ZRdb KZFP & Repeats
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Human_ZNF808

  • Protein
    Zinc finger protein 808
  • Length
    903
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    319.0 Mya
  • Time of Changing in binding specificity
    19.6 Mya
  • Uniprot_ID
    Q8N4W9
  • NCBI_ID
    388558
Sequence:
MLREEAAQKRKGKESGMALPQGRLTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNLEAVDISSKHMMKEVLSTGQGNREVIHTGTLQRHQSYHIGDFCFQEIEKEIHNIEFQCQEDERNGHEAPTTKIKKLTGSTDQHDHRHAGNKPIKDQLGSSFYSHLPELHIFQIKGEIANQLEKSTSDASSVSTSQRISCRPQIHISNNYGNNPLNSSLLPQKQEVHMREKSFPCNESGKAFNCSSLLRKHQIPHLGDKQYKCDVCGKLFNHKQYLACHRRCHTGEKPYKCKECGKSFSYKSSLTCHHRLHTGVKPYKCNECGKVFRQNSALVIHKAIHTGEKPYKCNECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKAFACHSYLANHTRIHSGEKTYKCNECGKAFNHQSSLARHHILHTGEKPYKCEECDKVFSQKSTLERHKRIHTGEKPYKCKVCDTAFTCNSQLARHRRIHTGEKTYKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASLVYHRRLHTLEKSYKCTVCNKVFMRNSVLAVHTRIHTAKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEACDKVFGQKSALESHKRIHTGEKPYRCQVCDTAFTWNSQLARHTRIHTGEKTYKCNECGKTFSYKSSLVWHRRLHGGEKSYKCKVCDKAFVCRSYVAKHTRIHSGMKPYKCNECSKTFSNRSSLVCHRRIHSGEKPYKCSECSKTFSQKATLLCHRRLHSGEKPYKCNDCGNTFRHWSSLVYHRRLHTGEKSYKCTVCDKAFVRNSYLARHIRIHTAEKPYKCNECGKAFNEQSHLSRHHRIHTGEKPYKCEACDKVFSRKSHLKRHRIIHTGEKPYKCNECGKAFSDRSTLIHHQAIHGIGKFD
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 24..98
2 dec2h2 231..253
3 C2h2 259..281
4 C2h2 287..309
5 C2h2 315..337
6 C2h2 343..365
7 C2h2 371..393
8 C2h2 399..421
9 C2h2 427..449
10 C2h2 455..477
11 C2h2 483..505
12 C2h2 511..533
13 C2h2 539..561
14 C2h2 567..589
15 C2h2 595..617
16 C2h2 623..645
17 C2h2 651..673
18 C2h2 679..701
19 C2h2 707..729
20 C2h2 735..757
21 C2h2 763..785
22 C2h2 791..813
23 C2h2 819..841
24 C2h2 847..869
25 C2h2 875..897
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER11A 765 **** 28.9 Moderately correlated
2 MER11B 330 **** 19.6 Highly correlated
3 MER11C 264 **** 19.6 Highly correlated
4 LTR7B 149 **** 28.9 Moderately correlated
5 L2a 61 n.s 99.0 Weakly correlated
6 L2c 49 ** 99.0 Weakly correlated
7 MIRb 41 n.s 99.0 Weakly correlated
8 LTR7Y 31 **** 8.6 Weakly correlated
9 MIR 25 n.s 99.0 Weakly correlated
10 L2b 19 n.s 99.0 Weakly correlated
11 AluJb 18 n.s 74.0 Weakly correlated
12 MIR3 18 * 99.0 Weakly correlated
13 MIRc 17 n.s 99.0 Weakly correlated
14 L1ME1 16 n.s 99.0 Weakly correlated
15 L1PA5 15 n.s 19.6 Highly correlated
16 L1PA7 13 n.s 74.0 Weakly correlated
17 L2 12 n.s 99.0 Weakly correlated
18 AluSp 10 n.s 74.0 Weakly correlated
19 L1MD2 10 n.s 99.0 Weakly correlated
20 L3 10 n.s 99.0 Weakly correlated
21 L1MB7 9 n.s 99.0 Weakly correlated
22 LTR8 9 **** 43.0 Weakly correlated
23 MER83C 9 **** 43.0 Weakly correlated
24 AluY 8 n.s 74.0 Weakly correlated
25 L1MC3 8 n.s 99.0 Weakly correlated
26 L1PA16 8 n.s 74.0 Weakly correlated
27 LTR45C 8 **** 99.0 Weakly correlated
28 MER83B 8 **** 43.0 Weakly correlated
29 AluJo 7 n.s 74.0 Weakly correlated
30 AluSx 7 n.s 74.0 Weakly correlated
31 LTR33 7 ** 99.0 Weakly correlated
32 MLT1B 7 n.s 99.0 Weakly correlated
33 AluJr 6 n.s 74.0 Weakly correlated
34 AluSq2 6 n.s 74.0 Weakly correlated
35 L1M4 6 n.s 99.0 Weakly correlated
36 L1MB8 6 n.s 99.0 Weakly correlated
37 L1MEg 6 n.s 99.0 Weakly correlated
38 L1PA8 6 n.s 74.0 Weakly correlated
39 MLT1A0 6 n.s 99.0 Weakly correlated
40 ERV3-16A3_I-int 5 n.s 99.0 Weakly correlated
41 HAL1 5 n.s 99.0 Weakly correlated
42 L1MA9 5 n.s 99.0 Weakly correlated
43 L1MC1 5 n.s 99.0 Weakly correlated
44 L1MC4 5 n.s 99.0 Weakly correlated
45 L1MD 5 n.s 99.0 Weakly correlated
46 L1MD1 5 n.s 99.0 Weakly correlated
47 L1MEf 5 n.s 99.0 Weakly correlated
48 L1PA13 5 n.s 74.0 Weakly correlated
49 MER50B 5 **** 43.0 Weakly correlated
50 MLT1K 5 n.s 99.0 Weakly correlated
51 THE1C 5 n.s 43.0 Weakly correlated
52 AluSc8 4 n.s 74.0 Weakly correlated
53 AluSx1 4 n.s 74.0 Weakly correlated
54 AluSz 4 n.s 74.0 Weakly correlated
55 L1MB2 4 n.s 99.0 Weakly correlated
56 L1MC4a 4 n.s 99.0 Weakly correlated
57 L1MDa 4 n.s 99.0 Weakly correlated
58 L1ME4b 4 n.s 99.0 Weakly correlated
59 L1MEd 4 n.s 99.0 Weakly correlated
60 L1PA10 4 n.s 74.0 Weakly correlated
61 L1PA2 4 n.s 15.2 Weakly correlated
62 L1PB1 4 n.s 74.0 Weakly correlated
63 LTR16C 4 n.s 99.0 Weakly correlated
64 MLT1A 4 n.s 99.0 Weakly correlated
65 MLT1C 4 n.s 94.0 Weakly correlated
66 MLT1D 4 n.s 99.0 Weakly correlated
67 MLT1H 4 n.s 99.0 Weakly correlated
68 MLT1I 4 n.s 99.0 Weakly correlated
69 MLT1L 4 n.s 99.0 Weakly correlated
70 THE1D 4 n.s 43.0 Weakly correlated
71 Alu 3 *** 74.0 Weakly correlated
72 AluSz6 3 n.s 74.0 Weakly correlated
73 ERVL-E-int 3 n.s 99.0 Weakly correlated
74 HAL1ME 3 n.s 99.0 Weakly correlated
75 L1M2 3 n.s 99.0 Weakly correlated
76 L1M4c 3 n.s 99.0 Weakly correlated
77 L1M5 3 n.s 99.0 Weakly correlated
78 L1MC 3 n.s 99.0 Weakly correlated
79 L1MC2 3 n.s 99.0 Weakly correlated
80 L1MCa 3 n.s 99.0 Weakly correlated
81 L1ME3G 3 n.s 99.0 Weakly correlated
82 L1ME5 3 * 99.0 Weakly correlated
83 L1MEc 3 n.s 99.0 Weakly correlated
84 L1PA11 3 n.s 74.0 Weakly correlated
85 L1PA6 3 n.s 28.9 Moderately correlated
86 L1PBa 3 n.s 74.0 Weakly correlated
87 LTR10A 3 **** 28.9 Moderately correlated
88 MER21B 3 n.s 99.0 Weakly correlated
89 MER51A 3 ** 43.0 Weakly correlated
90 MER70B 3 *** 87.0 Weakly correlated
91 MER74B 3 *** 99.0 Weakly correlated
92 MIR1_Amn 3 n.s 319.0 Weakly correlated
93 MLT1J 3 n.s 99.0 Weakly correlated
94 MLT2B4 3 n.s 99.0 Weakly correlated
95 MSTB-int 3 * 43.0 Weakly correlated
96 THE1B 3 n.s 43.0 Weakly correlated
97 AluSc 2 n.s 74.0 Weakly correlated
98 AluSg7 2 n.s 74.0 Weakly correlated
99 AluYc 2 n.s 74.0 Weakly correlated
100 FLAM_C 2 n.s 74.0 Weakly correlated
101 HERVFH19-int 2 *** 43.0 Weakly correlated
102 HERVH-int 2 n.s 28.9 Moderately correlated
103 HERVK-int 2 * 28.9 Moderately correlated
104 L1M1 2 n.s 74.0 Weakly correlated
105 L1M3 2 n.s 99.0 Weakly correlated
106 L1M4b 2 n.s 99.0 Weakly correlated
107 L1MA4 2 n.s 87.0 Weakly correlated
108 L1MA4A 2 n.s 87.0 Weakly correlated
109 L1MA7 2 n.s 87.0 Weakly correlated
110 L1MB4 2 n.s 99.0 Weakly correlated
111 L1MC5 2 n.s 99.0 Weakly correlated
112 L1MC5a 2 n.s 99.0 Weakly correlated
113 L1ME2 2 n.s 99.0 Weakly correlated
114 L1ME3 2 n.s 99.0 Weakly correlated
115 L1MEb 2 * 99.0 Weakly correlated
116 L1P1 2 n.s 19.6 Highly correlated
117 L1PA3 2 n.s 19.6 Highly correlated
118 L1PA4 2 n.s 19.6 Highly correlated
119 LTR16 2 n.s 99.0 Weakly correlated
120 LTR16B1 2 * 99.0 Weakly correlated
121 LTR26B 2 **** 74.0 Weakly correlated
122 LTR33C 2 ** 99.0 Weakly correlated
123 LTR50 2 n.s 99.0 Weakly correlated
124 LTR53-int 2 ** 99.0 Weakly correlated
125 LTR7 2 n.s 19.6 Highly correlated
126 LTR7A 2 **** 28.9 Moderately correlated
127 LTR89 2 ** 99.0 Weakly correlated
128 MER21C 2 n.s 99.0 Weakly correlated
129 MER31-int 2 * 99.0 Weakly correlated
130 MER52C 2 ** 74.0 Weakly correlated
131 MER54A 2 ** 87.0 Weakly correlated
132 MER66B 2 * 43.0 Weakly correlated
133 MER67A 2 *** 99.0 Weakly correlated
134 MER68 2 * 99.0 Weakly correlated
135 MLT1F 2 n.s 99.0 Weakly correlated
136 MLT1J-int 2 * 99.0 Weakly correlated
137 MLT1N2 2 n.s 99.0 Weakly correlated
138 MLT2F 2 * 99.0 Weakly correlated
139 MSTA 2 n.s 43.0 Weakly correlated
140 MSTA-int 2 n.s 43.0 Weakly correlated
141 THE1B-int 2 n.s 43.0 Weakly correlated
142 THE1D-int 2 n.s 28.9 Moderately correlated
143 AluJr4 1 n.s 74.0 Weakly correlated
144 AluSg 1 n.s 74.0 Weakly correlated
145 AluSg4 1 n.s 74.0 Weakly correlated
146 AluSq 1 n.s 74.0 Weakly correlated
147 AluYa8 1 ** 15.2 Weakly correlated
148 AluYc3 1 * 74.0 Weakly correlated
149 AluYh3 1 n.s 15.2 Weakly correlated
150 AluYh9 1 *** 15.2 Weakly correlated
151 AluYj4 1 n.s 0.0 Weakly correlated
152 AluYm1 1 n.s 19.6 Highly correlated
153 AmnSINE1 1 * 319.0 Weakly correlated
154 FRAM 1 n.s 74.0 Weakly correlated
155 HERVI-int 1 * 28.9 Moderately correlated
156 HERVIP10FH-int 1 n.s 28.9 Moderately correlated
157 HERVK22-int 1 n.s 43.0 Weakly correlated
158 HERVL-int 1 n.s 74.0 Weakly correlated
159 L1M3d 1 * 99.0 Weakly correlated
160 L1M3e 1 n.s 99.0 Weakly correlated
161 L1M3f 1 n.s 87.0 Weakly correlated
162 L1M6 1 n.s 99.0 Weakly correlated
163 L1M7 1 n.s 99.0 Weakly correlated
164 L1MA1 1 n.s 74.0 Weakly correlated
165 L1MA10 1 n.s 99.0 Weakly correlated
166 L1MA2 1 n.s 74.0 Weakly correlated
167 L1MA5 1 n.s 87.0 Weakly correlated
168 L1MA5A 1 n.s 87.0 Weakly correlated
169 L1MA6 1 n.s 87.0 Weakly correlated
170 L1MA8 1 n.s 87.0 Weakly correlated
171 L1MB3 1 n.s 99.0 Weakly correlated
172 L1MB5 1 n.s 99.0 Weakly correlated
173 L1MD3 1 n.s 99.0 Weakly correlated
174 L1MDb 1 n.s 99.0 Weakly correlated
175 L1ME2z 1 n.s 99.0 Weakly correlated
176 L1ME3A 1 n.s 99.0 Weakly correlated
177 L1ME3B 1 n.s 99.0 Weakly correlated
178 L1ME3Cz 1 n.s 99.0 Weakly correlated
179 L1ME3D 1 n.s 99.0 Weakly correlated
180 L1ME3E 1 n.s 99.0 Weakly correlated
181 L1ME4a 1 n.s 99.0 Weakly correlated
182 L1ME4c 1 n.s 99.0 Weakly correlated
183 L1MEj 1 n.s 99.0 Weakly correlated
184 L1P3 1 n.s 74.0 Weakly correlated
185 L1P4 1 n.s 74.0 Weakly correlated
186 L1PA12 1 n.s 74.0 Weakly correlated
187 L1PA15 1 n.s 74.0 Weakly correlated
188 L1PB2 1 n.s 74.0 Weakly correlated
189 L1PB3 1 n.s 74.0 Weakly correlated
190 L1PB4 1 n.s 99.0 Weakly correlated
191 L1PREC2 1 n.s 43.0 Weakly correlated
192 L2-1_AMi 1 * 319.0 Weakly correlated
193 L3b 1 n.s 99.0 Weakly correlated
194 L4_A_Mam 1 n.s 99.0 Weakly correlated
195 L4_B_Mam 1 n.s 99.0 Weakly correlated
196 LTR101_Mam 1 n.s 99.0 Weakly correlated
197 LTR10F 1 * 28.9 Moderately correlated
198 LTR12 1 n.s 28.9 Moderately correlated
199 LTR13 1 n.s 19.6 Highly correlated
200 LTR13_ 1 ** 28.9 Moderately correlated
201 LTR16A1 1 n.s 99.0 Weakly correlated
202 LTR16A2 1 n.s 99.0 Weakly correlated
203 LTR16B2 1 n.s 99.0 Weakly correlated
204 LTR16E1 1 n.s 99.0 Weakly correlated
205 LTR29 1 * 43.0 Weakly correlated
206 LTR31 1 ** 74.0 Weakly correlated
207 LTR34 1 ** 74.0 Weakly correlated
208 LTR37-int 1 n.s 99.0 Weakly correlated
209 LTR38A1 1 ** 74.0 Weakly correlated
210 LTR41 1 n.s 99.0 Weakly correlated
211 LTR41B 1 * 99.0 Weakly correlated
212 LTR44 1 ** 74.0 Weakly correlated
213 LTR49 1 n.s 74.0 Weakly correlated
214 LTR53 1 * 99.0 Weakly correlated
215 LTR57-int 1 * 74.0 Weakly correlated
216 LTR67B 1 n.s 99.0 Weakly correlated
217 LTR78 1 n.s 99.0 Weakly correlated
218 LTR82A 1 n.s 99.0 Weakly correlated
219 LTR87 1 * 99.0 Weakly correlated
220 LTR88a 1 * 99.0 Weakly correlated
221 LTR90A 1 ** 99.0 Weakly correlated
222 MER39B 1 n.s 74.0 Weakly correlated
223 MER41E 1 * 74.0 Weakly correlated
224 MER50-int 1 n.s 43.0 Weakly correlated
225 MER51E 1 ** 43.0 Weakly correlated
226 MER52-int 1 n.s 99.0 Weakly correlated
227 MER52D 1 n.s 74.0 Weakly correlated
228 MER65B 1 ** 74.0 Weakly correlated
229 MER65D 1 * 87.0 Weakly correlated
230 MER66-int 1 n.s 43.0 Weakly correlated
231 MER70A 1 * 87.0 Weakly correlated
232 MER74A 1 n.s 99.0 Weakly correlated
233 MER76 1 * 99.0 Weakly correlated
234 MER77B 1 n.s 99.0 Weakly correlated
235 MER92B 1 * 99.0 Weakly correlated
236 MER9a3 1 * 28.9 Moderately correlated
237 MLT1A1 1 n.s 87.0 Weakly correlated
238 MLT1A1-int 1 n.s 87.0 Weakly correlated
239 MLT1E 1 * 99.0 Weakly correlated
240 MLT1E1 1 n.s 99.0 Weakly correlated
241 MLT1E1A 1 n.s 99.0 Weakly correlated
242 MLT1E2 1 n.s 99.0 Weakly correlated
243 MLT1E3 1 n.s 99.0 Weakly correlated
244 MLT1F2 1 n.s 99.0 Weakly correlated
245 MLT1G1 1 n.s 99.0 Weakly correlated
246 MLT1G3 1 n.s 99.0 Weakly correlated
247 MLT1J2 1 n.s 99.0 Weakly correlated
248 MLT1J2-int 1 * 99.0 Weakly correlated
249 MLT1M 1 n.s 99.0 Weakly correlated
250 MLT2A2 1 n.s 74.0 Weakly correlated
251 MLT2B3 1 n.s 99.0 Weakly correlated
252 MLT2B5 1 ** 87.0 Weakly correlated
253 MLT2D 1 n.s 99.0 Weakly correlated
254 MSTB 1 n.s 43.0 Weakly correlated
255 MSTB1 1 n.s 74.0 Weakly correlated
256 MSTD 1 n.s 74.0 Weakly correlated
257 MamGypLTR2c 1 * 99.0 Weakly correlated
258 MamGypLTR3a 1 n.s 99.0 Weakly correlated
259 MamRTE1 1 n.s 99.0 Weakly correlated
260 MamSINE1 1 n.s 99.0 Weakly correlated
261 PRIMA4-int 1 * 74.0 Weakly correlated
262 SVA_D 1 n.s 15.2 Weakly correlated
263 THE1A 1 n.s 43.0 Weakly correlated
264 X6A_LINE 1 ** 99.0 Weakly correlated
265 X7A_LINE 1 ** 319.0 Weakly correlated
266 X7C_LINE 1 ** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER11A 752 **** 28.9 Moderately correlated
2 MER11B 320 **** 19.6 Highly correlated
3 MER11C 241 **** 19.6 Highly correlated
4 MIRb 4 n.s 99.0 Weakly correlated
5 L2c 3 n.s 99.0 Weakly correlated
6 L2a 2 n.s 99.0 Weakly correlated
7 L1ME1 2 n.s 99.0 Weakly correlated
8 LTR53-int 1 * 99.0 Weakly correlated
9 MIRc 1 n.s 99.0 Weakly correlated
10 MER83B 1 ** 43.0 Weakly correlated
11 MER31-int 1 n.s 99.0 Weakly correlated
12 L4_B_Mam 1 n.s 99.0 Weakly correlated
13 L1ME4a 1 n.s 99.0 Weakly correlated
14 L1PA16 1 n.s 74.0 Weakly correlated
15 HERVK22-int 1 n.s 43.0 Weakly correlated
16 MSTB-int 1 n.s 43.0 Weakly correlated
17 LTR57-int 1 * 74.0 Weakly correlated
18 L1P1 1 n.s 19.6 Highly correlated
19 L1M4b 1 n.s 99.0 Weakly correlated
20 MER67A 1 ** 99.0 Weakly correlated
21 L1MEd 1 n.s 99.0 Weakly correlated
22 MLT1K 1 n.s 99.0 Weakly correlated
23 LTR16C 1 n.s 99.0 Weakly correlated
24 LTR16B2 1 n.s 99.0 Weakly correlated
25 AluYh3 1 n.s 15.2 Weakly correlated
26 AluJb 1 n.s 74.0 Weakly correlated
27 MLT1H 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 MER11A 28.9 Moderately correlated
2 MER11B 19.6 Highly correlated