ZRdb KZFP & Repeats
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Human_ZNF780B

  • Protein
    Zinc finger protein 780B
  • Length
    833
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    74.0 Mya
  • Uniprot_ID
    Q9Y6R6
  • NCBI_ID
    163131
Sequence:
MVHGSVTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLGSSISKPDVITLLEQEKEPWIVVSKETSRWYPDLESKYGPEKISPENDIFEINLPKHVIKQISKTLGLEAFYFRNDSEYRSRFEGRQGHQEGYINQKIISYEEMPAYTHASPIHNTHKPYECKECGKYFSCGSNLIQHQSIHTGEKPYKCKECGKAFQLHIQLTRHQKFHTGEKTFECKECGKAFNLPTQLNRHKNIHTVKKLFECKECGKSFNRSSNLTQHQSIHAGVKPYQCKECGKAFNRGSNLIQHQKIHSNEKPFVCRECEMAFRYHYQLIEHCRIHTGEKPFECKECRKAFTLLTKLVRHQKIHMGEKPFECRECGKAFSLLNQLNRHKNIHTGEKPFECKECGKSFNRSSNLIQHQSIHADVKPYECKECGKGFNRGANLIQHQKIHSNEKPFVCRECEMAFRYHYQLIQHCQIHTGGKPFECKECGKAFSLLTQLARHKNIHTGEKPFECKDCGKAFNRGSNLVQHQSIHTGEKPYECKECGKAFRLHLQLSQHEKTHTGEKPFECKECGKFFRRGSNLNQHRSIHTGKKPFECKECGKAFRLHMHLIRHQKFHTGEKPFECKECGKAFSLHTQLNHHKNIHTGEKPFKCKECGKSFNRVSNLVQHQSIHAGVKPYECKECGKGFSRVSNLIQHQKTHSSAKPFVCKECRKTFRYHYQLTEHYRIHTGEKPFECKECGKAFGLLTQLAQHQIIHTGEKPFKCKECGKAFNRGSNLVQPQSIHTGEKPYECKECGKAFRLHLQLSLHQKLVQVRNPLNVRNVGQPSDISSNLLNIRKFILG
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 6..77
2 C2h2 165..187
3 C2h2 193..215
4 C2h2 221..243
5 C2h2 249..271
6 C2h2 277..299
7 C2h2 305..327
8 C2h2 333..355
9 C2h2 361..383
10 C2h2 389..411
11 C2h2 417..439
12 C2h2 445..467
13 C2h2 473..495
14 C2h2 501..523
15 C2h2 529..551
16 C2h2 557..579
17 C2h2 585..607
18 C2h2 613..635
19 C2h2 641..663
20 C2h2 669..691
21 C2h2 697..719
22 C2h2 725..747
23 dec2h2 753..775
24 dec2h2 781..803
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER65C 34 **** 74.0 Highly correlated
2 L2c 5 n.s 99.0 Weakly correlated
3 MIRb 4 n.s 99.0 Weakly correlated
4 LTR10A 4 **** 28.9 Weakly correlated
5 LTR67B 3 **** 99.0 Weakly correlated
6 AluY 3 n.s 74.0 Highly correlated
7 LTR1A1 3 **** 43.0 Weakly correlated
8 L2b 3 n.s 99.0 Weakly correlated
9 MamRTE1 2 *** 99.0 Weakly correlated
10 LTR78 2 *** 99.0 Weakly correlated
11 LTR51 2 **** 74.0 Highly correlated
12 LTR41C 2 **** 99.0 Weakly correlated
13 L1PB4 2 * 99.0 Weakly correlated
14 AluSx 2 n.s 74.0 Highly correlated
15 MIR 1 n.s 99.0 Weakly correlated
16 LTR50 1 ** 99.0 Weakly correlated
17 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
18 AluSx1 1 n.s 74.0 Highly correlated
19 LTR7 1 ** 19.6 Weakly correlated
20 LTR8B 1 ** 43.0 Weakly correlated
21 MER65B 1 **** 74.0 Highly correlated
22 AluSq 1 n.s 74.0 Highly correlated
23 FLAM_A 1 * 74.0 Highly correlated
24 MIR3 1 n.s 99.0 Weakly correlated
25 AluJo 1 n.s 74.0 Highly correlated
26 MLT1A0 1 n.s 99.0 Weakly correlated
27 MLT1J2 1 * 99.0 Weakly correlated
28 MLT1O 1 ** 99.0 Weakly correlated
29 MSTB1 1 * 74.0 Highly correlated
30 AluJb 1 n.s 74.0 Highly correlated
31 L1MC3 1 n.s 99.0 Weakly correlated
32 LTR41 1 ** 99.0 Weakly correlated
33 LTR1A2 1 ** 43.0 Weakly correlated
34 HAL1 1 n.s 99.0 Weakly correlated
35 LTR18B 1 *** 43.0 Weakly correlated
36 LTR12_ 1 *** 28.9 Weakly correlated
37 HAL1M8 1 ** 99.0 Weakly correlated
38 LTR104_Mam 1 ** 99.0 Weakly correlated
39 L3 1 n.s 99.0 Weakly correlated
40 L1M1 1 n.s 74.0 Highly correlated
41 L1M4a2 1 ** 99.0 Weakly correlated
42 L1MA4 1 n.s 87.0 Moderately correlated
43 L1PB1 1 n.s 74.0 Highly correlated
44 L1PA13 1 n.s 74.0 Highly correlated
45 L1MEc 1 n.s 99.0 Weakly correlated
46 L1ME1 1 n.s 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER65C 20 **** 74.0 Highly correlated
2 MIRb 2 n.s 99.0 Weakly correlated
3 LTR1A1 2 **** 43.0 Weakly correlated
4 L1PB4 2 * 99.0 Weakly correlated
5 LTR67B 2 *** 99.0 Weakly correlated
6 L1PA13 1 n.s 74.0 Highly correlated
7 LTR41 1 ** 99.0 Weakly correlated
8 HAL1 1 n.s 99.0 Weakly correlated
9 L2c 1 n.s 99.0 Weakly correlated
10 LTR104_Mam 1 ** 99.0 Weakly correlated
11 MLT1A0 1 n.s 99.0 Weakly correlated
12 MER65B 1 **** 74.0 Highly correlated
13 LTR78 1 * 99.0 Weakly correlated
14 LTR41C 1 *** 99.0 Weakly correlated
15 MamRTE1 1 * 99.0 Weakly correlated
16 L1PB1 1 n.s 74.0 Highly correlated
17 LTR8B 1 ** 43.0 Weakly correlated
18 HAL1M8 1 ** 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP