ZRdb KZFP & Repeats
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Human_ZNF850

  • Protein
    Zinc finger protein 850
  • Length
    1090
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    A8MQ14
  • NCBI_ID
    342892
Sequence:
MNMEGLVMFQDLSIDFSQEEWECLDAAQKDLYRDVMMENYSSLVSLGLSIPKPDVISLLEQGKEPWMVSRDVLGGWCRDSEFRCKTKDSCLPKEIYEVTSSQWVRMEKCHSLVGSSVRDDWECKGQFQHQDINQERYLEKAIMTYETTPTFCLQTSLTLHHRIHPGEKLYKSTECMAFKYGSELTQQQETHTGEKLYKCKECGKAFHHFSYLVKHQRIHTGEKPCACKEYGKAFISGSHLIQHQKMYTDERPHECQESVKAFRPSAHLIQHWRIHTGDKPYECKECGKSFTSGSTLNQHQQIHTGEKPYHCKQCGKSFTVGSTLIRHQQIHTGEKPYDCKECGKSFASGSALIRHQRIHTGEKPYDCKECGKSFTFHSALIRHQRIHTGEKPYDCKECGKSFTFRSGLIGHQAIHTGEKPYDCKECGKSFTAGSTLIQHQRIHTGEKPYDCKECGKSFASGSALLQHQRIHTGEKPYCCKECGKSFTFRSTRNRHQRIHTGEKPYNCKECGKSFASGSALLQHQRIHTGEKPYHCKECGKSFTFRSGLIGHQAVHTGEKPYDCKECGKSFTSRSALIQHQRIHTGEKPYHCKECGKSFTVGSTLLQHQQIHTGEKPYDCKECGKAFRLRLRLTQHQQIHTGEKPYQCQECGKAFVSVSGLTQHHRIHTGEKPYECPDCGKAFRQRTYLNQHRRIHTGEKPYECKECGKSFTFCSGLIQHQQNHTDEKPYDGKECGKSFTSHSTLIQHQQIHTGEKPYDCKECGKSFTSHSTLIQHQQIHTGEKLYDCKECGKSFTSHSTLIQHQPLHTGEKPYHCKECGKSFTLRSALIQHRPVHTGEKRYSCKECGKSFTSRSTLIEHQRIHTGEKPYHCKECGKSFAFRSAIIQHRRIHTGEKPYDCKECGKAFRRRSKLTQHQRIHTGEKPYRCHECGKAFVRFSGLTKHHSIHTGEKPYECKTCGKSFRQRTHLTLHQRIHTGDRPYECKECGKSFTCGSELIRHQRTHTGEKPYDCKECGKAFRCPSQLSQHKRIHTGEKTYQCPECGKAFFYASGLSRHQSVHTGEKPYECKTCGKAFKQLTQLTRHQRIHDLT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 7..78
2 C2h2 197..219
3 dec2h2 225..247
4 dec2h2 253..275
5 C2h2 281..303
6 C2h2 309..331
7 C2h2 337..359
8 C2h2 365..387
9 C2h2 393..415
10 C2h2 421..443
11 C2h2 449..471
12 C2h2 477..499
13 C2h2 505..527
14 C2h2 533..555
15 C2h2 561..583
16 C2h2 589..611
17 C2h2 617..639
18 C2h2 645..667
19 C2h2 673..695
20 C2h2 701..723
21 dec2h2 729..751
22 C2h2 757..779
23 C2h2 785..807
24 C2h2 813..835
25 C2h2 841..863
26 C2h2 869..891
27 C2h2 897..919
28 C2h2 925..947
29 C2h2 953..975
30 C2h2 981..1003
31 C2h2 1009..1031
32 C2h2 1037..1059
33 C2h2 1065..1087
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR12C 172 **** 19.6 Weakly correlated
2 LTR19A 84 **** 43.0 Moderately correlated
3 LTR19B 30 **** 43.0 Moderately correlated
4 LTR12E 26 **** 19.6 Weakly correlated
5 AluJb 15 n.s 74.0 Weakly correlated
6 AluYj4 10 **** 0.0 Weakly correlated
7 L1P3 10 **** 74.0 Weakly correlated
8 AluSc8 9 ** 74.0 Weakly correlated
9 L2c 9 n.s 99.0 Weakly correlated
10 L1ME3A 7 * 99.0 Weakly correlated
11 LTR8 7 **** 43.0 Moderately correlated
12 AluJo 6 n.s 74.0 Weakly correlated
13 LTR12D 6 **** 19.6 Weakly correlated
14 MIRb 6 n.s 99.0 Weakly correlated
15 AluYm1 5 *** 19.6 Weakly correlated
16 FRAM 5 **** 74.0 Weakly correlated
17 AluY 4 n.s 74.0 Weakly correlated
18 LTR10A 4 **** 28.9 Highly correlated
19 LTR19-int 4 **** 43.0 Moderately correlated
20 THE1B-int 4 n.s 43.0 Moderately correlated
21 AluSp 3 n.s 74.0 Weakly correlated
22 AluSx 3 n.s 74.0 Weakly correlated
23 HERV9NC-int 3 *** 19.6 Weakly correlated
24 L1PA5 3 n.s 19.6 Weakly correlated
25 L2a 3 n.s 99.0 Weakly correlated
26 LTR10F 3 **** 28.9 Highly correlated
27 MER21B 3 ** 99.0 Weakly correlated
28 THE1D-int 3 * 28.9 Highly correlated
29 AluJr 2 n.s 74.0 Weakly correlated
30 AluSq 2 n.s 74.0 Weakly correlated
31 AluSx1 2 n.s 74.0 Weakly correlated
32 AluSx3 2 n.s 74.0 Weakly correlated
33 HERVFH19-int 2 **** 43.0 Moderately correlated
34 HUERS-P3b-int 2 ** 43.0 Moderately correlated
35 L1MB8 2 n.s 99.0 Weakly correlated
36 L2b 2 n.s 99.0 Weakly correlated
37 LTR16 2 * 99.0 Weakly correlated
38 LTR79 2 ** 99.0 Weakly correlated
39 LTR8B 2 ** 43.0 Moderately correlated
40 MIR 2 n.s 99.0 Weakly correlated
41 MIR3 2 n.s 99.0 Weakly correlated
42 MIRc 2 n.s 99.0 Weakly correlated
43 Alu 1 ** 74.0 Weakly correlated
44 AluSg 1 n.s 74.0 Weakly correlated
45 AluSz 1 n.s 74.0 Weakly correlated
46 AluSz6 1 n.s 74.0 Weakly correlated
47 AluYa8 1 *** 15.2 Weakly correlated
48 AluYi6 1 ** 15.2 Weakly correlated
49 AluYk12 1 *** 15.2 Weakly correlated
50 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
51 ERVL-int 1 * 99.0 Weakly correlated
52 FLAM_C 1 n.s 74.0 Weakly correlated
53 HAL1 1 n.s 99.0 Weakly correlated
54 HERV17-int 1 n.s 28.9 Highly correlated
55 HERV9-int 1 n.s 28.9 Highly correlated
56 L1HS 1 n.s 8.6 Weakly correlated
57 L1M1 1 n.s 74.0 Weakly correlated
58 L1M3 1 n.s 99.0 Weakly correlated
59 L1M4 1 n.s 99.0 Weakly correlated
60 L1M4a1 1 n.s 99.0 Weakly correlated
61 L1MA2 1 n.s 74.0 Weakly correlated
62 L1MA4A 1 n.s 87.0 Weakly correlated
63 L1MA7 1 n.s 87.0 Weakly correlated
64 L1MA9 1 n.s 99.0 Weakly correlated
65 L1MB2 1 n.s 99.0 Weakly correlated
66 L1MB5 1 n.s 99.0 Weakly correlated
67 L1MB7 1 n.s 99.0 Weakly correlated
68 L1MC1 1 n.s 99.0 Weakly correlated
69 L1MC3 1 n.s 99.0 Weakly correlated
70 L1MC4 1 n.s 99.0 Weakly correlated
71 L1MC5a 1 n.s 99.0 Weakly correlated
72 L1MCa 1 n.s 99.0 Weakly correlated
73 L1MD1 1 n.s 99.0 Weakly correlated
74 L1MD3 1 n.s 99.0 Weakly correlated
75 L1MDa 1 n.s 99.0 Weakly correlated
76 L1ME1 1 n.s 99.0 Weakly correlated
77 L1ME3B 1 n.s 99.0 Weakly correlated
78 L1ME4a 1 n.s 99.0 Weakly correlated
79 L1P4 1 n.s 74.0 Weakly correlated
80 L1PA10 1 n.s 74.0 Weakly correlated
81 L1PA11 1 n.s 74.0 Weakly correlated
82 L1PA2 1 n.s 15.2 Weakly correlated
83 L1PA6 1 n.s 28.9 Highly correlated
84 L1PB1 1 n.s 74.0 Weakly correlated
85 L1PB3 1 n.s 74.0 Weakly correlated
86 L3b 1 n.s 99.0 Weakly correlated
87 LOR1-int 1 n.s 74.0 Weakly correlated
88 LTR10B1 1 *** 28.9 Highly correlated
89 LTR13 1 * 19.6 Weakly correlated
90 LTR1A2 1 * 43.0 Moderately correlated
91 LTR39-int 1 *** 43.0 Moderately correlated
92 LTR50 1 n.s 99.0 Weakly correlated
93 LTR78 1 n.s 99.0 Weakly correlated
94 MER21A 1 n.s 74.0 Weakly correlated
95 MER4-int 1 n.s 74.0 Weakly correlated
96 MER41A 1 n.s 74.0 Weakly correlated
97 MER41B 1 n.s 74.0 Weakly correlated
98 MER4A 1 * 74.0 Weakly correlated
99 MER4A1 1 n.s 74.0 Weakly correlated
100 MER4C 1 ** 74.0 Weakly correlated
101 MER61-int 1 n.s 43.0 Moderately correlated
102 MLT1E3 1 n.s 99.0 Weakly correlated
103 MLT1G3 1 n.s 99.0 Weakly correlated
104 MLT1H1 1 n.s 99.0 Weakly correlated
105 MLT1L 1 n.s 99.0 Weakly correlated
106 MSTB 1 n.s 43.0 Moderately correlated
107 MamRep605 1 n.s 99.0 Weakly correlated
108 SVA_C 1 * 15.2 Weakly correlated
109 THE1C-int 1 n.s 43.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR12C 174 **** 19.6 Weakly correlated
2 LTR19A 78 **** 43.0 Moderately correlated
3 LTR12E 26 **** 19.6 Weakly correlated
4 LTR19B 24 **** 43.0 Moderately correlated
5 LTR12D 6 **** 19.6 Weakly correlated
6 L1ME3A 3 n.s 99.0 Weakly correlated
7 L2c 2 n.s 99.0 Weakly correlated
8 AluSg 1 n.s 74.0 Weakly correlated
9 FRAM 1 n.s 74.0 Weakly correlated
10 AluYa8 1 *** 15.2 Weakly correlated
11 LTR79 1 n.s 99.0 Weakly correlated
12 MER41B 1 n.s 74.0 Weakly correlated
13 L3b 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 LTR12C 19.6 Weakly correlated
2 LTR12D 19.6 Weakly correlated
3 LTR12E 19.6 Weakly correlated
4 LTR19A 43.0 Moderately correlated
5 LTR19B 43.0 Moderately correlated