ZRdb KZFP & Repeats
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Human_ZNF789

  • Protein
    Zinc finger protein 789
  • Length
    425
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q5FWF6
  • NCBI_ID
    285989
Sequence:
MFPPARGKELLSFEDVAMYFTREEWGHLNWGQKDLYRDVMLENYRNMVLLGFQFPKPEMICQLENWDEQWILDLPRTGNRKASGSACPGSEARHKMKKLTPKQKFSEDLESYKISVVMQESAEKLSEKLHKCKEFVDSCRLTFPTSGDEYSRGFLQNLNLIQDQNAQTRWKQGRYDEDGKPFNQRSLLLGHERILTRAKSYECSECGKVIRRKAWFDQHQRIHFLENPFECKVCGQAFRQRSALTVHKQCHLQNKPYRCHDCGKCFRQLAYLVEHKRIHTKEKPYKCSKCEKTFSQNSTLIRHQVIHSGEKRHKCLECGKAFGRHSTLLCHQQIHSKPNTHKCSECGQSFGRNVDLIQHQRIHTKEEFFQCGECGKTFSFKRNLFRHQVIHTGSQPYQCVICGKSFKWHTSFIKHQGTHKGQIST
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 11..82
2 C2h2 201..223
3 C2h2 229..251
4 C2h2 257..279
5 C2h2 285..307
6 C2h2 313..335
7 C2h2 341..363
8 C2h2 369..391
9 C2h2 397..419
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleoplasm
2 Cellular Component nucleus
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER21C 36 **** 99.0 Highly correlated
2 AluJb 26 **** 74.0 Weakly correlated
3 MER77B 25 **** 99.0 Highly correlated
4 MER57A-int 18 **** 43.0 Weakly correlated
5 MIR 17 ** 99.0 Highly correlated
6 MER57-int 16 **** 87.0 Weakly correlated
7 AluSz 15 * 74.0 Weakly correlated
8 MER65A 15 **** 74.0 Weakly correlated
9 L2c 14 * 99.0 Highly correlated
10 MER21B 14 **** 99.0 Highly correlated
11 MER65-int 14 **** 87.0 Weakly correlated
12 MER21-int 13 **** 99.0 Highly correlated
13 MER57A1 13 **** 43.0 Weakly correlated
14 L2a 12 n.s 99.0 Highly correlated
15 AluJo 11 * 74.0 Weakly correlated
16 L2b 10 * 99.0 Highly correlated
17 AluSx 9 n.s 74.0 Weakly correlated
18 AluSx1 9 n.s 74.0 Weakly correlated
19 AluY 8 n.s 74.0 Weakly correlated
20 MIRb 8 n.s 99.0 Highly correlated
21 L2 7 n.s 99.0 Highly correlated
22 MER57B1 7 **** 43.0 Weakly correlated
23 MIRc 7 n.s 99.0 Highly correlated
24 MER65C 6 **** 74.0 Weakly correlated
25 MIR3 6 * 99.0 Highly correlated
26 AluJr 5 n.s 74.0 Weakly correlated
27 AluSq2 5 n.s 74.0 Weakly correlated
28 L1P3 5 *** 74.0 Weakly correlated
29 MLT1N2 5 **** 99.0 Highly correlated
30 THE1D 5 ** 43.0 Weakly correlated
31 AluSc 4 n.s 74.0 Weakly correlated
32 AluSp 4 n.s 74.0 Weakly correlated
33 AluSx3 4 n.s 74.0 Weakly correlated
34 AluSz6 4 n.s 74.0 Weakly correlated
35 ERV3-16A3_I-int 4 ** 99.0 Highly correlated
36 HAL1 4 n.s 99.0 Highly correlated
37 L1PA5 4 n.s 19.6 Weakly correlated
38 LTR10A 4 **** 28.9 Weakly correlated
39 MER57B2 4 **** 43.0 Weakly correlated
40 MER77 4 **** 99.0 Highly correlated
41 AluJr4 3 n.s 74.0 Weakly correlated
42 AluSc5 3 ** 74.0 Weakly correlated
43 AluSc8 3 n.s 74.0 Weakly correlated
44 AluSg 3 n.s 74.0 Weakly correlated
45 L1MC3 3 n.s 99.0 Highly correlated
46 L3 3 n.s 99.0 Highly correlated
47 LTR06 3 **** 74.0 Weakly correlated
48 MER52A 3 ** 74.0 Weakly correlated
49 MER57D 3 **** 87.0 Weakly correlated
50 MLT1C 3 n.s 94.0 Weakly correlated
51 MSTB 3 * 43.0 Weakly correlated
52 AluSq 2 n.s 74.0 Weakly correlated
53 AluYj4 2 ** 0.0 Weakly correlated
54 HERVK14-int 2 *** 28.9 Weakly correlated
55 L1MB4 2 n.s 99.0 Highly correlated
56 L1MB7 2 n.s 99.0 Highly correlated
57 L1MC4 2 n.s 99.0 Highly correlated
58 L1MD2 2 n.s 99.0 Highly correlated
59 L1MDb 2 *** 99.0 Highly correlated
60 L1ME3B 2 n.s 99.0 Highly correlated
61 L1ME4b 2 n.s 99.0 Highly correlated
62 L1PB1 2 n.s 74.0 Weakly correlated
63 LTR86B1 2 **** 99.0 Highly correlated
64 MER21A 2 ** 74.0 Weakly correlated
65 MER50 2 ** 43.0 Weakly correlated
66 MER57F 2 **** 74.0 Weakly correlated
67 MER61-int 2 ** 43.0 Weakly correlated
68 MLT1A 2 n.s 99.0 Highly correlated
69 MLT1D 2 n.s 99.0 Highly correlated
70 MLT1F1 2 ** 99.0 Highly correlated
71 MLT1J2 2 * 99.0 Highly correlated
72 MSTA 2 n.s 43.0 Weakly correlated
73 MSTA-int 2 n.s 43.0 Weakly correlated
74 THE1B 2 n.s 43.0 Weakly correlated
75 THE1B-int 2 n.s 43.0 Weakly correlated
76 THE1C-int 2 * 43.0 Weakly correlated
77 AluYc 1 * 74.0 Weakly correlated
78 AluYh9 1 **** 15.2 Weakly correlated
79 ERVL-B4-int 1 n.s 99.0 Highly correlated
80 ERVL-E-int 1 n.s 99.0 Highly correlated
81 FLAM_C 1 n.s 74.0 Weakly correlated
82 HAL1M8 1 * 99.0 Highly correlated
83 HERV35I-int 1 ** 43.0 Weakly correlated
84 HERVH-int 1 n.s 28.9 Weakly correlated
85 HERVIP10FH-int 1 ** 28.9 Weakly correlated
86 HERVL-int 1 n.s 74.0 Weakly correlated
87 HERVL40-int 1 * 99.0 Highly correlated
88 L1M1 1 n.s 74.0 Weakly correlated
89 L1M4 1 n.s 99.0 Highly correlated
90 L1M5 1 n.s 99.0 Highly correlated
91 L1MA2 1 n.s 74.0 Weakly correlated
92 L1MA4A 1 n.s 87.0 Weakly correlated
93 L1MB3 1 n.s 99.0 Highly correlated
94 L1MB8 1 n.s 99.0 Highly correlated
95 L1MC5a 1 n.s 99.0 Highly correlated
96 L1MCb 1 n.s 99.0 Highly correlated
97 L1MD 1 n.s 99.0 Highly correlated
98 L1MDa 1 n.s 99.0 Highly correlated
99 L1ME1 1 n.s 99.0 Highly correlated
100 L1ME3 1 n.s 99.0 Highly correlated
101 L1ME3A 1 n.s 99.0 Highly correlated
102 L1MEf 1 n.s 99.0 Highly correlated
103 L1MEg 1 n.s 99.0 Highly correlated
104 L1P1 1 n.s 19.6 Weakly correlated
105 L1P2 1 n.s 28.9 Weakly correlated
106 L1P4 1 n.s 74.0 Weakly correlated
107 L1PA10 1 n.s 74.0 Weakly correlated
108 L1PA14 1 n.s 74.0 Weakly correlated
109 L1PA16 1 n.s 74.0 Weakly correlated
110 L1PA2 1 n.s 15.2 Weakly correlated
111 L1PA8 1 n.s 74.0 Weakly correlated
112 L1PB4 1 n.s 99.0 Highly correlated
113 L2-3_Crp 1 ** 431.0 Weakly correlated
114 LTR13 1 ** 19.6 Weakly correlated
115 LTR16A 1 n.s 99.0 Highly correlated
116 LTR16C 1 n.s 99.0 Highly correlated
117 LTR16E1 1 * 99.0 Highly correlated
118 LTR1D1 1 ** 43.0 Weakly correlated
119 LTR33A_ 1 * 99.0 Highly correlated
120 LTR41 1 ** 99.0 Highly correlated
121 LTR48B 1 ** 74.0 Weakly correlated
122 LTR52 1 ** 99.0 Highly correlated
123 LTR5_Hs 1 * 0.0 Weakly correlated
124 LTR75B 1 *** 99.0 Highly correlated
125 LTR8 1 n.s 43.0 Weakly correlated
126 LTR85c 1 ** 99.0 Highly correlated
127 LTR86A2 1 *** 99.0 Highly correlated
128 LTR86B2 1 *** 99.0 Highly correlated
129 LTR89 1 ** 99.0 Highly correlated
130 MER101-int 1 * 74.0 Weakly correlated
131 MER31-int 1 * 99.0 Highly correlated
132 MER34B-int 1 ** 99.0 Highly correlated
133 MER39B 1 * 74.0 Weakly correlated
134 MER41-int 1 n.s 74.0 Weakly correlated
135 MER4A1 1 * 74.0 Weakly correlated
136 MER4B-int 1 * 99.0 Highly correlated
137 MER4E1 1 ** 74.0 Weakly correlated
138 MER54B 1 ** 87.0 Weakly correlated
139 MER57C1 1 *** 74.0 Weakly correlated
140 MER57C2 1 *** 87.0 Weakly correlated
141 MER57E1 1 *** 87.0 Weakly correlated
142 MER65D 1 *** 87.0 Weakly correlated
143 MER68 1 * 99.0 Highly correlated
144 MER68-int 1 ** 99.0 Highly correlated
145 MER70A 1 ** 87.0 Weakly correlated
146 MER72 1 ** 43.0 Weakly correlated
147 MLT1A0 1 n.s 99.0 Highly correlated
148 MLT1B 1 n.s 99.0 Highly correlated
149 MLT1E2 1 n.s 99.0 Highly correlated
150 MLT1G 1 * 99.0 Highly correlated
151 MLT1H 1 n.s 99.0 Highly correlated
152 MLT1I 1 n.s 99.0 Highly correlated
153 MLT1J 1 n.s 99.0 Highly correlated
154 MLT1K 1 n.s 99.0 Highly correlated
155 MLT1M 1 ** 99.0 Highly correlated
156 MLT2F 1 * 99.0 Highly correlated
157 MSTB1 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER21C 31 **** 99.0 Highly correlated
2 MER77B 23 **** 99.0 Highly correlated
3 MER57A-int 17 **** 43.0 Weakly correlated
4 AluJb 17 * 74.0 Weakly correlated
5 MER57-int 13 **** 87.0 Weakly correlated
6 AluSz 12 n.s 74.0 Weakly correlated
7 MER21B 11 **** 99.0 Highly correlated
8 MIR 10 n.s 99.0 Highly correlated
9 MER21-int 9 **** 99.0 Highly correlated
10 L2c 7 n.s 99.0 Highly correlated
11 L2 6 n.s 99.0 Highly correlated
12 MIRc 6 n.s 99.0 Highly correlated
13 MER65-int 6 **** 87.0 Weakly correlated
14 MLT1N2 5 **** 99.0 Highly correlated
15 THE1D 5 ** 43.0 Weakly correlated
16 MER77 4 **** 99.0 Highly correlated
17 HAL1 4 n.s 99.0 Highly correlated
18 AluSq2 3 n.s 74.0 Weakly correlated
19 ERV3-16A3_I-int 3 * 99.0 Highly correlated
20 AluSx1 3 n.s 74.0 Weakly correlated
21 MER65A 3 **** 74.0 Weakly correlated
22 L2b 3 n.s 99.0 Highly correlated
23 AluJr 3 n.s 74.0 Weakly correlated
24 AluSx3 3 n.s 74.0 Weakly correlated
25 AluJo 3 n.s 74.0 Weakly correlated
26 AluSg 3 n.s 74.0 Weakly correlated
27 MIRb 3 n.s 99.0 Highly correlated
28 L2a 2 n.s 99.0 Highly correlated
29 AluJr4 2 n.s 74.0 Weakly correlated
30 L1MC3 2 n.s 99.0 Highly correlated
31 MLT1D 2 n.s 99.0 Highly correlated
32 THE1B-int 2 n.s 43.0 Weakly correlated
33 L3 2 n.s 99.0 Highly correlated
34 L1ME4b 2 n.s 99.0 Highly correlated
35 HERVK14-int 2 *** 28.9 Weakly correlated
36 MER52A 2 * 74.0 Weakly correlated
37 MSTA-int 2 n.s 43.0 Weakly correlated
38 MIR3 2 n.s 99.0 Highly correlated
39 L1MD2 2 n.s 99.0 Highly correlated
40 MLT1J 1 n.s 99.0 Highly correlated
41 LTR86B1 1 *** 99.0 Highly correlated
42 LTR52 1 ** 99.0 Highly correlated
43 HERVIP10FH-int 1 ** 28.9 Weakly correlated
44 MLT1K 1 n.s 99.0 Highly correlated
45 MER34B-int 1 ** 99.0 Highly correlated
46 LTR33A_ 1 * 99.0 Highly correlated
47 MLT1G 1 * 99.0 Highly correlated
48 MLT1A0 1 n.s 99.0 Highly correlated
49 MER4A1 1 * 74.0 Weakly correlated
50 MLT1E2 1 n.s 99.0 Highly correlated
51 AluY 1 n.s 74.0 Weakly correlated
52 HERVH-int 1 n.s 28.9 Weakly correlated
53 HERVL-int 1 n.s 74.0 Weakly correlated
54 HERVL40-int 1 * 99.0 Highly correlated
55 L1MCb 1 n.s 99.0 Highly correlated
56 L1ME3A 1 n.s 99.0 Highly correlated
57 L1PB4 1 n.s 99.0 Highly correlated
58 LTR75B 1 *** 99.0 Highly correlated
59 L1MA4A 1 n.s 87.0 Weakly correlated
60 MLT1H 1 n.s 99.0 Highly correlated
61 L1PA8 1 n.s 74.0 Weakly correlated
62 AluSx 1 n.s 74.0 Weakly correlated
63 LTR1D1 1 ** 43.0 Weakly correlated
64 MER31-int 1 * 99.0 Highly correlated
65 MER50 1 n.s 43.0 Weakly correlated
66 L1MC4 1 n.s 99.0 Highly correlated
67 AluSc8 1 n.s 74.0 Weakly correlated
68 L1MB8 1 n.s 99.0 Highly correlated
69 ERVL-B4-int 1 n.s 99.0 Highly correlated
70 MER61-int 1 * 43.0 Weakly correlated
71 L1PA16 1 n.s 74.0 Weakly correlated
72 AluSc 1 n.s 74.0 Weakly correlated
73 L1MB4 1 n.s 99.0 Highly correlated
74 AluSq 1 n.s 74.0 Weakly correlated
75 L1MDb 1 * 99.0 Highly correlated
76 HERV35I-int 1 ** 43.0 Weakly correlated
77 L1PA10 1 n.s 74.0 Weakly correlated
78 L1PA14 1 n.s 74.0 Weakly correlated
79 LTR16C 1 n.s 99.0 Highly correlated
80 MER68-int 1 ** 99.0 Highly correlated
81 THE1C-int 1 n.s 43.0 Weakly correlated
82 MLT1C 1 n.s 94.0 Weakly correlated
83 MLT1J2 1 n.s 99.0 Highly correlated
84 MLT1M 1 ** 99.0 Highly correlated
85 MLT2F 1 * 99.0 Highly correlated
86 L1MB3 1 n.s 99.0 Highly correlated
87 L1MC5a 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L2 99.0 Highly correlated