ZRdb KZFP & Repeats
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Human_ZNF805

  • Protein
    Zinc finger protein 805
  • Length
    627
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q5CZA5
  • NCBI_ID
    390980
Sequence:
MAMALTDPAQVSVTFDDVAVTFTQEEWGQLDLAQRTLYQEVMLENCGLLVSLGCPVPRPELIYHLEHGQEPWTRKEDLSQGTCPGDKGKPKSTEPTTCELALSEGISFWGQLTQGASGDSQLGQPKDQDGFSEMQGERLRPGLDSQKEKLPGKMSPKHDGLGTADSVCSRIIQDRVSLGDDVHDCDSHGSGKNPVIQEEENIFKCNECEKVFNKKRLLARHERIHSGVKPYECTECGKTFSKSTYLLQHHMVHTGEKPYKCMECGKAFNRKSHLTQHQRIHSGEKPYKCSECGKAFTHRSTFVLHNRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHSGENPYECFECGKVFKHRSYLMWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPYVCSECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNRADLIRHFSIHTGEKPYECMECGKAFNRRSGLTRHQRIHSGEKPYECIECGKTFCWSTNLIRHSIIHTGEKPYECSECGKAFSRSSSLTQHQRMHTGRNPISVTDVGRPFTSGQTSVNIQELLLGKNFLNVTTEENLLQEEASYMASDRTYQRETPQVSSL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 13..84
2 C2h2 203..225
3 C2h2 231..253
4 C2h2 259..281
5 C2h2 287..309
6 C2h2 315..337
7 C2h2 343..365
8 C2h2 371..393
9 C2h2 399..421
10 C2h2 427..449
11 C2h2 455..477
12 C2h2 483..505
13 C2h2 511..533
14 C2h2 539..561
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1D 197 **** 99.0 Highly correlated
2 MLT1C 81 **** 94.0 Weakly correlated
3 AluJb 5 n.s 74.0 Weakly correlated
4 AluJo 4 n.s 74.0 Weakly correlated
5 AluYj4 3 **** 0.0 Weakly correlated
6 L1PA5 3 n.s 19.6 Weakly correlated
7 LTR10A 3 **** 28.9 Weakly correlated
8 AluJr 3 n.s 74.0 Weakly correlated
9 AluY 2 n.s 74.0 Weakly correlated
10 MLT1E2 2 ** 99.0 Highly correlated
11 L1PA2 2 n.s 15.2 Weakly correlated
12 L2a 2 n.s 99.0 Highly correlated
13 MLT1J2 1 n.s 99.0 Highly correlated
14 MSTA 1 n.s 43.0 Weakly correlated
15 SVA_D 1 n.s 15.2 Weakly correlated
16 MLT1C-int 1 ** 94.0 Weakly correlated
17 SVA_B 1 * 15.2 Weakly correlated
18 MLT1B 1 n.s 99.0 Highly correlated
19 MIRb 1 n.s 99.0 Highly correlated
20 MIR 1 n.s 99.0 Highly correlated
21 LTR13 1 ** 19.6 Weakly correlated
22 SVA_C 1 ** 15.2 Weakly correlated
23 L2b 1 n.s 99.0 Highly correlated
24 L1P1 1 n.s 19.6 Weakly correlated
25 L1MC4 1 n.s 99.0 Highly correlated
26 L1MB5 1 n.s 99.0 Highly correlated
27 L1MA9 1 n.s 99.0 Highly correlated
28 L1M4 1 n.s 99.0 Highly correlated
29 HERVL18-int 1 ** 43.0 Weakly correlated
30 HAL1 1 n.s 99.0 Highly correlated
31 AluYm1 1 n.s 19.6 Weakly correlated
32 AluYh9 1 **** 15.2 Weakly correlated
33 AluYe5 1 ** 74.0 Weakly correlated
34 AluSz 1 n.s 74.0 Weakly correlated
35 AluSx3 1 n.s 74.0 Weakly correlated
36 AluSx 1 n.s 74.0 Weakly correlated
37 AluSc8 1 n.s 74.0 Weakly correlated
38 AluJr4 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1D 181 **** 99.0 Highly correlated
2 MLT1C 79 **** 94.0 Weakly correlated
3 MLT1E2 2 ** 99.0 Highly correlated
4 MLT1C-int 1 ** 94.0 Weakly correlated
5 AluJo 1 n.s 74.0 Weakly correlated
6 AluJr 1 n.s 74.0 Weakly correlated
7 MLT1B 1 n.s 99.0 Highly correlated
8 AluSx 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP