ZRdb KZFP & Repeats
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Human_ZNF860

  • Protein
    Zinc finger protein 860
  • Length
    632
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    6.4 Mya
  • Time of Changing in binding specificity
    0.0 Mya
  • Uniprot_ID
    A6NHJ4
  • NCBI_ID
    344787
Sequence:
MLREEAAQKRKEKEPGMALPQGHLTFRDVAIEFSLEEWKCLDPTQRALYRAMMLENYRNLHSVDISSKCMMKKFSSTAQGNTEVDTGTLERHESHHIGDFCFQKIGKDIHDFEFQWQEDKRNSHEATMTQIKKLTGSTDRYDRRHPGNKPIKDQLGLSFHSHLPELHIFQTKGKVGNQVEKSINDASSVLTSQRISSRPKIHISNNYENNFFHSSLLTLKQEVHIREKSFQCNESGKAFNCSSLLRKHQIIYLGGKQYKCDVCGKVFNQKRYLACHHRCHTGEKPYKCNECGKVFNQQSNLASHHRLHTGEKPYKCEECDKVFSRKSNLERHRRIHTGEKPYKCKVCEKAFRRDSHLTQHTRIHTGEKPYKCNECGKAFSGQSTLIHHQAIHGIGKLYKCNDCHKVFSNATTIANHWRIHNEERSYKCNKCGKFFRRRSYLVVHWRTHTGEKPYKCNECGKTFHHNSALVIHKAIHTGEKPYKCNECGKTFRHNSALVIHKAIHTGEKPYKCNECGKVFNQQATLARHHRLHTGEKPYKCEECDTVFSRKSHHETHKRIHTGEKPYKCDDFDEAFSQASSYAKQRRIHMGEKHHKCDDCGKAFTSHSHRIRHQRIHTGQKSYKCHKRGKVFS
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 24..99
2 dec2h2 230..252
3 C2h2 258..280
4 C2h2 286..308
5 C2h2 314..336
6 C2h2 342..364
7 C2h2 370..392
8 C2h2 398..420
9 C2h2 426..448
10 C2h2 454..476
11 C2h2 482..504
12 C2h2 510..532
13 C2h2 538..560
14 dec2h2 566..588
15 C2h2 594..616
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR10A 4 **** 28.9 Weakly correlated
2 MIRb 4 n.s 99.0 Weakly correlated
3 AluSc8 3 * 74.0 Weakly correlated
4 MIR 3 n.s 99.0 Weakly correlated
5 MIRc 3 n.s 99.0 Weakly correlated
6 AluSx3 2 n.s 74.0 Weakly correlated
7 AluY 2 n.s 74.0 Weakly correlated
8 L1MEc 2 n.s 99.0 Weakly correlated
9 L1P3 2 * 74.0 Weakly correlated
10 L1PA2 2 n.s 15.2 Weakly correlated
11 L1PA5 2 n.s 19.6 Weakly correlated
12 MIR3 1 n.s 99.0 Weakly correlated
13 MamGypLTR3 1 *** 99.0 Weakly correlated
14 MER50-int 1 ** 43.0 Weakly correlated
15 MER50 1 * 43.0 Weakly correlated
16 MER39B 1 ** 74.0 Weakly correlated
17 LTR16 1 * 99.0 Weakly correlated
18 LTR13 1 ** 19.6 Weakly correlated
19 MamRTE1 1 * 99.0 Weakly correlated
20 L2c 1 n.s 99.0 Weakly correlated
21 L2a 1 n.s 99.0 Weakly correlated
22 L1PA15-16 1 * 74.0 Weakly correlated
23 L1P4 1 * 74.0 Weakly correlated
24 L1P2 1 n.s 28.9 Weakly correlated
25 L1MA9 1 n.s 99.0 Weakly correlated
26 HAL1 1 n.s 99.0 Weakly correlated
27 FLAM_C 1 n.s 74.0 Weakly correlated
28 AluSz6 1 n.s 74.0 Weakly correlated
29 AluSz 1 n.s 74.0 Weakly correlated
30 AluSx1 1 n.s 74.0 Weakly correlated
31 AluSp 1 n.s 74.0 Weakly correlated
32 AluSg 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MIR3 1 n.s 99.0 Weakly correlated
2 L1PA5 1 n.s 19.6 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP