ZRdb KZFP & Repeats
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Human_ZNF814

  • Protein
    Zinc finger protein 814
  • Length
    855
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    0.0 Mya
  • Uniprot_ID
    B7Z6K7
  • NCBI_ID
    730051
Sequence:
MAAAATLRLSAQGTVTFEDVAVNFTWEEWNLLSEAQRCLYRDVTLENLALISSLGCWCGVEDEAAPSKQSIYIQRETQVRTPMAGVSPKKAHPCEMCGPILGDILHVADHQGTHHKQKLHRCEAWGNKLYDSGNFHQHQNEHIGEKPYRGSVEEALFAKRCKLHVSGESSVFSESGKDFLPRSGLLQQEASHTGEKSNSKTECVSPIQCGGAHYSCGESMKHFSTKHILSQHQRLLTREECYVCCECGKSFSKYASLSNHQRVHTEKKHECGECGKSFSKYVSFSNHQRVHTEKKHECGECGKSFSKYVSFSNHQRVHTGKRPYECGECGKSFSKYASFSNHQRVHTEKKHYECGECGKSFSKYVSFSNHQRVHTGKRPYECGECGKSFSKYASFSNHQRVHTDKKHYECGECGKSFSQKSSLIQHQRFHTGEKPYGCEECGKSFSSEGHLRSHQRVHAGERPFKCGECVKSFSHKRSLVHHQRVHSGERPYQCGECGKSFSQKGNLVLHQRVHTGARPYECGECGKSFSSKGHLRNHQQIHTGDRLYECGECGKSFSHKGTLILHQRVHPRERSYGCGECGKSFSSIGHLRSHQRVHTGERPYECGECGKSFSHKRSLVHHQRMHTGERPYKCGDCGKSFNEKGHLRNHQRVHTTERPFKCGECGKCFSHKGNLILHQHGHTGERPYVCRECGKLFKKKSHLLVHQRIHNGEKPYACEACQKFFRNKYQLIAHQRVHTGERPYECNDCGKSFTHSSTFCVHKRIHTGEKPYECSECGKSFAESSSFTKHKRVHTGEKPYECSECGKSFAESSSLTKHKRVHTGEKPYKCEKCGKLFNKKSHLLVHQSSHWRKAI
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 15..91
2 dec2h2 120..142
3 C2h2 242..264
4 C2h2 269..291
5 C2h2 296..318
6 C2h2 324..346
7 C2h2 352..374
8 C2h2 380..402
9 C2h2 408..430
10 C2h2 436..458
11 C2h2 464..486
12 C2h2 492..514
13 C2h2 520..542
14 C2h2 548..570
15 C2h2 576..598
16 C2h2 604..626
17 C2h2 632..654
18 C2h2 660..682
19 C2h2 688..710
20 C2h2 716..738
21 C2h2 744..766
22 C2h2 772..794
23 C2h2 800..822
24 C2h2 828..850
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 8 **** 74.0 Weakly correlated
2 LTR8 8 **** 43.0 Weakly correlated
3 AluSc8 7 *** 74.0 Weakly correlated
4 AluYj4 7 **** 0.0 Highly correlated
5 LTR10A 4 **** 28.9 Weakly correlated
6 MER21B 4 **** 99.0 Weakly correlated
7 AluJo 3 n.s 74.0 Weakly correlated
8 LTR10F 3 **** 28.9 Weakly correlated
9 FRAM 3 *** 74.0 Weakly correlated
10 AluYa8 3 **** 15.2 Weakly correlated
11 AluYm1 2 ** 19.6 Weakly correlated
12 AluY 2 n.s 74.0 Weakly correlated
13 AluSp 2 n.s 74.0 Weakly correlated
14 AluJr 2 n.s 74.0 Weakly correlated
15 MLT1L 1 n.s 99.0 Weakly correlated
16 AluJb 1 n.s 74.0 Weakly correlated
17 LTR10B1 1 *** 28.9 Weakly correlated
18 SVA_C 1 ** 15.2 Weakly correlated
19 LTR1 1 *** 43.0 Weakly correlated
20 L2a 1 n.s 99.0 Weakly correlated
21 L1PA5 1 n.s 19.6 Weakly correlated
22 L1PA2 1 n.s 15.2 Weakly correlated
23 L1P4 1 n.s 74.0 Weakly correlated
24 L1MC4 1 n.s 99.0 Weakly correlated
25 L1MB8 1 n.s 99.0 Weakly correlated
26 L1M3 1 n.s 99.0 Weakly correlated
27 AluYi6 1 *** 15.2 Weakly correlated
28 AluSx 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 3 **** 0.0 Highly correlated
2 FRAM 2 ** 74.0 Weakly correlated
3 AluYa8 2 **** 15.2 Weakly correlated
4 AluJo 1 n.s 74.0 Weakly correlated
5 MER21B 1 * 99.0 Weakly correlated
6 AluY 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP