ZRdb KZFP & Repeats
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Human_ZNF727

  • Protein
    Putative zinc finger protein 727
  • Length
    499
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    19.6 Mya
  • Time of Changing in binding specificity
    19.6 Mya
  • Uniprot_ID
    A8MUV8
  • NCBI_ID
    442319
Sequence:
MRVLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLFSLGLAIFKPDLITYLEQRKEPWNARRQKTVAKHPAGSLHFTAEILLEHDINDSFQKVILRKSGSCDLNTLRLKKDYQRVGNCKGQKSSYNGIHQCLSATRSKTCQYNKCGKAFGLCSIFTEHKKIFSREKCYKCEECGKDCRLSDFTIQKRIHTADRSYKCEECGKACKKFSNLTEHNRVHTGKKPYKCEECGKTFTCSSALTKHKRNHTGDRPYKCEECHKAFRCCSDLTKHKRIHTGEKPYKCKECHKAFRCCSDLTKHKRIHTGEKPYKCNECGKAFMWISALSQHNRIHTGEKPYICEECGKAFTYSSTLISHKRIHMELRPYKCEECGKTFKWFSDLTNHKRIHTGEKPYKCEECGKSFTCSSNLIKHKRIHMEVRPYKCEECGKTFKWFPDLTNHKRIHTGEKPYKCEECGKTFTCSSSLIKHKRSHTGDRPTSAKNVAKPLGGSQTLLNIR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..75
2 dec2h2 143..167
3 C2h2 200..222
4 C2h2 228..250
5 C2h2 256..278
6 C2h2 284..306
7 C2h2 312..334
8 C2h2 340..362
9 C2h2 368..390
10 C2h2 396..418
11 C2h2 424..446
12 C2h2 452..474
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of DNA-templated transcription
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER11C 120 **** 19.6 Highly correlated
2 MER11B 99 **** 19.6 Highly correlated
3 L2a 21 n.s 99.0 Weakly correlated
4 AluSc8 10 ** 74.0 Weakly correlated
5 MIR 10 n.s 99.0 Weakly correlated
6 MIRb 10 n.s 99.0 Weakly correlated
7 L1P3 9 **** 74.0 Weakly correlated
8 L2b 9 n.s 99.0 Weakly correlated
9 AluYj4 8 **** 0.0 Weakly correlated
10 AluJb 7 n.s 74.0 Weakly correlated
11 MIRc 6 n.s 99.0 Weakly correlated
12 L2c 5 n.s 99.0 Weakly correlated
13 AluSx 4 n.s 74.0 Weakly correlated
14 AluY 4 n.s 74.0 Weakly correlated
15 AluYm1 4 ** 19.6 Highly correlated
16 L1MC1 4 n.s 99.0 Weakly correlated
17 L3 4 n.s 99.0 Weakly correlated
18 LTR10A 4 **** 28.9 Moderately correlated
19 MER11A 4 *** 28.9 Moderately correlated
20 AluJr 3 n.s 74.0 Weakly correlated
21 AluJr4 3 n.s 74.0 Weakly correlated
22 AluSz 3 n.s 74.0 Weakly correlated
23 FRAM 3 ** 74.0 Weakly correlated
24 L1MC4 3 n.s 99.0 Weakly correlated
25 MLT1B 3 n.s 99.0 Weakly correlated
26 AluSq2 2 n.s 74.0 Weakly correlated
27 AluSz6 2 n.s 74.0 Weakly correlated
28 AluYa8 2 **** 15.2 Weakly correlated
29 HAL1 2 n.s 99.0 Weakly correlated
30 HAL1ME 2 n.s 99.0 Weakly correlated
31 HERVK11-int 2 ** 28.9 Moderately correlated
32 HERVL74-int 2 *** 99.0 Weakly correlated
33 L1MC 2 n.s 99.0 Weakly correlated
34 L1ME3Cz 2 n.s 99.0 Weakly correlated
35 L1ME4a 2 n.s 99.0 Weakly correlated
36 L1MEg 2 n.s 99.0 Weakly correlated
37 L1PA17 2 n.s 74.0 Weakly correlated
38 L1PA5 2 n.s 19.6 Highly correlated
39 L2 2 n.s 99.0 Weakly correlated
40 LTR41B 2 *** 99.0 Weakly correlated
41 MER21B 2 * 99.0 Weakly correlated
42 MLT1C 2 n.s 94.0 Weakly correlated
43 MLT1J 2 n.s 99.0 Weakly correlated
44 MLT1L 2 n.s 99.0 Weakly correlated
45 AluJo 1 n.s 74.0 Weakly correlated
46 AluSc 1 n.s 74.0 Weakly correlated
47 AluSg 1 n.s 74.0 Weakly correlated
48 AluSq 1 n.s 74.0 Weakly correlated
49 AluSx1 1 n.s 74.0 Weakly correlated
50 AluSx3 1 n.s 74.0 Weakly correlated
51 AluSx4 1 n.s 74.0 Weakly correlated
52 AluYi6 1 ** 15.2 Weakly correlated
53 CR1-13_AMi 1 **** 319.0 Weakly correlated
54 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
55 FLAM_A 1 n.s 74.0 Weakly correlated
56 HERVIP10F-int 1 * 28.9 Moderately correlated
57 HERVL18-int 1 * 43.0 Weakly correlated
58 L1HS 1 n.s 8.6 Weakly correlated
59 L1M3 1 n.s 99.0 Weakly correlated
60 L1M4 1 n.s 99.0 Weakly correlated
61 L1MA4A 1 n.s 87.0 Weakly correlated
62 L1MB2 1 n.s 99.0 Weakly correlated
63 L1MB3 1 n.s 99.0 Weakly correlated
64 L1MB7 1 n.s 99.0 Weakly correlated
65 L1MB8 1 n.s 99.0 Weakly correlated
66 L1MC2 1 n.s 99.0 Weakly correlated
67 L1MC5a 1 n.s 99.0 Weakly correlated
68 L1MCa 1 n.s 99.0 Weakly correlated
69 L1MD2 1 n.s 99.0 Weakly correlated
70 L1MDa 1 n.s 99.0 Weakly correlated
71 L1ME2 1 n.s 99.0 Weakly correlated
72 L1ME3G 1 n.s 99.0 Weakly correlated
73 L1ME4b 1 n.s 99.0 Weakly correlated
74 L1MEf 1 n.s 99.0 Weakly correlated
75 L1MEg1 1 * 99.0 Weakly correlated
76 L1P4 1 n.s 74.0 Weakly correlated
77 L1PA8 1 n.s 74.0 Weakly correlated
78 L1PREC2 1 n.s 43.0 Weakly correlated
79 L4_B_Mam 1 n.s 99.0 Weakly correlated
80 LTR10B1 1 *** 28.9 Moderately correlated
81 LTR13 1 * 19.6 Highly correlated
82 LTR13_ 1 *** 28.9 Moderately correlated
83 LTR16A1 1 n.s 99.0 Weakly correlated
84 LTR16A2 1 * 99.0 Weakly correlated
85 LTR18A 1 *** 43.0 Weakly correlated
86 LTR22B1 1 ** 28.9 Moderately correlated
87 LTR29 1 ** 43.0 Weakly correlated
88 LTR33 1 n.s 99.0 Weakly correlated
89 LTR48 1 * 74.0 Weakly correlated
90 LTR52 1 * 99.0 Weakly correlated
91 LTR76 1 ** 74.0 Weakly correlated
92 LTR79 1 n.s 99.0 Weakly correlated
93 MER57-int 1 n.s 87.0 Weakly correlated
94 MER61E 1 ** 43.0 Weakly correlated
95 MER67B 1 ** 99.0 Weakly correlated
96 MIR1_Amn 1 n.s 319.0 Weakly correlated
97 MIR3 1 n.s 99.0 Weakly correlated
98 MLT1A0 1 n.s 99.0 Weakly correlated
99 MLT1H 1 n.s 99.0 Weakly correlated
100 MSTA-int 1 n.s 43.0 Weakly correlated
101 MSTB1 1 n.s 74.0 Weakly correlated
102 MSTC 1 n.s 74.0 Weakly correlated
103 MSTD 1 n.s 74.0 Weakly correlated
104 SVA_C 1 * 15.2 Weakly correlated
105 THE1A 1 n.s 43.0 Weakly correlated
106 THE1C 1 n.s 43.0 Weakly correlated
107 THE1D 1 n.s 43.0 Weakly correlated
108 THE1D-int 1 n.s 28.9 Moderately correlated
109 X6B_LINE 1 ** 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER11C 111 **** 19.6 Highly correlated
2 MER11B 86 **** 19.6 Highly correlated
3 AluYj4 3 ** 0.0 Weakly correlated
4 L1MC1 1 n.s 99.0 Weakly correlated
5 AluYa8 1 *** 15.2 Weakly correlated
6 L1HS 1 n.s 8.6 Weakly correlated
7 MER11A 1 n.s 28.9 Moderately correlated
8 FRAM 1 n.s 74.0 Weakly correlated
9 L1MDa 1 n.s 99.0 Weakly correlated
10 MIR 1 n.s 99.0 Weakly correlated
11 MIRb 1 n.s 99.0 Weakly correlated
12 MLT1J 1 n.s 99.0 Weakly correlated
13 AluSc8 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP