ZRdb KZFP & Repeats
...

Human_ZNF813

  • Protein
    Zinc finger protein 813
  • Length
    617
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q6ZN06
  • NCBI_ID
    126017
Sequence:
MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKEFSSTAQGNREVIHTGTLQRHESHHTGDFRFQEIDKDIHNLEFQWQEDERNSHEAPMTEIKKLTGSADRYDQRHAGNKPIKDQLGSSFHSHLPELHMFQTQGKIGNQVEKSINDASSISTSQRISCRPKTHISNNYGNNFRNSSLLTQKQEVHMREKSFQCNESGKAFNYSSLLRKHQIIHLGEKQYKCDVCGKVFNRKRNLVCHRRCHTGEKPYRCNECGKTFSQTYSLTCHRRLHTGEKPYKCEECDKAFSFKSNLKRHRRIHAGEKPYKCNECGKTFSQTSSLTCHRRLHTGEKPFKCNECGKTFSRKSSLTCHHRLHTGEKPYKCNECGKTFSQELTLKCHRRLHTGEKPYKCNECGKVFNKKANLARHHRLHSGEKPYKCTECVKTFSRNSALVIHKAIHIGEKRYKCNECGKTFSRISALVIHTAIHTGEKPYKCNECGKGFNRKTHLACHHRLHTGEKPYKCNECGKVFNRKTHLAHHHRLHTGDKPYKCNECGKVFNQKAHLARHHRLHTGEKPYKCNECGKVFNQKANLARHHRLHTGEKPYKFNECGKAFN
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 8..81
2 dec2h2 215..237
3 C2h2 243..265
4 C2h2 271..293
5 C2h2 299..321
6 C2h2 327..349
7 C2h2 355..377
8 C2h2 383..405
9 C2h2 411..433
10 C2h2 439..461
11 C2h2 467..489
12 C2h2 495..517
13 C2h2 523..545
14 C2h2 551..573
15 C2h2 579..601
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR2 67 **** 28.9 Highly correlated
2 LTR2C 26 **** 19.6 Weakly correlated
3 AluJb 15 n.s 74.0 Weakly correlated
4 SVA_F 12 **** 0.0 Weakly correlated
5 LTR8 9 **** 43.0 Moderately correlated
6 HERVE_a-int 9 **** 28.9 Highly correlated
7 L1P3 8 *** 74.0 Weakly correlated
8 AluSc8 8 * 74.0 Weakly correlated
9 LTR2B 8 **** 19.6 Weakly correlated
10 AluY 7 n.s 74.0 Weakly correlated
11 MIRb 6 n.s 99.0 Weakly correlated
12 AluSx 5 n.s 74.0 Weakly correlated
13 SVA_D 5 ** 15.2 Weakly correlated
14 AluYj4 4 *** 0.0 Weakly correlated
15 FRAM 4 ** 74.0 Weakly correlated
16 LTR13 4 **** 19.6 Weakly correlated
17 LTR10A 4 **** 28.9 Highly correlated
18 MER21B 4 ** 99.0 Weakly correlated
19 SVA_E 4 **** 0.0 Weakly correlated
20 AluSp 4 n.s 74.0 Weakly correlated
21 MIRc 4 n.s 99.0 Weakly correlated
22 AluSx1 3 n.s 74.0 Weakly correlated
23 L1PA5 3 n.s 19.6 Weakly correlated
24 L2a 3 n.s 99.0 Weakly correlated
25 L2c 3 n.s 99.0 Weakly correlated
26 AluJo 3 n.s 74.0 Weakly correlated
27 Harlequin-int 3 ** 74.0 Weakly correlated
28 L1P4 3 * 74.0 Weakly correlated
29 HAL1 3 n.s 99.0 Weakly correlated
30 MIR3 3 n.s 99.0 Weakly correlated
31 MIR 3 n.s 99.0 Weakly correlated
32 L1MB8 3 n.s 99.0 Weakly correlated
33 L1PA2 2 n.s 15.2 Weakly correlated
34 L1PA4 2 n.s 19.6 Weakly correlated
35 L1MEd 2 n.s 99.0 Weakly correlated
36 LTR53-int 2 *** 99.0 Weakly correlated
37 LTR84b 2 ** 99.0 Weakly correlated
38 MER4-int 2 n.s 74.0 Weakly correlated
39 MIR1_Amn 2 n.s 319.0 Weakly correlated
40 MLT1K 2 n.s 99.0 Weakly correlated
41 AluYa8 2 **** 15.2 Weakly correlated
42 ERV3-16A3_I-int 2 n.s 99.0 Weakly correlated
43 L1ME1 2 n.s 99.0 Weakly correlated
44 AluSz6 2 n.s 74.0 Weakly correlated
45 AluYm1 2 n.s 19.6 Weakly correlated
46 L1M4b 2 n.s 99.0 Weakly correlated
47 L1M4 2 n.s 99.0 Weakly correlated
48 MER50 1 n.s 43.0 Moderately correlated
49 AluYh9 1 **** 15.2 Weakly correlated
50 MER84 1 ** 43.0 Moderately correlated
51 MER66A 1 ** 43.0 Moderately correlated
52 MER52A 1 n.s 74.0 Weakly correlated
53 LTR79 1 n.s 99.0 Weakly correlated
54 AluYk11 1 ** 15.2 Weakly correlated
55 LTR85c 1 ** 99.0 Weakly correlated
56 FLAM_A 1 n.s 74.0 Weakly correlated
57 HERVIP10F-int 1 * 28.9 Highly correlated
58 AluYc 1 n.s 74.0 Weakly correlated
59 AluSz 1 n.s 74.0 Weakly correlated
60 MLT1A0 1 n.s 99.0 Weakly correlated
61 MLT1C 1 n.s 94.0 Weakly correlated
62 MLT1E3 1 n.s 99.0 Weakly correlated
63 MLT1H1 1 n.s 99.0 Weakly correlated
64 AluSq 1 n.s 74.0 Weakly correlated
65 MLT1L 1 n.s 99.0 Weakly correlated
66 MSTB2 1 n.s 74.0 Weakly correlated
67 AluSg4 1 n.s 74.0 Weakly correlated
68 AluJr4 1 n.s 74.0 Weakly correlated
69 AluJr 1 n.s 74.0 Weakly correlated
70 THE1B-int 1 n.s 43.0 Moderately correlated
71 L2b 1 n.s 99.0 Weakly correlated
72 L1ME4a 1 n.s 99.0 Weakly correlated
73 L1ME4b 1 n.s 99.0 Weakly correlated
74 L1ME2 1 n.s 99.0 Weakly correlated
75 L1MC4 1 n.s 99.0 Weakly correlated
76 L1PA14 1 n.s 74.0 Weakly correlated
77 L1PA16 1 n.s 74.0 Weakly correlated
78 Alu 1 * 74.0 Weakly correlated
79 L1MA9 1 n.s 99.0 Weakly correlated
80 L1MA7 1 n.s 87.0 Weakly correlated
81 L1PA6 1 n.s 28.9 Highly correlated
82 L1PB3 1 n.s 74.0 Weakly correlated
83 L2 1 n.s 99.0 Weakly correlated
84 L1MA5 1 n.s 87.0 Weakly correlated
85 HERVE-int 1 n.s 19.6 Weakly correlated
86 L1MA3 1 n.s 74.0 Weakly correlated
87 L3 1 n.s 99.0 Weakly correlated
88 LTR10B1 1 *** 28.9 Highly correlated
89 LTR12D 1 * 19.6 Weakly correlated
90 LTR16B1 1 * 99.0 Weakly correlated
91 L1M3 1 n.s 99.0 Weakly correlated
92 LTR23 1 ** 74.0 Weakly correlated
93 LTR2752 1 ** 43.0 Moderately correlated
94 LTR28C 1 * 43.0 Moderately correlated
95 L1HS 1 n.s 8.6 Weakly correlated
96 L1ME3A 1 n.s 99.0 Weakly correlated
97 LTR33 1 n.s 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 3 n.s 74.0 Weakly correlated
2 LTR2 3 *** 28.9 Highly correlated
3 L1PA5 1 n.s 19.6 Weakly correlated
4 LTR2C 1 ** 19.6 Weakly correlated
5 AluJb 1 n.s 74.0 Weakly correlated
6 AluSz6 1 n.s 74.0 Weakly correlated
7 L1PA2 1 n.s 15.2 Weakly correlated
8 LTR2B 1 ** 19.6 Weakly correlated
9 L2a 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP