ZRdb KZFP & Repeats
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Human_ZNF716

  • Protein
    Zinc finger protein 716
  • Length
    495
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    19.6 Mya
  • Uniprot_ID
    A6NP11
  • NCBI_ID
    441234
Sequence:
MAKRPGPPGSREMGLLTFRDIAIEFSLAEWQCLDHAQQNLYRDVMLENYRNLVSLGIAVSKPDLITCLEQNKEPQNIKRNEMVAKHPVTCSHFTQDLQSEQGIKDSLQKVILRRYGKCGQEDLQVKKCCKSVGECEVHKGGYNYVNQCLSATQNKTFQTHKCVKVFGKFSNSNRHKTRHTGKKHFKCKNDGKSFCMLSRLNQHQIIHTREKSYKCEECGKSFNCSSTLTRHKRIHTGEKPYRCEECGKAFSWSASLTKHKRIHTGEKPYTCEERGKVFSRSTLTNYKRIHTGEKPYTCEECGKAFSRSSTLTNHKRIHTGERPYKCEECGKAFSLSSTLKKHKIVHTGEKLYTCEECGKAFTFSSTLNTHKRIHTGEKPYTCEECGKAFSLPSTFTYHKRTHTGEKPYKCEECGKAFNCSSTLKKHKIIHTGEKLYKCKECGKAFTFSSTLNTHKRIHTGEKPYKCEECDQTFKWHSSLANHKNMHTGEKPYKYE
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 16..87
2 dec2h2 157..179
3 dec2h2 185..207
4 C2h2 213..235
5 C2h2 241..263
6 dec2h2 269..290
7 C2h2 296..318
8 C2h2 324..346
9 C2h2 352..374
10 C2h2 380..402
11 C2h2 408..430
12 C2h2 436..458
13 C2h2 464..486
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of DNA-templated transcription
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2c 34 **** 99.0 Weakly correlated
2 MIRb 34 **** 99.0 Weakly correlated
3 L2a 28 n.s 99.0 Weakly correlated
4 MIR 21 * 99.0 Weakly correlated
5 L2b 20 *** 99.0 Weakly correlated
6 L2 18 *** 99.0 Weakly correlated
7 HAL1 17 **** 99.0 Weakly correlated
8 AluJb 14 n.s 74.0 Weakly correlated
9 MIRc 13 ** 99.0 Weakly correlated
10 AluSz6 10 n.s 74.0 Weakly correlated
11 AluSx 9 n.s 74.0 Weakly correlated
12 L1ME1 9 n.s 99.0 Weakly correlated
13 L3 9 * 99.0 Weakly correlated
14 AluJo 8 n.s 74.0 Weakly correlated
15 L1MC3 8 * 99.0 Weakly correlated
16 MIR3 8 n.s 99.0 Weakly correlated
17 AluJr 7 n.s 74.0 Weakly correlated
18 AluSg 7 n.s 74.0 Weakly correlated
19 AluSz 7 n.s 74.0 Weakly correlated
20 L1MB7 7 n.s 99.0 Weakly correlated
21 L1MC5a 7 ** 99.0 Weakly correlated
22 AluSp 6 n.s 74.0 Weakly correlated
23 L1MC4 6 n.s 99.0 Weakly correlated
24 HERVH-int 5 n.s 28.9 Moderately correlated
25 L1MB4 5 * 99.0 Weakly correlated
26 L1ME4a 5 n.s 99.0 Weakly correlated
27 L1MEc 5 n.s 99.0 Weakly correlated
28 L1MEf 5 n.s 99.0 Weakly correlated
29 AluSq 4 n.s 74.0 Weakly correlated
30 AluSx1 4 n.s 74.0 Weakly correlated
31 HAL1ME 4 ** 99.0 Weakly correlated
32 HERV17-int 4 **** 28.9 Moderately correlated
33 L1MA3 4 n.s 74.0 Weakly correlated
34 LTR6A 4 **** 28.9 Moderately correlated
35 MLT1K 4 * 99.0 Weakly correlated
36 AluSq2 3 n.s 74.0 Weakly correlated
37 AluY 3 n.s 74.0 Weakly correlated
38 L1M4 3 n.s 99.0 Weakly correlated
39 L1M4b 3 * 99.0 Weakly correlated
40 L1M5 3 n.s 99.0 Weakly correlated
41 L1MA9 3 n.s 99.0 Weakly correlated
42 L1MB2 3 n.s 99.0 Weakly correlated
43 L1MC5 3 n.s 99.0 Weakly correlated
44 L1ME3A 3 n.s 99.0 Weakly correlated
45 L1PA5 3 n.s 19.6 Highly correlated
46 LTR10A 3 **** 28.9 Moderately correlated
47 LTR10F 3 **** 28.9 Moderately correlated
48 LTR33 3 * 99.0 Weakly correlated
49 MLT1I 3 * 99.0 Weakly correlated
50 MamRTE1 3 ** 99.0 Weakly correlated
51 Plat_L3 3 *** 99.0 Weakly correlated
52 THE1D 3 n.s 43.0 Weakly correlated
53 ERV3-16A3_I-int 2 n.s 99.0 Weakly correlated
54 FLAM_C 2 n.s 74.0 Weakly correlated
55 HERVK3-int 2 ** 28.9 Moderately correlated
56 L1M4a2 2 * 99.0 Weakly correlated
57 L1MC 2 n.s 99.0 Weakly correlated
58 L1MD2 2 n.s 99.0 Weakly correlated
59 L1MDa 2 n.s 99.0 Weakly correlated
60 L1ME3 2 n.s 99.0 Weakly correlated
61 L1MEg 2 n.s 99.0 Weakly correlated
62 L1P1 2 n.s 19.6 Highly correlated
63 L1P3 2 n.s 74.0 Weakly correlated
64 LTR16C 2 n.s 99.0 Weakly correlated
65 LTR48B 2 *** 74.0 Weakly correlated
66 LTR90A 2 **** 99.0 Weakly correlated
67 MER21-int 2 ** 99.0 Weakly correlated
68 MER21C 2 n.s 99.0 Weakly correlated
69 MER39 2 * 74.0 Weakly correlated
70 MER39B 2 ** 74.0 Weakly correlated
71 MER4B-int 2 ** 99.0 Weakly correlated
72 MER57A-int 2 * 43.0 Weakly correlated
73 MER92C 2 **** 99.0 Weakly correlated
74 MIR1_Amn 2 * 319.0 Weakly correlated
75 MLT1D 2 n.s 99.0 Weakly correlated
76 MLT1F2 2 n.s 99.0 Weakly correlated
77 MLT1H2 2 * 99.0 Weakly correlated
78 MLT1J 2 n.s 99.0 Weakly correlated
79 MLT1L 2 n.s 99.0 Weakly correlated
80 MSTD 2 n.s 74.0 Weakly correlated
81 MamRep1151 2 *** 99.0 Weakly correlated
82 MamSINE1 2 ** 99.0 Weakly correlated
83 THE1B-int 2 n.s 43.0 Weakly correlated
84 AluJr4 1 n.s 74.0 Weakly correlated
85 AluSc 1 n.s 74.0 Weakly correlated
86 AluSc8 1 n.s 74.0 Weakly correlated
87 AluYa5 1 n.s 15.2 Weakly correlated
88 AluYc 1 n.s 74.0 Weakly correlated
89 AluYj4 1 n.s 0.0 Weakly correlated
90 AluYk4 1 * 15.2 Weakly correlated
91 AmnSINE1 1 ** 319.0 Weakly correlated
92 CR1-3_Croc 1 ** 319.0 Weakly correlated
93 ERVL-B4-int 1 n.s 99.0 Weakly correlated
94 ERVL-E-int 1 n.s 99.0 Weakly correlated
95 FRAM 1 n.s 74.0 Weakly correlated
96 HERVE_a-int 1 * 28.9 Moderately correlated
97 HERVIP10B3-int 1 * 28.9 Moderately correlated
98 HERVK11-int 1 * 28.9 Moderately correlated
99 HERVL-int 1 n.s 74.0 Weakly correlated
100 HERVS71-int 1 * 28.9 Moderately correlated
101 Harlequin-int 1 n.s 74.0 Weakly correlated
102 L1M1 1 n.s 74.0 Weakly correlated
103 L1M2 1 n.s 99.0 Weakly correlated
104 L1M4c 1 n.s 99.0 Weakly correlated
105 L1MA2 1 n.s 74.0 Weakly correlated
106 L1MA4A 1 n.s 87.0 Weakly correlated
107 L1MA8 1 n.s 87.0 Weakly correlated
108 L1MB1 1 n.s 99.0 Weakly correlated
109 L1MB8 1 n.s 99.0 Weakly correlated
110 L1MC1 1 n.s 99.0 Weakly correlated
111 L1MC4a 1 n.s 99.0 Weakly correlated
112 L1MCc 1 n.s 99.0 Weakly correlated
113 L1MD3 1 n.s 99.0 Weakly correlated
114 L1MDb 1 * 99.0 Weakly correlated
115 L1ME3C 1 n.s 99.0 Weakly correlated
116 L1ME3Cz 1 n.s 99.0 Weakly correlated
117 L1ME4b 1 n.s 99.0 Weakly correlated
118 L1ME4c 1 n.s 99.0 Weakly correlated
119 L1MEb 1 * 99.0 Weakly correlated
120 L1MEd 1 n.s 99.0 Weakly correlated
121 L1P4 1 n.s 74.0 Weakly correlated
122 L1PA13 1 n.s 74.0 Weakly correlated
123 L1PA2 1 n.s 15.2 Weakly correlated
124 L1PA4 1 n.s 19.6 Highly correlated
125 L1PA7 1 n.s 74.0 Weakly correlated
126 L1PB 1 n.s 74.0 Weakly correlated
127 L1PBb 1 * 74.0 Weakly correlated
128 L2-3_Crp 1 * 431.0 Weakly correlated
129 L3b 1 n.s 99.0 Weakly correlated
130 LOR1-int 1 n.s 74.0 Weakly correlated
131 LTR1 1 ** 43.0 Weakly correlated
132 LTR104_Mam 1 * 99.0 Weakly correlated
133 LTR105_Mam 1 ** 99.0 Weakly correlated
134 LTR13 1 * 19.6 Highly correlated
135 LTR16D 1 ** 99.0 Weakly correlated
136 LTR4 1 *** 28.9 Moderately correlated
137 LTR40c 1 ** 99.0 Weakly correlated
138 LTR41 1 * 99.0 Weakly correlated
139 LTR41C 1 ** 99.0 Weakly correlated
140 LTR44 1 *** 74.0 Weakly correlated
141 LTR49 1 * 74.0 Weakly correlated
142 LTR49-int 1 n.s 74.0 Weakly correlated
143 LTR50 1 * 99.0 Weakly correlated
144 LTR52 1 ** 99.0 Weakly correlated
145 LTR65 1 ** 99.0 Weakly correlated
146 LTR67B 1 * 99.0 Weakly correlated
147 LTR69 1 *** 99.0 Weakly correlated
148 LTR78B 1 * 99.0 Weakly correlated
149 LTR81A 1 ** 99.0 Weakly correlated
150 LTR82B 1 * 99.0 Weakly correlated
151 LTR88b 1 ** 99.0 Weakly correlated
152 LTR89 1 ** 99.0 Weakly correlated
153 MER11A 1 n.s 28.9 Moderately correlated
154 MER31A 1 * 87.0 Weakly correlated
155 MER41-int 1 n.s 74.0 Weakly correlated
156 MER49 1 * 43.0 Weakly correlated
157 MER50 1 n.s 43.0 Weakly correlated
158 MER50-int 1 * 43.0 Weakly correlated
159 MER57-int 1 n.s 87.0 Weakly correlated
160 MER57C1 1 *** 74.0 Weakly correlated
161 MER68B 1 ** 99.0 Weakly correlated
162 MER70C 1 ** 99.0 Weakly correlated
163 MER83B-int 1 ** 99.0 Weakly correlated
164 MLT1A 1 n.s 99.0 Weakly correlated
165 MLT1B 1 n.s 99.0 Weakly correlated
166 MLT1B-int 1 ** 99.0 Weakly correlated
167 MLT1C 1 n.s 94.0 Weakly correlated
168 MLT1E1A 1 n.s 99.0 Weakly correlated
169 MLT1E2 1 n.s 99.0 Weakly correlated
170 MLT1E3 1 * 99.0 Weakly correlated
171 MLT1F1 1 n.s 99.0 Weakly correlated
172 MLT1H-int 1 * 99.0 Weakly correlated
173 MLT1M 1 * 99.0 Weakly correlated
174 MLT1N2 1 n.s 99.0 Weakly correlated
175 MLT2B4 1 n.s 99.0 Weakly correlated
176 MLT2C2 1 * 99.0 Weakly correlated
177 MSTA-int 1 n.s 43.0 Weakly correlated
178 MSTB 1 n.s 43.0 Weakly correlated
179 MSTC 1 n.s 74.0 Weakly correlated
180 MamRep605 1 n.s 99.0 Weakly correlated
181 PRIMA4-int 1 ** 74.0 Weakly correlated
182 Penelope1_Vert 1 ** 319.0 Weakly correlated
183 X6A_LINE 1 ** 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2c 15 n.s 99.0 Weakly correlated
2 L2a 15 n.s 99.0 Weakly correlated
3 HAL1 10 ** 99.0 Weakly correlated
4 L2b 8 n.s 99.0 Weakly correlated
5 MIR 7 n.s 99.0 Weakly correlated
6 L1MC3 7 * 99.0 Weakly correlated
7 MIRb 6 n.s 99.0 Weakly correlated
8 L2 5 n.s 99.0 Weakly correlated
9 L1ME1 4 n.s 99.0 Weakly correlated
10 L1MEf 4 n.s 99.0 Weakly correlated
11 AluJb 4 n.s 74.0 Weakly correlated
12 L3 4 n.s 99.0 Weakly correlated
13 MIRc 4 n.s 99.0 Weakly correlated
14 AluSz6 3 n.s 74.0 Weakly correlated
15 HERVH-int 3 n.s 28.9 Moderately correlated
16 AluSx1 3 n.s 74.0 Weakly correlated
17 L1MC5 3 n.s 99.0 Weakly correlated
18 L1MB4 3 n.s 99.0 Weakly correlated
19 L1ME4a 3 n.s 99.0 Weakly correlated
20 L1MC4 3 n.s 99.0 Weakly correlated
21 AluJr 3 n.s 74.0 Weakly correlated
22 L1M4b 2 n.s 99.0 Weakly correlated
23 AluSq 2 n.s 74.0 Weakly correlated
24 L1MEc 2 n.s 99.0 Weakly correlated
25 L1MB7 2 n.s 99.0 Weakly correlated
26 AluJo 2 n.s 74.0 Weakly correlated
27 MLT1I 2 n.s 99.0 Weakly correlated
28 L1MA3 2 n.s 74.0 Weakly correlated
29 MER92C 2 **** 99.0 Weakly correlated
30 ERV3-16A3_I-int 2 n.s 99.0 Weakly correlated
31 LTR33 2 n.s 99.0 Weakly correlated
32 L1MEg 2 n.s 99.0 Weakly correlated
33 L1M4a2 2 * 99.0 Weakly correlated
34 HAL1ME 2 n.s 99.0 Weakly correlated
35 L1MC5a 2 n.s 99.0 Weakly correlated
36 LTR81A 1 ** 99.0 Weakly correlated
37 L1MD2 1 n.s 99.0 Weakly correlated
38 L1M5 1 n.s 99.0 Weakly correlated
39 MamRep605 1 n.s 99.0 Weakly correlated
40 L1ME3 1 n.s 99.0 Weakly correlated
41 LOR1-int 1 n.s 74.0 Weakly correlated
42 L1P1 1 n.s 19.6 Highly correlated
43 MLT1L 1 n.s 99.0 Weakly correlated
44 Penelope1_Vert 1 ** 319.0 Weakly correlated
45 HERVIP10B3-int 1 * 28.9 Moderately correlated
46 L1M1 1 n.s 74.0 Weakly correlated
47 L1MA8 1 n.s 87.0 Weakly correlated
48 LTR105_Mam 1 ** 99.0 Weakly correlated
49 LTR89 1 ** 99.0 Weakly correlated
50 MER21C 1 n.s 99.0 Weakly correlated
51 MLT1B 1 n.s 99.0 Weakly correlated
52 MER68B 1 ** 99.0 Weakly correlated
53 ERVL-E-int 1 n.s 99.0 Weakly correlated
54 HERVL-int 1 n.s 74.0 Weakly correlated
55 L1MA2 1 n.s 74.0 Weakly correlated
56 L1MDa 1 n.s 99.0 Weakly correlated
57 L1ME4c 1 n.s 99.0 Weakly correlated
58 LTR41 1 * 99.0 Weakly correlated
59 MER41-int 1 n.s 74.0 Weakly correlated
60 MLT1E1A 1 n.s 99.0 Weakly correlated
61 L1MCc 1 n.s 99.0 Weakly correlated
62 L1ME3A 1 n.s 99.0 Weakly correlated
63 L1ME3C 1 n.s 99.0 Weakly correlated
64 L1PBb 1 * 74.0 Weakly correlated
65 LTR16C 1 n.s 99.0 Weakly correlated
66 MER11A 1 n.s 28.9 Moderately correlated
67 L1MD3 1 n.s 99.0 Weakly correlated
68 MLT1M 1 * 99.0 Weakly correlated
69 HERVK11-int 1 * 28.9 Moderately correlated
70 L1M4 1 n.s 99.0 Weakly correlated
71 L1MC 1 n.s 99.0 Weakly correlated
72 MLT1F2 1 n.s 99.0 Weakly correlated
73 L1ME3Cz 1 n.s 99.0 Weakly correlated
74 LTR69 1 *** 99.0 Weakly correlated
75 MER70C 1 ** 99.0 Weakly correlated
76 MSTD 1 n.s 74.0 Weakly correlated
77 AluSz 1 n.s 74.0 Weakly correlated
78 AluYj4 1 n.s 0.0 Weakly correlated
79 ERVL-B4-int 1 n.s 99.0 Weakly correlated
80 L1MA9 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP