ZRdb KZFP & Repeats
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Human_ZNF845

  • Protein
    Zinc finger protein 845
  • Length
    970
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q96IR2
  • NCBI_ID
    91664
Sequence:
MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKEFSSTAQGNTEVIHTGTLQRHERHHIGDFCFQEMEKDIHDFEFQWKEDERNSHEAPMTEIKQLTGSTNRHDQRHAGNKPIKDQLGSSFHSHLPELHMFQTEGKIGNQVEKSINSASLVSTSQRISCRPKTHISKNYGNNFLNSSLLTQKQEVHMREKSFQCNESGKAFNYSSVLRKHQIIHLGAKQYKCDVCGKVFNQKRYLACHRRCHTGKKPYKCNDCGKTFSQELTLTCHHRLHTGEKHYKCSECGKTFSRNSALVIHKAIHTGEKSYKCNECGKTFSQTSYLVYHRRLHTGEKPYKCEECDKAFSFKSNLERHRKIHTGEKPYKCNECSRTFSRKSSLTRHRRLHTGEKPYKCNDCGKTFSQMSSLVYHRRLHTGEKPYKCEECDEAFSFKSNLERHRRIHTGEKPYKCNDCGKTFSQTSSLVYHRRLHTGEKPYKCEECDEAFSFKSNLERHRIIHTGEKLYKCNECGKTFSRKSSLTRHCRLHTGEKPYQCNECGKAFRGQSALIYHQAIHGIGKLYKCNDCHQVFSNATTIANHWRIHNEERSYKCNRCGKFFRHRSYLAVHWRTHSGEKPYKCEECDEAFSFKSNLQRHRRIHTGEKPYRCNECGKTFSRKSYLTCHRRLHTGEKPYKCNECGKTFGRNSALIIHKAIHTGEKPYKCNECGKAFSQKSSLTCHLRLHTGEKPYKCEECDKVFSRKSSLEKHRRIHTGEKPYKCKVCDKAFGRDSHLAQHTRIHTGEKPYKCNECGKNFRHNSALVIHKAIHSGEKPYKCNECGKTFRHNSALEIHKAIHTGEKPYKCSECGKVFNRKANLSRHHRLHTGEKPYKCNKCGKVFNQQAHLACHHRIHTGEKPYKCNECGKTFRHNSVLVIHKTIHTGEKPYKCNECGKVFNRKAKLARHHRIHTGKKH
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..81
2 dec2h2 215..237
3 C2h2 243..265
4 C2h2 271..293
5 C2h2 299..321
6 C2h2 327..349
7 C2h2 355..377
8 C2h2 383..405
9 C2h2 411..433
10 C2h2 439..461
11 C2h2 467..489
12 C2h2 495..517
13 C2h2 523..545
14 C2h2 551..573
15 C2h2 579..601
16 C2h2 607..629
17 C2h2 635..657
18 C2h2 663..685
19 C2h2 691..713
20 C2h2 719..741
21 C2h2 747..769
22 C2h2 775..797
23 C2h2 803..825
24 C2h2 831..853
25 C2h2 859..881
26 C2h2 887..909
27 C2h2 915..937
28 C2h2 943..965
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR76 65 **** 74.0 Weakly correlated
2 LTR4 52 **** 28.9 Highly correlated
3 L2a 35 n.s 99.0 Weakly correlated
4 L2c 31 ** 99.0 Weakly correlated
5 HERVH-int 26 **** 28.9 Highly correlated
6 AluJb 23 n.s 74.0 Weakly correlated
7 LTR61 22 **** 43.0 Moderately correlated
8 L2b 17 n.s 99.0 Weakly correlated
9 LTR8 17 **** 43.0 Moderately correlated
10 MIRb 16 n.s 99.0 Weakly correlated
11 AluYj4 14 **** 0.0 Weakly correlated
12 AluSx 13 n.s 74.0 Weakly correlated
13 HERV3-int 13 **** 28.9 Highly correlated
14 LTR13A 13 **** 28.9 Highly correlated
15 AluY 12 n.s 74.0 Weakly correlated
16 L2 12 n.s 99.0 Weakly correlated
17 MIR 12 n.s 99.0 Weakly correlated
18 AluJr 11 n.s 74.0 Weakly correlated
19 AluSx1 11 n.s 74.0 Weakly correlated
20 MIRc 11 n.s 99.0 Weakly correlated
21 AluJo 10 n.s 74.0 Weakly correlated
22 AluSc8 9 * 74.0 Weakly correlated
23 L1P3 9 **** 74.0 Weakly correlated
24 LTR15 9 **** 28.9 Highly correlated
25 AluSz 8 n.s 74.0 Weakly correlated
26 AluSp 6 n.s 74.0 Weakly correlated
27 HERV1_LTRe 6 **** 43.0 Moderately correlated
28 MIR3 6 n.s 99.0 Weakly correlated
29 MLT1C 6 n.s 94.0 Weakly correlated
30 FLAM_C 5 * 74.0 Weakly correlated
31 L1MC1 5 n.s 99.0 Weakly correlated
32 L1PA13 5 n.s 74.0 Weakly correlated
33 LTR22E 5 **** 28.9 Highly correlated
34 MLT1D 5 n.s 99.0 Weakly correlated
35 AluSq2 4 n.s 74.0 Weakly correlated
36 AluYm1 4 ** 19.6 Weakly correlated
37 FRAM 4 ** 74.0 Weakly correlated
38 L1MA4A 4 n.s 87.0 Weakly correlated
39 L1ME1 4 n.s 99.0 Weakly correlated
40 L1MEc 4 n.s 99.0 Weakly correlated
41 L1PB1 4 n.s 74.0 Weakly correlated
42 LTR10A 4 **** 28.9 Highly correlated
43 MSTB 4 n.s 43.0 Moderately correlated
44 AluSc 3 n.s 74.0 Weakly correlated
45 AluSq 3 n.s 74.0 Weakly correlated
46 AluSx4 3 n.s 74.0 Weakly correlated
47 AluSz6 3 n.s 74.0 Weakly correlated
48 ERV3-16A3_I-int 3 n.s 99.0 Weakly correlated
49 L1M1 3 n.s 74.0 Weakly correlated
50 L1MB8 3 n.s 99.0 Weakly correlated
51 L1MC5 3 n.s 99.0 Weakly correlated
52 L1ME2 3 n.s 99.0 Weakly correlated
53 L1PREC2 3 n.s 43.0 Moderately correlated
54 LTR10F 3 **** 28.9 Highly correlated
55 LTR12C 3 n.s 19.6 Weakly correlated
56 LTR12D 3 *** 19.6 Weakly correlated
57 MER21B 3 * 99.0 Weakly correlated
58 MIR1_Amn 3 * 319.0 Weakly correlated
59 AluSg 2 n.s 74.0 Weakly correlated
60 AluSx3 2 n.s 74.0 Weakly correlated
61 AluYa8 2 **** 15.2 Weakly correlated
62 AluYf1 2 ** 19.6 Weakly correlated
63 HAL1 2 n.s 99.0 Weakly correlated
64 L1M4 2 n.s 99.0 Weakly correlated
65 L1M4a1 2 n.s 99.0 Weakly correlated
66 L1M5 2 n.s 99.0 Weakly correlated
67 L1MB1 2 n.s 99.0 Weakly correlated
68 L1MB5 2 n.s 99.0 Weakly correlated
69 L1MB7 2 n.s 99.0 Weakly correlated
70 L1MC2 2 n.s 99.0 Weakly correlated
71 L1MC4a 2 n.s 99.0 Weakly correlated
72 L1MC5a 2 n.s 99.0 Weakly correlated
73 L1MDa 2 n.s 99.0 Weakly correlated
74 L1ME5 2 * 99.0 Weakly correlated
75 L1MEg 2 n.s 99.0 Weakly correlated
76 L1PA5 2 n.s 19.6 Weakly correlated
77 L3 2 n.s 99.0 Weakly correlated
78 LTR23 2 *** 74.0 Weakly correlated
79 LTR5_Hs 2 * 0.0 Weakly correlated
80 MER52A 2 n.s 74.0 Weakly correlated
81 MER65A 2 ** 74.0 Weakly correlated
82 MLT1A0 2 n.s 99.0 Weakly correlated
83 MLT1L 2 n.s 99.0 Weakly correlated
84 MLT1O 2 * 99.0 Weakly correlated
85 MamGypsy2-I 2 ** 99.0 Weakly correlated
86 MamSINE1 2 * 99.0 Weakly correlated
87 THE1B 2 n.s 43.0 Moderately correlated
88 AluSc5 1 n.s 74.0 Weakly correlated
89 AluSq4 1 n.s 74.0 Weakly correlated
90 AluYb8 1 n.s 15.2 Weakly correlated
91 AluYe5 1 * 74.0 Weakly correlated
92 AluYg6 1 ** 15.2 Weakly correlated
93 AluYi6 1 ** 15.2 Weakly correlated
94 ERV3-16A3_LTR 1 * 99.0 Weakly correlated
95 ERVL-E-int 1 n.s 99.0 Weakly correlated
96 HERV17-int 1 n.s 28.9 Highly correlated
97 HERV35I-int 1 * 43.0 Moderately correlated
98 HERV9NC-int 1 n.s 19.6 Weakly correlated
99 HERVFH19-int 1 ** 43.0 Moderately correlated
100 L1HS 1 n.s 8.6 Weakly correlated
101 L1M2 1 n.s 99.0 Weakly correlated
102 L1M3 1 n.s 99.0 Weakly correlated
103 L1M3f 1 n.s 87.0 Weakly correlated
104 L1MA1 1 n.s 74.0 Weakly correlated
105 L1MA10 1 n.s 99.0 Weakly correlated
106 L1MA2 1 n.s 74.0 Weakly correlated
107 L1MA3 1 n.s 74.0 Weakly correlated
108 L1MA7 1 n.s 87.0 Weakly correlated
109 L1MA8 1 n.s 87.0 Weakly correlated
110 L1MA9 1 n.s 99.0 Weakly correlated
111 L1MB2 1 n.s 99.0 Weakly correlated
112 L1MB3 1 n.s 99.0 Weakly correlated
113 L1MB4 1 n.s 99.0 Weakly correlated
114 L1MC 1 n.s 99.0 Weakly correlated
115 L1MC4 1 n.s 99.0 Weakly correlated
116 L1MCb 1 n.s 99.0 Weakly correlated
117 L1MD 1 n.s 99.0 Weakly correlated
118 L1MD1 1 n.s 99.0 Weakly correlated
119 L1MDb 1 n.s 99.0 Weakly correlated
120 L1ME3A 1 n.s 99.0 Weakly correlated
121 L1ME3B 1 n.s 99.0 Weakly correlated
122 L1ME3Cz 1 n.s 99.0 Weakly correlated
123 L1ME4a 1 n.s 99.0 Weakly correlated
124 L1ME4b 1 n.s 99.0 Weakly correlated
125 L1MEd 1 n.s 99.0 Weakly correlated
126 L1P4 1 n.s 74.0 Weakly correlated
127 L1PA11 1 n.s 74.0 Weakly correlated
128 L1PA12 1 n.s 74.0 Weakly correlated
129 L1PA14 1 n.s 74.0 Weakly correlated
130 L1PA15-16 1 n.s 74.0 Weakly correlated
131 L1PA2 1 n.s 15.2 Weakly correlated
132 L1PA4 1 n.s 19.6 Weakly correlated
133 L1PB 1 n.s 74.0 Weakly correlated
134 L1PBa 1 n.s 74.0 Weakly correlated
135 L4_A_Mam 1 n.s 99.0 Weakly correlated
136 L4_C_Mam 1 n.s 99.0 Weakly correlated
137 LFSINE_Vert 1 * 319.0 Weakly correlated
138 LOR1-int 1 n.s 74.0 Weakly correlated
139 LTR10B1 1 *** 28.9 Highly correlated
140 LTR16 1 n.s 99.0 Weakly correlated
141 LTR16A 1 n.s 99.0 Weakly correlated
142 LTR1A2 1 n.s 43.0 Moderately correlated
143 LTR27D 1 ** 43.0 Moderately correlated
144 LTR33 1 n.s 99.0 Weakly correlated
145 LTR35B 1 *** 43.0 Moderately correlated
146 LTR38A1 1 *** 74.0 Weakly correlated
147 LTR41 1 * 99.0 Weakly correlated
148 LTR67B 1 n.s 99.0 Weakly correlated
149 LTR78B 1 n.s 99.0 Weakly correlated
150 LTR86C 1 ** 99.0 Weakly correlated
151 LTR9C 1 ** 43.0 Moderately correlated
152 MER21-int 1 n.s 99.0 Weakly correlated
153 MER34A 1 * 99.0 Weakly correlated
154 MER41-int 1 n.s 74.0 Weakly correlated
155 MER41G 1 *** 74.0 Weakly correlated
156 MER4CL34 1 * 43.0 Moderately correlated
157 MER50-int 1 * 43.0 Moderately correlated
158 MER57B2 1 * 43.0 Moderately correlated
159 MER57E1 1 ** 87.0 Weakly correlated
160 MER57E3 1 *** 74.0 Weakly correlated
161 MER76 1 * 99.0 Weakly correlated
162 MER90a 1 * 99.0 Weakly correlated
163 MLT1A 1 n.s 99.0 Weakly correlated
164 MLT1A0-int 1 n.s 99.0 Weakly correlated
165 MLT1A1 1 n.s 87.0 Weakly correlated
166 MLT1B 1 n.s 99.0 Weakly correlated
167 MLT1E1A 1 n.s 99.0 Weakly correlated
168 MLT1J-int 1 * 99.0 Weakly correlated
169 MLT2B3 1 n.s 99.0 Weakly correlated
170 MSTA 1 n.s 43.0 Moderately correlated
171 MSTC 1 n.s 74.0 Weakly correlated
172 MSTD 1 n.s 74.0 Weakly correlated
173 MamGypLTR1a 1 * 99.0 Weakly correlated
174 MamRTE1 1 n.s 99.0 Weakly correlated
175 THE1B-int 1 n.s 43.0 Moderately correlated
176 THE1C 1 n.s 43.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR4 8 **** 28.9 Highly correlated
2 LTR76 6 **** 74.0 Weakly correlated
3 L2a 1 n.s 99.0 Weakly correlated
4 LTR61 1 ** 43.0 Moderately correlated
5 MIR3 1 n.s 99.0 Weakly correlated
6 AluJo 1 n.s 74.0 Weakly correlated
7 HAL1 1 n.s 99.0 Weakly correlated
8 L1MA2 1 n.s 74.0 Weakly correlated
9 THE1B-int 1 n.s 43.0 Moderately correlated
10 AluSq2 1 n.s 74.0 Weakly correlated
11 L1M4 1 n.s 99.0 Weakly correlated
12 AluY 1 n.s 74.0 Weakly correlated
13 MSTD 1 n.s 74.0 Weakly correlated
14 L1PA2 1 n.s 15.2 Weakly correlated
15 LTR12C 1 n.s 19.6 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP