ZRdb KZFP & Repeats
...

Human_ZNF773

  • Protein
    Zinc finger protein 773
  • Length
    442
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q6PK81
  • NCBI_ID
    374928
Sequence:
MAAATLRDPAQQGYVTFEDVAVYFSQEEWRLLDDAQRLLYRNVMLENFTLLASLGLASSKTHEITQLESWEEPFMPAWEVVTSAILRGSWQGAKAEAAAEQSASVEVPSSNVQQHQKQHCGEKPLKRQEGRVPVLRSCRVHLSEKSLQSREVGKDLLTSSGVLKHQVTHTGEKSHRSSKSREAFHAGKRHYKCSECGKAFGQKYLLVQHQRLHTGEKPYECSECGKLFSHKSNLFIHQIVHTGERPYGCSDCGKSFSRNADLIQHQRVHTGEKPFTCSECGKAFRHNSTLVQHHRIHTGVRPYECSECGKLFSFNSSLMKHQRVHTGERPYKCSECGKFYSHKSSLINHWRVHTGERPYECSECGKFFSQSSSLMQHRKVHTGEKPFKCNECGRFFSENSSLVKHQRVHTGAKPYECRECGKFFRHSSSLVKHRRIHTGEIQ
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 15..86
2 C2h2 191..213
3 C2h2 219..241
4 C2h2 247..269
5 C2h2 275..297
6 C2h2 303..325
7 C2h2 331..353
8 C2h2 359..381
9 C2h2 387..409
10 C2h2 415..437
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR10A 4 **** 28.9 Weakly correlated
2 AluY 3 n.s 74.0 Weakly correlated
3 L1MCb 3 **** 99.0 Moderately correlated
4 L1PA10 3 * 74.0 Weakly correlated
5 FRAM 2 *** 74.0 Weakly correlated
6 L1MB8 2 n.s 99.0 Moderately correlated
7 MER21B 2 ** 99.0 Moderately correlated
8 AluYi6 1 *** 15.2 Weakly correlated
9 AluYj4 1 ** 0.0 Weakly correlated
10 L1HS 1 n.s 8.6 Weakly correlated
11 L1M4 1 n.s 99.0 Moderately correlated
12 L1PA4 1 n.s 19.6 Weakly correlated
13 L1PA8A 1 n.s 74.0 Weakly correlated
14 LTR41B 1 *** 99.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA10 1 n.s 74.0 Weakly correlated
2 AluY 1 n.s 74.0 Weakly correlated
3 FRAM 1 * 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP