ZRdb KZFP & Repeats
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Human_ZNF729

  • Protein
    Zinc finger protein 729
  • Length
    1252
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    8.6 Mya
  • Uniprot_ID
    A6NN14
  • NCBI_ID
    100287226
Sequence:
MPGAPGSLEMGPLTFRDVTIEFSLEEWQCLDTVQQNLYRDVMLENYRNLVFLGMAVFKPDLITCLKQGKEPWNMKRHEMVTKPPVMRSHFTQDLWPDQSTKDSFQEVILRTYARCGHKNLRLRKDCKSANEGKMHKEGYNKLNQCRTATQRKIFQCNKHMKVFHKYSNRNKVRHTKKKTFKCIKCSKSFFMLSCLIRHKRIHIRQNIYKCEERGKAFKSFSTLTKHKIIHTEDKPYKYKKCGNAFKFSSTFTKHKRIHTGETPFRCEECGKAFNQSSNLTDHKRIHTGEKTYKCEECGKAFKGSSNFNAHKVIHTAEKPYKCEDCGKTFNHFSALRKHKIIHTGKKPYKREECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSKLTVHKVVHTGEKPYKCEECGKAFSQFSTLKKHKIIHTGKKPYKCEECGKAFNSSSTLMKHKIIHTGEKPYKCEECGKAFRQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSDLRRHKIIHTGKKPYKCEECGKAFSQSSTLRNHQIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTGEKPCKCEECGKAFKHFSALRKHKVIHTREKLYKCEECGKAFNNSSILAKHKIIHTGKKPYKCEECGKAFRQSSHLTRHKAIHTGEKPYKCEECGKAFSHFSALRRHKIIHTGKKPYKCEECGKAFSHFSALRRHKIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKSFKHFSALRKHKVIHTREKLYKCEECVKAFNSFSALMKHKVIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTGEKPCKCEECGKAFKHFSALRKHKVIHTGKKPYKCEECGKAFSQSSSLRKHEIIHSGEKPYKCEECGKAFKWLSKLTVHKVIHTAEKPCKCEECGKAFKHFSALRKHKIIHTGKKPYKCEECGKAFNDSSTLMKHKIIHTGKKPYKCAECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKDFNNSSTLKKHKLIHTREKLYKCEECVKAFNNFSALMKHKIIHTGEKPYKCEECGKAFKWSSKLTEHKVIHTGEKPCKCEECDKAFKHFSALRKHKVIHTGKKPYQCDECGKAFNNSSTLTKHKIIHTGEKPYKCEECGKAFSQSSILTKHKIIHSVEKPYKCEECGKAFNQSSHLTRHKTIHTGEKPYKCEECGKAFIQCSYLIRHKTIHTREKPTNVKKVPKLLSNPHTLLDKTIHTGEKPYKCEECAKAF
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 13..84
2 C2h2 180..202
3 dec2h2 208..230
4 dec2h2 236..258
5 C2h2 264..286
6 C2h2 292..314
7 C2h2 320..342
8 dec2h2 348..370
9 C2h2 376..398
10 C2h2 404..426
11 C2h2 432..454
12 C2h2 460..482
13 C2h2 488..510
14 C2h2 516..538
15 C2h2 544..566
16 C2h2 572..594
17 C2h2 600..622
18 C2h2 628..650
19 C2h2 656..678
20 C2h2 684..706
21 C2h2 712..734
22 C2h2 740..762
23 C2h2 768..790
24 C2h2 796..818
25 C2h2 824..846
26 C2h2 852..874
27 C2h2 880..902
28 C2h2 908..930
29 C2h2 936..958
30 C2h2 964..986
31 C2h2 992..1014
32 C2h2 1020..1042
33 C2h2 1048..1070
34 C2h2 1076..1098
35 C2h2 1104..1126
36 C2h2 1132..1154
37 C2h2 1160..1182
38 C2h2 1188..1210
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 11 **** 74.0 Weakly correlated
2 AluSc8 8 ** 74.0 Weakly correlated
3 AluYj4 7 **** 0.0 Weakly correlated
4 LTR8 6 **** 43.0 Weakly correlated
5 LTR10A 4 **** 28.9 Weakly correlated
6 AluYm1 4 *** 19.6 Moderately correlated
7 FRAM 4 **** 74.0 Weakly correlated
8 MER21B 3 ** 99.0 Weakly correlated
9 AluYa8 3 **** 15.2 Moderately correlated
10 AluJo 2 n.s 74.0 Weakly correlated
11 L1PA5 2 n.s 19.6 Moderately correlated
12 L1PA2 2 n.s 15.2 Moderately correlated
13 L1M3 2 n.s 99.0 Weakly correlated
14 AluY 2 n.s 74.0 Weakly correlated
15 HUERS-P3b-int 2 *** 43.0 Weakly correlated
16 AluYi6 1 *** 15.2 Moderately correlated
17 MLT1L 1 n.s 99.0 Weakly correlated
18 AluJb 1 n.s 74.0 Weakly correlated
19 AluSq 1 n.s 74.0 Weakly correlated
20 LTR13 1 * 19.6 Moderately correlated
21 LTR10B1 1 *** 28.9 Weakly correlated
22 AluSx 1 n.s 74.0 Weakly correlated
23 L2c 1 n.s 99.0 Weakly correlated
24 L1PA10 1 n.s 74.0 Weakly correlated
25 L1P4 1 n.s 74.0 Weakly correlated
26 HAL1 1 n.s 99.0 Weakly correlated
27 L1P1 1 n.s 19.6 Moderately correlated
28 L1MD 1 n.s 99.0 Weakly correlated
29 L1M4 1 n.s 99.0 Weakly correlated
30 HERV17-int 1 * 28.9 Weakly correlated
31 L1HS 1 n.s 8.6 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 FRAM 2 ** 74.0 Weakly correlated
2 L1P1 1 n.s 19.6 Moderately correlated
3 AluSc8 1 n.s 74.0 Weakly correlated
4 AluSq 1 n.s 74.0 Weakly correlated
5 AluY 1 n.s 74.0 Weakly correlated
6 AluYa8 1 *** 15.2 Moderately correlated
7 AluYj4 1 * 0.0 Weakly correlated
8 L1HS 1 n.s 8.6 Highly correlated
9 AluJo 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP