ZRdb KZFP & Repeats
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Human_ZNF791

  • Protein
    Zinc finger protein 791
  • Length
    576
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    87.0 Mya
  • Uniprot_ID
    Q3KP31
  • NCBI_ID
    163049
Sequence:
MDSVAFEDVSVSFSQEEWALLAPSQKKLYRDVMQETFKNLASIGEKWEDPNVEDQHKNQGRNLRSHTGERLCEGKEGSQCAENFSPNLSVTKKTAGVKPYECTICGKAFMRLSSLTRHMRSHTGYELFEKPYKCKECEKAFSYLKSFQRHERSHTGEKPYKCKQCGKTFIYHQPFQRHERTHIGEKPYECKQCGKALSCSSSLRVHERIHTGEKPYECKQCGKAFSCSSSIRVHERTHTGEKPYACKECGKAFISHTSVLTHMITHNGDRPYKCKECGKAFIFPSFLRVHERIHTGEKPYKCKQCGKAFRCSTSIQIHERIHTGEKPYKCKECGKSFSARPAFRVHVRVHTGEKPYKCKECGKAFSRISYFRIHERTHTGEKPYECKKCGKTFNYPLDLKIHKRNHTGEKPYECKECAKTFISLENFRRHMITHTGDGPYKCRDCGKVFIFPSALRTHERTHTGEKPYECKQCGKAFSCSSYIRIHKRTHTGEKPYECKECGKAFIYPTSFQGHMRMHTGEKPYKCKECGKAFSLHSSFQRHTRIHNYEKPLECKQCGKAFSVSTSLKKHMRMHNR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..90
2 C2h2 100..122
3 C2h2 132..154
4 C2h2 160..182
5 C2h2 188..210
6 C2h2 216..238
7 C2h2 244..266
8 C2h2 272..294
9 C2h2 300..322
10 C2h2 328..350
11 C2h2 356..378
12 C2h2 384..406
13 C2h2 412..434
14 C2h2 440..462
15 C2h2 468..490
16 C2h2 496..518
17 C2h2 524..546
18 C2h2 552..574
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 10 * 74.0 Weakly correlated
2 AluJb 6 n.s 74.0 Weakly correlated
3 LTR8 6 **** 43.0 Weakly correlated
4 L1MEf 6 **** 99.0 Moderately correlated
5 L1MEc 6 *** 99.0 Moderately correlated
6 LTR10A 4 **** 28.9 Weakly correlated
7 AluSx 4 n.s 74.0 Weakly correlated
8 L1M4a1 3 **** 99.0 Moderately correlated
9 AluSq2 3 n.s 74.0 Weakly correlated
10 MER50 3 **** 43.0 Weakly correlated
11 L1PA2 3 n.s 15.2 Weakly correlated
12 L1M4 3 * 99.0 Moderately correlated
13 AluSx1 3 n.s 74.0 Weakly correlated
14 AluSz6 3 n.s 74.0 Weakly correlated
15 L1PA5 2 n.s 19.6 Weakly correlated
16 L1M4b 2 ** 99.0 Moderately correlated
17 L1M4c 2 ** 99.0 Moderately correlated
18 AluYm1 2 ** 19.6 Weakly correlated
19 MIRb 2 n.s 99.0 Moderately correlated
20 L1P3 2 ** 74.0 Weakly correlated
21 AluSc8 2 n.s 74.0 Weakly correlated
22 AluSp 2 n.s 74.0 Weakly correlated
23 LTR12C 1 n.s 19.6 Weakly correlated
24 LTR13 1 ** 19.6 Weakly correlated
25 LTR10F 1 *** 28.9 Weakly correlated
26 THE1D 1 n.s 43.0 Weakly correlated
27 LTR14B 1 *** 28.9 Weakly correlated
28 MER101-int 1 ** 74.0 Weakly correlated
29 MER39B 1 ** 74.0 Weakly correlated
30 MER4-int 1 * 74.0 Weakly correlated
31 MER50-int 1 ** 43.0 Weakly correlated
32 MLT1B 1 n.s 99.0 Moderately correlated
33 MLT1F1 1 ** 99.0 Moderately correlated
34 MLT1H1 1 * 99.0 Moderately correlated
35 MamRTE1 1 * 99.0 Moderately correlated
36 SVA_C 1 ** 15.2 Weakly correlated
37 THE1B 1 n.s 43.0 Weakly correlated
38 L1MB1 1 n.s 99.0 Moderately correlated
39 AluJr4 1 n.s 74.0 Weakly correlated
40 AluYh9 1 **** 15.2 Weakly correlated
41 FRAM 1 * 74.0 Weakly correlated
42 L1M1 1 n.s 74.0 Weakly correlated
43 L1M2a 1 ** 87.0 Highly correlated
44 L1M3c 1 ** 99.0 Moderately correlated
45 L1MA8 1 n.s 87.0 Highly correlated
46 L1MA9 1 n.s 99.0 Moderately correlated
47 LTR1 1 *** 43.0 Weakly correlated
48 L1MB3 1 n.s 99.0 Moderately correlated
49 L1MB4 1 n.s 99.0 Moderately correlated
50 L1MCc 1 * 99.0 Moderately correlated
51 L1ME4b 1 n.s 99.0 Moderately correlated
52 L1P1 1 n.s 19.6 Weakly correlated
53 L1P4 1 * 74.0 Weakly correlated
54 L2a 1 n.s 99.0 Moderately correlated
55 L2c 1 n.s 99.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEc 1 n.s 99.0 Moderately correlated
2 L1MA9 1 n.s 99.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP