ZRdb KZFP & Repeats
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Human_ZNF705G

  • Protein
    Putative zinc finger protein 705G
  • Length
    300
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    A8MUZ8
  • NCBI_ID
    100131980
Sequence:
MHSLKKLTFEDVAIDFTQEEWAMMDTSKRKLYRDVMLENISHLVSLGYQISKSYIILQLEQGKELWREGRVFLQDQNPNRESALKKTHMISMHPITRKDASTSMTMENSLILEDPFECNDSGEDCTRSSTITQCLLTHSGKKPYVSKQCGKSLRNLLSTEPHKQIHTKGKSYQCNLCEKAYTNCFHLRRHKMTHTGERPYACHLCRKAFTQCSHLRRHEKTHTGQRPYKCHQYGKVFIQSFNLQRHERTHLGKKCYECDKSGKAFSQSSGFRGNKIIHTGEKPHACLLCGKAFSLSSNLR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 7..78
2 C2h2 172..194
3 C2h2 200..222
4 dec2h2 228..250
5 dec2h2 256..278
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 4 **** 74.0 Weakly correlated
2 L1PA5 3 n.s 19.6 Weakly correlated
3 LTR10A 3 **** 28.9 Highly correlated
4 MIR 2 n.s 99.0 Weakly correlated
5 AluSx1 1 n.s 74.0 Weakly correlated
6 L1MA8 1 n.s 87.0 Weakly correlated
7 L1P1 1 * 19.6 Weakly correlated
8 L1P4 1 * 74.0 Weakly correlated
9 L1PA2 1 n.s 15.2 Weakly correlated
10 L1PB3 1 * 74.0 Weakly correlated
11 L2c 1 n.s 99.0 Weakly correlated
12 LTR13 1 *** 19.6 Weakly correlated
13 MER39B 1 *** 74.0 Weakly correlated
14 MIRb 1 n.s 99.0 Weakly correlated
15 MLT1A 1 * 99.0 Weakly correlated
16 MSTB1 1 * 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MIRb 1 n.s 99.0 Weakly correlated
2 L1PA2 1 n.s 15.2 Weakly correlated
3 L2c 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP