ZRdb KZFP & Repeats
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Human_ZNF709

  • Protein
    Zinc finger protein 709
  • Length
    641
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    87.0 Mya
  • Time of Changing in binding specificity
    87.0 Mya
  • Uniprot_ID
    Q8N972
  • NCBI_ID
    163051
Sequence:
MDSVVFEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASIGENWEEKNIEDHKNQGRKLRSHMVERLCERKEGSQFGETISQTPNPKPNKKTFTRVKPYECSVCGKDYMCHSSLNRHMRSHTEHRSYEYHKYGEKSYECKECGKRFSFRSSFRIHERTHTGEKPYKCKQCGKAFSWPSSFQIHERTHTGEKPYECKECGKAFIYHTTFRGHMRMHTGEKPYKCKECGKTFSHPSSFRNHERTHSGEKPYECKQCGKAFRYYQTFQIHERTHTGEKPYQCKQCGKALSCPTSFRSHERIHTGEKPYKCKKCGKAFSFPSSFRKHERIHTGEKPYDCKECGKAFISLPSYRRHMIMHTGNGPYKCKECGKAFDCPSSFQIHERTHTGEKPYECKQCGKAFSCSSSFRMHERTHTGEKPHECKQCGKAFSCSSSVRIHERTHTGEKPYECKQCGKAFSCSSSFRMHERIHTGEKPYECKQCGKAFSFSSSFRMHERTHTGEKPYECKQCGKAFSCSSSFRMHERTHTGEKPYECKQCGKAFSCSSSIRIHERTHTGEKPYECKQCGKAFSCSSSVRMHERTHTGVKPYECKQCDKAFSCSRSFRIHERTHTGEKPYACQQCGKAFKCSRSFRIHERVHSGE
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..75
2 C2h2 102..124
3 C2h2 140..162
4 C2h2 168..190
5 C2h2 196..218
6 C2h2 224..246
7 C2h2 252..274
8 C2h2 280..302
9 C2h2 308..330
10 C2h2 336..358
11 C2h2 364..386
12 C2h2 392..414
13 C2h2 420..442
14 C2h2 448..470
15 C2h2 476..498
16 C2h2 504..526
17 C2h2 532..554
18 C2h2 560..582
19 C2h2 588..610
20 C2h2 616..638
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 5 n.s 74.0 Weakly correlated
2 AluYb8 4 **** 15.2 Weakly correlated
3 AluYh7 4 **** 0.0 Weakly correlated
4 LTR10A 4 **** 28.9 Weakly correlated
5 AluYa5 3 **** 15.2 Weakly correlated
6 AluSp 2 n.s 74.0 Weakly correlated
7 FRAM 2 *** 74.0 Weakly correlated
8 MER21B 2 ** 99.0 Moderately correlated
9 MLT1L 1 n.s 99.0 Moderately correlated
10 AluJb 1 n.s 74.0 Weakly correlated
11 LTR1A2 1 ** 43.0 Weakly correlated
12 LTR10B1 1 **** 28.9 Weakly correlated
13 L1PA2 1 n.s 15.2 Weakly correlated
14 L1PA10 1 n.s 74.0 Weakly correlated
15 L1MC4 1 n.s 99.0 Moderately correlated
16 L1MA8 1 n.s 87.0 Highly correlated
17 L1HS 1 n.s 8.6 Weakly correlated
18 HUERS-P3-int 1 ** 43.0 Weakly correlated
19 AluYj4 1 ** 0.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP