ZRdb KZFP & Repeats
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Human_ZNF81

  • Protein
    Zinc finger protein 81
  • Length
    661
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    P51508
  • NCBI_ID
    347344
Sequence:
MPANEDAPQPGEHGSACEVSVSFEDVTVDFSREEWQQLDSTQRRLYQDVMLENYSHLLSVGFEVPKPEVIFKLEQGEGPWTLEGEAPHQSCSDGKFGIKPSQRRISGKSTFHSEMEGEDTRDDSLYSILEELWQDAEQIKRCQEKHNKLLSRTTFLNKKILNTEWDYEYKDFGKFVHPSPNLILSQKRPHKRDSFGKSFKHNLDLHIHNKSNAAKNLDKTIGHGQVFTQNSSYSHHENTHTGVKFCERNQCGKVLSLKHSLSQNVKFPIGEKANTCTEFGKIFTQRSHFFAPQKIHTVEKPHELSKCVNVFTQKPLLSIYLRVHRDEKLYICTKCGKAFIQNSELIMHEKTHTREKPYKCNECGKSFFQVSSLLRHQTTHTGEKLFECSECGKGFSLNSALNIHQKIHTGERHHKCSECGKAFTQKSTLRMHQRIHTGERSYICTQCGQAFIQKAHLIAHQRIHTGEKPYECSDCGKSFPSKSQLQMHKRIHTGEKPYICTECGKAFTNRSNLNTHQKSHTGEKSYICAECGKAFTDRSNFNKHQTIHTGEKPYVCADCGRAFIQKSELITHQRIHTTEKPYKCPDCEKSFSKKPHLKVHQRIHTGEKPYICAECGKAFTDRSNFNKHQTIHTGDKPYKCSDCGKGFTQKSVLSMHRNIHT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 21..92
2 C2h2 330..352
3 C2h2 358..380
4 C2h2 386..408
5 C2h2 414..436
6 C2h2 442..464
7 C2h2 470..492
8 C2h2 498..520
9 C2h2 526..548
10 C2h2 554..576
11 C2h2 582..604
12 C2h2 610..632
13 C2h2 638..660
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PB1 315 **** 74.0 Weakly correlated
2 L1ME1 109 **** 99.0 Highly correlated
3 L1PB2 76 **** 74.0 Weakly correlated
4 L1ME3A 55 **** 99.0 Highly correlated
5 L1MB7 44 **** 99.0 Highly correlated
6 L1M5 37 **** 99.0 Highly correlated
7 L1ME3 36 **** 99.0 Highly correlated
8 L1ME2 34 **** 99.0 Highly correlated
9 AluY 30 ** 74.0 Weakly correlated
10 L1MB8 29 **** 99.0 Highly correlated
11 L1MB3 24 **** 99.0 Highly correlated
12 L1MB2 22 **** 99.0 Highly correlated
13 AluJb 20 n.s 74.0 Weakly correlated
14 AluSx 20 n.s 74.0 Weakly correlated
15 L1MA9 20 **** 99.0 Highly correlated
16 L1ME3B 19 **** 99.0 Highly correlated
17 AluSx1 15 n.s 74.0 Weakly correlated
18 L1PB 15 **** 74.0 Weakly correlated
19 L1M4 13 *** 99.0 Highly correlated
20 L1MD2 13 **** 99.0 Highly correlated
21 AluSq2 11 n.s 74.0 Weakly correlated
22 L1MD 11 **** 99.0 Highly correlated
23 L1MA4A 10 *** 87.0 Weakly correlated
24 L1MB4 10 **** 99.0 Highly correlated
25 L1MC1 9 ** 99.0 Highly correlated
26 AluJo 8 n.s 74.0 Weakly correlated
27 AluSp 8 n.s 74.0 Weakly correlated
28 L1M3 8 **** 99.0 Highly correlated
29 L1MA3 8 * 74.0 Weakly correlated
30 L1ME2z 8 **** 99.0 Highly correlated
31 L1ME3Cz 8 *** 99.0 Highly correlated
32 L1MA10 7 **** 99.0 Highly correlated
33 L1MD1 7 ** 99.0 Highly correlated
34 L1ME3E 7 **** 99.0 Highly correlated
35 L1ME3F 7 **** 99.0 Highly correlated
36 L1P5 7 **** 74.0 Weakly correlated
37 AluSc 6 n.s 74.0 Weakly correlated
38 AluSg 6 n.s 74.0 Weakly correlated
39 AluSx3 6 n.s 74.0 Weakly correlated
40 AluSz 6 n.s 74.0 Weakly correlated
41 L1MA2 6 n.s 74.0 Weakly correlated
42 L1MB5 6 ** 99.0 Highly correlated
43 L1PA5 6 n.s 19.6 Weakly correlated
44 LTR10A 6 **** 28.9 Weakly correlated
45 MIRb 6 n.s 99.0 Highly correlated
46 AluJr 5 n.s 74.0 Weakly correlated
47 AluSc8 5 n.s 74.0 Weakly correlated
48 L1MA1 5 * 74.0 Weakly correlated
49 L1MB1 5 ** 99.0 Highly correlated
50 L1MC2 5 ** 99.0 Highly correlated
51 L1MC3 5 n.s 99.0 Highly correlated
52 L1P3 5 ** 74.0 Weakly correlated
53 AluSg7 4 * 74.0 Weakly correlated
54 AluSz6 4 n.s 74.0 Weakly correlated
55 FLAM_A 4 ** 74.0 Weakly correlated
56 FLAM_C 4 * 74.0 Weakly correlated
57 L1M2 4 n.s 99.0 Highly correlated
58 L1MA4 4 n.s 87.0 Weakly correlated
59 L1MA7 4 n.s 87.0 Weakly correlated
60 L1MA8 4 n.s 87.0 Weakly correlated
61 L1MC4 4 n.s 99.0 Highly correlated
62 L1ME3D 4 ** 99.0 Highly correlated
63 L2a 4 n.s 99.0 Highly correlated
64 AluSq 3 n.s 74.0 Weakly correlated
65 AluYm1 3 ** 19.6 Weakly correlated
66 FRAM 3 ** 74.0 Weakly correlated
67 L1MDa 3 n.s 99.0 Highly correlated
68 L1MEc 3 n.s 99.0 Highly correlated
69 L1MEf 3 n.s 99.0 Highly correlated
70 L1PA17 3 n.s 74.0 Weakly correlated
71 L1PA2 3 n.s 15.2 Weakly correlated
72 L1PA4 3 n.s 19.6 Weakly correlated
73 L1PA7 3 n.s 74.0 Weakly correlated
74 L1PB3 3 n.s 74.0 Weakly correlated
75 L1PBa 3 n.s 74.0 Weakly correlated
76 L2b 3 n.s 99.0 Highly correlated
77 L3 3 n.s 99.0 Highly correlated
78 MIR 3 n.s 99.0 Highly correlated
79 MIR3 3 n.s 99.0 Highly correlated
80 AluSx4 2 n.s 74.0 Weakly correlated
81 AluYc 2 * 74.0 Weakly correlated
82 L1M1 2 n.s 74.0 Weakly correlated
83 L1MA5 2 n.s 87.0 Weakly correlated
84 L1MA5A 2 n.s 87.0 Weakly correlated
85 L1MC 2 n.s 99.0 Highly correlated
86 L1MC5 2 n.s 99.0 Highly correlated
87 L1MD3 2 n.s 99.0 Highly correlated
88 L1P1 2 n.s 19.6 Weakly correlated
89 L1P4 2 n.s 74.0 Weakly correlated
90 L1PA13 2 n.s 74.0 Weakly correlated
91 L1PA16 2 n.s 74.0 Weakly correlated
92 L1PA8 2 n.s 74.0 Weakly correlated
93 L3b 2 * 99.0 Highly correlated
94 MER50 2 * 43.0 Weakly correlated
95 MIRc 2 n.s 99.0 Highly correlated
96 MLT1B 2 n.s 99.0 Highly correlated
97 MLT1C 2 n.s 94.0 Weakly correlated
98 MLT1K 2 n.s 99.0 Highly correlated
99 MSTB 2 n.s 43.0 Weakly correlated
100 Alu 1 ** 74.0 Weakly correlated
101 AluSc5 1 n.s 74.0 Weakly correlated
102 AluSg4 1 n.s 74.0 Weakly correlated
103 AluSq4 1 * 74.0 Weakly correlated
104 AluYf1 1 * 19.6 Weakly correlated
105 AluYh9 1 **** 15.2 Weakly correlated
106 AluYj4 1 n.s 0.0 Weakly correlated
107 AluYk12 1 *** 15.2 Weakly correlated
108 ERVL-B4-int 1 n.s 99.0 Highly correlated
109 HAL1 1 n.s 99.0 Highly correlated
110 HERVL66-int 1 ** 43.0 Weakly correlated
111 L1M4b 1 n.s 99.0 Highly correlated
112 L1MC4a 1 n.s 99.0 Highly correlated
113 L1MC5a 1 n.s 99.0 Highly correlated
114 L1MCa 1 n.s 99.0 Highly correlated
115 L1ME3C 1 n.s 99.0 Highly correlated
116 L1ME3G 1 n.s 99.0 Highly correlated
117 L1ME5 1 n.s 99.0 Highly correlated
118 L1MEd 1 n.s 99.0 Highly correlated
119 L1MEg 1 n.s 99.0 Highly correlated
120 L1PA14 1 n.s 74.0 Weakly correlated
121 L1PA6 1 n.s 28.9 Weakly correlated
122 L1PB4 1 n.s 99.0 Highly correlated
123 L2 1 n.s 99.0 Highly correlated
124 L2c 1 n.s 99.0 Highly correlated
125 L4_B_Mam 1 n.s 99.0 Highly correlated
126 LTR106_Mam 1 ** 99.0 Highly correlated
127 LTR12C 1 n.s 19.6 Weakly correlated
128 LTR13 1 * 19.6 Weakly correlated
129 LTR16E2 1 * 99.0 Highly correlated
130 LTR22A 1 *** 43.0 Weakly correlated
131 LTR30 1 ** 28.9 Weakly correlated
132 LTR41C 1 ** 99.0 Highly correlated
133 LTR78 1 n.s 99.0 Highly correlated
134 LTR79 1 n.s 99.0 Highly correlated
135 MER21C 1 n.s 99.0 Highly correlated
136 MER34 1 * 87.0 Weakly correlated
137 MER39B 1 * 74.0 Weakly correlated
138 MER49 1 * 43.0 Weakly correlated
139 MER4D0 1 ** 74.0 Weakly correlated
140 MER50-int 1 * 43.0 Weakly correlated
141 MER65A 1 * 74.0 Weakly correlated
142 MER66B 1 * 43.0 Weakly correlated
143 MLT1D 1 n.s 99.0 Highly correlated
144 MLT1F 1 n.s 99.0 Highly correlated
145 MLT1F1 1 n.s 99.0 Highly correlated
146 MLT1G3 1 n.s 99.0 Highly correlated
147 MLT1H 1 n.s 99.0 Highly correlated
148 MLT1I 1 n.s 99.0 Highly correlated
149 MLT1J-int 1 * 99.0 Highly correlated
150 MLT2B3 1 n.s 99.0 Highly correlated
151 MLT2B4 1 n.s 99.0 Highly correlated
152 MamRep605 1 n.s 99.0 Highly correlated
153 SVA_C 1 * 15.2 Weakly correlated
154 THE1D 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PB1 293 **** 74.0 Weakly correlated
2 L1ME1 98 **** 99.0 Highly correlated
3 L1PB2 71 **** 74.0 Weakly correlated
4 L1ME3A 50 **** 99.0 Highly correlated
5 L1MB7 38 **** 99.0 Highly correlated
6 L1M5 36 **** 99.0 Highly correlated
7 L1ME3 33 **** 99.0 Highly correlated
8 L1ME2 32 **** 99.0 Highly correlated
9 L1MB8 25 **** 99.0 Highly correlated
10 L1MB3 23 **** 99.0 Highly correlated
11 L1MB2 20 **** 99.0 Highly correlated
12 L1MA9 19 **** 99.0 Highly correlated
13 L1ME3B 18 **** 99.0 Highly correlated
14 L1PB 14 **** 74.0 Weakly correlated
15 L1MD2 13 **** 99.0 Highly correlated
16 L1M4 11 ** 99.0 Highly correlated
17 L1MD 10 **** 99.0 Highly correlated
18 L1MA4A 9 *** 87.0 Weakly correlated
19 L1MB4 9 **** 99.0 Highly correlated
20 L1ME2z 9 **** 99.0 Highly correlated
21 L1M3 8 **** 99.0 Highly correlated
22 L1ME3Cz 8 *** 99.0 Highly correlated
23 L1MC1 8 * 99.0 Highly correlated
24 L1MA3 8 * 74.0 Weakly correlated
25 L1P5 7 **** 74.0 Weakly correlated
26 L1MD1 7 ** 99.0 Highly correlated
27 L1ME3E 7 **** 99.0 Highly correlated
28 L1MA2 6 n.s 74.0 Weakly correlated
29 L1ME3F 6 **** 99.0 Highly correlated
30 L1MB5 6 ** 99.0 Highly correlated
31 L1MC2 5 ** 99.0 Highly correlated
32 L1MA4 4 n.s 87.0 Weakly correlated
33 L1MA10 4 ** 99.0 Highly correlated
34 L1MA8 4 n.s 87.0 Weakly correlated
35 L1M2 4 n.s 99.0 Highly correlated
36 L1MC3 4 n.s 99.0 Highly correlated
37 L1MB1 4 * 99.0 Highly correlated
38 L1ME3D 4 ** 99.0 Highly correlated
39 L1MA1 4 n.s 74.0 Weakly correlated
40 MIRb 4 n.s 99.0 Highly correlated
41 L1MA7 3 n.s 87.0 Weakly correlated
42 L1PA17 3 n.s 74.0 Weakly correlated
43 L1MEc 3 n.s 99.0 Highly correlated
44 L1MC4 3 n.s 99.0 Highly correlated
45 L1PB3 2 n.s 74.0 Weakly correlated
46 L1M1 2 n.s 74.0 Weakly correlated
47 L1PA5 2 n.s 19.6 Weakly correlated
48 L1PA4 2 n.s 19.6 Weakly correlated
49 L1MEf 2 n.s 99.0 Highly correlated
50 L1MC 2 n.s 99.0 Highly correlated
51 L1PA8 2 n.s 74.0 Weakly correlated
52 L1PA7 2 n.s 74.0 Weakly correlated
53 MLT1K 2 n.s 99.0 Highly correlated
54 L1MD3 2 n.s 99.0 Highly correlated
55 L1MC5 2 n.s 99.0 Highly correlated
56 L1MA5 2 n.s 87.0 Weakly correlated
57 L1PBa 2 n.s 74.0 Weakly correlated
58 L1MA5A 2 n.s 87.0 Weakly correlated
59 L3 2 n.s 99.0 Highly correlated
60 L1ME3G 1 n.s 99.0 Highly correlated
61 L1PB4 1 n.s 99.0 Highly correlated
62 HERVL66-int 1 ** 43.0 Weakly correlated
63 L1P1 1 n.s 19.6 Weakly correlated
64 L1PA16 1 n.s 74.0 Weakly correlated
65 L1P4 1 n.s 74.0 Weakly correlated
66 L1ME5 1 n.s 99.0 Highly correlated
67 MLT1I 1 n.s 99.0 Highly correlated
68 AluJo 1 n.s 74.0 Weakly correlated
69 L4_B_Mam 1 n.s 99.0 Highly correlated
70 MLT1D 1 n.s 99.0 Highly correlated
71 L1ME3C 1 n.s 99.0 Highly correlated
72 L1MEd 1 n.s 99.0 Highly correlated
73 AluSg7 1 n.s 74.0 Weakly correlated
74 L1M4b 1 n.s 99.0 Highly correlated
75 AluJb 1 n.s 74.0 Weakly correlated
76 L1MCa 1 n.s 99.0 Highly correlated
77 LTR106_Mam 1 ** 99.0 Highly correlated
78 L2b 1 n.s 99.0 Highly correlated
79 MLT1G3 1 n.s 99.0 Highly correlated
80 L2 1 n.s 99.0 Highly correlated
81 L1PA13 1 n.s 74.0 Weakly correlated
82 L1MC4a 1 n.s 99.0 Highly correlated
83 L1PA6 1 n.s 28.9 Weakly correlated
84 LTR16E2 1 * 99.0 Highly correlated
85 MIR3 1 n.s 99.0 Highly correlated
86 MLT1H 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1MC1 99.0 Highly correlated
2 L1ME3CZ 99.0 Highly correlated
3 L1ME3E 99.0 Highly correlated
4 L1ME3F 99.0 Highly correlated