ZRdb KZFP & Repeats
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Human_ZNF761

  • Protein
    Zinc finger protein 761
  • Length
    746
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    19.6 Mya
  • Uniprot_ID
    Q86XN6
  • NCBI_ID
    388561
Sequence:
MAFSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCTMKEFLSTAQGNREVFHAGTLQIHESHHNGDFCYQDVDKDIHDYEFQWQEDERNGHEAPMTKIKKLTGITERYDQSHARNKPIKDQLGSSFHSHLPEMHIFQTEEKIDNQVVKSVHDASLVSTAQRISCRPKTHISNNHGNNFWNSSLLTQKQEVHMREKSFQCNESGKAFNYSSLLRKHQIIHLADKYKCDVCGKLFNQKRNLACHRRCHTGENPYKCNECGKTFSQTSSLTCHRRLHTGEKPYKCEECDKAFHFKSILERHRIIHTEEKPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNECGKTFSHKSSLTCHHRLHTGEKPYKCNECGKTFSHKSSLTCHRRLHTGEKPYKCEECDKAYSFRSNFEIHRKIHTEDNAYKCNECGKTFSRTSSLTCHRRRHTGEQPYKCEECDKAFRFKSNLERHRRIHTGEKPYKCNECGKTFSRKSYLTCHHRLHTGEKAYKCNECGKTFSWKSSLTCHRRLHSGEKPYKCKECGKTFNQQLTLKRHRRLHSGENPYKCEDSDKAYSFKSNLEIHQKIHTEENPYKCNECGKTFSRTSSLTCHRRLHTGEKPYKCEECDKAFRVKSNLEGHRRIHTGEKPYKCNECGKTFSRKSYFICHHRLHTGEKPYKCNECGKNFSQKSSLICHHRLHTGEKPYKCNECGKTFSQKSNLTCHRRLHTGEKQV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..81
2 dec2h2 215..237
3 C2h2 242..264
4 C2h2 270..292
5 C2h2 298..320
6 C2h2 326..348
7 C2h2 354..376
8 C2h2 382..404
9 C2h2 410..432
10 C2h2 438..460
11 C2h2 466..488
12 C2h2 494..516
13 C2h2 522..544
14 C2h2 550..572
15 dec2h2 578..600
16 C2h2 606..628
17 C2h2 634..656
18 C2h2 662..684
19 C2h2 690..712
20 C2h2 718..740
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER9a3 173 **** 28.9 Moderately correlated
2 MER9a1 90 **** 19.6 Highly correlated
3 MER9a2 81 **** 19.6 Highly correlated
4 AluSc8 9 ** 74.0 Weakly correlated
5 AluY 7 n.s 74.0 Weakly correlated
6 LTR8 6 **** 43.0 Weakly correlated
7 AluJb 6 n.s 74.0 Weakly correlated
8 FRAM 5 **** 74.0 Weakly correlated
9 LTR10A 4 **** 28.9 Moderately correlated
10 AluYm1 4 *** 19.6 Highly correlated
11 AluYj4 4 **** 0.0 Weakly correlated
12 L1P3 3 * 74.0 Weakly correlated
13 LTR10F 3 **** 28.9 Moderately correlated
14 L2a 3 n.s 99.0 Weakly correlated
15 MER21B 3 ** 99.0 Weakly correlated
16 MLT1A0 3 n.s 99.0 Weakly correlated
17 L1MB8 3 n.s 99.0 Weakly correlated
18 AluSq2 3 n.s 74.0 Weakly correlated
19 AluSx 2 n.s 74.0 Weakly correlated
20 AluJo 2 n.s 74.0 Weakly correlated
21 L1PA10 2 n.s 74.0 Weakly correlated
22 LTR78 2 * 99.0 Weakly correlated
23 AluSz6 2 n.s 74.0 Weakly correlated
24 L1MC1 2 n.s 99.0 Weakly correlated
25 L1MB7 2 n.s 99.0 Weakly correlated
26 L1PA5 2 n.s 19.6 Highly correlated
27 AluSx1 2 n.s 74.0 Weakly correlated
28 AluSx3 2 n.s 74.0 Weakly correlated
29 SVA_C 1 * 15.2 Weakly correlated
30 LTR1D 1 ** 43.0 Weakly correlated
31 LTR16A 1 n.s 99.0 Weakly correlated
32 LTR78B 1 * 99.0 Weakly correlated
33 LTR13 1 * 19.6 Highly correlated
34 SVA_D 1 n.s 15.2 Weakly correlated
35 MER52A 1 n.s 74.0 Weakly correlated
36 MER52D 1 * 74.0 Weakly correlated
37 MER9B 1 **** 28.9 Moderately correlated
38 MIR 1 n.s 99.0 Weakly correlated
39 MIRb 1 n.s 99.0 Weakly correlated
40 MIRc 1 n.s 99.0 Weakly correlated
41 MLT1E3 1 * 99.0 Weakly correlated
42 MLT2D 1 n.s 99.0 Weakly correlated
43 MLT1G 1 n.s 99.0 Weakly correlated
44 MLT1L 1 n.s 99.0 Weakly correlated
45 L1MC4 1 n.s 99.0 Weakly correlated
46 AluJr4 1 n.s 74.0 Weakly correlated
47 AluSq 1 n.s 74.0 Weakly correlated
48 AluSz 1 n.s 74.0 Weakly correlated
49 AluYa5 1 n.s 15.2 Weakly correlated
50 AluYb8 1 n.s 15.2 Weakly correlated
51 CR1_Mam 1 * 99.0 Weakly correlated
52 HERV1_I-int 1 ** 43.0 Weakly correlated
53 L1HS 1 n.s 8.6 Weakly correlated
54 L1M1 1 n.s 74.0 Weakly correlated
55 L1M4 1 n.s 99.0 Weakly correlated
56 L1M5 1 n.s 99.0 Weakly correlated
57 L1MB1 1 n.s 99.0 Weakly correlated
58 L2c 1 n.s 99.0 Weakly correlated
59 L1MC5a 1 n.s 99.0 Weakly correlated
60 L1MCc 1 n.s 99.0 Weakly correlated
61 L1ME1 1 n.s 99.0 Weakly correlated
62 L1ME2 1 n.s 99.0 Weakly correlated
63 L1ME4c 1 n.s 99.0 Weakly correlated
64 L1P4 1 n.s 74.0 Weakly correlated
65 L1PA2 1 n.s 15.2 Weakly correlated
66 L1PA4 1 n.s 19.6 Highly correlated
67 L1PA8A 1 n.s 74.0 Weakly correlated
68 L2 1 n.s 99.0 Weakly correlated
69 L2b 1 n.s 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER9a3 171 **** 28.9 Moderately correlated
2 MER9a1 87 **** 19.6 Highly correlated
3 MER9a2 79 **** 19.6 Highly correlated
4 FRAM 2 * 74.0 Weakly correlated
5 L1MC1 1 n.s 99.0 Weakly correlated
6 AluYj4 1 * 0.0 Weakly correlated
7 MER52D 1 * 74.0 Weakly correlated
8 AluSq 1 n.s 74.0 Weakly correlated
9 AluSq2 1 n.s 74.0 Weakly correlated
10 L1PA5 1 n.s 19.6 Highly correlated
11 MER9B 1 **** 28.9 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 MER9A1 19.6 Highly correlated
2 MER9A2 19.6 Highly correlated
3 MER9A3 28.9 Moderately correlated