ZRdb KZFP & Repeats
...

Human_ZNF765

  • Protein
    Zinc finger protein 765
  • Length
    523
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    8.6 Mya
  • Time of Changing in binding specificity
    8.6 Mya
  • Uniprot_ID
    Q7L2R6
  • NCBI_ID
    91661
Sequence:
MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKEFSSTAQGNREVFHAGTSQRHESHHNGDFCFQDIDKDIHDIEFQWQEDERNGHEALMTKIKKLTGSTERYDQNYAGNKPVKYQLGFSFHSHLPELHIFHTEEKIDNQVVKSIHDASLVSTAQRISCRPETHISNDYGNNFLNSSLFTQKQEVHMREKSFQCNDSGKAYNCSSLLRKHQLIHLGEKQYKCDICGKVFNSKRYVARHRRCHTGEKPYKCNECGKTFSQTYYLTCHRRLHTGEKPYKCEECDKAFHFKSKLQIHRRIHTGEKPYKCNECGKTFSQKSYLTCHRRLHTGEKPYKCNECGKTFSRKSHFTCHHRVHTGEKPYKCNECSKTFSHKSSLTYHRRLHTEEKPYKCNECGKTFNQQLTLNICRLHSGEKPYKCEECDKAYSFKSNLEIHQKIHTEENPYKCNECGKTFSRTSSLTYHHRLHTGQKPYKCEDCDEAFSFKSNLERHRRIYTGEKLHV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 8..81
2 dec2h2 215..237
3 C2h2 243..265
4 C2h2 271..293
5 C2h2 299..321
6 C2h2 327..349
7 C2h2 355..377
8 C2h2 383..405
9 C2h2 411..432
10 C2h2 438..460
11 C2h2 466..488
12 dec2h2 494..516
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA5 788 **** 19.6 Moderately correlated
2 L1PA4 462 **** 19.6 Moderately correlated
3 L1PA6 462 **** 28.9 Weakly correlated
4 THE1B-int 266 **** 43.0 Weakly correlated
5 L1P1 148 **** 19.6 Moderately correlated
6 L1P2 146 **** 28.9 Weakly correlated
7 THE1C-int 133 **** 43.0 Weakly correlated
8 MSTA-int 123 **** 43.0 Weakly correlated
9 THE1D-int 111 **** 28.9 Weakly correlated
10 THE1A-int 60 **** 43.0 Weakly correlated
11 MIRb 43 n.s 99.0 Weakly correlated
12 L2b 34 n.s 99.0 Weakly correlated
13 L2a 24 n.s 99.0 Weakly correlated
14 AluY 23 n.s 74.0 Weakly correlated
15 L2c 23 n.s 99.0 Weakly correlated
16 L1PA7 22 n.s 74.0 Weakly correlated
17 L1PA3 21 n.s 19.6 Moderately correlated
18 AluJb 16 n.s 74.0 Weakly correlated
19 MIR 16 n.s 99.0 Weakly correlated
20 L1PA2 14 n.s 15.2 Moderately correlated
21 AluJo 13 n.s 74.0 Weakly correlated
22 MIR3 13 n.s 99.0 Weakly correlated
23 MIRc 13 n.s 99.0 Weakly correlated
24 MSTB-int 12 **** 43.0 Weakly correlated
25 AluJr 11 n.s 74.0 Weakly correlated
26 AluSx 11 n.s 74.0 Weakly correlated
27 AluSx1 11 n.s 74.0 Weakly correlated
28 AluSz 8 n.s 74.0 Weakly correlated
29 AluSq2 7 n.s 74.0 Weakly correlated
30 L2 6 n.s 99.0 Weakly correlated
31 MLT1K 6 n.s 99.0 Weakly correlated
32 AluSc8 5 n.s 74.0 Weakly correlated
33 L1HS 5 n.s 8.6 Highly correlated
34 L1MB8 5 n.s 99.0 Weakly correlated
35 L1P3 5 n.s 74.0 Weakly correlated
36 L1PA8 5 n.s 74.0 Weakly correlated
37 L1PB1 5 n.s 74.0 Weakly correlated
38 AluJr4 4 n.s 74.0 Weakly correlated
39 AluSg 4 n.s 74.0 Weakly correlated
40 AluSp 4 n.s 74.0 Weakly correlated
41 AluSx3 4 n.s 74.0 Weakly correlated
42 AluSz6 4 n.s 74.0 Weakly correlated
43 FLAM_C 4 n.s 74.0 Weakly correlated
44 HAL1 4 n.s 99.0 Weakly correlated
45 L1MA4 4 n.s 87.0 Weakly correlated
46 L1MEc 4 n.s 99.0 Weakly correlated
47 LTR10A 4 **** 28.9 Weakly correlated
48 MER52A 4 n.s 74.0 Weakly correlated
49 MER66B 4 ** 43.0 Weakly correlated
50 MST-int 4 **** 74.0 Weakly correlated
51 THE1-int 4 **** 43.0 Weakly correlated
52 FRAM 3 n.s 74.0 Weakly correlated
53 L1M1 3 n.s 74.0 Weakly correlated
54 L1MA8 3 n.s 87.0 Weakly correlated
55 L1MA9 3 n.s 99.0 Weakly correlated
56 L1PA16 3 n.s 74.0 Weakly correlated
57 L1PREC2 3 n.s 43.0 Weakly correlated
58 LTR16A1 3 * 99.0 Weakly correlated
59 LTR19A 3 *** 43.0 Weakly correlated
60 LTR1A2 3 * 43.0 Weakly correlated
61 LTR33 3 n.s 99.0 Weakly correlated
62 LTR4 3 **** 28.9 Weakly correlated
63 MER50 3 n.s 43.0 Weakly correlated
64 MER57E1 3 **** 87.0 Weakly correlated
65 MLT1C 3 n.s 94.0 Weakly correlated
66 MLT1D 3 n.s 99.0 Weakly correlated
67 AluSc 2 n.s 74.0 Weakly correlated
68 HERV9NC-int 2 n.s 19.6 Moderately correlated
69 HERVI-int 2 ** 28.9 Weakly correlated
70 L1M5 2 n.s 99.0 Weakly correlated
71 L1MA3 2 n.s 74.0 Weakly correlated
72 L1MB7 2 n.s 99.0 Weakly correlated
73 L1ME3 2 n.s 99.0 Weakly correlated
74 L1PA10 2 n.s 74.0 Weakly correlated
75 L1PB4 2 n.s 99.0 Weakly correlated
76 L3 2 n.s 99.0 Weakly correlated
77 L3b 2 n.s 99.0 Weakly correlated
78 LTR10F 2 ** 28.9 Weakly correlated
79 LTR12C 2 n.s 19.6 Moderately correlated
80 LTR12D 2 * 19.6 Moderately correlated
81 LTR13 2 * 19.6 Moderately correlated
82 LTR28C 2 ** 43.0 Weakly correlated
83 LTR41 2 * 99.0 Weakly correlated
84 LTR76 2 *** 74.0 Weakly correlated
85 LTR78 2 n.s 99.0 Weakly correlated
86 MER21A 2 n.s 74.0 Weakly correlated
87 MER4B 2 n.s 74.0 Weakly correlated
88 MER4E1 2 * 74.0 Weakly correlated
89 MIR1_Amn 2 n.s 319.0 Weakly correlated
90 MLT1F1 2 n.s 99.0 Weakly correlated
91 MLT1J 2 n.s 99.0 Weakly correlated
92 MamGypLTR3a 2 * 99.0 Weakly correlated
93 MamRTE1 2 n.s 99.0 Weakly correlated
94 THE1B 2 n.s 43.0 Weakly correlated
95 THE1C 2 n.s 43.0 Weakly correlated
96 Alu 1 n.s 74.0 Weakly correlated
97 AluSc5 1 n.s 74.0 Weakly correlated
98 AluSg7 1 n.s 74.0 Weakly correlated
99 AluSx4 1 n.s 74.0 Weakly correlated
100 AluYa5 1 n.s 15.2 Moderately correlated
101 AluYb8 1 n.s 15.2 Moderately correlated
102 AluYf1 1 n.s 19.6 Moderately correlated
103 AluYk11 1 * 15.2 Moderately correlated
104 AluYk3 1 n.s 19.6 Moderately correlated
105 AluYk4 1 n.s 15.2 Moderately correlated
106 AluYm1 1 n.s 19.6 Moderately correlated
107 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
108 ERVL-E-int 1 n.s 99.0 Weakly correlated
109 FAM 1 n.s 87.0 Weakly correlated
110 HERV15-int 1 * 28.9 Weakly correlated
111 HERV17-int 1 n.s 28.9 Weakly correlated
112 HERV3-int 1 n.s 28.9 Weakly correlated
113 HERVH-int 1 n.s 28.9 Weakly correlated
114 HERVIP10F-int 1 n.s 28.9 Weakly correlated
115 HERVK14-int 1 n.s 28.9 Weakly correlated
116 HERVK22-int 1 n.s 43.0 Weakly correlated
117 HERVK9-int 1 n.s 28.9 Weakly correlated
118 L1M2 1 n.s 99.0 Weakly correlated
119 L1M2a 1 n.s 87.0 Weakly correlated
120 L1M2a1 1 * 79.0 Weakly correlated
121 L1M3c 1 n.s 99.0 Weakly correlated
122 L1M3e 1 n.s 99.0 Weakly correlated
123 L1M4 1 n.s 99.0 Weakly correlated
124 L1M4a1 1 n.s 99.0 Weakly correlated
125 L1M8 1 n.s 99.0 Weakly correlated
126 L1MA2 1 n.s 74.0 Weakly correlated
127 L1MA4A 1 n.s 87.0 Weakly correlated
128 L1MA5 1 n.s 87.0 Weakly correlated
129 L1MA5A 1 n.s 87.0 Weakly correlated
130 L1MB3 1 n.s 99.0 Weakly correlated
131 L1MC3 1 n.s 99.0 Weakly correlated
132 L1MC4 1 n.s 99.0 Weakly correlated
133 L1MC5 1 n.s 99.0 Weakly correlated
134 L1ME1 1 n.s 99.0 Weakly correlated
135 L1ME3E 1 n.s 99.0 Weakly correlated
136 L1ME4b 1 n.s 99.0 Weakly correlated
137 L1P4 1 n.s 74.0 Weakly correlated
138 L1PA11 1 n.s 74.0 Weakly correlated
139 L1PA12 1 n.s 74.0 Weakly correlated
140 L1PA13 1 n.s 74.0 Weakly correlated
141 L1PA8A 1 n.s 74.0 Weakly correlated
142 L1PB2 1 n.s 74.0 Weakly correlated
143 L1PBa 1 n.s 74.0 Weakly correlated
144 LOR1-int 1 n.s 74.0 Weakly correlated
145 LTR102_Mam 1 * 99.0 Weakly correlated
146 LTR10B2 1 ** 28.9 Weakly correlated
147 LTR14A 1 ** 28.9 Weakly correlated
148 LTR16A2 1 n.s 99.0 Weakly correlated
149 LTR16D1 1 ** 99.0 Weakly correlated
150 LTR17 1 n.s 28.9 Weakly correlated
151 LTR27C 1 * 43.0 Weakly correlated
152 LTR27E 1 * 43.0 Weakly correlated
153 LTR29 1 n.s 43.0 Weakly correlated
154 LTR2B 1 * 19.6 Moderately correlated
155 LTR33A_ 1 n.s 99.0 Weakly correlated
156 LTR47B4 1 ** 74.0 Weakly correlated
157 LTR49-int 1 n.s 74.0 Weakly correlated
158 LTR69 1 ** 99.0 Weakly correlated
159 LTR85b 1 n.s 99.0 Weakly correlated
160 LTR86B2 1 ** 99.0 Weakly correlated
161 LTR88c 1 * 99.0 Weakly correlated
162 LTR91 1 ** 99.0 Weakly correlated
163 MER31A 1 n.s 87.0 Weakly correlated
164 MER39B 1 n.s 74.0 Weakly correlated
165 MER50-int 1 n.s 43.0 Weakly correlated
166 MER51-int 1 n.s 43.0 Weakly correlated
167 MER51A 1 n.s 43.0 Weakly correlated
168 MER51C 1 ** 43.0 Weakly correlated
169 MER57A-int 1 n.s 43.0 Weakly correlated
170 MER57D 1 * 87.0 Weakly correlated
171 MER61-int 1 n.s 43.0 Weakly correlated
172 MER61A 1 n.s 43.0 Weakly correlated
173 MER61D 1 * 43.0 Weakly correlated
174 MER67C 1 n.s 99.0 Weakly correlated
175 MER68-int 1 * 99.0 Weakly correlated
176 MER74A 1 n.s 99.0 Weakly correlated
177 MER77B 1 n.s 99.0 Weakly correlated
178 MER9a3 1 n.s 28.9 Weakly correlated
179 MLT1A0 1 n.s 99.0 Weakly correlated
180 MLT1E3 1 n.s 99.0 Weakly correlated
181 MLT1F 1 n.s 99.0 Weakly correlated
182 MLT1F2 1 n.s 99.0 Weakly correlated
183 MLT1H 1 n.s 99.0 Weakly correlated
184 MLT1J1-int 1 * 99.0 Weakly correlated
185 MLT1J2 1 n.s 99.0 Weakly correlated
186 MLT1L 1 n.s 99.0 Weakly correlated
187 MLT2D 1 n.s 99.0 Weakly correlated
188 MSTA 1 n.s 43.0 Weakly correlated
189 MSTB 1 n.s 43.0 Weakly correlated
190 MSTB1 1 n.s 74.0 Weakly correlated
191 MSTC 1 n.s 74.0 Weakly correlated
192 MSTD 1 n.s 74.0 Weakly correlated
193 MamRep605 1 n.s 99.0 Weakly correlated
194 SVA_A 1 n.s 19.6 Moderately correlated
195 SVA_C 1 n.s 15.2 Moderately correlated
196 THE1A 1 n.s 43.0 Weakly correlated
197 THE1D 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA5 723 **** 19.6 Moderately correlated
2 L1PA4 437 **** 19.6 Moderately correlated
3 L1PA6 435 **** 28.9 Weakly correlated
4 L1P2 130 **** 28.9 Weakly correlated
5 L1P1 126 **** 19.6 Moderately correlated
6 L1PA3 19 n.s 19.6 Moderately correlated
7 L1PA7 17 n.s 74.0 Weakly correlated
8 AluY 11 n.s 74.0 Weakly correlated
9 L1PA2 9 n.s 15.2 Moderately correlated
10 AluJb 6 n.s 74.0 Weakly correlated
11 L1PA8 5 n.s 74.0 Weakly correlated
12 AluSx1 5 n.s 74.0 Weakly correlated
13 L1HS 4 n.s 8.6 Highly correlated
14 MIRb 2 n.s 99.0 Weakly correlated
15 L1PA8A 2 n.s 74.0 Weakly correlated
16 L1MB8 2 n.s 99.0 Weakly correlated
17 AluSx 1 n.s 74.0 Weakly correlated
18 AluSx4 1 n.s 74.0 Weakly correlated
19 L1PA16 1 n.s 74.0 Weakly correlated
20 AluYk11 1 * 15.2 Moderately correlated
21 THE1B-int 1 n.s 43.0 Weakly correlated
22 MER68-int 1 * 99.0 Weakly correlated
23 MER67C 1 n.s 99.0 Weakly correlated
24 AluYk4 1 n.s 15.2 Moderately correlated
25 THE1C-int 1 n.s 43.0 Weakly correlated
26 L2a 1 n.s 99.0 Weakly correlated
27 HERVK14-int 1 n.s 28.9 Weakly correlated
28 L1MA2 1 n.s 74.0 Weakly correlated
29 L1PB1 1 n.s 74.0 Weakly correlated
30 L1PB4 1 n.s 99.0 Weakly correlated
31 MER50 1 n.s 43.0 Weakly correlated
32 MIRc 1 n.s 99.0 Weakly correlated
33 MSTA-int 1 n.s 43.0 Weakly correlated
34 AluSc8 1 n.s 74.0 Weakly correlated
35 L1MA4A 1 n.s 87.0 Weakly correlated
36 HAL1 1 n.s 99.0 Weakly correlated
37 AluSc 1 n.s 74.0 Weakly correlated
38 L1MA9 1 n.s 99.0 Weakly correlated
39 L1MC5 1 n.s 99.0 Weakly correlated
40 AluJr 1 n.s 74.0 Weakly correlated
41 FAM 1 n.s 87.0 Weakly correlated
42 L1M3e 1 n.s 99.0 Weakly correlated
43 MER50-int 1 n.s 43.0 Weakly correlated
44 THE1D-int 1 n.s 28.9 Weakly correlated
45 AluJo 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 ALUJB 74.0 Weakly correlated
2 ALUY 74.0 Weakly correlated