ZRdb KZFP & Repeats
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Human_ZNF730

  • Protein
    Putative zinc finger protein 730
  • Length
    503
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    19.6 Mya
  • Uniprot_ID
    Q6ZMV8
  • NCBI_ID
    100129543
Sequence:
MGALTFRDVAIEFSLEEWQCLDTEQQNLYRNVMLDNYRNLVFLGIAVSKPDLITCLEQEKEPWNLKTHDMVAKPPVICSHIAQDLWPEQGIKDYFQEVILRQYKKCRHENLLLRKGCKNVDEFKMHKKGYNRHNQCLTTSHSKIFQCDKYVKVFHKFSNSNRHKIRHTSKKPFKCKECGKLFCILSHLAQHKKIHTGEKSYKCEEYGKAFNESSNCTTHKRITEKKPYKCKECGKAFNWFSHFTTHKRIHTGEKPYQCEKCGKFFNQSTNLTTHKRIHTGEKPYKCEECGKAFNQSSNLTEHKKIHTKEQPYKCEKCGKAFKWSSTLTKHKRIHNGEKPYKCEECGKAFNRSSTLNRHKITHTGGKPYKYKECGKAFNQSSTLTIHKIIHTVEKFYKCEECGKAFSRISHLTTHKRIHTGEKPYKCEECGRAFNQSSTLTTHKRIHTGEKPYECEECGKAFNRSSTLTTHKIIHSGEKIYKCKECGKAFRRFSHLTRHKTIHT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..75
2 dec2h2 145..167
3 C2h2 173..195
4 C2h2 228..250
5 C2h2 256..278
6 C2h2 284..306
7 C2h2 312..334
8 C2h2 340..362
9 dec2h2 368..390
10 C2h2 396..418
11 C2h2 424..446
12 C2h2 452..474
13 C2h2 480..502
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of DNA-templated transcription
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 PABL_A 122 **** 43.0 Weakly correlated
2 AluJb 47 **** 74.0 Weakly correlated
3 AluSx 33 *** 74.0 Weakly correlated
4 AluY 28 ** 74.0 Weakly correlated
5 AluJr 25 **** 74.0 Weakly correlated
6 MIRb 23 n.s 99.0 Weakly correlated
7 AluJo 21 *** 74.0 Weakly correlated
8 AluSq2 21 *** 74.0 Weakly correlated
9 L2a 20 n.s 99.0 Weakly correlated
10 MLT1A0 20 **** 99.0 Weakly correlated
11 AluSx1 19 n.s 74.0 Weakly correlated
12 MIR 19 n.s 99.0 Weakly correlated
13 AluSz 16 n.s 74.0 Weakly correlated
14 L2c 16 n.s 99.0 Weakly correlated
15 THE1C-int 13 **** 43.0 Weakly correlated
16 AluSc 12 ** 74.0 Weakly correlated
17 AluSp 12 n.s 74.0 Weakly correlated
18 AluSg 11 * 74.0 Weakly correlated
19 AluSz6 11 * 74.0 Weakly correlated
20 AluSx3 10 ** 74.0 Weakly correlated
21 L2 9 n.s 99.0 Weakly correlated
22 L2b 9 n.s 99.0 Weakly correlated
23 LTR12C 9 **** 19.6 Highly correlated
24 MIRc 9 n.s 99.0 Weakly correlated
25 FLAM_C 8 **** 74.0 Weakly correlated
26 PABL_A-int 8 **** 74.0 Weakly correlated
27 PABL_B 8 **** 43.0 Weakly correlated
28 THE1B-int 8 ** 43.0 Weakly correlated
29 L1M5 7 n.s 99.0 Weakly correlated
30 HUERS-P3b-int 6 **** 43.0 Weakly correlated
31 L1PA4 6 n.s 19.6 Highly correlated
32 THE1D-int 6 *** 28.9 Moderately correlated
33 AluSc8 5 n.s 74.0 Weakly correlated
34 L1MC4 5 n.s 99.0 Weakly correlated
35 L1ME1 5 n.s 99.0 Weakly correlated
36 L1MEf 5 n.s 99.0 Weakly correlated
37 L1P3 5 ** 74.0 Weakly correlated
38 MIR3 5 n.s 99.0 Weakly correlated
39 MLT1A 5 ** 99.0 Weakly correlated
40 MLT1B 5 n.s 99.0 Weakly correlated
41 MLT1J 5 * 99.0 Weakly correlated
42 MamGypLTR3a 5 **** 99.0 Weakly correlated
43 SVA_F 5 **** 0.0 Weakly correlated
44 AluJr4 4 n.s 74.0 Weakly correlated
45 L1M4 4 n.s 99.0 Weakly correlated
46 L1MC 4 * 99.0 Weakly correlated
47 L1ME4b 4 n.s 99.0 Weakly correlated
48 L1MEc 4 n.s 99.0 Weakly correlated
49 L1MEg 4 n.s 99.0 Weakly correlated
50 L3 4 n.s 99.0 Weakly correlated
51 LTR10A 4 **** 28.9 Moderately correlated
52 LTR33 4 ** 99.0 Weakly correlated
53 MLT1I 4 ** 99.0 Weakly correlated
54 MLT1K 4 n.s 99.0 Weakly correlated
55 MSTB1 4 ** 74.0 Weakly correlated
56 SVA_D 4 ** 15.2 Weakly correlated
57 AluSc5 3 * 74.0 Weakly correlated
58 AluSq 3 n.s 74.0 Weakly correlated
59 AluYh3 3 *** 15.2 Weakly correlated
60 FRAM 3 ** 74.0 Weakly correlated
61 HUERS-P3-int 3 *** 43.0 Weakly correlated
62 L1M1 3 n.s 74.0 Weakly correlated
63 L1MA9 3 n.s 99.0 Weakly correlated
64 L1MB7 3 n.s 99.0 Weakly correlated
65 L1ME4a 3 n.s 99.0 Weakly correlated
66 L1MEd 3 n.s 99.0 Weakly correlated
67 L1PA5 3 n.s 19.6 Highly correlated
68 LTR67B 3 *** 99.0 Weakly correlated
69 MER50-int 3 **** 43.0 Weakly correlated
70 MER52A 3 * 74.0 Weakly correlated
71 MIR1_Amn 3 ** 319.0 Weakly correlated
72 MLT1C 3 n.s 94.0 Weakly correlated
73 MSTA-int 3 n.s 43.0 Weakly correlated
74 AluSg7 2 n.s 74.0 Weakly correlated
75 AluYa5 2 * 15.2 Weakly correlated
76 AluYc 2 * 74.0 Weakly correlated
77 ERVL-B4-int 2 n.s 99.0 Weakly correlated
78 HAL1b 2 * 99.0 Weakly correlated
79 L1M2 2 n.s 99.0 Weakly correlated
80 L1M4a1 2 * 99.0 Weakly correlated
81 L1M4c 2 n.s 99.0 Weakly correlated
82 L1MA3 2 n.s 74.0 Weakly correlated
83 L1MA4A 2 n.s 87.0 Weakly correlated
84 L1MA5 2 n.s 87.0 Weakly correlated
85 L1MA6 2 n.s 87.0 Weakly correlated
86 L1MB4 2 n.s 99.0 Weakly correlated
87 L1MB8 2 n.s 99.0 Weakly correlated
88 L1MC2 2 n.s 99.0 Weakly correlated
89 L1MC3 2 n.s 99.0 Weakly correlated
90 L1MCc 2 * 99.0 Weakly correlated
91 L1MD 2 n.s 99.0 Weakly correlated
92 L1MD1 2 n.s 99.0 Weakly correlated
93 L1PA17 2 n.s 74.0 Weakly correlated
94 L1PREC2 2 n.s 43.0 Weakly correlated
95 L4_C_Mam 2 * 99.0 Weakly correlated
96 LTR10F 2 *** 28.9 Moderately correlated
97 LTR13 2 ** 19.6 Highly correlated
98 MER41A 2 * 74.0 Weakly correlated
99 MER4B-int 2 ** 99.0 Weakly correlated
100 MER77 2 ** 99.0 Weakly correlated
101 MLT1A1 2 n.s 87.0 Weakly correlated
102 MLT1F 2 * 99.0 Weakly correlated
103 MLT1F1 2 * 99.0 Weakly correlated
104 MLT1F2 2 n.s 99.0 Weakly correlated
105 MLT1H2 2 * 99.0 Weakly correlated
106 MLT1O 2 * 99.0 Weakly correlated
107 MSTD 2 n.s 74.0 Weakly correlated
108 MamGypLTR1b 2 *** 99.0 Weakly correlated
109 THE1B 2 n.s 43.0 Weakly correlated
110 Alu 1 ** 74.0 Weakly correlated
111 AluSg4 1 n.s 74.0 Weakly correlated
112 AluSq10 1 * 74.0 Weakly correlated
113 AluSq4 1 * 74.0 Weakly correlated
114 AluSx4 1 n.s 74.0 Weakly correlated
115 AluYg6 1 ** 15.2 Weakly correlated
116 AluYh9 1 **** 15.2 Weakly correlated
117 AluYk11 1 ** 15.2 Weakly correlated
118 AluYk3 1 * 19.6 Highly correlated
119 AluYm1 1 n.s 19.6 Highly correlated
120 CR1-3_Croc 1 ** 319.0 Weakly correlated
121 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
122 ERVL-E-int 1 n.s 99.0 Weakly correlated
123 FAM 1 * 87.0 Weakly correlated
124 FLAM_A 1 n.s 74.0 Weakly correlated
125 HAL1 1 n.s 99.0 Weakly correlated
126 HAL1ME 1 n.s 99.0 Weakly correlated
127 HERVL-int 1 n.s 74.0 Weakly correlated
128 HERVP71A-int 1 ** 43.0 Weakly correlated
129 HUERS-P1-int 1 * 43.0 Weakly correlated
130 L1HS 1 n.s 8.6 Weakly correlated
131 L1M3c 1 * 99.0 Weakly correlated
132 L1M7 1 n.s 99.0 Weakly correlated
133 L1M8 1 n.s 99.0 Weakly correlated
134 L1MA1 1 n.s 74.0 Weakly correlated
135 L1MA4 1 n.s 87.0 Weakly correlated
136 L1MA8 1 n.s 87.0 Weakly correlated
137 L1MB1 1 n.s 99.0 Weakly correlated
138 L1MC1 1 n.s 99.0 Weakly correlated
139 L1MC4a 1 n.s 99.0 Weakly correlated
140 L1MC5 1 n.s 99.0 Weakly correlated
141 L1MD2 1 n.s 99.0 Weakly correlated
142 L1MD3 1 n.s 99.0 Weakly correlated
143 L1MDa 1 n.s 99.0 Weakly correlated
144 L1ME3A 1 n.s 99.0 Weakly correlated
145 L1ME3Cz 1 n.s 99.0 Weakly correlated
146 L1ME3G 1 n.s 99.0 Weakly correlated
147 L1MEh 1 n.s 99.0 Weakly correlated
148 L1MEi 1 n.s 99.0 Weakly correlated
149 L1P1 1 n.s 19.6 Highly correlated
150 L1P4 1 n.s 74.0 Weakly correlated
151 L1PA15 1 n.s 74.0 Weakly correlated
152 L1PA15-16 1 n.s 74.0 Weakly correlated
153 L1PA2 1 n.s 15.2 Weakly correlated
154 L1PA3 1 n.s 19.6 Highly correlated
155 L1PB4 1 n.s 99.0 Weakly correlated
156 L2-3_Crp 1 * 431.0 Weakly correlated
157 L3b 1 n.s 99.0 Weakly correlated
158 L4_A_Mam 1 n.s 99.0 Weakly correlated
159 LTR10B1 1 *** 28.9 Moderately correlated
160 LTR12E 1 ** 19.6 Highly correlated
161 LTR16C 1 n.s 99.0 Weakly correlated
162 LTR18A 1 *** 43.0 Weakly correlated
163 LTR37-int 1 * 99.0 Weakly correlated
164 LTR56 1 * 74.0 Weakly correlated
165 LTR57-int 1 ** 74.0 Weakly correlated
166 LTR76 1 ** 74.0 Weakly correlated
167 LTR8 1 n.s 43.0 Weakly correlated
168 LTR81A 1 ** 99.0 Weakly correlated
169 LTR88b 1 ** 99.0 Weakly correlated
170 LTR8A 1 * 43.0 Weakly correlated
171 LTR8B 1 n.s 43.0 Weakly correlated
172 MER110A 1 ** 99.0 Weakly correlated
173 MER21C 1 n.s 99.0 Weakly correlated
174 MER34C2 1 ** 74.0 Weakly correlated
175 MER39B 1 * 74.0 Weakly correlated
176 MER41B 1 n.s 74.0 Weakly correlated
177 MER4A1 1 n.s 74.0 Weakly correlated
178 MER4C 1 ** 74.0 Weakly correlated
179 MER50 1 n.s 43.0 Weakly correlated
180 MER51C 1 *** 43.0 Weakly correlated
181 MER57A-int 1 n.s 43.0 Weakly correlated
182 MER65A 1 * 74.0 Weakly correlated
183 MER68 1 * 99.0 Weakly correlated
184 MER92A 1 *** 99.0 Weakly correlated
185 MLT1A1-int 1 * 87.0 Weakly correlated
186 MLT1D 1 n.s 99.0 Weakly correlated
187 MLT1E1A-int 1 *** 99.0 Weakly correlated
188 MLT1E2 1 n.s 99.0 Weakly correlated
189 MLT1F1-int 1 *** 99.0 Weakly correlated
190 MLT1F2-int 1 ** 99.0 Weakly correlated
191 MLT1H-int 1 * 99.0 Weakly correlated
192 MLT1L 1 n.s 99.0 Weakly correlated
193 MLT1N2 1 n.s 99.0 Weakly correlated
194 MLT2A2 1 n.s 74.0 Weakly correlated
195 MLT2C2 1 * 99.0 Weakly correlated
196 MSTA 1 n.s 43.0 Weakly correlated
197 MSTC 1 n.s 74.0 Weakly correlated
198 MamGypsy2-LTR 1 ** 99.0 Weakly correlated
199 SVA_B 1 * 15.2 Weakly correlated
200 SVA_C 1 * 15.2 Weakly correlated
201 SVA_E 1 * 0.0 Weakly correlated
202 THE1C 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 PABL_A 114 **** 43.0 Weakly correlated
2 PABL_B 5 **** 43.0 Weakly correlated
3 AluSq2 3 n.s 74.0 Weakly correlated
4 MIR 2 n.s 99.0 Weakly correlated
5 AluSx1 2 n.s 74.0 Weakly correlated
6 AluY 2 n.s 74.0 Weakly correlated
7 THE1C-int 2 n.s 43.0 Weakly correlated
8 MER52A 1 n.s 74.0 Weakly correlated
9 L1MD 1 n.s 99.0 Weakly correlated
10 FAM 1 * 87.0 Weakly correlated
11 AluJo 1 n.s 74.0 Weakly correlated
12 LTR57-int 1 ** 74.0 Weakly correlated
13 L2b 1 n.s 99.0 Weakly correlated
14 L1PA5 1 n.s 19.6 Highly correlated
15 AluSz 1 n.s 74.0 Weakly correlated
16 MLT1H2 1 n.s 99.0 Weakly correlated
17 L1ME4b 1 n.s 99.0 Weakly correlated
18 MLT1F2 1 n.s 99.0 Weakly correlated
19 AluSp 1 n.s 74.0 Weakly correlated
20 AluSg 1 n.s 74.0 Weakly correlated
21 AluJr 1 n.s 74.0 Weakly correlated
22 AluJb 1 n.s 74.0 Weakly correlated
23 L1MA5 1 n.s 87.0 Weakly correlated
24 L1PA2 1 n.s 15.2 Weakly correlated
25 AluSq10 1 * 74.0 Weakly correlated
26 HUERS-P3b-int 1 * 43.0 Weakly correlated
27 HUERS-P3-int 1 * 43.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP