ZRdb KZFP & Repeats
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Human_ZNF700

  • Protein
    Zinc finger protein 700
  • Length
    742
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q9H0M5
  • NCBI_ID
    90592
Sequence:
MPCCSHRSCREDPGTSESREMDPVAFEDVAVNFTQEEWTLLDISQKNLFREVMLETFRNLTSIGKKWSDQNIEYEYQNPRRSFRSLIEEKVNEIKEDSHCGETFTQVPDDRLNFQEKKASPEVKSCDSFVCAEVGIGNSSFNMSIRGDTGHKAYEYQEYGPKPYKCQQPKNKKAFRYRPSIRTQERDHTGEKPYACKVCGKTFIFHSSIRRHMVMHSGDGTYKCKFCGKAFHSFSLYLIHERTHTGEKPYECKQCGKSFTYSATLQIHERTHTGEKPYECSKCDKAFHSSSSYHRHERSHMGEKPYQCKECGKAFAYTSSLRRHERTHSGKKPYECKQYGEGLSYLISFQTHIRMNSGERPYKCKICGKGFYSAKSFQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTGEKPYECKQCGKAFRSASQLRVHGGTHTGEKPYECKECGKAFRSTSHLRVHGRTHTGEKPYECKECGKAFRYVKHLQIHERTEKHIRMPSGERPYKCSICEKGFYSAKSFQTHEKTHTGEKPYECNQCGKAFRCCNSLRYHERTHTGEKPYECKQCGKAFRSASHLRMHERTHTGEKPYECKQCGKAFSCASNLRKHGRTHTGEKPYECKQCGKAFRSASNLQMHERTHTGEKPYECKECEKAFCKFSSFQIHERKHRGEKPYECKHCGNGFTSAKILQIHARTHIGEKHYECKECGKAFNYFSSLHIHARTHMGEKPYECKDCGKAFS
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 24..104
2 C2h2 194..216
3 C2h2 222..244
4 C2h2 250..272
5 C2h2 278..300
6 C2h2 306..328
7 C2h2 362..384
8 C2h2 390..412
9 C2h2 418..440
10 C2h2 446..468
11 dec2h2 474..502
12 C2h2 508..530
13 C2h2 536..558
14 C2h2 564..586
15 C2h2 592..614
16 C2h2 620..642
17 C2h2 648..670
18 C2h2 676..698
19 C2h2 704..726
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR7 115 **** 19.6 Weakly correlated
2 LTR7C 97 **** 28.9 Highly correlated
3 AluY 60 **** 74.0 Weakly correlated
4 HERVH-int 35 **** 28.9 Highly correlated
5 AluJb 26 n.s 74.0 Weakly correlated
6 AluSc 22 **** 74.0 Weakly correlated
7 AluSc8 21 **** 74.0 Weakly correlated
8 LTR7B 20 **** 28.9 Highly correlated
9 L2c 16 n.s 99.0 Weakly correlated
10 MIRb 13 n.s 99.0 Weakly correlated
11 AluSx 12 n.s 74.0 Weakly correlated
12 MIR 12 n.s 99.0 Weakly correlated
13 L1P3 10 **** 74.0 Weakly correlated
14 LTR8 10 **** 43.0 Moderately correlated
15 L2a 8 n.s 99.0 Weakly correlated
16 AluSx1 7 n.s 74.0 Weakly correlated
17 AluSz 7 n.s 74.0 Weakly correlated
18 AluYm1 7 **** 19.6 Weakly correlated
19 AluJr 6 n.s 74.0 Weakly correlated
20 AluSz6 6 n.s 74.0 Weakly correlated
21 AluYj4 6 **** 0.0 Weakly correlated
22 ERV3-16A3_I-int 6 * 99.0 Weakly correlated
23 L1ME1 6 n.s 99.0 Weakly correlated
24 AluSg 5 n.s 74.0 Weakly correlated
25 L1MC3 5 n.s 99.0 Weakly correlated
26 L1MEc 5 n.s 99.0 Weakly correlated
27 L2 5 n.s 99.0 Weakly correlated
28 MIR3 5 n.s 99.0 Weakly correlated
29 MIRc 5 n.s 99.0 Weakly correlated
30 MLT1L 5 * 99.0 Weakly correlated
31 AluJo 4 n.s 74.0 Weakly correlated
32 AluSc5 4 * 74.0 Weakly correlated
33 FRAM 4 ** 74.0 Weakly correlated
34 L1PA7 4 n.s 74.0 Weakly correlated
35 LTR10A 4 **** 28.9 Highly correlated
36 LTR50 4 *** 99.0 Weakly correlated
37 MER21B 4 ** 99.0 Weakly correlated
38 MLT1A0 4 n.s 99.0 Weakly correlated
39 HAL1 3 n.s 99.0 Weakly correlated
40 L1MA9 3 n.s 99.0 Weakly correlated
41 L1MB7 3 n.s 99.0 Weakly correlated
42 L1MDa 3 n.s 99.0 Weakly correlated
43 L1MEf 3 n.s 99.0 Weakly correlated
44 L1PA10 3 n.s 74.0 Weakly correlated
45 L1PA5 3 n.s 19.6 Weakly correlated
46 L2b 3 n.s 99.0 Weakly correlated
47 L3 3 n.s 99.0 Weakly correlated
48 MLT1K 3 n.s 99.0 Weakly correlated
49 MSTA-int 3 n.s 43.0 Moderately correlated
50 AluJr4 2 n.s 74.0 Weakly correlated
51 AluSg7 2 n.s 74.0 Weakly correlated
52 AluSp 2 n.s 74.0 Weakly correlated
53 AluSq2 2 n.s 74.0 Weakly correlated
54 AluYa5 2 n.s 15.2 Weakly correlated
55 L1M5 2 n.s 99.0 Weakly correlated
56 L1M6 2 n.s 99.0 Weakly correlated
57 L1M6B 2 *** 99.0 Weakly correlated
58 L1MA3 2 n.s 74.0 Weakly correlated
59 L1MA6 2 n.s 87.0 Weakly correlated
60 L1MA7 2 n.s 87.0 Weakly correlated
61 L1MB3 2 n.s 99.0 Weakly correlated
62 L1MC1 2 n.s 99.0 Weakly correlated
63 L1MC4 2 n.s 99.0 Weakly correlated
64 L1MC4a 2 n.s 99.0 Weakly correlated
65 L1ME3A 2 n.s 99.0 Weakly correlated
66 L1ME4a 2 n.s 99.0 Weakly correlated
67 L1P4 2 n.s 74.0 Weakly correlated
68 L1PA11 2 n.s 74.0 Weakly correlated
69 L1PA14 2 n.s 74.0 Weakly correlated
70 L1PA2 2 n.s 15.2 Weakly correlated
71 L1PA3 2 n.s 19.6 Weakly correlated
72 L1PA8 2 n.s 74.0 Weakly correlated
73 L1PB1 2 n.s 74.0 Weakly correlated
74 L1PREC2 2 n.s 43.0 Moderately correlated
75 LTR2 2 ** 28.9 Highly correlated
76 LTR41 2 ** 99.0 Weakly correlated
77 LTR7Y 2 **** 8.6 Weakly correlated
78 LTR9 2 ** 43.0 Moderately correlated
79 MER41A 2 * 74.0 Weakly correlated
80 MER4E1 2 ** 74.0 Weakly correlated
81 MER50 2 n.s 43.0 Moderately correlated
82 MER50B 2 ** 43.0 Moderately correlated
83 MLT1E1A 2 n.s 99.0 Weakly correlated
84 THE1A 2 n.s 43.0 Moderately correlated
85 THE1B-int 2 n.s 43.0 Moderately correlated
86 THE1D 2 n.s 43.0 Moderately correlated
87 AluSq 1 n.s 74.0 Weakly correlated
88 AluSq10 1 n.s 74.0 Weakly correlated
89 AluSx3 1 n.s 74.0 Weakly correlated
90 AluYb8 1 n.s 15.2 Weakly correlated
91 AluYe5 1 * 74.0 Weakly correlated
92 AluYh9 1 **** 15.2 Weakly correlated
93 AluYi6 1 ** 15.2 Weakly correlated
94 AluYk4 1 * 15.2 Weakly correlated
95 ERV24_Prim-int 1 * 74.0 Weakly correlated
96 ERVL-B4-int 1 n.s 99.0 Weakly correlated
97 ERVL-E-int 1 n.s 99.0 Weakly correlated
98 ERVL47-int 1 ** 74.0 Weakly correlated
99 FLAM_C 1 n.s 74.0 Weakly correlated
100 HERV9N-int 1 * 19.6 Weakly correlated
101 HERVI-int 1 ** 28.9 Highly correlated
102 HERVIP10B3-int 1 * 28.9 Highly correlated
103 HERVK-int 1 n.s 28.9 Highly correlated
104 HERVK14C-int 1 ** 28.9 Highly correlated
105 HERVL-int 1 n.s 74.0 Weakly correlated
106 HERVL74-int 1 ** 99.0 Weakly correlated
107 HUERS-P1-int 1 * 43.0 Moderately correlated
108 L1HS 1 n.s 8.6 Weakly correlated
109 L1M1 1 n.s 74.0 Weakly correlated
110 L1M3 1 n.s 99.0 Weakly correlated
111 L1M3d 1 * 99.0 Weakly correlated
112 L1M4 1 n.s 99.0 Weakly correlated
113 L1M4b 1 n.s 99.0 Weakly correlated
114 L1M8 1 n.s 99.0 Weakly correlated
115 L1MA10 1 n.s 99.0 Weakly correlated
116 L1MA2 1 n.s 74.0 Weakly correlated
117 L1MA4 1 n.s 87.0 Weakly correlated
118 L1MA8 1 n.s 87.0 Weakly correlated
119 L1MB2 1 n.s 99.0 Weakly correlated
120 L1MB8 1 n.s 99.0 Weakly correlated
121 L1MC5 1 n.s 99.0 Weakly correlated
122 L1MC5a 1 n.s 99.0 Weakly correlated
123 L1MCb 1 n.s 99.0 Weakly correlated
124 L1MD 1 n.s 99.0 Weakly correlated
125 L1ME2 1 n.s 99.0 Weakly correlated
126 L1ME3 1 n.s 99.0 Weakly correlated
127 L1ME3B 1 n.s 99.0 Weakly correlated
128 L1ME3Cz 1 n.s 99.0 Weakly correlated
129 L1ME3E 1 n.s 99.0 Weakly correlated
130 L1ME3G 1 n.s 99.0 Weakly correlated
131 L1ME4b 1 n.s 99.0 Weakly correlated
132 L1PA13 1 n.s 74.0 Weakly correlated
133 L1PA15 1 n.s 74.0 Weakly correlated
134 L1PA16 1 n.s 74.0 Weakly correlated
135 L1PA6 1 n.s 28.9 Highly correlated
136 L1PA8A 1 n.s 74.0 Weakly correlated
137 L1PB2 1 n.s 74.0 Weakly correlated
138 L1PB4 1 n.s 99.0 Weakly correlated
139 LTR10B1 1 ** 28.9 Highly correlated
140 LTR12F 1 * 28.9 Highly correlated
141 LTR13 1 * 19.6 Weakly correlated
142 LTR16 1 n.s 99.0 Weakly correlated
143 LTR16B 1 * 99.0 Weakly correlated
144 LTR16C 1 n.s 99.0 Weakly correlated
145 LTR16E1 1 n.s 99.0 Weakly correlated
146 LTR1F1 1 ** 43.0 Moderately correlated
147 LTR24B 1 ** 74.0 Weakly correlated
148 LTR26B 1 *** 74.0 Weakly correlated
149 LTR33B 1 * 99.0 Weakly correlated
150 LTR40a 1 n.s 99.0 Weakly correlated
151 LTR48B 1 * 74.0 Weakly correlated
152 LTR49-int 1 n.s 74.0 Weakly correlated
153 LTR56 1 * 74.0 Weakly correlated
154 LTR59 1 *** 43.0 Moderately correlated
155 LTR78 1 n.s 99.0 Weakly correlated
156 LTR85c 1 * 99.0 Weakly correlated
157 LTR8A 1 n.s 43.0 Moderately correlated
158 LTR9A1 1 * 43.0 Moderately correlated
159 LTR9B 1 * 43.0 Moderately correlated
160 MER21C 1 n.s 99.0 Weakly correlated
161 MER31A 1 * 87.0 Weakly correlated
162 MER31B 1 n.s 99.0 Weakly correlated
163 MER4-int 1 n.s 74.0 Weakly correlated
164 MER41B 1 n.s 74.0 Weakly correlated
165 MER4A 1 * 74.0 Weakly correlated
166 MER4A1 1 n.s 74.0 Weakly correlated
167 MER4B-int 1 n.s 99.0 Weakly correlated
168 MER57A-int 1 n.s 43.0 Moderately correlated
169 MER66-int 1 n.s 43.0 Moderately correlated
170 MER66A 1 ** 43.0 Moderately correlated
171 MER66B 1 * 43.0 Moderately correlated
172 MER66C 1 ** 43.0 Moderately correlated
173 MER68-int 1 ** 99.0 Weakly correlated
174 MER77 1 n.s 99.0 Weakly correlated
175 MER84-int 1 ** 74.0 Weakly correlated
176 MIR1_Amn 1 n.s 319.0 Weakly correlated
177 MLT1B 1 n.s 99.0 Weakly correlated
178 MLT1C 1 n.s 94.0 Weakly correlated
179 MLT1D 1 n.s 99.0 Weakly correlated
180 MLT1G3 1 n.s 99.0 Weakly correlated
181 MLT1H2 1 n.s 99.0 Weakly correlated
182 MLT1J 1 n.s 99.0 Weakly correlated
183 MLT2A1 1 n.s 74.0 Weakly correlated
184 MLT2B1 1 n.s 99.0 Weakly correlated
185 MLT2B3 1 n.s 99.0 Weakly correlated
186 MSTB 1 n.s 43.0 Moderately correlated
187 MSTD-int 1 n.s 74.0 Weakly correlated
188 MamGypLTR3 1 ** 99.0 Weakly correlated
189 PABL_A-int 1 * 74.0 Weakly correlated
190 PRIMA4-int 1 * 74.0 Weakly correlated
191 THE1B 1 n.s 43.0 Moderately correlated
192 THE1D-int 1 n.s 28.9 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 9 n.s 74.0 Weakly correlated
2 AluSc8 6 n.s 74.0 Weakly correlated
3 AluYm1 3 * 19.6 Weakly correlated
4 AluJb 2 n.s 74.0 Weakly correlated
5 AluSc5 2 n.s 74.0 Weakly correlated
6 AluSc 2 n.s 74.0 Weakly correlated
7 L1MEf 1 n.s 99.0 Weakly correlated
8 L1MA4 1 n.s 87.0 Weakly correlated
9 ERVL-B4-int 1 n.s 99.0 Weakly correlated
10 L1MEc 1 n.s 99.0 Weakly correlated
11 AluSx 1 n.s 74.0 Weakly correlated
12 AluJo 1 n.s 74.0 Weakly correlated
13 L1MA3 1 n.s 74.0 Weakly correlated
14 ERV3-16A3_I-int 1 n.s 99.0 Weakly correlated
15 AluJr 1 n.s 74.0 Weakly correlated
16 MIRc 1 n.s 99.0 Weakly correlated
17 L2b 1 n.s 99.0 Weakly correlated
18 LTR7C 1 ** 28.9 Highly correlated
19 ERVL-E-int 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 ALUSC8 74.0 Weakly correlated
2 ALUY 74.0 Weakly correlated