ZRdb KZFP & Repeats
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Human_ZNF836

  • Protein
    Zinc finger protein 836
  • Length
    936
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q6ZNA1
  • NCBI_ID
    162962
Sequence:
MALTQGPLTFRDVAIEFSQEEWKSLDPVQKALYWDVMLENYRNLVFLGILPKCMTKELPPIGNSNTGEKCQTVTLERHECYDVENFYLREIQKNLQDLEFQWKDGEINYKEVPMTYKNNLNGKRGQHSQEDVENKCIENQLTLSFQSRLTELQKFQTEGKIYECNQSEKTVNNSSLVSPLQRILPSVQTNISKKYENEFLQLSLPTQLEKTHIREKPYMCKGCGKAFRVSSSLINHQMVHTTEKPYKCNECGKAFHRGSLLTIHQIVHTRGKPYQCGVCGKIFRQNSDLVNHRRSHTGEKPYKCNECGKSFSQSYNLAIHQRIHTGEKPYKCNECGKTFKQGSCLTTHQIIHTGEKPYQCDICGKVFRQNSNLVNHQRIHTGEKPYKCNICGKSFSQSSNLATHQTVHSGNKPYKCDECGKTFKRSSSLTTHQIIHTGEKPYTCDVCDKVFSQRSQLARHQRSHTGEKPYKCNECGKVFSQTSHLVGHRRIHTGEKPYKCDKCGKAFKQGSLLTRHKIIHTREKRYQCGECGKVFSENSCLVRHLRIHTGEQPYKCNVCGKVFNYSGNLSIHKRIHTGEKPFQCNECGTVFRNYSCLARHLRIHTGQKPYKCNVCGKVFNDSGNLSNHKRIHTGEKPFQCNECGKVFSYYSCLARHRKIHTGEKPYKCNDCGKAYTQRSSLTKHLIIHTGEKPYNCNEFGGAFIQSSKLARYHRNPTGEKPHKCSHCGRTFSHITGLTYHQRRHTGEMPYKCIECGQVFNSTSNLARHRRIHTGEKPYKCNECGKVFRHQSTLARHRSIHTGEKPYVCNECGKAFRVRSILVNHQKMHTGDKPYKCNECGKAFIERSKLVYHQRNHTGEKPYKCIECGKAFGRFSCLNKHQMIHSGEKPYKCNECGKSFISRSGLTKHQTKHTAESLKTKFNVEKPLDVLLTSGFK
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..83
2 C2h2 218..240
3 C2h2 246..268
4 C2h2 274..296
5 C2h2 302..324
6 C2h2 330..352
7 C2h2 358..380
8 C2h2 386..408
9 C2h2 414..436
10 C2h2 442..464
11 C2h2 470..492
12 C2h2 498..520
13 C2h2 526..548
14 C2h2 554..576
15 C2h2 582..604
16 C2h2 610..632
17 C2h2 638..660
18 C2h2 666..688
19 dec2h2 694..716
20 C2h2 722..744
21 C2h2 750..772
22 C2h2 778..800
23 C2h2 806..828
24 C2h2 834..856
25 C2h2 862..884
26 C2h2 890..912
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MSTA-int 48 **** 43.0 Highly correlated
2 MSTB-int 13 **** 43.0 Highly correlated
3 L1MC3 4 ** 99.0 Weakly correlated
4 LTR10A 4 **** 28.9 Weakly correlated
5 AluSx1 3 n.s 74.0 Weakly correlated
6 AluSx 2 n.s 74.0 Weakly correlated
7 AluY 2 n.s 74.0 Weakly correlated
8 MER21B 2 ** 99.0 Weakly correlated
9 L1PA10 2 n.s 74.0 Weakly correlated
10 MSTD-int 1 ** 74.0 Weakly correlated
11 AluJb 1 n.s 74.0 Weakly correlated
12 MSTB1-int 1 *** 74.0 Weakly correlated
13 MLT1L 1 n.s 99.0 Weakly correlated
14 MLT1C-int 1 *** 94.0 Weakly correlated
15 LTR10B1 1 **** 28.9 Weakly correlated
16 L1PB1 1 n.s 74.0 Weakly correlated
17 L1MB8 1 n.s 99.0 Weakly correlated
18 L1M4 1 n.s 99.0 Weakly correlated
19 L1HS 1 n.s 8.6 Weakly correlated
20 AluSz6 1 n.s 74.0 Weakly correlated
21 AluSz 1 n.s 74.0 Weakly correlated
22 AluSx3 1 n.s 74.0 Weakly correlated
23 AluSp 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MSTA-int 33 **** 43.0 Highly correlated
2 MSTB-int 10 **** 43.0 Highly correlated
3 L1PA10 1 n.s 74.0 Weakly correlated
4 AluSp 1 n.s 74.0 Weakly correlated
5 MSTB1-int 1 *** 74.0 Weakly correlated
6 MSTD-int 1 ** 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP