ZRdb KZFP & Repeats
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Human_ZNF846

  • Protein
    Zinc finger protein 846
  • Length
    533
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    74.0 Mya
  • Uniprot_ID
    Q147U1
  • NCBI_ID
    162993
Sequence:
MDSSQHLVTFEDVAVDFTQEEWTLLDQAQRDLYRDVMLENYKNLIILAGSELFKRSLMSGLEQMEELRTGVTGVLQELDLQLKTKGSPLLQDISAERSPNGVQLERSNTAEKLYDSNHSGKVFNEHPFLMTHMITHIGEKTSEDNQSGKALRKNFPHSFYKKSHAEGKMPKCVKHEKAFNQFPNLTRQNKTHTQEKLCECKDCWRTFLNQSSLKLHIRSHNGDKHYVCKECGKAFSNSSHLIGHGRIHSGEKPYVCKECGKAFTQSTGLKLHIRTHSGEKPYKCKECGKAFTHSSYLTDHTRIHSGKKPYVCMECGKAFTRSTGLILHMRIHTGEKPYECKECGKAFIHSSYLTKHVRIHSGEKLYLCKACGKAFTRSSGLVLHMRTHTGEKPYECKECGKAFNNSSMLSQHVRIHTGEKPYECKECGKAFTQSSGLSTHLRTHTGEKACECKECGKAFARSTNLNMHMRTHTGEKPYACKECGKAFRYSTYLNVHTRTHTGAKPYECKKCGKNFTQSSALAKHLRTKACEKT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..80
2 dec2h2 114..136
3 dec2h2 170..192
4 C2h2 198..220
5 C2h2 226..248
6 C2h2 254..276
7 C2h2 282..304
8 C2h2 310..332
9 C2h2 338..360
10 C2h2 366..388
11 C2h2 394..416
12 C2h2 422..444
13 C2h2 450..472
14 C2h2 478..500
15 dec2h2 506..528
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 6 n.s 74.0 Highly correlated
2 AluJb 5 n.s 74.0 Highly correlated
3 L1PA6 5 n.s 28.9 Weakly correlated
4 L1PA5 5 n.s 19.6 Weakly correlated
5 AluSx 5 n.s 74.0 Highly correlated
6 L1PA2 4 n.s 15.2 Weakly correlated
7 AluSp 4 n.s 74.0 Highly correlated
8 MLT1F1-int 4 **** 99.0 Weakly correlated
9 LTR10A 4 **** 28.9 Weakly correlated
10 MIRb 3 n.s 99.0 Weakly correlated
11 L2a 3 n.s 99.0 Weakly correlated
12 MLT1H-int 3 **** 99.0 Weakly correlated
13 LTR12E 2 **** 19.6 Weakly correlated
14 L1PA4 2 n.s 19.6 Weakly correlated
15 MER50 2 * 43.0 Weakly correlated
16 Alu 2 *** 74.0 Highly correlated
17 MIR3 2 n.s 99.0 Weakly correlated
18 L1MC4 2 n.s 99.0 Weakly correlated
19 LTR78 2 * 99.0 Weakly correlated
20 L1M4b 2 n.s 99.0 Weakly correlated
21 MLT1G1-int 2 **** 99.0 Weakly correlated
22 AluYa5 2 * 15.2 Weakly correlated
23 LTR10F 2 *** 28.9 Weakly correlated
24 LTR12C 2 n.s 19.6 Weakly correlated
25 AluSx3 2 n.s 74.0 Highly correlated
26 AluSx1 2 n.s 74.0 Highly correlated
27 AluSc8 2 n.s 74.0 Highly correlated
28 AluSq2 2 n.s 74.0 Highly correlated
29 LTR41B 1 ** 99.0 Weakly correlated
30 LTR13 1 * 19.6 Weakly correlated
31 MER39B 1 * 74.0 Highly correlated
32 MER50-int 1 * 43.0 Weakly correlated
33 MLT1F-int 1 ** 99.0 Weakly correlated
34 MER52-int 1 * 99.0 Weakly correlated
35 MER52D 1 * 74.0 Highly correlated
36 MER65C 1 ** 74.0 Highly correlated
37 MIR 1 n.s 99.0 Weakly correlated
38 L1PBa 1 n.s 74.0 Highly correlated
39 MLT1F1 1 n.s 99.0 Weakly correlated
40 MLT1F2-int 1 ** 99.0 Weakly correlated
41 MLT1G-int 1 *** 99.0 Weakly correlated
42 MLT1H1-int 1 ** 99.0 Weakly correlated
43 MLT1H2-int 1 ** 99.0 Weakly correlated
44 MLT1J2 1 n.s 99.0 Weakly correlated
45 MamGypsy2-LTR 1 ** 99.0 Weakly correlated
46 SVA_D 1 n.s 15.2 Weakly correlated
47 L1ME2 1 n.s 99.0 Weakly correlated
48 AluSg4 1 n.s 74.0 Highly correlated
49 AluSz 1 n.s 74.0 Highly correlated
50 AluSc 1 n.s 74.0 Highly correlated
51 AluYj4 1 * 0.0 Weakly correlated
52 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
53 FAM 1 * 87.0 Moderately correlated
54 L1M1 1 n.s 74.0 Highly correlated
55 L1M4 1 n.s 99.0 Weakly correlated
56 L1MA9 1 n.s 99.0 Weakly correlated
57 L1MB7 1 n.s 99.0 Weakly correlated
58 L1MDb 1 * 99.0 Weakly correlated
59 LTR10B1 1 *** 28.9 Weakly correlated
60 L1ME4b 1 n.s 99.0 Weakly correlated
61 L1MEf 1 n.s 99.0 Weakly correlated
62 L1P1 1 n.s 19.6 Weakly correlated
63 L1P2 1 n.s 28.9 Weakly correlated
64 L1PA10 1 n.s 74.0 Highly correlated
65 L1PA17 1 n.s 74.0 Highly correlated
66 L1PA3 1 n.s 19.6 Weakly correlated
67 AluJr 1 n.s 74.0 Highly correlated
68 AluSg 1 n.s 74.0 Highly correlated
69 L2b 1 n.s 99.0 Weakly correlated
70 L2c 1 n.s 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1F1-int 4 **** 99.0 Weakly correlated
2 L1PA6 4 n.s 28.9 Weakly correlated
3 L1PA5 4 n.s 19.6 Weakly correlated
4 MLT1H-int 2 *** 99.0 Weakly correlated
5 AluY 2 n.s 74.0 Highly correlated
6 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
7 MER65C 1 ** 74.0 Highly correlated
8 MLT1G1-int 1 ** 99.0 Weakly correlated
9 MER50 1 n.s 43.0 Weakly correlated
10 MLT1F2-int 1 ** 99.0 Weakly correlated
11 MER52-int 1 * 99.0 Weakly correlated
12 AluSx 1 n.s 74.0 Highly correlated
13 MIR3 1 n.s 99.0 Weakly correlated
14 FAM 1 * 87.0 Moderately correlated
15 LTR13 1 * 19.6 Weakly correlated
16 LTR10B1 1 *** 28.9 Weakly correlated
17 L1PA2 1 n.s 15.2 Weakly correlated
18 AluSg4 1 n.s 74.0 Highly correlated
19 AluSc8 1 n.s 74.0 Highly correlated
20 MLT1H2-int 1 ** 99.0 Weakly correlated
21 AluSx1 1 n.s 74.0 Highly correlated
22 MER52D 1 * 74.0 Highly correlated
23 MER39B 1 * 74.0 Highly correlated
24 L1PA10 1 n.s 74.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP