Human_ZNF85
-
ProteinZinc finger protein 85
-
Length595
-
OrganismHomo sapiens (Human)
-
Time of emergence74.0 Mya
-
Time of Changing in binding specificity28.9 Mya
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Uniprot_ID
-
NCBI_ID
Sequence:
MGPLTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLGITVSKPDLITCLEQGKEAWSMKRHEIMVAKPTVMCSHFAQDLWPEQNIKDSFQKVTLKRYGKCRHENLPLRKGCESMDECKMHKGGCNGLNQCLTATQSKIFQCDKYVKVAHKFSNSNRHEIRHTKKKPFKCTKCGKSFGMISCLTEHSRIHTRVNFYKCEECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNQSSNLIKHKKIHTGEKPYKCEECGKTFNRFSTLTTHKIIHTGEKPYKCKECGKAFNRSSTLTTHRKIHTGEKPYKCEECGKAFKQSSNLTTHKIIHTGEKPYKCKKCGKAFNQSAHLTTHEVIHTGEKPYKCEKCGKAFNHFSHLTTHKIIHTGEKPYKCKECGKAFKHSSTLTKHKIIHTGEKPYKCKECEKAFNQSSKLTEHKKIHTGEKPYECEKCGKAFNQSSNLTRHKKSHTEEKPYKCEECGKGFKWPSTLTIHKIIHTGEKPYKCEECGKAFNQSSKLTKHKKIHTGEKPYTCEECGKAFNQSSNLTKHKRIHTGEKPYKCEECDKAFKWSSVLTKHKIIHTGEKLQI
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 4..75 | |
| 2 | dec2h2 | 146..168 | |
| 3 | C2h2 | 174..196 | |
| 4 | C2h2 | 202..224 | |
| 5 | C2h2 | 230..252 | |
| 6 | C2h2 | 258..280 | |
| 7 | C2h2 | 286..308 | |
| 8 | C2h2 | 314..336 | |
| 9 | C2h2 | 342..364 | |
| 10 | C2h2 | 370..392 | |
| 11 | C2h2 | 398..420 | |
| 12 | dec2h2 | 426..448 | |
| 13 | C2h2 | 454..476 | |
| 14 | C2h2 | 482..504 | |
| 15 | C2h2 | 510..532 | |
| 16 | C2h2 | 538..560 | |
| 17 | C2h2 | 566..588 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | nucleoplasm | |
| 2 | Cellular Component | nucleus | |
| 3 | Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
| 4 | Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
| 5 | Molecular Function | metal ion binding | |
| 6 | Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
| 7 | Biological Process | regulation of DNA-templated transcription |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MER41-int | 135 | **** | 74.0 | Weakly correlated | |
| 2 | MER4-int | 126 | **** | 74.0 | Weakly correlated | |
| 3 | L1PA7 | 57 | **** | 74.0 | Weakly correlated | |
| 4 | MER61-int | 32 | **** | 43.0 | Moderately correlated | |
| 5 | L1PA5 | 31 | **** | 19.6 | Weakly correlated | |
| 6 | L2a | 30 | n.s | 99.0 | Weakly correlated | |
| 7 | L1PA6 | 24 | **** | 28.9 | Highly correlated | |
| 8 | AluSx1 | 19 | n.s | 74.0 | Weakly correlated | |
| 9 | LTR25-int | 19 | **** | 43.0 | Moderately correlated | |
| 10 | PABL_A-int | 18 | **** | 74.0 | Weakly correlated | |
| 11 | AluSz | 16 | n.s | 74.0 | Weakly correlated | |
| 12 | L1PA4 | 16 | n.s | 19.6 | Weakly correlated | |
| 13 | AluJb | 15 | n.s | 74.0 | Weakly correlated | |
| 14 | AluSx | 14 | n.s | 74.0 | Weakly correlated | |
| 15 | MIR | 13 | n.s | 99.0 | Weakly correlated | |
| 16 | AluJo | 12 | n.s | 74.0 | Weakly correlated | |
| 17 | AluY | 12 | n.s | 74.0 | Weakly correlated | |
| 18 | L2 | 11 | n.s | 99.0 | Weakly correlated | |
| 19 | L2b | 11 | n.s | 99.0 | Weakly correlated | |
| 20 | L2c | 11 | n.s | 99.0 | Weakly correlated | |
| 21 | L1PA3 | 10 | n.s | 19.6 | Weakly correlated | |
| 22 | L3 | 9 | n.s | 99.0 | Weakly correlated | |
| 23 | MIR3 | 9 | n.s | 99.0 | Weakly correlated | |
| 24 | AluSz6 | 8 | n.s | 74.0 | Weakly correlated | |
| 25 | MER50-int | 8 | **** | 43.0 | Moderately correlated | |
| 26 | AluSq2 | 7 | n.s | 74.0 | Weakly correlated | |
| 27 | L1ME4a | 7 | n.s | 99.0 | Weakly correlated | |
| 28 | L1P1 | 7 | *** | 19.6 | Weakly correlated | |
| 29 | HUERS-P1-int | 6 | **** | 43.0 | Moderately correlated | |
| 30 | L1M4 | 6 | n.s | 99.0 | Weakly correlated | |
| 31 | LTR10A | 6 | **** | 28.9 | Highly correlated | |
| 32 | MIRb | 6 | n.s | 99.0 | Weakly correlated | |
| 33 | MIRc | 6 | n.s | 99.0 | Weakly correlated | |
| 34 | HAL1 | 5 | n.s | 99.0 | Weakly correlated | |
| 35 | L1MEc | 5 | n.s | 99.0 | Weakly correlated | |
| 36 | AluJr | 4 | n.s | 74.0 | Weakly correlated | |
| 37 | AluJr4 | 4 | n.s | 74.0 | Weakly correlated | |
| 38 | AluSc8 | 4 | n.s | 74.0 | Weakly correlated | |
| 39 | AluSg | 4 | n.s | 74.0 | Weakly correlated | |
| 40 | AluSp | 4 | n.s | 74.0 | Weakly correlated | |
| 41 | FLAM_A | 4 | ** | 74.0 | Weakly correlated | |
| 42 | HUERS-P3b-int | 4 | **** | 43.0 | Moderately correlated | |
| 43 | L1MC1 | 4 | n.s | 99.0 | Weakly correlated | |
| 44 | L1MD | 4 | * | 99.0 | Weakly correlated | |
| 45 | L1PA8 | 4 | n.s | 74.0 | Weakly correlated | |
| 46 | L1PA8A | 4 | n.s | 74.0 | Weakly correlated | |
| 47 | AluYj4 | 3 | ** | 0.0 | Weakly correlated | |
| 48 | HERV35I-int | 3 | *** | 43.0 | Moderately correlated | |
| 49 | L1MA6 | 3 | n.s | 87.0 | Weakly correlated | |
| 50 | L1MA9 | 3 | n.s | 99.0 | Weakly correlated | |
| 51 | L1MB3 | 3 | n.s | 99.0 | Weakly correlated | |
| 52 | L1MD3 | 3 | * | 99.0 | Weakly correlated | |
| 53 | L1ME1 | 3 | n.s | 99.0 | Weakly correlated | |
| 54 | L1MEf | 3 | n.s | 99.0 | Weakly correlated | |
| 55 | L1P3 | 3 | n.s | 74.0 | Weakly correlated | |
| 56 | L1PA2 | 3 | n.s | 15.2 | Weakly correlated | |
| 57 | LTR33 | 3 | n.s | 99.0 | Weakly correlated | |
| 58 | MER52-int | 3 | *** | 99.0 | Weakly correlated | |
| 59 | MLT1I | 3 | n.s | 99.0 | Weakly correlated | |
| 60 | AluSx3 | 2 | n.s | 74.0 | Weakly correlated | |
| 61 | AluYi6_4d | 2 | **** | 0.0 | Weakly correlated | |
| 62 | FLAM_C | 2 | n.s | 74.0 | Weakly correlated | |
| 63 | FRAM | 2 | * | 74.0 | Weakly correlated | |
| 64 | L1M5 | 2 | n.s | 99.0 | Weakly correlated | |
| 65 | L1MB7 | 2 | n.s | 99.0 | Weakly correlated | |
| 66 | L1MC3 | 2 | n.s | 99.0 | Weakly correlated | |
| 67 | L1MC4 | 2 | n.s | 99.0 | Weakly correlated | |
| 68 | L1MC5a | 2 | n.s | 99.0 | Weakly correlated | |
| 69 | L1MCa | 2 | n.s | 99.0 | Weakly correlated | |
| 70 | L1MD2 | 2 | n.s | 99.0 | Weakly correlated | |
| 71 | L1ME3 | 2 | n.s | 99.0 | Weakly correlated | |
| 72 | L1ME4b | 2 | n.s | 99.0 | Weakly correlated | |
| 73 | L1ME4c | 2 | n.s | 99.0 | Weakly correlated | |
| 74 | L1MEd | 2 | n.s | 99.0 | Weakly correlated | |
| 75 | L1MEi | 2 | n.s | 99.0 | Weakly correlated | |
| 76 | L1P2 | 2 | n.s | 28.9 | Highly correlated | |
| 77 | L1PA14 | 2 | n.s | 74.0 | Weakly correlated | |
| 78 | LTR10F | 2 | *** | 28.9 | Highly correlated | |
| 79 | LTR54B | 2 | *** | 74.0 | Weakly correlated | |
| 80 | LTR67B | 2 | * | 99.0 | Weakly correlated | |
| 81 | LTR78 | 2 | n.s | 99.0 | Weakly correlated | |
| 82 | MER50 | 2 | * | 43.0 | Moderately correlated | |
| 83 | MER57-int | 2 | * | 87.0 | Weakly correlated | |
| 84 | MLT1D | 2 | n.s | 99.0 | Weakly correlated | |
| 85 | MLT1L | 2 | n.s | 99.0 | Weakly correlated | |
| 86 | MSTB | 2 | n.s | 43.0 | Moderately correlated | |
| 87 | MamGypLTR3 | 2 | *** | 99.0 | Weakly correlated | |
| 88 | MamRTE1 | 2 | n.s | 99.0 | Weakly correlated | |
| 89 | THE1B | 2 | n.s | 43.0 | Moderately correlated | |
| 90 | AluSc | 1 | n.s | 74.0 | Weakly correlated | |
| 91 | AluSg4 | 1 | n.s | 74.0 | Weakly correlated | |
| 92 | AluSg7 | 1 | n.s | 74.0 | Weakly correlated | |
| 93 | AluSq | 1 | n.s | 74.0 | Weakly correlated | |
| 94 | AluSx4 | 1 | n.s | 74.0 | Weakly correlated | |
| 95 | AluYa5 | 1 | n.s | 15.2 | Weakly correlated | |
| 96 | AluYa8 | 1 | *** | 15.2 | Weakly correlated | |
| 97 | AluYb8 | 1 | n.s | 15.2 | Weakly correlated | |
| 98 | AluYc | 1 | n.s | 74.0 | Weakly correlated | |
| 99 | ERVL-B4-int | 1 | n.s | 99.0 | Weakly correlated | |
| 100 | HAL1ME | 1 | n.s | 99.0 | Weakly correlated | |
| 101 | HAL1b | 1 | n.s | 99.0 | Weakly correlated | |
| 102 | HERV9NC-int | 1 | n.s | 19.6 | Weakly correlated | |
| 103 | L1M2 | 1 | n.s | 99.0 | Weakly correlated | |
| 104 | L1M2a | 1 | * | 87.0 | Weakly correlated | |
| 105 | L1M3e | 1 | * | 99.0 | Weakly correlated | |
| 106 | L1M6 | 1 | n.s | 99.0 | Weakly correlated | |
| 107 | L1MA3 | 1 | n.s | 74.0 | Weakly correlated | |
| 108 | L1MA4A | 1 | n.s | 87.0 | Weakly correlated | |
| 109 | L1MC5 | 1 | n.s | 99.0 | Weakly correlated | |
| 110 | L1MD1 | 1 | n.s | 99.0 | Weakly correlated | |
| 111 | L1MDa | 1 | n.s | 99.0 | Weakly correlated | |
| 112 | L1ME3A | 1 | n.s | 99.0 | Weakly correlated | |
| 113 | L1ME3F | 1 | n.s | 99.0 | Weakly correlated | |
| 114 | L1MEg | 1 | n.s | 99.0 | Weakly correlated | |
| 115 | L1PA10 | 1 | n.s | 74.0 | Weakly correlated | |
| 116 | L1PA13 | 1 | n.s | 74.0 | Weakly correlated | |
| 117 | L1PA16 | 1 | n.s | 74.0 | Weakly correlated | |
| 118 | L1PA17 | 1 | n.s | 74.0 | Weakly correlated | |
| 119 | L1PB1 | 1 | n.s | 74.0 | Weakly correlated | |
| 120 | L3b | 1 | n.s | 99.0 | Weakly correlated | |
| 121 | LTR104_Mam | 1 | * | 99.0 | Weakly correlated | |
| 122 | LTR13 | 1 | * | 19.6 | Weakly correlated | |
| 123 | LTR13_ | 1 | *** | 28.9 | Highly correlated | |
| 124 | LTR16C | 1 | n.s | 99.0 | Weakly correlated | |
| 125 | LTR16D1 | 1 | *** | 99.0 | Weakly correlated | |
| 126 | LTR16E1 | 1 | n.s | 99.0 | Weakly correlated | |
| 127 | LTR16E2 | 1 | n.s | 99.0 | Weakly correlated | |
| 128 | LTR2 | 1 | * | 28.9 | Highly correlated | |
| 129 | LTR28B | 1 | ** | 43.0 | Moderately correlated | |
| 130 | LTR32 | 1 | * | 43.0 | Moderately correlated | |
| 131 | LTR33A | 1 | * | 99.0 | Weakly correlated | |
| 132 | LTR33C | 1 | * | 99.0 | Weakly correlated | |
| 133 | LTR37A | 1 | * | 99.0 | Weakly correlated | |
| 134 | LTR49-int | 1 | n.s | 74.0 | Weakly correlated | |
| 135 | LTR65 | 1 | ** | 99.0 | Weakly correlated | |
| 136 | LTR68 | 1 | ** | 99.0 | Weakly correlated | |
| 137 | LTR79 | 1 | n.s | 99.0 | Weakly correlated | |
| 138 | LTR8 | 1 | n.s | 43.0 | Moderately correlated | |
| 139 | LTR85b | 1 | * | 99.0 | Weakly correlated | |
| 140 | LTR86A1 | 1 | ** | 99.0 | Weakly correlated | |
| 141 | LTR9 | 1 | * | 43.0 | Moderately correlated | |
| 142 | MER21B | 1 | n.s | 99.0 | Weakly correlated | |
| 143 | MER39B | 1 | * | 74.0 | Weakly correlated | |
| 144 | MER50C | 1 | *** | 43.0 | Moderately correlated | |
| 145 | MER52A | 1 | n.s | 74.0 | Weakly correlated | |
| 146 | MER57A-int | 1 | n.s | 43.0 | Moderately correlated | |
| 147 | MER67C | 1 | * | 99.0 | Weakly correlated | |
| 148 | MER68 | 1 | n.s | 99.0 | Weakly correlated | |
| 149 | MER77 | 1 | * | 99.0 | Weakly correlated | |
| 150 | MER77B | 1 | * | 99.0 | Weakly correlated | |
| 151 | MIR1_Amn | 1 | n.s | 319.0 | Weakly correlated | |
| 152 | MLT1A | 1 | n.s | 99.0 | Weakly correlated | |
| 153 | MLT1A0 | 1 | n.s | 99.0 | Weakly correlated | |
| 154 | MLT1A1 | 1 | n.s | 87.0 | Weakly correlated | |
| 155 | MLT1B | 1 | n.s | 99.0 | Weakly correlated | |
| 156 | MLT1C | 1 | n.s | 94.0 | Weakly correlated | |
| 157 | MLT2A2 | 1 | n.s | 74.0 | Weakly correlated | |
| 158 | MSTB1 | 1 | n.s | 74.0 | Weakly correlated | |
| 159 | MSTC | 1 | n.s | 74.0 | Weakly correlated | |
| 160 | PRIMA41-int | 1 | * | 74.0 | Weakly correlated | |
| 161 | THE1A | 1 | n.s | 43.0 | Moderately correlated | |
| 162 | THE1C | 1 | n.s | 43.0 | Moderately correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MER41-int | 94 | **** | 74.0 | Weakly correlated | |
| 2 | MER4-int | 90 | **** | 74.0 | Weakly correlated | |
| 3 | L1PA7 | 34 | **** | 74.0 | Weakly correlated | |
| 4 | MER61-int | 26 | **** | 43.0 | Moderately correlated | |
| 5 | L1PA5 | 19 | ** | 19.6 | Weakly correlated | |
| 6 | LTR25-int | 15 | **** | 43.0 | Moderately correlated | |
| 7 | L1PA4 | 14 | n.s | 19.6 | Weakly correlated | |
| 8 | L1PA6 | 13 | * | 28.9 | Highly correlated | |
| 9 | PABL_A-int | 12 | **** | 74.0 | Weakly correlated | |
| 10 | L1PA3 | 11 | n.s | 19.6 | Weakly correlated | |
| 11 | MER50-int | 6 | **** | 43.0 | Moderately correlated | |
| 12 | L2a | 4 | n.s | 99.0 | Weakly correlated | |
| 13 | HUERS-P1-int | 4 | **** | 43.0 | Moderately correlated | |
| 14 | L1PA8 | 4 | n.s | 74.0 | Weakly correlated | |
| 15 | HUERS-P3b-int | 3 | *** | 43.0 | Moderately correlated | |
| 16 | L2 | 3 | n.s | 99.0 | Weakly correlated | |
| 17 | HERV35I-int | 3 | *** | 43.0 | Moderately correlated | |
| 18 | L1MEc | 2 | n.s | 99.0 | Weakly correlated | |
| 19 | L1P2 | 2 | n.s | 28.9 | Highly correlated | |
| 20 | L1M4 | 2 | n.s | 99.0 | Weakly correlated | |
| 21 | L1P3 | 2 | n.s | 74.0 | Weakly correlated | |
| 22 | L1PA2 | 2 | n.s | 15.2 | Weakly correlated | |
| 23 | L2b | 2 | n.s | 99.0 | Weakly correlated | |
| 24 | L1PA8A | 2 | n.s | 74.0 | Weakly correlated | |
| 25 | L1ME4a | 1 | n.s | 99.0 | Weakly correlated | |
| 26 | HERV9NC-int | 1 | n.s | 19.6 | Weakly correlated | |
| 27 | MER77B | 1 | * | 99.0 | Weakly correlated | |
| 28 | MER57A-int | 1 | n.s | 43.0 | Moderately correlated | |
| 29 | L1MA4A | 1 | n.s | 87.0 | Weakly correlated | |
| 30 | L1PA14 | 1 | n.s | 74.0 | Weakly correlated | |
| 31 | L1MEf | 1 | n.s | 99.0 | Weakly correlated | |
| 32 | L1MB7 | 1 | n.s | 99.0 | Weakly correlated | |
| 33 | HAL1 | 1 | n.s | 99.0 | Weakly correlated | |
| 34 | MIR3 | 1 | n.s | 99.0 | Weakly correlated | |
| 35 | L1P1 | 1 | n.s | 19.6 | Weakly correlated | |
| 36 | L1MCa | 1 | n.s | 99.0 | Weakly correlated | |
| 37 | MLT1B | 1 | n.s | 99.0 | Weakly correlated | |
| 38 | MIRc | 1 | n.s | 99.0 | Weakly correlated | |
| 39 | MER77 | 1 | * | 99.0 | Weakly correlated | |
| 40 | LTR49-int | 1 | n.s | 74.0 | Weakly correlated | |
| 41 | L1MC1 | 1 | n.s | 99.0 | Weakly correlated |
Motif in Repeats Consensus
: