ZRdb KZFP & Repeats
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Human_ZNF74

  • Protein
    Zinc finger protein 74
  • Length
    644
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q16587
  • NCBI_ID
    7625
Sequence:
MEIPAPEPEKTALSSQDPALSLKENLEDISGWGLPEARSKESVSFKDVAVDFTQEEWGQLDSPQRALYRDVMLENYQNLLALGPPLHKPDVISHLERGEEPWSMQREVPRGPCPEWELKAVPSQQQGICKEEPAQEPIMERPLGGAQAWGRQAGALQRSQAAPWAPAPAMVWDVPVEEFPLRCPLFAQQRVPEGGPLLDTRKNVQATEGRTKAPARLCAGENASTPSEPEKFPQVRRQRGAGAGEGEFVCGECGKAFRQSSSLTLHRRWHSREKAYKCDECGKAFTWSTNLLEHRRIHTGEKPFFCGECGKAFSCHSSLNVHQRIHTGERPYKCSACEKAFSCSSLLSMHLRVHTGEKPYRCGECGKAFNQRTHLTRHHRIHTGEKPYQCGSCGKAFTCHSSLTVHEKIHSGDKPFKCSDCEKAFNSRSRLTLHQRTHTGEKPFKCADCGKGFSCHAYLLVHRRIHSGEKPFKCNECGKAFSSHAYLIVHRRIHTGEKPFDCSQCWKAFSCHSSLIVHQRIHTGEKPYKCSECGRAFSQNHCLIKHQKIHSGEKSFKCEKCGEMFNWSSHLTEHQRLHSEGKPLAIQFNKHLLSTYYVPGSLLGAGDAGLRDVDPIDALDVAKLLCVVPPRAGRNFSLGSKPRN
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 43..114
2 C2h2 248..270
3 C2h2 276..298
4 C2h2 304..326
5 C2h2 332..354
6 C2h2 360..382
7 C2h2 388..410
8 C2h2 416..438
9 C2h2 444..466
10 C2h2 472..494
11 C2h2 500..522
12 C2h2 528..550
13 C2h2 556..578
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component actin cytoskeleton
2 Cellular Component nucleoplasm
3 Cellular Component nucleus
4 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA binding
7 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
8 Biological Process regulation of DNA-templated transcription
9 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1ME4c 22 **** 99.0 Highly correlated
2 L1ME4a 19 **** 99.0 Highly correlated
3 L1ME3G 12 **** 99.0 Highly correlated
4 L1M5 11 **** 99.0 Highly correlated
5 L1ME3Cz 6 **** 99.0 Highly correlated
6 LTR8 6 **** 43.0 Weakly correlated
7 AluJb 5 n.s 74.0 Weakly correlated
8 L1PA5 4 n.s 19.6 Weakly correlated
9 AluSz 4 n.s 74.0 Weakly correlated
10 L1ME4b 4 ** 99.0 Highly correlated
11 L2c 4 n.s 99.0 Highly correlated
12 L1PA2 3 n.s 15.2 Weakly correlated
13 AluSx 3 n.s 74.0 Weakly correlated
14 LTR10A 3 **** 28.9 Weakly correlated
15 L1P3 2 * 74.0 Weakly correlated
16 MLT1A0 2 n.s 99.0 Highly correlated
17 AluJo 2 n.s 74.0 Weakly correlated
18 AluJr 2 n.s 74.0 Weakly correlated
19 AluY 2 n.s 74.0 Weakly correlated
20 AluSz6 2 n.s 74.0 Weakly correlated
21 AluSc8 2 n.s 74.0 Weakly correlated
22 AluSp 2 n.s 74.0 Weakly correlated
23 AluSx1 1 n.s 74.0 Weakly correlated
24 MLT2B3 1 * 99.0 Highly correlated
25 MER50 1 * 43.0 Weakly correlated
26 MER39B 1 ** 74.0 Weakly correlated
27 AluSc 1 n.s 74.0 Weakly correlated
28 LTR48B 1 ** 74.0 Weakly correlated
29 LTR13 1 ** 19.6 Weakly correlated
30 L2a 1 n.s 99.0 Highly correlated
31 L2 1 n.s 99.0 Highly correlated
32 L1M4 1 n.s 99.0 Highly correlated
33 L1PA4 1 n.s 19.6 Weakly correlated
34 AluSx3 1 n.s 74.0 Weakly correlated
35 L1P4 1 * 74.0 Weakly correlated
36 AluSx4 1 n.s 74.0 Weakly correlated
37 L1P1 1 n.s 19.6 Weakly correlated
38 L1ME5 1 * 99.0 Highly correlated
39 AluYh9 1 **** 15.2 Weakly correlated
40 AluYm1 1 * 19.6 Weakly correlated
41 HAL1 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1ME4a 18 **** 99.0 Highly correlated
2 L1ME4c 13 **** 99.0 Highly correlated
3 L1M5 11 **** 99.0 Highly correlated
4 L1ME3G 6 **** 99.0 Highly correlated
5 L1ME3Cz 5 **** 99.0 Highly correlated
6 L1ME4b 2 n.s 99.0 Highly correlated
7 AluSz 1 n.s 74.0 Weakly correlated
8 L1ME5 1 * 99.0 Highly correlated
9 AluYh9 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP