ZRdb KZFP & Repeats
...

Human_ZNF782

  • Protein
    Zinc finger protein 782
  • Length
    699
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q6ZMW2
  • NCBI_ID
    158431
Sequence:
MNTFQASVSFQDVTVEFSQEEWQHMGPVERTLYRDVMLENYSHLVSVGYCFTKPELIFTLEQGEDPWLLEKEKGFLSRNSPEDSQPDEISEKSPENQGKHLLQVLFTNKLLTTEQEISGKPHNRDINIFRARMMPCKCDIAGSACQGLSLMAPHCQYSKEKAHERNVCDKWLISIKDGRTNTQEKSFAYSKIVKTLHHKEEVIQHQTIQTLGQDFEYNESRKAFLEKAALVTSNSTHPKGKSYNFNKFGENKYDKSTFIIPQNMNPEKSHYEFNDTGNCFCRITHKTLTGGKSFSQKSHIREHHRVHIGVKPFEYGKSFNRNSTLPVHQRTHATDKYSDYHPCTETFSYQSTFSVHQKVHIRAKPYEYNECGKSCSMNSHLIWPQKSHTGEKPYECPECGKAFSEKSRLRKHQRTHTGEKPYKCDGCDKAFSAKSGLRIHQRTHTGEKPFECHECGKSFNYKSILIVHQRTHTGEKPFECNECGKSFSHMSGLRNHRRTHTGERPYKCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCGKAFGQKSQLRGHHRIHTGEKPYKCNHCGEAFSQKSNLRVHHRTHTGEKPYQCEECGKTFRQKSNLRGHQRTHTGEKPYECNECGKAFSEKSVLRKHQRTHTGEKPYNCNQCGEAFSQKSNLRVHQRTHTGEKPYKCDKCGRTFSQKSSLREHQKAHPGD
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 8..79
2 dec2h2 279..307
3 dec2h2 316..332
4 dec2h2 337..360
5 dec2h2 366..388
6 C2h2 394..416
7 C2h2 422..444
8 C2h2 450..472
9 C2h2 478..500
10 C2h2 506..528
11 C2h2 534..556
12 C2h2 562..584
13 C2h2 590..612
14 C2h2 618..640
15 C2h2 646..668
16 C2h2 674..696
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M4b 17 **** 99.0 Highly correlated
2 L1M4a2 9 **** 99.0 Highly correlated
3 L1M4 7 **** 99.0 Highly correlated
4 L1M4a1 4 **** 99.0 Highly correlated
5 L1PA2 3 * 15.2 Weakly correlated
6 LTR10A 3 **** 28.9 Weakly correlated
7 AluSz 3 n.s 74.0 Weakly correlated
8 L1MEf 2 * 99.0 Highly correlated
9 L2a 2 n.s 99.0 Highly correlated
10 AluSx 2 n.s 74.0 Weakly correlated
11 L1MB7 2 n.s 99.0 Highly correlated
12 LTR9B 1 *** 43.0 Weakly correlated
13 L1MB8 1 n.s 99.0 Highly correlated
14 L1PA5 1 n.s 19.6 Weakly correlated
15 MLT1A0 1 n.s 99.0 Highly correlated
16 LTR13 1 ** 19.6 Weakly correlated
17 LTR16B2 1 ** 99.0 Highly correlated
18 MER50-int 1 ** 43.0 Weakly correlated
19 MLT1A 1 * 99.0 Highly correlated
20 MIRb 1 n.s 99.0 Highly correlated
21 MIR 1 n.s 99.0 Highly correlated
22 MER21A 1 ** 74.0 Weakly correlated
23 MER39B 1 ** 74.0 Weakly correlated
24 MER50 1 ** 43.0 Weakly correlated
25 MER52A 1 * 74.0 Weakly correlated
26 L1MEb 1 ** 99.0 Highly correlated
27 L1MD2 1 n.s 99.0 Highly correlated
28 AluJb 1 n.s 74.0 Weakly correlated
29 L1MB4 1 n.s 99.0 Highly correlated
30 L1MB3 1 n.s 99.0 Highly correlated
31 L1MA9 1 n.s 99.0 Highly correlated
32 AluYm1 1 * 19.6 Weakly correlated
33 AluYh9 1 **** 15.2 Weakly correlated
34 AluSz6 1 n.s 74.0 Weakly correlated
35 AluSx3 1 n.s 74.0 Weakly correlated
36 AluSx1 1 n.s 74.0 Weakly correlated
37 AluSq2 1 n.s 74.0 Weakly correlated
38 AluSg 1 n.s 74.0 Weakly correlated
39 AluSc8 1 n.s 74.0 Weakly correlated
40 AluJo 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M4b 8 **** 99.0 Highly correlated
2 L1M4 4 ** 99.0 Highly correlated
3 L1M4a2 3 **** 99.0 Highly correlated
4 AluYh9 1 **** 15.2 Weakly correlated
5 L1PA5 1 n.s 19.6 Weakly correlated
6 L1MB4 1 n.s 99.0 Highly correlated
7 L1M4a1 1 ** 99.0 Highly correlated
8 AluSg 1 n.s 74.0 Weakly correlated
9 L1MEb 1 ** 99.0 Highly correlated
10 L1MA9 1 n.s 99.0 Highly correlated
11 L1MB8 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1M4B 99.0 Highly correlated