ZRdb KZFP & Repeats
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Human_ZNF746

  • Protein
    Zinc finger protein 746
  • Length
    644
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    160.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q6NUN9
  • NCBI_ID
    155061
Sequence:
MAEAVAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGESPKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGGVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKTPARGQPLPTPPAPPDPFKSPASKGPLASTDLVTDWTCGLSVLGPTDGGDM
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 96..167
2 dec2h2 453..478
3 C2h2 510..532
4 C2h2 538..560
5 C2h2 566..588
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component cytoplasm
2 Cellular Component cytosol
3 Cellular Component nucleoplasm
4 Cellular Component nucleus
5 Molecular Function DNA-binding transcription factor activity
6 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
7 Molecular Function metal ion binding
8 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
9 Molecular Function transcription cis-regulatory region binding
10 Molecular Function ubiquitin protein ligase binding
11 Biological Process negative regulation of DNA-templated transcription
12 Biological Process negative regulation of transcription by RNA polymerase II
13 Biological Process positive regulation of neuron death
14 Biological Process positive regulation of transcription by RNA polymerase II
15 Biological Process protein heterooligomerization
16 Biological Process protein homooligomerization
17 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 12 **** 0.0 Weakly correlated
2 AluSc8 8 ** 74.0 Weakly correlated
3 FRAM 6 **** 74.0 Weakly correlated
4 MER21B 4 *** 99.0 Highly correlated
5 AluYm1 3 ** 19.6 Weakly correlated
6 AluJo 2 n.s 74.0 Weakly correlated
7 L1PA4 2 n.s 19.6 Weakly correlated
8 L1PA2 2 n.s 15.2 Weakly correlated
9 HUERS-P3b-int 2 *** 43.0 Weakly correlated
10 AluYh9 2 **** 15.2 Weakly correlated
11 AluYa8 2 **** 15.2 Weakly correlated
12 AluY 2 n.s 74.0 Weakly correlated
13 AluSx 2 n.s 74.0 Weakly correlated
14 AluYi6 1 *** 15.2 Weakly correlated
15 L1P1 1 n.s 19.6 Weakly correlated
16 L1PA10 1 n.s 74.0 Weakly correlated
17 AluSq 1 n.s 74.0 Weakly correlated
18 L1PA5 1 n.s 19.6 Weakly correlated
19 L2 1 n.s 99.0 Highly correlated
20 L2b 1 n.s 99.0 Highly correlated
21 LTR13 1 * 19.6 Weakly correlated
22 AluJb 1 n.s 74.0 Weakly correlated
23 MIRb 1 n.s 99.0 Highly correlated
24 MLT-int 1 ** 99.0 Highly correlated
25 SVA_C 1 * 15.2 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 FRAM 4 *** 74.0 Weakly correlated
2 AluYj4 3 *** 0.0 Weakly correlated
3 HUERS-P3b-int 2 *** 43.0 Weakly correlated
4 AluSc8 2 n.s 74.0 Weakly correlated
5 AluJb 1 n.s 74.0 Weakly correlated
6 AluJo 1 n.s 74.0 Weakly correlated
7 AluSq 1 n.s 74.0 Weakly correlated
8 AluYa8 1 *** 15.2 Weakly correlated
9 AluY 1 n.s 74.0 Weakly correlated
10 L1P1 1 n.s 19.6 Weakly correlated
11 AluSx 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP