ZRdb KZFP & Repeats
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Human_ZNF749

  • Protein
    Zinc finger protein 749
  • Length
    778
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    O43361
  • NCBI_ID
    388567
Sequence:
MNLTEDCMVFEDVAIYFSQEEWGILNDAQRHLHSNVMLENFALLSSVGCWHGAKDEEVPSKQCVSVRVLQVTIPKPALSTLKAQPCKMCSSILKDILHLAEHDGTHPEQGLYTCAAEHDLHQKEQIREKLTRSDEWRPSFVNHSAHVGERNFTCTQGGKDFTASSDLLQQQVLNSGWKLYRDTQDGEAFQGEQNDFNSSQGGKDFCHQHGLFEHQKTHNGERPYEFSECGELFRYNSNLIKYQQNHAGERPYEGTEYGKTFIRKSNLVQHQKIHSEGFLSKRSDPIEHQEILSRPTPYECTQCGKAFLTQAHLVGHQKTHTGEQPYECNKCGKFFMYNSKLIRHQKVHTGERRYECSECGKLFMDSFTLGRHQRVHTGERPFECSICGKFFSHRSTLNMHQRVHAGKRLYKCSECGKAFSLKHNVVQHLKIHTGERPYECTECEKAFVRKSHLVQHQKIHTDAFSKRSDLIQHKRIDIRPRPYTCSECGKAFLTQAHLVGHQKIHTGERPYECTQCAKAFVRKSHLVQHEKIHTDAFSKRSDLIQHKRIDLRPRPYVCSECGKAFLTQAHLDGHQKIQTGERRYECNECGKFFLDSYKLVIHQRIHTGEKPYKCSKCGKFFRYRCTLSRHQKVHTGERPYECSECGKFFRDSYKLIIHQRVHTGEKPYECSNCGKFLRYRSTFIKHHKVCTGEKPHECSKCRELFRTKSSLIIHQQSHTGESPFKLRECGKDFNKCNTGQRQKTHTGERSYECGESSKVFKYNSSLIKHQIIHTGKRP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..101
2 dec2h2 152..174
3 dec2h2 196..218
4 dec2h2 224..246
5 dec2h2 252..274
6 C2h2 298..320
7 C2h2 326..348
8 C2h2 354..376
9 C2h2 382..404
10 C2h2 410..432
11 C2h2 438..460
12 C2h2 483..505
13 C2h2 511..533
14 dec2h2 556..578
15 C2h2 584..606
16 C2h2 612..634
17 C2h2 640..662
18 C2h2 668..690
19 C2h2 696..718
20 dec2h2 751..773
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR3B_ 9 **** 28.9 Highly correlated
2 LTR3B 7 **** 28.9 Highly correlated
3 L2a 5 n.s 99.0 Weakly correlated
4 AluJb 5 n.s 74.0 Weakly correlated
5 L2b 4 n.s 99.0 Weakly correlated
6 AluJr 4 n.s 74.0 Weakly correlated
7 MER50 3 **** 43.0 Moderately correlated
8 L1PA5 3 n.s 19.6 Weakly correlated
9 LTR10A 3 **** 28.9 Highly correlated
10 L1P3 3 ** 74.0 Weakly correlated
11 L1MA2 3 * 74.0 Weakly correlated
12 AluSq2 3 n.s 74.0 Weakly correlated
13 L1ME2z 2 * 99.0 Weakly correlated
14 AluJo 2 n.s 74.0 Weakly correlated
15 AluSc8 2 n.s 74.0 Weakly correlated
16 L1PB 2 *** 74.0 Weakly correlated
17 AluSp 2 n.s 74.0 Weakly correlated
18 AluSq10 2 *** 74.0 Weakly correlated
19 L1PA2 2 n.s 15.2 Weakly correlated
20 L1P1 2 * 19.6 Weakly correlated
21 LTR16A 2 ** 99.0 Weakly correlated
22 LTR39 2 *** 43.0 Moderately correlated
23 AluSx3 2 n.s 74.0 Weakly correlated
24 AluSx 2 n.s 74.0 Weakly correlated
25 HERVP71A-int 2 **** 43.0 Moderately correlated
26 MLT1K 1 n.s 99.0 Weakly correlated
27 MLT1F1 1 * 99.0 Weakly correlated
28 L4_B_Mam 1 ** 99.0 Weakly correlated
29 LTR105_Mam 1 *** 99.0 Weakly correlated
30 MLT1D 1 n.s 99.0 Weakly correlated
31 MLT1B 1 n.s 99.0 Weakly correlated
32 MIRc 1 n.s 99.0 Weakly correlated
33 LTR10F 1 *** 28.9 Highly correlated
34 MLT2F 1 ** 99.0 Weakly correlated
35 MIR 1 n.s 99.0 Weakly correlated
36 LTR12D 1 ** 19.6 Weakly correlated
37 LTR13 1 ** 19.6 Weakly correlated
38 MamSINE1 1 ** 99.0 Weakly correlated
39 MLT1O 1 * 99.0 Weakly correlated
40 LTR1A2 1 ** 43.0 Moderately correlated
41 L1MC 1 n.s 99.0 Weakly correlated
42 AluSz 1 n.s 74.0 Weakly correlated
43 AluSz6 1 n.s 74.0 Weakly correlated
44 AluY 1 n.s 74.0 Weakly correlated
45 AluYh9 1 **** 15.2 Weakly correlated
46 HAL1 1 n.s 99.0 Weakly correlated
47 L1M4 1 n.s 99.0 Weakly correlated
48 L1M4a2 1 * 99.0 Weakly correlated
49 L1M5 1 n.s 99.0 Weakly correlated
50 L1MB7 1 n.s 99.0 Weakly correlated
51 L1MB8 1 n.s 99.0 Weakly correlated
52 L3 1 n.s 99.0 Weakly correlated
53 L1MC4 1 n.s 99.0 Weakly correlated
54 L1ME1 1 n.s 99.0 Weakly correlated
55 L1ME2 1 n.s 99.0 Weakly correlated
56 L1ME3A 1 n.s 99.0 Weakly correlated
57 L1ME3Cz 1 n.s 99.0 Weakly correlated
58 L1MEd 1 n.s 99.0 Weakly correlated
59 L1P4 1 * 74.0 Weakly correlated
60 L1PA4 1 n.s 19.6 Weakly correlated
61 L1PA7 1 n.s 74.0 Weakly correlated
62 L1PBa 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2a 3 n.s 99.0 Weakly correlated
2 L1MA2 3 * 74.0 Weakly correlated
3 LTR16A 2 ** 99.0 Weakly correlated
4 L1ME2z 2 * 99.0 Weakly correlated
5 AluSx3 2 n.s 74.0 Weakly correlated
6 AluJr 2 n.s 74.0 Weakly correlated
7 AluSq2 2 n.s 74.0 Weakly correlated
8 LTR3B_ 1 *** 28.9 Highly correlated
9 L2b 1 n.s 99.0 Weakly correlated
10 L1MEd 1 n.s 99.0 Weakly correlated
11 L1PA7 1 n.s 74.0 Weakly correlated
12 L3 1 n.s 99.0 Weakly correlated
13 L1MC4 1 n.s 99.0 Weakly correlated
14 L1MB7 1 n.s 99.0 Weakly correlated
15 L1ME3A 1 n.s 99.0 Weakly correlated
16 MamSINE1 1 ** 99.0 Weakly correlated
17 L1M4a2 1 * 99.0 Weakly correlated
18 L1MB8 1 n.s 99.0 Weakly correlated
19 AluSc8 1 n.s 74.0 Weakly correlated
20 LTR105_Mam 1 *** 99.0 Weakly correlated
21 MER50 1 * 43.0 Moderately correlated
22 HERVP71A-int 1 ** 43.0 Moderately correlated
23 AluSp 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP