ZRdb KZFP & Repeats
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Human_ZNF705E

  • Protein
    Putative zinc finger protein 705EP
  • Length
    300
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    0.0 Mya
  • Time of Changing in binding specificity
    0.0 Mya
  • Uniprot_ID
    A8MWA4
  • NCBI_ID
    100131539
Sequence:
MHSLKKVTFEDVAIDFTQEEWAMMDTSKRKLYRDVMLENISHLVSLGYQISKSYIILQLEQGKELWQEGREFLQDQNPDRESALKKTHMISMHPIIRKDAPTSMTMENSLILEDPFECNDSGEDCTHSSTIIQCLLTHSGKKPYVSKQCGKSLSNLLSPKPHKQIHTKGKSYQCNLCEKAYTNCFHLRRPKMTHTGERPYTCHLCRKAFTQCSHLRRHEKTHTGERPYKCHQCGKAFIQSFNLRRHERTHLGEKWYECDNSGKAFSQSSGFRGNKIIHTGEKPHACLLCGKAFSLSSDLR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 7..78
2 dec2h2 172..194
3 C2h2 200..222
4 C2h2 228..250
5 dec2h2 256..278
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_D 92 **** 15.2 Weakly correlated
2 SVA_F 49 **** 0.0 Highly correlated
3 AluJb 16 n.s 74.0 Weakly correlated
4 SVA_E 15 **** 0.0 Highly correlated
5 SVA_C 12 **** 15.2 Weakly correlated
6 SVA_B 9 **** 15.2 Weakly correlated
7 L1P3 9 **** 74.0 Weakly correlated
8 AluSc8 8 * 74.0 Weakly correlated
9 AluYj4 7 **** 0.0 Highly correlated
10 LTR8 7 **** 43.0 Weakly correlated
11 AluSx 6 n.s 74.0 Weakly correlated
12 L2c 5 n.s 99.0 Weakly correlated
13 MIRb 4 n.s 99.0 Weakly correlated
14 LTR10A 4 **** 28.9 Weakly correlated
15 SVA_A 4 **** 19.6 Weakly correlated
16 L1MB8 4 n.s 99.0 Weakly correlated
17 FRAM 4 *** 74.0 Weakly correlated
18 AluJo 4 n.s 74.0 Weakly correlated
19 AluSz 4 n.s 74.0 Weakly correlated
20 AluSx1 4 n.s 74.0 Weakly correlated
21 AluY 4 n.s 74.0 Weakly correlated
22 LTR10F 3 **** 28.9 Weakly correlated
23 AluSc 3 n.s 74.0 Weakly correlated
24 AluSp 3 n.s 74.0 Weakly correlated
25 MER21B 3 ** 99.0 Weakly correlated
26 AluSq2 3 n.s 74.0 Weakly correlated
27 L2a 2 n.s 99.0 Weakly correlated
28 L1PREC2 2 n.s 43.0 Weakly correlated
29 L1PA4 2 n.s 19.6 Weakly correlated
30 L1PA16 2 n.s 74.0 Weakly correlated
31 L1PA14 2 n.s 74.0 Weakly correlated
32 MIRc 2 n.s 99.0 Weakly correlated
33 L1MC2 2 n.s 99.0 Weakly correlated
34 L1MB7 2 n.s 99.0 Weakly correlated
35 MLT1J 2 n.s 99.0 Weakly correlated
36 MLT1E3 2 ** 99.0 Weakly correlated
37 AluYm1 2 n.s 19.6 Weakly correlated
38 L1M5 2 n.s 99.0 Weakly correlated
39 L1M4 2 n.s 99.0 Weakly correlated
40 FLAM_C 2 n.s 74.0 Weakly correlated
41 AluYa8 2 **** 15.2 Weakly correlated
42 AluJr 1 n.s 74.0 Weakly correlated
43 AluYh9 1 **** 15.2 Weakly correlated
44 AluSx4 1 n.s 74.0 Weakly correlated
45 LTR10B1 1 *** 28.9 Weakly correlated
46 AluJr4 1 n.s 74.0 Weakly correlated
47 LTR12C 1 n.s 19.6 Weakly correlated
48 LTR13 1 * 19.6 Weakly correlated
49 AluSg4 1 n.s 74.0 Weakly correlated
50 LTR14B 1 ** 28.9 Weakly correlated
51 LTR27D 1 ** 43.0 Weakly correlated
52 LTR3B_ 1 ** 28.9 Weakly correlated
53 LTR49-int 1 n.s 74.0 Weakly correlated
54 AluSq 1 n.s 74.0 Weakly correlated
55 MLT1L 1 n.s 99.0 Weakly correlated
56 MER41B 1 n.s 74.0 Weakly correlated
57 MER52A 1 n.s 74.0 Weakly correlated
58 MER66B 1 * 43.0 Weakly correlated
59 MIR3 1 n.s 99.0 Weakly correlated
60 MLT1D 1 n.s 99.0 Weakly correlated
61 MLT1J2 1 n.s 99.0 Weakly correlated
62 L1ME1 1 n.s 99.0 Weakly correlated
63 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
64 FAM 1 n.s 87.0 Weakly correlated
65 HAL1 1 n.s 99.0 Weakly correlated
66 HERVL66-int 1 ** 43.0 Weakly correlated
67 L1HS 1 n.s 8.6 Moderately correlated
68 L1M1 1 n.s 74.0 Weakly correlated
69 L1M3 1 n.s 99.0 Weakly correlated
70 L1MA8 1 n.s 87.0 Weakly correlated
71 L1MB4 1 n.s 99.0 Weakly correlated
72 L1MB5 1 n.s 99.0 Weakly correlated
73 L1MC4 1 n.s 99.0 Weakly correlated
74 L1MC4a 1 n.s 99.0 Weakly correlated
75 L1MD 1 n.s 99.0 Weakly correlated
76 L1MD2 1 n.s 99.0 Weakly correlated
77 L2b 1 n.s 99.0 Weakly correlated
78 L1ME3 1 n.s 99.0 Weakly correlated
79 L1ME3G 1 n.s 99.0 Weakly correlated
80 L1ME4b 1 n.s 99.0 Weakly correlated
81 L1MEd 1 n.s 99.0 Weakly correlated
82 L1MEf 1 n.s 99.0 Weakly correlated
83 AluSz6 1 n.s 74.0 Weakly correlated
84 L1P4 1 n.s 74.0 Weakly correlated
85 L1PA12 1 n.s 74.0 Weakly correlated
86 L1PA15-16 1 n.s 74.0 Weakly correlated
87 L1PA2 1 n.s 15.2 Weakly correlated
88 L1PA3 1 n.s 19.6 Weakly correlated
89 L1PA5 1 n.s 19.6 Weakly correlated
90 L1PB 1 n.s 74.0 Weakly correlated
91 L1PB2 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSz 2 n.s 74.0 Weakly correlated
2 L1MB4 1 n.s 99.0 Weakly correlated
3 L1PA4 1 n.s 19.6 Weakly correlated
4 L1MB7 1 n.s 99.0 Weakly correlated
5 SVA_B 1 n.s 15.2 Weakly correlated
6 AluYj4 1 n.s 0.0 Highly correlated
7 AluJo 1 n.s 74.0 Weakly correlated
8 AluSx 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP