ZRdb KZFP & Repeats
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Human_ZNF717

  • Protein
    Zinc finger protein 717
  • Length
    914
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    15.2 Mya
  • Time of Changing in binding specificity
    0.0 Mya
  • Uniprot_ID
    Q9BY31
  • NCBI_ID
    100131827
Sequence:
MFPVFSGCFQELQEKNKSLELVSFEEVAVHFTWEEWQDLDDAQRTLYRDVMLETYSSLVSLGHYITKPEMIFKLEQGAEPWIVEETPNLRLSAVQIIDDLIERSHESHDRFFWQIVITNSNTSTQERVELGKTFNLNSNHVLNLIINNGNSSGMKPGQFNDCQNMLFPIKPGETQSGEKPHVCDITRRSHRHHEHLTQHHKIQTLLQTFQCNEQGKTFNTEAMFFIHKRVHIVQTFGKYNEYEKACNNSAVIVQVITQVGQPTCCRKSDFTKHQQTHTGEKPYECVECEKPSISKSDLMLQCKMPTEEKPYACNWCEKLFSYKSSLIIHQRIHTGEKPYGCNECGKTFRRKSFLTLHERTHTGDKPYKCIECGKTFHCKSLLTLHHRTHSGEKPYQCSECGKTFSQKSYLTIHHRTHTGEKPYACDHCEEAFSHKSRLTVHQRTHTGEKPYECNECGKPFINKSNLRLHQRTHTGEKPYECNECGKTFHRKSFLTIHQWTHTGEKPYECNECGKTFRCKSFLTVHQRTHAGEKPYACNECGKTYSHKSYLTVHHRTHTGEKPYECNECGKSFHCKSFLTIHQRTHAGKKPYECNECEKTFINKLNLGIHKRTHTGERPYECNECGKTFRQKSNLSTHQGTHTGEKPYVCNECGKTFHRKSFLTIHQRTHTGKNRMDVMNVEKLFVRNHTLLYIRELTPGKSPMNVMNVENPFIRRQIFRSIKVFTRGRNPMNVANVEKPCQKSVLTVHHRTHTGEKPYECNECGKTFCHKSNLSTHQGTHSGEKPYECDECRKTFYDKTVLTIHQRTHTGEKPFECKECRKTFSQKSKLFVHHRTHTGEKPFRCNECRKTFSQKSGLSIHQRTHTGEKPYECKECGKTFCQKSHLSRHQQTHIGEKSDVAEAGYVFPQNHSFFP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 22..93
2 dec2h2 209..231
3 dec2h2 266..277
4 dec2h2 283..305
5 C2h2 311..333
6 C2h2 339..361
7 C2h2 367..389
8 C2h2 395..417
9 C2h2 423..445
10 C2h2 451..473
11 C2h2 479..501
12 C2h2 507..529
13 C2h2 535..557
14 C2h2 563..585
15 C2h2 591..613
16 C2h2 619..641
17 dec2h2 649..669
18 dec2h2 741..752
19 C2h2 758..780
20 C2h2 786..808
21 C2h2 814..836
22 C2h2 842..864
23 C2h2 870..892
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 10 **** 74.0 Weakly correlated
2 AluSc8 8 *** 74.0 Weakly correlated
3 AluJb 6 n.s 74.0 Weakly correlated
4 AluYj4 6 **** 0.0 Highly correlated
5 AluY 5 n.s 74.0 Weakly correlated
6 AluYm1 5 **** 19.6 Weakly correlated
7 LTR10A 4 **** 28.9 Weakly correlated
8 MER21B 3 ** 99.0 Weakly correlated
9 LTR10F 3 **** 28.9 Weakly correlated
10 FRAM 3 *** 74.0 Weakly correlated
11 L1PA5 2 n.s 19.6 Weakly correlated
12 L1PA2 2 n.s 15.2 Weakly correlated
13 AluYa8 2 **** 15.2 Weakly correlated
14 LTR13 1 * 19.6 Weakly correlated
15 LTR10B1 1 *** 28.9 Weakly correlated
16 MLT1L 1 n.s 99.0 Weakly correlated
17 SVA_D 1 n.s 15.2 Weakly correlated
18 L1PA8A 1 n.s 74.0 Weakly correlated
19 SVA_F 1 * 0.0 Highly correlated
20 L1MC4 1 n.s 99.0 Weakly correlated
21 L1PA4 1 n.s 19.6 Weakly correlated
22 L1P4 1 n.s 74.0 Weakly correlated
23 L1M3 1 n.s 99.0 Weakly correlated
24 L1HS 1 n.s 8.6 Moderately correlated
25 HERV17-int 1 * 28.9 Weakly correlated
26 AluYi6 1 *** 15.2 Weakly correlated
27 AluSz 1 n.s 74.0 Weakly correlated
28 AluSx 1 n.s 74.0 Weakly correlated
29 AluSp 1 n.s 74.0 Weakly correlated
30 AluJo 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 5 *** 74.0 Weakly correlated
2 L1M3 1 n.s 99.0 Weakly correlated
3 L1PA2 1 n.s 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP