ZRdb KZFP & Repeats
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Human_ZNF852

  • Protein
    Zinc finger protein 852
  • Length
    543
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q6ZMS4
  • NCBI_ID
    285346
Sequence:
MVRPQDTVAYEDLSEDYTQKKWKGLALSQRALHWNMMLENDRSMASLGRNMMESSELTPKQEIFKGSESSNSTSGGLFGVVPGGTETGDVCEDTFKELEGQPSNEEGSRLESDFLEIIDEDKKKSTKDRYEEYKEVEEHPPLSSSPVEHEGVLKGQKSYRCDECGKAFYWSSHLIGHRRIHTGEKPYECNECGKTFRQTSQLIVHLRTHTGEKPYECSECGKAYRHSSHLIQHQRLHNGEKPYKCNECAKAFNQSSKLFDHQRTHTGEKPYECKECGAAFSRSKNLVRHQFLHTGKKPYKCNECGRAFCSNRNLIDHQRTHTGEKPYKCNECGKAFSRSKCLIRHQSLHTGEKPYKCSECGKAFNQISQLVEHERIHTGEKPFKCSECGKAFGLSKCLIRHQRLHTSEKPYKCNECGKSFNQNSYLIIHQRIHTGEKPYECNECGKVFSYNSSLMVHQRTHTGEKPYKCNSCGKAFSDSSQLTVHQRVHTGEKNLMNVLSVGKPLVSVPLLITTSELMLERSPQVWLGHLLKAWFSETDSKDL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..82
2 C2h2 159..181
3 C2h2 187..209
4 C2h2 215..237
5 C2h2 243..265
6 C2h2 271..293
7 C2h2 299..321
8 C2h2 327..349
9 C2h2 355..377
10 C2h2 383..405
11 C2h2 411..433
12 C2h2 439..461
13 C2h2 467..489
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_F 8 **** 0.0 Weakly correlated
2 MER21B 5 **** 99.0 Moderately correlated
3 LTR10A 4 **** 28.9 Weakly correlated
4 L1PA10 3 n.s 74.0 Weakly correlated
5 AluSc8 2 n.s 74.0 Weakly correlated
6 AluJb 2 n.s 74.0 Weakly correlated
7 AluY 2 n.s 74.0 Weakly correlated
8 MLT1E3 2 ** 99.0 Moderately correlated
9 L1MA8 2 n.s 87.0 Weakly correlated
10 L1MB8 2 n.s 99.0 Moderately correlated
11 L2c 2 n.s 99.0 Moderately correlated
12 L1PA5 2 n.s 19.6 Weakly correlated
13 LTR19C 1 *** 43.0 Weakly correlated
14 THE1B-int 1 n.s 43.0 Weakly correlated
15 LTR76 1 *** 74.0 Weakly correlated
16 MER34A 1 * 99.0 Moderately correlated
17 MER50 1 n.s 43.0 Weakly correlated
18 MER52A 1 n.s 74.0 Weakly correlated
19 MIRc 1 n.s 99.0 Moderately correlated
20 MLT1L 1 n.s 99.0 Moderately correlated
21 LTR13 1 * 19.6 Weakly correlated
22 LTR10B1 1 *** 28.9 Weakly correlated
23 L2b 1 n.s 99.0 Moderately correlated
24 L2a 1 n.s 99.0 Moderately correlated
25 L1PA2 1 n.s 15.2 Weakly correlated
26 L1MC4 1 n.s 99.0 Moderately correlated
27 L1HS 1 n.s 8.6 Weakly correlated
28 ERV3-16A3_I-int 1 n.s 99.0 Moderately correlated
29 AluYa8 1 *** 15.2 Weakly correlated
30 AluSz6 1 n.s 74.0 Weakly correlated
31 AluSx 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER21B 2 * 99.0 Moderately correlated
2 L1PA10 1 n.s 74.0 Weakly correlated
3 L2c 1 n.s 99.0 Moderately correlated
4 AluYa8 1 *** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP