Human_ZNF75A
-
ProteinZinc finger protein 75A
-
Length296
-
OrganismHomo sapiens (Human)
-
Time of emergence94.0 Mya
-
Time of Changing in binding specificity94.0 Mya
-
Uniprot_ID
-
NCBI_ID
Sequence:
MYFSQEEWELLDPTQKALYNDVMQENYETVISLALFVLPKPKVISCLEQGEEPWVQVSPEFKDSAGKSPTGLKLKNDTENHQPVSLSDLEIQASAGVISKKAKVKVPQKTAGKENHFDMHRVGKWHQDFPVKKRKKLSTWKQELLKLMDRHKKDCAREKPFKCQECGKTFRVSSDLIKHQRIHTEEKPYKCQQCDKRFRWSSDLNKHLTTHQGIKPYKCSWCGKSFSQNTNLHTHQRTHTGEKPFTCHECGKKFSQNSHLIKHRRTHTGEQPYTCSICRRNFSRRSSLLRHQKLHL
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 1..66 | |
| 2 | C2h2 | 161..183 | |
| 3 | C2h2 | 189..211 | |
| 4 | C2h2 | 217..239 | |
| 5 | C2h2 | 245..267 | |
| 6 | C2h2 | 273..295 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | nucleus | |
| 2 | Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
| 3 | Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
| 4 | Molecular Function | metal ion binding | |
| 5 | Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
| 6 | Molecular Function | sequence-specific double-stranded DNA binding | |
| 7 | Biological Process | negative regulation of transcription by RNA polymerase II | |
| 8 | Biological Process | regulation of transcription by RNA polymerase II |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | MIRb | 45 | n.s | 99.0 | Moderately correlated | |
| 2 | L2a | 32 | n.s | 99.0 | Moderately correlated | |
| 3 | L2b | 25 | n.s | 99.0 | Moderately correlated | |
| 4 | L2c | 24 | n.s | 99.0 | Moderately correlated | |
| 5 | MIRc | 23 | n.s | 99.0 | Moderately correlated | |
| 6 | MIR | 21 | n.s | 99.0 | Moderately correlated | |
| 7 | MIR3 | 17 | n.s | 99.0 | Moderately correlated | |
| 8 | AluJb | 16 | n.s | 74.0 | Weakly correlated | |
| 9 | AluSz | 15 | n.s | 74.0 | Weakly correlated | |
| 10 | LTR50 | 15 | **** | 99.0 | Moderately correlated | |
| 11 | AluSx1 | 14 | n.s | 74.0 | Weakly correlated | |
| 12 | MLT1J | 14 | *** | 99.0 | Moderately correlated | |
| 13 | AluSx | 12 | n.s | 74.0 | Weakly correlated | |
| 14 | L2 | 11 | n.s | 99.0 | Moderately correlated | |
| 15 | LTR9 | 9 | **** | 43.0 | Weakly correlated | |
| 16 | L1M5 | 8 | n.s | 99.0 | Moderately correlated | |
| 17 | AluJo | 6 | n.s | 74.0 | Weakly correlated | |
| 18 | AluJr | 6 | n.s | 74.0 | Weakly correlated | |
| 19 | AluSp | 6 | n.s | 74.0 | Weakly correlated | |
| 20 | LTR33A | 6 | **** | 99.0 | Moderately correlated | |
| 21 | AluY | 5 | n.s | 74.0 | Weakly correlated | |
| 22 | MER66C | 5 | **** | 43.0 | Weakly correlated | |
| 23 | AluSq2 | 4 | n.s | 74.0 | Weakly correlated | |
| 24 | AluSz6 | 4 | n.s | 74.0 | Weakly correlated | |
| 25 | FLAM_C | 4 | n.s | 74.0 | Weakly correlated | |
| 26 | MIR1_Amn | 4 | * | 319.0 | Weakly correlated | |
| 27 | MLT1H2 | 4 | * | 99.0 | Moderately correlated | |
| 28 | MLT1J1 | 4 | * | 99.0 | Moderately correlated | |
| 29 | AluSc | 3 | n.s | 74.0 | Weakly correlated | |
| 30 | AluSc8 | 3 | n.s | 74.0 | Weakly correlated | |
| 31 | AluSg4 | 3 | n.s | 74.0 | Weakly correlated | |
| 32 | AluSx4 | 3 | n.s | 74.0 | Weakly correlated | |
| 33 | FRAM | 3 | n.s | 74.0 | Weakly correlated | |
| 34 | HAL1 | 3 | n.s | 99.0 | Moderately correlated | |
| 35 | L1MC4 | 3 | n.s | 99.0 | Moderately correlated | |
| 36 | L1ME2 | 3 | n.s | 99.0 | Moderately correlated | |
| 37 | L1ME4c | 3 | n.s | 99.0 | Moderately correlated | |
| 38 | L1MEf | 3 | n.s | 99.0 | Moderately correlated | |
| 39 | L1MEg | 3 | n.s | 99.0 | Moderately correlated | |
| 40 | L1P2 | 3 | n.s | 28.9 | Weakly correlated | |
| 41 | L1PA6 | 3 | n.s | 28.9 | Weakly correlated | |
| 42 | L3 | 3 | n.s | 99.0 | Moderately correlated | |
| 43 | LTR16B2 | 3 | ** | 99.0 | Moderately correlated | |
| 44 | LTR41B | 3 | *** | 99.0 | Moderately correlated | |
| 45 | LTR41C | 3 | *** | 99.0 | Moderately correlated | |
| 46 | LTR91 | 3 | **** | 99.0 | Moderately correlated | |
| 47 | MLT1C | 3 | n.s | 94.0 | Highly correlated | |
| 48 | MLT1J2 | 3 | n.s | 99.0 | Moderately correlated | |
| 49 | MLT1K | 3 | n.s | 99.0 | Moderately correlated | |
| 50 | MamRTE1 | 3 | n.s | 99.0 | Moderately correlated | |
| 51 | Alu | 2 | ** | 74.0 | Weakly correlated | |
| 52 | AluSg | 2 | n.s | 74.0 | Weakly correlated | |
| 53 | AluSx3 | 2 | n.s | 74.0 | Weakly correlated | |
| 54 | AluYb8 | 2 | n.s | 15.2 | Weakly correlated | |
| 55 | AluYc | 2 | n.s | 74.0 | Weakly correlated | |
| 56 | AmnSINE1 | 2 | ** | 319.0 | Weakly correlated | |
| 57 | HERVI-int | 2 | ** | 28.9 | Weakly correlated | |
| 58 | L1M1 | 2 | n.s | 74.0 | Weakly correlated | |
| 59 | L1M3e | 2 | n.s | 99.0 | Moderately correlated | |
| 60 | L1M6 | 2 | n.s | 99.0 | Moderately correlated | |
| 61 | L1MA3 | 2 | n.s | 74.0 | Weakly correlated | |
| 62 | L1MA8 | 2 | n.s | 87.0 | Weakly correlated | |
| 63 | L1MB3 | 2 | n.s | 99.0 | Moderately correlated | |
| 64 | L1MC1 | 2 | n.s | 99.0 | Moderately correlated | |
| 65 | L1MC5a | 2 | n.s | 99.0 | Moderately correlated | |
| 66 | L1ME3 | 2 | n.s | 99.0 | Moderately correlated | |
| 67 | L1ME3A | 2 | n.s | 99.0 | Moderately correlated | |
| 68 | L1ME3C | 2 | n.s | 99.0 | Moderately correlated | |
| 69 | L1ME3G | 2 | n.s | 99.0 | Moderately correlated | |
| 70 | L1ME4a | 2 | n.s | 99.0 | Moderately correlated | |
| 71 | L1ME4b | 2 | n.s | 99.0 | Moderately correlated | |
| 72 | L1MEd | 2 | n.s | 99.0 | Moderately correlated | |
| 73 | L1PA3 | 2 | n.s | 19.6 | Weakly correlated | |
| 74 | L2-1_AMi | 2 | ** | 319.0 | Weakly correlated | |
| 75 | L3b | 2 | n.s | 99.0 | Moderately correlated | |
| 76 | LTR3A | 2 | *** | 28.9 | Weakly correlated | |
| 77 | LTR4 | 2 | **** | 28.9 | Weakly correlated | |
| 78 | LTR8 | 2 | n.s | 43.0 | Weakly correlated | |
| 79 | LTR83 | 2 | ** | 99.0 | Moderately correlated | |
| 80 | LTR8B | 2 | n.s | 43.0 | Weakly correlated | |
| 81 | MER4A | 2 | * | 74.0 | Weakly correlated | |
| 82 | MLT1F2 | 2 | n.s | 99.0 | Moderately correlated | |
| 83 | MLT1G | 2 | n.s | 99.0 | Moderately correlated | |
| 84 | MLT1I | 2 | n.s | 99.0 | Moderately correlated | |
| 85 | AluJr4 | 1 | n.s | 74.0 | Weakly correlated | |
| 86 | AluSc5 | 1 | n.s | 74.0 | Weakly correlated | |
| 87 | AluSq | 1 | n.s | 74.0 | Weakly correlated | |
| 88 | AluSq10 | 1 | n.s | 74.0 | Weakly correlated | |
| 89 | AluYm1 | 1 | n.s | 19.6 | Weakly correlated | |
| 90 | CR1-3_Croc | 1 | * | 319.0 | Weakly correlated | |
| 91 | ERV3-16A3_I-int | 1 | n.s | 99.0 | Moderately correlated | |
| 92 | ERVL-B4-int | 1 | n.s | 99.0 | Moderately correlated | |
| 93 | ERVL-E-int | 1 | n.s | 99.0 | Moderately correlated | |
| 94 | FLAM_A | 1 | n.s | 74.0 | Weakly correlated | |
| 95 | HERV-Fc1_LTR3 | 1 | **** | 8.6 | Weakly correlated | |
| 96 | HERV16-int | 1 | n.s | 99.0 | Moderately correlated | |
| 97 | HERVIP10FH-int | 1 | n.s | 28.9 | Weakly correlated | |
| 98 | HERVL40-int | 1 | n.s | 99.0 | Moderately correlated | |
| 99 | L1M2 | 1 | n.s | 99.0 | Moderately correlated | |
| 100 | L1M4 | 1 | n.s | 99.0 | Moderately correlated | |
| 101 | L1M8 | 1 | n.s | 99.0 | Moderately correlated | |
| 102 | L1MA4 | 1 | n.s | 87.0 | Weakly correlated | |
| 103 | L1MB2 | 1 | n.s | 99.0 | Moderately correlated | |
| 104 | L1MB8 | 1 | n.s | 99.0 | Moderately correlated | |
| 105 | L1MC3 | 1 | n.s | 99.0 | Moderately correlated | |
| 106 | L1MC5 | 1 | n.s | 99.0 | Moderately correlated | |
| 107 | L1MCa | 1 | n.s | 99.0 | Moderately correlated | |
| 108 | L1MCc | 1 | n.s | 99.0 | Moderately correlated | |
| 109 | L1MD2 | 1 | n.s | 99.0 | Moderately correlated | |
| 110 | L1MDb | 1 | n.s | 99.0 | Moderately correlated | |
| 111 | L1MEi | 1 | n.s | 99.0 | Moderately correlated | |
| 112 | L1PA11 | 1 | n.s | 74.0 | Weakly correlated | |
| 113 | L1PA15-16 | 1 | n.s | 74.0 | Weakly correlated | |
| 114 | L1PA16 | 1 | n.s | 74.0 | Weakly correlated | |
| 115 | L1PA5 | 1 | n.s | 19.6 | Weakly correlated | |
| 116 | L1PB3 | 1 | n.s | 74.0 | Weakly correlated | |
| 117 | L1PBa1 | 1 | n.s | 74.0 | Weakly correlated | |
| 118 | L2-3_Crp | 1 | n.s | 431.0 | Weakly correlated | |
| 119 | L4_B_Mam | 1 | n.s | 99.0 | Moderately correlated | |
| 120 | LTR104_Mam | 1 | n.s | 99.0 | Moderately correlated | |
| 121 | LTR10A | 1 | * | 28.9 | Weakly correlated | |
| 122 | LTR12C | 1 | n.s | 19.6 | Weakly correlated | |
| 123 | LTR13_ | 1 | ** | 28.9 | Weakly correlated | |
| 124 | LTR16 | 1 | n.s | 99.0 | Moderately correlated | |
| 125 | LTR16A | 1 | n.s | 99.0 | Moderately correlated | |
| 126 | LTR16A1 | 1 | n.s | 99.0 | Moderately correlated | |
| 127 | LTR16C | 1 | n.s | 99.0 | Moderately correlated | |
| 128 | LTR16E1 | 1 | n.s | 99.0 | Moderately correlated | |
| 129 | LTR16E2 | 1 | n.s | 99.0 | Moderately correlated | |
| 130 | LTR19B | 1 | * | 43.0 | Weakly correlated | |
| 131 | LTR22B | 1 | ** | 28.9 | Weakly correlated | |
| 132 | LTR2752 | 1 | * | 43.0 | Weakly correlated | |
| 133 | LTR33 | 1 | n.s | 99.0 | Moderately correlated | |
| 134 | LTR33A_ | 1 | n.s | 99.0 | Moderately correlated | |
| 135 | LTR35A | 1 | ** | 43.0 | Weakly correlated | |
| 136 | LTR37A | 1 | n.s | 99.0 | Moderately correlated | |
| 137 | LTR38 | 1 | * | 74.0 | Weakly correlated | |
| 138 | LTR3B | 1 | ** | 28.9 | Weakly correlated | |
| 139 | LTR41 | 1 | n.s | 99.0 | Moderately correlated | |
| 140 | LTR47A | 1 | * | 74.0 | Weakly correlated | |
| 141 | LTR47A2 | 1 | ** | 74.0 | Weakly correlated | |
| 142 | LTR55 | 1 | * | 99.0 | Moderately correlated | |
| 143 | LTR57 | 1 | ** | 74.0 | Weakly correlated | |
| 144 | LTR75 | 1 | * | 99.0 | Moderately correlated | |
| 145 | LTR78B | 1 | n.s | 99.0 | Moderately correlated | |
| 146 | LTR79 | 1 | n.s | 99.0 | Moderately correlated | |
| 147 | LTR81B | 1 | n.s | 99.0 | Moderately correlated | |
| 148 | LTR82B | 1 | n.s | 99.0 | Moderately correlated | |
| 149 | LTR85a | 1 | n.s | 99.0 | Moderately correlated | |
| 150 | LTR89 | 1 | * | 99.0 | Moderately correlated | |
| 151 | MER110 | 1 | * | 99.0 | Moderately correlated | |
| 152 | MER110-int | 1 | * | 99.0 | Moderately correlated | |
| 153 | MER11A | 1 | n.s | 28.9 | Weakly correlated | |
| 154 | MER31A | 1 | n.s | 87.0 | Weakly correlated | |
| 155 | MER39 | 1 | n.s | 74.0 | Weakly correlated | |
| 156 | MER39B | 1 | n.s | 74.0 | Weakly correlated | |
| 157 | MER41B | 1 | n.s | 74.0 | Weakly correlated | |
| 158 | MER41C | 1 | n.s | 74.0 | Weakly correlated | |
| 159 | MER41D | 1 | * | 74.0 | Weakly correlated | |
| 160 | MER49 | 1 | n.s | 43.0 | Weakly correlated | |
| 161 | MER4B | 1 | n.s | 74.0 | Weakly correlated | |
| 162 | MER4D | 1 | n.s | 74.0 | Weakly correlated | |
| 163 | MER50 | 1 | n.s | 43.0 | Weakly correlated | |
| 164 | MER52D | 1 | n.s | 74.0 | Weakly correlated | |
| 165 | MER57B1 | 1 | n.s | 43.0 | Weakly correlated | |
| 166 | MER57B2 | 1 | n.s | 43.0 | Weakly correlated | |
| 167 | MER66A | 1 | * | 43.0 | Weakly correlated | |
| 168 | MER66B | 1 | n.s | 43.0 | Weakly correlated | |
| 169 | MER88 | 1 | ** | 99.0 | Moderately correlated | |
| 170 | MLT1B | 1 | n.s | 99.0 | Moderately correlated | |
| 171 | MLT1D | 1 | n.s | 99.0 | Moderately correlated | |
| 172 | MLT1E1A | 1 | n.s | 99.0 | Moderately correlated | |
| 173 | MLT1L | 1 | n.s | 99.0 | Moderately correlated | |
| 174 | MLT1M | 1 | n.s | 99.0 | Moderately correlated | |
| 175 | MLT1O | 1 | n.s | 99.0 | Moderately correlated | |
| 176 | MLT2B4 | 1 | n.s | 99.0 | Moderately correlated | |
| 177 | MLT2D | 1 | n.s | 99.0 | Moderately correlated | |
| 178 | MLT2F | 1 | n.s | 99.0 | Moderately correlated | |
| 179 | MSTA | 1 | n.s | 43.0 | Weakly correlated | |
| 180 | MamGypsy2-LTR | 1 | * | 99.0 | Moderately correlated | |
| 181 | Plat_L3 | 1 | n.s | 99.0 | Moderately correlated | |
| 182 | SVA_E | 1 | n.s | 0.0 | Weakly correlated | |
| 183 | SVA_F | 1 | n.s | 0.0 | Weakly correlated | |
| 184 | X6A_LINE | 1 | * | 99.0 | Moderately correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | LTR50 | 11 | **** | 99.0 | Moderately correlated | |
| 2 | LTR33A | 3 | * | 99.0 | Moderately correlated | |
| 3 | L2b | 3 | n.s | 99.0 | Moderately correlated | |
| 4 | MER66C | 3 | *** | 43.0 | Weakly correlated | |
| 5 | MLT1J | 3 | n.s | 99.0 | Moderately correlated | |
| 6 | MIR3 | 3 | n.s | 99.0 | Moderately correlated | |
| 7 | MLT1C | 2 | n.s | 94.0 | Highly correlated | |
| 8 | LTR41C | 2 | ** | 99.0 | Moderately correlated | |
| 9 | L2a | 2 | n.s | 99.0 | Moderately correlated | |
| 10 | LTR91 | 2 | **** | 99.0 | Moderately correlated | |
| 11 | MIRc | 2 | n.s | 99.0 | Moderately correlated | |
| 12 | MLT1J2 | 2 | n.s | 99.0 | Moderately correlated | |
| 13 | LTR55 | 1 | * | 99.0 | Moderately correlated | |
| 14 | MER57B2 | 1 | n.s | 43.0 | Weakly correlated | |
| 15 | MLT1K | 1 | n.s | 99.0 | Moderately correlated | |
| 16 | HERVI-int | 1 | * | 28.9 | Weakly correlated | |
| 17 | LTR16B2 | 1 | n.s | 99.0 | Moderately correlated | |
| 18 | LTR2752 | 1 | * | 43.0 | Weakly correlated | |
| 19 | MER66B | 1 | n.s | 43.0 | Weakly correlated | |
| 20 | L1MB3 | 1 | n.s | 99.0 | Moderately correlated | |
| 21 | LTR8B | 1 | n.s | 43.0 | Weakly correlated | |
| 22 | L3b | 1 | n.s | 99.0 | Moderately correlated | |
| 23 | LTR104_Mam | 1 | n.s | 99.0 | Moderately correlated | |
| 24 | AmnSINE1 | 1 | n.s | 319.0 | Weakly correlated | |
| 25 | L1M6 | 1 | n.s | 99.0 | Moderately correlated | |
| 26 | HERV-Fc1_LTR3 | 1 | **** | 8.6 | Weakly correlated | |
| 27 | LTR79 | 1 | n.s | 99.0 | Moderately correlated | |
| 28 | L3 | 1 | n.s | 99.0 | Moderately correlated | |
| 29 | LTR16C | 1 | n.s | 99.0 | Moderately correlated | |
| 30 | LTR41 | 1 | n.s | 99.0 | Moderately correlated | |
| 31 | MER66A | 1 | * | 43.0 | Weakly correlated | |
| 32 | MLT1F2 | 1 | n.s | 99.0 | Moderately correlated | |
| 33 | MLT2F | 1 | n.s | 99.0 | Moderately correlated | |
| 34 | HERVIP10FH-int | 1 | n.s | 28.9 | Weakly correlated | |
| 35 | L1P2 | 1 | n.s | 28.9 | Weakly correlated | |
| 36 | L1PBa1 | 1 | n.s | 74.0 | Weakly correlated | |
| 37 | MER41B | 1 | n.s | 74.0 | Weakly correlated | |
| 38 | ERV3-16A3_I-int | 1 | n.s | 99.0 | Moderately correlated | |
| 39 | FLAM_C | 1 | n.s | 74.0 | Weakly correlated | |
| 40 | L1ME4a | 1 | n.s | 99.0 | Moderately correlated | |
| 41 | L1PA6 | 1 | n.s | 28.9 | Weakly correlated | |
| 42 | MIR | 1 | n.s | 99.0 | Moderately correlated | |
| 43 | MIRb | 1 | n.s | 99.0 | Moderately correlated |
Motif in Repeats Consensus
:
| # | Repeats name | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|
| 1 | LTR50 | 99.0 | Moderately correlated |