ZRdb KZFP & Repeats
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Human_ZNF777

  • Protein
    Zinc finger protein 777
  • Length
    831
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    319.0 Mya
  • Time of Changing in binding specificity
    319.0 Mya
  • Uniprot_ID
    Q9ULD5
  • NCBI_ID
    27153
Sequence:
MENQRSSPLSFPSVPQEETLRQAPAGLPRETLFQSRVLPPKEIPSLSPTIPRQGSLPQTSSAPKQETSGRMPHVLQKGPSLLCSAASEQETSLQGPLASQEGTQYPPPAAAEQEVSLLSHSPHHQEAPVHSPEAPEKDPLTLSPTVPETDMDPLLQSPVSQKDTPFQISSAVQKEQPLPTAEITRLAVWAAVQAVERKLEAQAMRLLTLEGRTGTNEKKIADCEKTAVEFANHLESKWVVLGTLLQEYGLLQRRLENMENLLKNRNFWILRLPPGSNGEVPKVPVTFDDVAVHFSEQEWGNLSEWQKELYKNVMRGNYESLVSMDYAISKPDLMSQMERGERPTMQEQEDSEEGETPTDPSAAHDGIVIKIEVQTNDEGSESLETPEPLMGQVEEHGFQDSELGDPCGEQPDLDMQEPENTLEESTEGSSEFSELKQMLVQQRNCTEGIVIKTEEQDEEEEEEEEDELPQHLQSLGQLSGRYEASMYQTPLPGEMSPEGEESPPPLQLGNPAVKRLAPSVHGERHLSENRGASSQQQRNRRGERPFTCMECGKSFRLKINLIIHQRNHIKEGPYECAECEISFRHKQQLTLHQRIHRVRGGCVSPERGPTFNPKHALKPRPKSPSSGSGGGGPKPYKCPECDSSFSHKSSLTKHQITHTGERPYTCPECKKSFRLHISLVIHQRVHAGKHEVSFICSLCGKSFSRPSHLLRHQRTHTGERPFKCPECEKSFSEKSKLTNHCRVHSRERPHACPECGKSFIRKHHLLEHRRIHTGERPYHCAECGKRFTQKHHLLEHQRAHTGERPYPCTHCAKCFRYKQSLKYHLRTHTGE
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 285..356
2 C2h2 546..568
3 C2h2 574..596
4 C2h2 636..658
5 C2h2 664..686
6 C2h2 694..716
7 C2h2 722..744
8 C2h2 750..772
9 C2h2 778..800
10 C2h2 806..828
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process negative regulation of cell population proliferation
6 Biological Process negative regulation of DNA-templated transcription
7 Biological Process protein heterooligomerization
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2c 17 n.s 99.0 Weakly correlated
2 L2a 15 n.s 99.0 Weakly correlated
3 AluJb 9 n.s 74.0 Weakly correlated
4 AluSx1 9 n.s 74.0 Weakly correlated
5 LTR12C 9 **** 19.6 Weakly correlated
6 AluSx 8 n.s 74.0 Weakly correlated
7 L1P3 8 **** 74.0 Weakly correlated
8 L2 8 n.s 99.0 Weakly correlated
9 L2b 8 n.s 99.0 Weakly correlated
10 L1PA7 7 n.s 74.0 Weakly correlated
11 MIRb 7 n.s 99.0 Weakly correlated
12 AluJo 6 n.s 74.0 Weakly correlated
13 L1PA5 6 n.s 19.6 Weakly correlated
14 LTR8 6 **** 43.0 Weakly correlated
15 L1PA8 5 n.s 74.0 Weakly correlated
16 L1PB1 5 n.s 74.0 Weakly correlated
17 MIR 5 n.s 99.0 Weakly correlated
18 AluJr 4 n.s 74.0 Weakly correlated
19 AluSq2 4 n.s 74.0 Weakly correlated
20 AluSz6 4 n.s 74.0 Weakly correlated
21 L1MA6 4 * 87.0 Weakly correlated
22 L3 4 n.s 99.0 Weakly correlated
23 MIR3 4 n.s 99.0 Weakly correlated
24 AluSg 3 n.s 74.0 Weakly correlated
25 AluSq 3 n.s 74.0 Weakly correlated
26 Harlequin-int 3 *** 74.0 Weakly correlated
27 L1MC4 3 n.s 99.0 Weakly correlated
28 L1PA13 3 n.s 74.0 Weakly correlated
29 LTR10A 3 **** 28.9 Weakly correlated
30 MLT1H 3 * 99.0 Weakly correlated
31 AluSp 2 n.s 74.0 Weakly correlated
32 AluSx4 2 n.s 74.0 Weakly correlated
33 AluSz 2 n.s 74.0 Weakly correlated
34 AluY 2 n.s 74.0 Weakly correlated
35 HAL1 2 n.s 99.0 Weakly correlated
36 HERVH-int 2 n.s 28.9 Weakly correlated
37 L1MA8 2 n.s 87.0 Weakly correlated
38 L1MA9 2 n.s 99.0 Weakly correlated
39 L1MB7 2 n.s 99.0 Weakly correlated
40 L1MC1 2 n.s 99.0 Weakly correlated
41 L1ME1 2 n.s 99.0 Weakly correlated
42 L1ME3G 2 n.s 99.0 Weakly correlated
43 L1P4 2 * 74.0 Weakly correlated
44 L1PA10 2 n.s 74.0 Weakly correlated
45 L1PA2 2 n.s 15.2 Weakly correlated
46 L1PA6 2 n.s 28.9 Weakly correlated
47 L1PREC2 2 n.s 43.0 Weakly correlated
48 LTR10F 2 **** 28.9 Weakly correlated
49 LTR16A 2 * 99.0 Weakly correlated
50 MLT1A 2 n.s 99.0 Weakly correlated
51 MLT1E3 2 ** 99.0 Weakly correlated
52 MLT1J 2 n.s 99.0 Weakly correlated
53 MLT1K 2 n.s 99.0 Weakly correlated
54 MLT1N2 2 ** 99.0 Weakly correlated
55 MSTA 2 n.s 43.0 Weakly correlated
56 AluJr4 1 n.s 74.0 Weakly correlated
57 AluSc 1 n.s 74.0 Weakly correlated
58 AluSc5 1 n.s 74.0 Weakly correlated
59 AluSc8 1 n.s 74.0 Weakly correlated
60 AluYh9 1 **** 15.2 Weakly correlated
61 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
62 ERVL-B4-int 1 n.s 99.0 Weakly correlated
63 HAL1ME 1 n.s 99.0 Weakly correlated
64 HERVL74-int 1 ** 99.0 Weakly correlated
65 L1M2 1 n.s 99.0 Weakly correlated
66 L1M4 1 n.s 99.0 Weakly correlated
67 L1M4c 1 n.s 99.0 Weakly correlated
68 L1M5 1 n.s 99.0 Weakly correlated
69 L1MA2 1 n.s 74.0 Weakly correlated
70 L1MA4A 1 n.s 87.0 Weakly correlated
71 L1MA5A 1 n.s 87.0 Weakly correlated
72 L1MB2 1 n.s 99.0 Weakly correlated
73 L1MC 1 n.s 99.0 Weakly correlated
74 L1MC2 1 n.s 99.0 Weakly correlated
75 L1MC3 1 n.s 99.0 Weakly correlated
76 L1MC5 1 n.s 99.0 Weakly correlated
77 L1MCb 1 n.s 99.0 Weakly correlated
78 L1MD1 1 n.s 99.0 Weakly correlated
79 L1ME3A 1 n.s 99.0 Weakly correlated
80 L1ME3E 1 n.s 99.0 Weakly correlated
81 L1MEd 1 n.s 99.0 Weakly correlated
82 L1MEj 1 * 99.0 Weakly correlated
83 L1P1 1 n.s 19.6 Weakly correlated
84 L1PA15 1 n.s 74.0 Weakly correlated
85 L1PA15-16 1 n.s 74.0 Weakly correlated
86 L1PA16 1 n.s 74.0 Weakly correlated
87 L1PA3 1 n.s 19.6 Weakly correlated
88 L1PA8A 1 n.s 74.0 Weakly correlated
89 L1PB2 1 n.s 74.0 Weakly correlated
90 LTR1 1 ** 43.0 Weakly correlated
91 LTR13 1 * 19.6 Weakly correlated
92 LTR16A2 1 * 99.0 Weakly correlated
93 LTR64 1 ** 74.0 Weakly correlated
94 LTR79 1 * 99.0 Weakly correlated
95 LTR81A 1 ** 99.0 Weakly correlated
96 LTR87 1 ** 99.0 Weakly correlated
97 MER21C 1 n.s 99.0 Weakly correlated
98 MER39B 1 * 74.0 Weakly correlated
99 MER4A 1 * 74.0 Weakly correlated
100 MER50B 1 ** 43.0 Weakly correlated
101 MER66B 1 * 43.0 Weakly correlated
102 MER70-int 1 ** 99.0 Weakly correlated
103 MER9a1 1 ** 19.6 Weakly correlated
104 MIR1_Amn 1 n.s 319.0 Highly correlated
105 MIRc 1 n.s 99.0 Weakly correlated
106 MLT1A-int 1 ** 99.0 Weakly correlated
107 MLT1A0 1 n.s 99.0 Weakly correlated
108 MLT1B 1 n.s 99.0 Weakly correlated
109 MLT1C 1 n.s 94.0 Weakly correlated
110 MLT1D 1 n.s 99.0 Weakly correlated
111 MLT1E2 1 n.s 99.0 Weakly correlated
112 MSTA1 1 ** 74.0 Weakly correlated
113 MSTB 1 n.s 43.0 Weakly correlated
114 MSTB-int 1 n.s 43.0 Weakly correlated
115 MSTC 1 n.s 74.0 Weakly correlated
116 MSTD 1 n.s 74.0 Weakly correlated
117 Plat_L3 1 * 99.0 Weakly correlated
118 THE1B 1 n.s 43.0 Weakly correlated
119 THE1D 1 n.s 43.0 Weakly correlated
120 THE1D-int 1 n.s 28.9 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 4 ** 74.0 Weakly correlated
2 L1MB7 2 n.s 99.0 Weakly correlated
3 L2 1 n.s 99.0 Weakly correlated
4 L1M4c 1 n.s 99.0 Weakly correlated
5 L1PA16 1 n.s 74.0 Weakly correlated
6 L1MD1 1 n.s 99.0 Weakly correlated
7 AluSx 1 n.s 74.0 Weakly correlated
8 L2c 1 n.s 99.0 Weakly correlated
9 L1P4 1 n.s 74.0 Weakly correlated
10 MSTB 1 n.s 43.0 Weakly correlated
11 L2b 1 n.s 99.0 Weakly correlated
12 L1ME3A 1 n.s 99.0 Weakly correlated
13 MIR 1 n.s 99.0 Weakly correlated
14 L1PB2 1 n.s 74.0 Weakly correlated
15 L1MEj 1 * 99.0 Weakly correlated
16 L2a 1 n.s 99.0 Weakly correlated
17 AluYh9 1 **** 15.2 Weakly correlated
18 MLT1K 1 n.s 99.0 Weakly correlated
19 L1MA6 1 n.s 87.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP