ZRdb KZFP & Repeats
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Human_ZNF763

  • Protein
    Zinc finger protein 763
  • Length
    394
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    15.2 Mya
  • Uniprot_ID
    Q0D2J5
  • NCBI_ID
    284390
Sequence:
MDPVACEDVAVNFTQEEWALLDISQRKLYREVMLETFRNLTSIGKKWKDQNIEYEYQNPRRNFRSLIEGNVNEIKEDSHCGETFTQVPDDRLNFQEKKASPEAKSCDNFVCGEVGIGNSSFNMNIRGDIGHKAYEYQDYAPKPYKCQQPKKAFRYHPSFRTQERNHTGEKPYACKECGKTFISHSGIRRRMVMHSGDGPYKCKFCGKAVHCLRLYLIHERTHTGEKPYECKQCVKSFSYSATHRIHERTHTGEKPYECQQCGKAFHSSSSFQAHKRTHTGGKPYECKQCGKSFSWCHSFQIHERTHTGEKPCECSKCNKAFRSYRSYLRHKRSHTGEKPYQCKECRKAFTYPSSLRRHERTHSAKKPYECKQCGKALSYKFSNTPKNALWRKTL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..86
2 dec2h2 144..166
3 dec2h2 172..194
4 C2h2 200..222
5 C2h2 228..250
6 C2h2 256..278
7 C2h2 284..306
8 C2h2 312..334
9 C2h2 340..362
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_F 46 **** 0.0 Weakly correlated
2 SVA_D 39 **** 15.2 Highly correlated
3 AluY 23 * 74.0 Weakly correlated
4 SVA_E 22 **** 0.0 Weakly correlated
5 LTR12C 19 **** 19.6 Moderately correlated
6 AluJb 16 n.s 74.0 Weakly correlated
7 L1P3 11 **** 74.0 Weakly correlated
8 AluYj4 10 **** 0.0 Weakly correlated
9 LTR8 9 **** 43.0 Weakly correlated
10 AluSc8 9 ** 74.0 Weakly correlated
11 AluYm1 7 **** 19.6 Moderately correlated
12 AluSz 6 n.s 74.0 Weakly correlated
13 AluSq2 4 n.s 74.0 Weakly correlated
14 MER21B 4 *** 99.0 Weakly correlated
15 MER52A 4 ** 74.0 Weakly correlated
16 AluYb8 4 **** 15.2 Highly correlated
17 LTR10A 4 **** 28.9 Moderately correlated
18 SVA_C 4 **** 15.2 Highly correlated
19 AluSx 4 n.s 74.0 Weakly correlated
20 AluSg4 4 ** 74.0 Weakly correlated
21 AluSp 4 n.s 74.0 Weakly correlated
22 AluJo 3 n.s 74.0 Weakly correlated
23 LTR2752 3 **** 43.0 Weakly correlated
24 ERV3-16A3_I-int 3 n.s 99.0 Weakly correlated
25 LTR10F 3 **** 28.9 Moderately correlated
26 MIRc 3 n.s 99.0 Weakly correlated
27 AluYa5 3 ** 15.2 Highly correlated
28 AluSx1 3 n.s 74.0 Weakly correlated
29 AluJr 3 n.s 74.0 Weakly correlated
30 SVA_B 2 ** 15.2 Highly correlated
31 LTR12D 2 ** 19.6 Moderately correlated
32 THE1B-int 2 n.s 43.0 Weakly correlated
33 L2a 2 n.s 99.0 Weakly correlated
34 L1PA5 2 n.s 19.6 Moderately correlated
35 L1PA4 2 n.s 19.6 Moderately correlated
36 FRAM 2 * 74.0 Weakly correlated
37 MLT1L 1 n.s 99.0 Weakly correlated
38 AluYf1 1 * 19.6 Moderately correlated
39 MER39B 1 * 74.0 Weakly correlated
40 AluYe5 1 * 74.0 Weakly correlated
41 MER52D 1 * 74.0 Weakly correlated
42 MER61A 1 ** 43.0 Weakly correlated
43 MER66A 1 ** 43.0 Weakly correlated
44 AluYc 1 n.s 74.0 Weakly correlated
45 MLT1E3 1 * 99.0 Weakly correlated
46 MLT1G1 1 n.s 99.0 Weakly correlated
47 LTR7 1 n.s 19.6 Moderately correlated
48 MSTD 1 n.s 74.0 Weakly correlated
49 SVA_A 1 * 19.6 Moderately correlated
50 AluYa8 1 *** 15.2 Highly correlated
51 AluSz6 1 n.s 74.0 Weakly correlated
52 AluSx4 1 n.s 74.0 Weakly correlated
53 AluSq4 1 * 74.0 Weakly correlated
54 AluSg7 1 n.s 74.0 Weakly correlated
55 THE1B 1 n.s 43.0 Weakly correlated
56 AluSc5 1 n.s 74.0 Weakly correlated
57 THE1D 1 n.s 43.0 Weakly correlated
58 LTR1 1 ** 43.0 Weakly correlated
59 L1P4 1 n.s 74.0 Weakly correlated
60 L1PA11 1 n.s 74.0 Weakly correlated
61 L1PA2 1 n.s 15.2 Highly correlated
62 L1MD 1 n.s 99.0 Weakly correlated
63 L1MC4 1 n.s 99.0 Weakly correlated
64 L1PA6 1 n.s 28.9 Moderately correlated
65 L1PA7 1 n.s 74.0 Weakly correlated
66 L1PREC2 1 n.s 43.0 Weakly correlated
67 L1MB8 1 n.s 99.0 Weakly correlated
68 L2c 1 n.s 99.0 Weakly correlated
69 AluYi6 1 *** 15.2 Highly correlated
70 L1M3 1 n.s 99.0 Weakly correlated
71 LTR10B1 1 *** 28.9 Moderately correlated
72 L1M1 1 n.s 74.0 Weakly correlated
73 L1HS 1 n.s 8.6 Weakly correlated
74 LTR13 1 * 19.6 Moderately correlated
75 LTR17 1 * 28.9 Moderately correlated
76 LTR1A2 1 * 43.0 Weakly correlated
77 FLAM_C 1 n.s 74.0 Weakly correlated
78 L1MD3 1 n.s 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 4 **** 0.0 Weakly correlated
2 FRAM 1 n.s 74.0 Weakly correlated
3 L2a 1 n.s 99.0 Weakly correlated
4 LTR2752 1 ** 43.0 Weakly correlated
5 AluSc8 1 n.s 74.0 Weakly correlated
6 AluYe5 1 * 74.0 Weakly correlated
7 AluY 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP