ZRdb KZFP & Repeats
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Human_ZNF736

  • Protein
    Zinc finger protein 736
  • Length
    427
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    B4DX44
  • NCBI_ID
    728927
Sequence:
MGVLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLGLAIFKPDLMTCLEQRKEPWKVKRQEAVAKHPAGSFHFTAEILPDHDIKDSFQKVILRKYGSCDLNNLHLKKDYQSVGNCKGQKSSYNGLHQCLSATHSKTCQCNKCGRGFQLCSIFTEHKDIFSREKCHKCEECGKDCRLFSDFTRHKKIHTVERCYKCEECGKAFKKFSNLTEHKRVHTGEKPYKCEGCGKTFTCSSTLVKHKRNHTGDRPYKCEECGKAFKCFSDLTNHKRIHTGEKPYKCEECNKAYRWFSDLAKHKIIHTGDKPYTCNECGKAFKWFSALSKHKRIHTGEKPYICEECGKAFTRSSTLFNHKRIHMEERPYKCEECSKTFKCFSDLTNHKRIHTGEKPYKCEECGKASSWFSHLIRHKRIHTREKLHKC
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..75
2 dec2h2 145..167
3 C2h2 173..195
4 C2h2 201..223
5 C2h2 229..251
6 C2h2 257..279
7 C2h2 285..307
8 C2h2 313..335
9 C2h2 341..363
10 C2h2 369..391
11 C2h2 397..419
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of DNA-templated transcription
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER52A 379 **** 74.0 Weakly correlated
2 MER52D 145 **** 74.0 Weakly correlated
3 LTR28C 131 **** 43.0 Highly correlated
4 MER52C 121 **** 74.0 Weakly correlated
5 LTR1D 88 **** 43.0 Highly correlated
6 LTR2752 70 **** 43.0 Highly correlated
7 LTR1D1 62 **** 43.0 Highly correlated
8 LTR27E 61 **** 43.0 Highly correlated
9 LTR28B 60 **** 43.0 Highly correlated
10 LTR27D 52 **** 43.0 Highly correlated
11 LTR27C 51 **** 43.0 Highly correlated
12 LTR28 41 **** 43.0 Highly correlated
13 LTR27B 39 **** 43.0 Highly correlated
14 L2a 17 n.s 99.0 Weakly correlated
15 AluY 16 n.s 74.0 Weakly correlated
16 LTR25 12 **** 43.0 Highly correlated
17 MIRb 12 n.s 99.0 Weakly correlated
18 AluSx1 11 n.s 74.0 Weakly correlated
19 AluSx 10 n.s 74.0 Weakly correlated
20 L2b 8 n.s 99.0 Weakly correlated
21 AluJb 7 n.s 74.0 Weakly correlated
22 L2c 7 n.s 99.0 Weakly correlated
23 LTR1E 7 **** 43.0 Highly correlated
24 MIR 7 n.s 99.0 Weakly correlated
25 LTR1A1 6 **** 43.0 Highly correlated
26 THE1B 6 n.s 43.0 Highly correlated
27 AluSq2 5 n.s 74.0 Weakly correlated
28 AluSz6 5 n.s 74.0 Weakly correlated
29 L2 5 n.s 99.0 Weakly correlated
30 LTR27 5 **** 43.0 Highly correlated
31 MLT1J2 5 *** 99.0 Weakly correlated
32 L1ME1 4 n.s 99.0 Weakly correlated
33 LTR10A 4 **** 28.9 Weakly correlated
34 MER51A 4 **** 43.0 Highly correlated
35 MLT1L 4 * 99.0 Weakly correlated
36 AluJo 3 n.s 74.0 Weakly correlated
37 AluSx4 3 n.s 74.0 Weakly correlated
38 AluSz 3 n.s 74.0 Weakly correlated
39 HUERS-P2-int 3 **** 43.0 Highly correlated
40 L1M1 3 n.s 74.0 Weakly correlated
41 L1MB3 3 n.s 99.0 Weakly correlated
42 L1MB7 3 n.s 99.0 Weakly correlated
43 L1MC5a 3 n.s 99.0 Weakly correlated
44 L1MCb 3 ** 99.0 Weakly correlated
45 L1ME4a 3 n.s 99.0 Weakly correlated
46 L1PA15-16 3 ** 74.0 Weakly correlated
47 L3b 3 ** 99.0 Weakly correlated
48 LTR8B 3 *** 43.0 Highly correlated
49 MER52-int 3 *** 99.0 Weakly correlated
50 MIR3 3 n.s 99.0 Weakly correlated
51 MIRc 3 n.s 99.0 Weakly correlated
52 AluJr 2 n.s 74.0 Weakly correlated
53 AluSc 2 n.s 74.0 Weakly correlated
54 AluSc8 2 n.s 74.0 Weakly correlated
55 AluSg 2 n.s 74.0 Weakly correlated
56 AluSg4 2 n.s 74.0 Weakly correlated
57 AluSq 2 n.s 74.0 Weakly correlated
58 AluSq10 2 ** 74.0 Weakly correlated
59 AluSx3 2 n.s 74.0 Weakly correlated
60 HERVL74-int 2 *** 99.0 Weakly correlated
61 L1M5 2 n.s 99.0 Weakly correlated
62 L1MA10 2 n.s 99.0 Weakly correlated
63 L1MA9 2 n.s 99.0 Weakly correlated
64 L1MC2 2 n.s 99.0 Weakly correlated
65 L1MC4 2 n.s 99.0 Weakly correlated
66 L1MEc 2 n.s 99.0 Weakly correlated
67 L1MEd 2 n.s 99.0 Weakly correlated
68 L1MEi 2 n.s 99.0 Weakly correlated
69 L1P4 2 n.s 74.0 Weakly correlated
70 L1PA11 2 n.s 74.0 Weakly correlated
71 L3 2 n.s 99.0 Weakly correlated
72 LTR1 2 **** 43.0 Highly correlated
73 LTR12 2 ** 28.9 Weakly correlated
74 LTR16C 2 n.s 99.0 Weakly correlated
75 LTR1A2 2 ** 43.0 Highly correlated
76 LTR67B 2 ** 99.0 Weakly correlated
77 LTR85c 2 *** 99.0 Weakly correlated
78 LTR88a 2 **** 99.0 Weakly correlated
79 MER4-int 2 n.s 74.0 Weakly correlated
80 MER41-int 2 * 74.0 Weakly correlated
81 MER61E 2 **** 43.0 Highly correlated
82 MIR1_Amn 2 * 319.0 Weakly correlated
83 MLT1F2 2 n.s 99.0 Weakly correlated
84 MLT1K 2 n.s 99.0 Weakly correlated
85 MamRep605 2 ** 99.0 Weakly correlated
86 Alu 1 ** 74.0 Weakly correlated
87 AluSp 1 n.s 74.0 Weakly correlated
88 AluYj4 1 n.s 0.0 Weakly correlated
89 AmnSINE1 1 ** 319.0 Weakly correlated
90 CR1-3_Croc 1 ** 319.0 Weakly correlated
91 ERVL47-int 1 ** 74.0 Weakly correlated
92 FLAM_C 1 n.s 74.0 Weakly correlated
93 HAL1 1 n.s 99.0 Weakly correlated
94 HERV16-int 1 n.s 99.0 Weakly correlated
95 L1M3 1 n.s 99.0 Weakly correlated
96 L1M4 1 n.s 99.0 Weakly correlated
97 L1M6B 1 ** 99.0 Weakly correlated
98 L1MA5A 1 n.s 87.0 Weakly correlated
99 L1MA6 1 n.s 87.0 Weakly correlated
100 L1MA8 1 n.s 87.0 Weakly correlated
101 L1MB2 1 n.s 99.0 Weakly correlated
102 L1MB8 1 n.s 99.0 Weakly correlated
103 L1MC 1 n.s 99.0 Weakly correlated
104 L1MC3 1 n.s 99.0 Weakly correlated
105 L1MC4a 1 n.s 99.0 Weakly correlated
106 L1MC5 1 n.s 99.0 Weakly correlated
107 L1MCa 1 n.s 99.0 Weakly correlated
108 L1MD1 1 n.s 99.0 Weakly correlated
109 L1MD2 1 n.s 99.0 Weakly correlated
110 L1MDa 1 n.s 99.0 Weakly correlated
111 L1ME2z 1 n.s 99.0 Weakly correlated
112 L1ME3 1 n.s 99.0 Weakly correlated
113 L1ME3B 1 n.s 99.0 Weakly correlated
114 L1ME3C 1 n.s 99.0 Weakly correlated
115 L1ME3Cz 1 n.s 99.0 Weakly correlated
116 L1ME4b 1 n.s 99.0 Weakly correlated
117 L1ME4c 1 n.s 99.0 Weakly correlated
118 L1MEg 1 n.s 99.0 Weakly correlated
119 L1MEh 1 n.s 99.0 Weakly correlated
120 L1P3 1 n.s 74.0 Weakly correlated
121 L1PA14 1 n.s 74.0 Weakly correlated
122 L1PA16 1 n.s 74.0 Weakly correlated
123 L1PA4 1 n.s 19.6 Weakly correlated
124 L1PA5 1 n.s 19.6 Weakly correlated
125 L1PA6 1 n.s 28.9 Weakly correlated
126 L1PA7 1 n.s 74.0 Weakly correlated
127 L1PB3 1 n.s 74.0 Weakly correlated
128 L1PREC2 1 n.s 43.0 Highly correlated
129 LOR1-int 1 n.s 74.0 Weakly correlated
130 LTR103b_Mam 1 ** 99.0 Weakly correlated
131 LTR12_ 1 * 28.9 Weakly correlated
132 LTR16A2 1 * 99.0 Weakly correlated
133 LTR16B 1 ** 99.0 Weakly correlated
134 LTR1F2 1 *** 43.0 Highly correlated
135 LTR24C 1 ** 74.0 Weakly correlated
136 LTR26D 1 *** 0.0 Weakly correlated
137 LTR32 1 * 43.0 Highly correlated
138 LTR3B_ 1 ** 28.9 Weakly correlated
139 LTR49 1 * 74.0 Weakly correlated
140 MER101-int 1 * 74.0 Weakly correlated
141 MER21A 1 n.s 74.0 Weakly correlated
142 MER21B 1 n.s 99.0 Weakly correlated
143 MER21C 1 n.s 99.0 Weakly correlated
144 MER31B 1 * 99.0 Weakly correlated
145 MER34B-int 1 ** 99.0 Weakly correlated
146 MER39 1 n.s 74.0 Weakly correlated
147 MER4D 1 * 74.0 Weakly correlated
148 MER57-int 1 n.s 87.0 Weakly correlated
149 MER57A1 1 * 43.0 Highly correlated
150 MER57D 1 ** 87.0 Weakly correlated
151 MER61D 1 ** 43.0 Highly correlated
152 MER67C 1 * 99.0 Weakly correlated
153 MER70-int 1 ** 99.0 Weakly correlated
154 MER74B 1 * 99.0 Weakly correlated
155 MER84 1 ** 43.0 Highly correlated
156 MLT1A0 1 n.s 99.0 Weakly correlated
157 MLT1B 1 n.s 99.0 Weakly correlated
158 MLT1C 1 n.s 94.0 Weakly correlated
159 MLT1C-int 1 ** 94.0 Weakly correlated
160 MLT1D 1 n.s 99.0 Weakly correlated
161 MLT1E3 1 n.s 99.0 Weakly correlated
162 MLT1F1 1 n.s 99.0 Weakly correlated
163 MLT1J1 1 n.s 99.0 Weakly correlated
164 MLT2C2 1 * 99.0 Weakly correlated
165 MSTA 1 n.s 43.0 Highly correlated
166 MSTB 1 n.s 43.0 Highly correlated
167 THE1D 1 n.s 43.0 Highly correlated
168 THE1D-int 1 n.s 28.9 Weakly correlated
169 X7A_LINE 1 ** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER52A 369 **** 74.0 Weakly correlated
2 MER52D 131 **** 74.0 Weakly correlated
3 LTR28C 128 **** 43.0 Highly correlated
4 MER52C 118 **** 74.0 Weakly correlated
5 LTR1D 87 **** 43.0 Highly correlated
6 LTR2752 68 **** 43.0 Highly correlated
7 LTR1D1 61 **** 43.0 Highly correlated
8 LTR28B 60 **** 43.0 Highly correlated
9 LTR27E 60 **** 43.0 Highly correlated
10 LTR27D 52 **** 43.0 Highly correlated
11 LTR27C 48 **** 43.0 Highly correlated
12 LTR28 41 **** 43.0 Highly correlated
13 LTR27B 36 **** 43.0 Highly correlated
14 LTR25 10 **** 43.0 Highly correlated
15 LTR1A1 6 **** 43.0 Highly correlated
16 LTR1E 6 **** 43.0 Highly correlated
17 LTR27 4 **** 43.0 Highly correlated
18 AluSx1 4 n.s 74.0 Weakly correlated
19 LTR8B 3 *** 43.0 Highly correlated
20 AluSx 3 n.s 74.0 Weakly correlated
21 AluSq 2 n.s 74.0 Weakly correlated
22 L2b 2 n.s 99.0 Weakly correlated
23 MIRb 2 n.s 99.0 Weakly correlated
24 LTR1A2 2 ** 43.0 Highly correlated
25 L1MC5a 1 n.s 99.0 Weakly correlated
26 MLT1C 1 n.s 94.0 Weakly correlated
27 THE1D 1 n.s 43.0 Highly correlated
28 AluSx4 1 n.s 74.0 Weakly correlated
29 L1M5 1 n.s 99.0 Weakly correlated
30 MER57D 1 ** 87.0 Weakly correlated
31 LTR1F2 1 *** 43.0 Highly correlated
32 MER4-int 1 n.s 74.0 Weakly correlated
33 HERV16-int 1 n.s 99.0 Weakly correlated
34 L1MCb 1 n.s 99.0 Weakly correlated
35 L2a 1 n.s 99.0 Weakly correlated
36 AluY 1 n.s 74.0 Weakly correlated
37 L1ME4c 1 n.s 99.0 Weakly correlated
38 AluSz6 1 n.s 74.0 Weakly correlated
39 AluSq2 1 n.s 74.0 Weakly correlated
40 AluJo 1 n.s 74.0 Weakly correlated
41 LTR12 1 * 28.9 Weakly correlated
42 MER67C 1 * 99.0 Weakly correlated
43 LTR1 1 ** 43.0 Highly correlated
44 LTR88a 1 ** 99.0 Weakly correlated
45 LTR85c 1 ** 99.0 Weakly correlated
46 AluSg4 1 n.s 74.0 Weakly correlated
47 AluSq10 1 * 74.0 Weakly correlated
48 HERVL74-int 1 ** 99.0 Weakly correlated
49 L1MB3 1 n.s 99.0 Weakly correlated
50 L1ME3B 1 n.s 99.0 Weakly correlated
51 LTR16A2 1 * 99.0 Weakly correlated
52 LTR16B 1 ** 99.0 Weakly correlated
53 L3 1 n.s 99.0 Weakly correlated
54 L1PA15-16 1 n.s 74.0 Weakly correlated
55 L1M1 1 n.s 74.0 Weakly correlated
56 MSTB 1 n.s 43.0 Highly correlated
57 AluSz 1 n.s 74.0 Weakly correlated
58 L2 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP