 n.s 43.0 Highly correlated
203 MER4E1 1 n.s 74.0 Weakly correlated
204 MER50 1 n.s 43.0 Highly correlated
205 MER52C 1 * 74.0 Weakly correlated
206 MER57-int 1 n.s 87.0 Weakly correlated
207 MER67C 1 n.s 99.0 Weakly correlated
208 MLT1B 1 n.s 99.0 Weakly correlated
209 MLT1E3 1 n.s 99.0 Weakly correlated
210 MLT1H 1 n.s 99.0 Weakly correlated
211 MLT1H2 1 n.s 99.0 Weakly correlated
212 MLT1I 1 n.s 99.0 Weakly correlated
213 MLT1J1 1 n.s 99.0 Weakly correlated
214 MLT1N2 1 n.s 99.0 Weakly correlated
215 MLT2F 1 n.s 99.0 Weakly correlated
216 MSTA 1 n.s 43.0 Highly correlated
217 MamGypLTR1a 1 * 99.0 Weakly correlated
218 MamGypLTR1c 1 * 99.0 Weakly correlated
219 MamGypLTR3a 1 * 99.0 Weakly correlated
220 MamGypsy2-LTR 1 ** 99.0 Weakly correlated
221 PABL_A-int 1 * 74.0 Weakly correlated
222 PRIMA41-int 1 n.s 74.0 Weakly correlated
223 PRIMA4_LTR 1 * 74.0 Weakly correlated
224 Plat_L3 1 n.s 99.0 Weakly correlated
225 SVA_A 1 n.s 19.6 Weakly correlated
226 SVA_C 1 n.s 15.2 Weakly correlated
227 THE1A 1 n.s 43.0 Highly correlated
228 THE1A-int 1 n.s 43.0 Highly correlated
229 THE1B-int 1 n.s 43.0 Highly correlated
230 THE1C 1 n.s 43.0 Highly correlated
231 THE1D-int 1 n.s 28.9 Weakly correlated
232 X6B_LINE 1 ** 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJr 3 n.s 74.0 Weakly correlated
2 AluSp 2 n.s 74.0 Weakly correlated
3 AluSx3 2 n.s 74.0 Weakly correlated
4 L1ME1 2 n.s 99.0 Weakly correlated
5 L1MEd 1 n.s 99.0 Weakly correlated
6 MER66-int 1 n.s 43.0 Highly correlated
7 AluSq2 1 n.s 74.0 Weakly correlated
8 MER11A 1 n.s 28.9 Weakly correlated
9 L1PB 1 n.s 74.0 Weakly correlated
10 L1MEg2 1 * 99.0 Weakly correlated
11 L1M5 1 n.s 99.0 Weakly correlated
12 L1M4b 1 n.s 99.0 Weakly correlated
13 HERV15-int 1 * 28.9 Weakly correlated
14 AluJb 1 n.s 74.0 Weakly correlated
15 L2 1 n.s 99.0 Weakly correlated
16 AluSz6 1 n.s 74.0 Weakly correlated
17 L2a 1 n.s 99.0 Weakly correlated
18 L1PA7 1 n.s 74.0 Weakly correlated
19 L1MA4A 1 n.s 87.0 Weakly correlated
20 L1M4 1 n.s 99.0 Weakly correlated
21 LTR86B1 1 ** 99.0 Weakly correlated
22 L1MDa 1 n.s 99.0 Weakly correlated
23 L1MD 1 n.s 99.0 Weakly correlated
24 MIRb 1 n.s 99.0 Weakly correlated
25 L2c 1 n.s 99.0 Weakly correlated
26 L1MCa 1 n.s 99.0 Weakly correlated
27 AluSx1 1 n.s 74.0 Weakly correlated
28 LTR24B 1 ** 74.0 Weakly correlated
29 L1PA2 1 n.s 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP