ZRdb KZFP & Repeats
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Human_ZNF7

  • Protein
    Zinc finger protein 7
  • Length
    686
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    P17097
  • NCBI_ID
    7553
Sequence:
MEVVTFGDVAVHFSREEWQCLDPGQRALYREVMLENHSSVAGLAGFLVFKPELISRLEQGEEPWVLDLQGAEGTEAPRTSKTDSTIRTENEQACEDMDILKSESYGTVVRISPQDFPQNPGFGDVSDSEVWLDSHLGSPGLKVTGFTFQNNCLNEETVVPKTFTKDAPQGCKELGSSGLDCQPLESQGESAEGMSQRCEECGKGIRATSDIALHWEINTQKISRCQECQKKLSDCLQGKHTNNCHGEKPYECAECGKVFRLCSQLNQHQRIHTGEKPFKCTECGKAFRLSSKLIQHQRIHTGEKPYRCEECGKAFGQSSSLIHHQRIHTGERPYGCRECGKAFSQQSQLVRHQRTHTGERPYPCKECGKAFSQSSTLAQHQRMHTGEKAQILKASDSPSLVAHQRIHAVEKPFKCDECGKAFRWISRLSQHQLIHTGEKPYKCNKCTKAFGCSSRLIRHQRTHTGEKPFKCDECGKGFVQGSHLIQHQRIHTGEKPYVCNDCGKAFSQSSSLIYHQRIHKGEKPYECLQCGKAFSMSTQLTIHQRVHTGERPYKCNECGKAFSQNSTLFQHQIIHAGVKPYECSECGKAFSRSSYLIEHQRIHTRAQWFYEYGNALEGSTFVSRKKVNTIKKLHQCEDCEKIFRWRSHLIIHQRIHTGEKPYKCNDCGKAFNRSSRLTQHQKIHMG
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..76
2 C2h2 223..245
3 C2h2 250..272
4 C2h2 278..300
5 C2h2 306..328
6 C2h2 334..356
7 C2h2 362..384
8 C2h2 413..435
9 C2h2 441..463
10 C2h2 469..491
11 C2h2 497..519
12 C2h2 525..547
13 C2h2 553..575
14 C2h2 581..603
15 C2h2 634..656
16 C2h2 662..684
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA binding
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1ME1 19 **** 99.0 Highly correlated
2 L1MB7 9 **** 99.0 Highly correlated
3 L1M5 8 ** 99.0 Highly correlated
4 AluJb 6 n.s 74.0 Weakly correlated
5 L1ME3A 5 ** 99.0 Highly correlated
6 MIRc 5 * 99.0 Highly correlated
7 L1MB8 5 ** 99.0 Highly correlated
8 L1ME2 4 ** 99.0 Highly correlated
9 AluJr 4 n.s 74.0 Weakly correlated
10 L1ME3 4 *** 99.0 Highly correlated
11 L1MC2 4 *** 99.0 Highly correlated
12 L1MC1 4 * 99.0 Highly correlated
13 LTR13 4 **** 19.6 Weakly correlated
14 MIRb 4 n.s 99.0 Highly correlated
15 L1P3 4 *** 74.0 Weakly correlated
16 AluSp 3 n.s 74.0 Weakly correlated
17 L1ME3Cz 3 ** 99.0 Highly correlated
18 AluJo 3 n.s 74.0 Weakly correlated
19 L2a 3 n.s 99.0 Highly correlated
20 AluSx1 3 n.s 74.0 Weakly correlated
21 LTR10A 3 **** 28.9 Weakly correlated
22 AluSz 2 n.s 74.0 Weakly correlated
23 AluSx 2 n.s 74.0 Weakly correlated
24 MER101-int 2 *** 74.0 Weakly correlated
25 L1PA7 2 n.s 74.0 Weakly correlated
26 L1PA5 2 n.s 19.6 Weakly correlated
27 L1MC 2 * 99.0 Highly correlated
28 L1ME3C 2 ** 99.0 Highly correlated
29 L1MB3 2 n.s 99.0 Highly correlated
30 MER61-int 2 ** 43.0 Weakly correlated
31 L1ME3D 2 ** 99.0 Highly correlated
32 L2c 2 n.s 99.0 Highly correlated
33 AluY 2 n.s 74.0 Weakly correlated
34 L1M4 2 n.s 99.0 Highly correlated
35 AluYa5 2 ** 15.2 Weakly correlated
36 L1MEg 2 n.s 99.0 Highly correlated
37 L1PA2 2 n.s 15.2 Weakly correlated
38 LTR18A 1 **** 43.0 Weakly correlated
39 LTR33B 1 ** 99.0 Highly correlated
40 MER50 1 * 43.0 Weakly correlated
41 LTR10F 1 *** 28.9 Weakly correlated
42 MLT1B-int 1 *** 99.0 Highly correlated
43 AluSq10 1 ** 74.0 Weakly correlated
44 PRIMA4-int 1 *** 74.0 Weakly correlated
45 MamRTE1 1 * 99.0 Highly correlated
46 MLT2B3 1 * 99.0 Highly correlated
47 MLT1J 1 n.s 99.0 Highly correlated
48 MLT1F1 1 * 99.0 Highly correlated
49 MLT1F 1 * 99.0 Highly correlated
50 MLT1D 1 n.s 99.0 Highly correlated
51 LTR50 1 ** 99.0 Highly correlated
52 MIR1_Amn 1 * 319.0 Weakly correlated
53 MIR 1 n.s 99.0 Highly correlated
54 MER50C 1 **** 43.0 Weakly correlated
55 MER50-int 1 ** 43.0 Weakly correlated
56 SVA_E 1 ** 0.0 Weakly correlated
57 MER11B 1 ** 19.6 Weakly correlated
58 LTR9B 1 ** 43.0 Weakly correlated
59 L1MA9 1 n.s 99.0 Highly correlated
60 AluSq2 1 n.s 74.0 Weakly correlated
61 AluSx3 1 n.s 74.0 Weakly correlated
62 AluSx4 1 n.s 74.0 Weakly correlated
63 AluSz6 1 n.s 74.0 Weakly correlated
64 AluYh3 1 ** 15.2 Weakly correlated
65 AluYh3a3 1 *** 15.2 Weakly correlated
66 AluYh9 1 **** 15.2 Weakly correlated
67 AluYj4 1 ** 0.0 Weakly correlated
68 AluYm1 1 * 19.6 Weakly correlated
69 FRAM 1 * 74.0 Weakly correlated
70 L1M6 1 * 99.0 Highly correlated
71 L1MA3 1 n.s 74.0 Weakly correlated
72 L1MA4 1 n.s 87.0 Weakly correlated
73 L2b 1 n.s 99.0 Highly correlated
74 L1MB2 1 n.s 99.0 Highly correlated
75 L1MB5 1 n.s 99.0 Highly correlated
76 AluSc8 1 n.s 74.0 Weakly correlated
77 AluJr4 1 n.s 74.0 Weakly correlated
78 L1MD 1 n.s 99.0 Highly correlated
79 L1MD2 1 n.s 99.0 Highly correlated
80 L1ME2z 1 n.s 99.0 Highly correlated
81 Alu 1 ** 74.0 Weakly correlated
82 L1ME3B 1 n.s 99.0 Highly correlated
83 L1ME3E 1 * 99.0 Highly correlated
84 L1P1 1 n.s 19.6 Weakly correlated
85 L1P4 1 * 74.0 Weakly correlated
86 L1PA3 1 n.s 19.6 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1ME1 16 **** 99.0 Highly correlated
2 L1MB7 8 *** 99.0 Highly correlated
3 L1M5 6 * 99.0 Highly correlated
4 L1ME3A 5 ** 99.0 Highly correlated
5 L1ME3 4 *** 99.0 Highly correlated
6 L1MC1 4 * 99.0 Highly correlated
7 L1ME2 4 ** 99.0 Highly correlated
8 L1MC2 3 ** 99.0 Highly correlated
9 L1ME3D 2 ** 99.0 Highly correlated
10 LTR13 2 **** 19.6 Weakly correlated
11 L1MB3 2 n.s 99.0 Highly correlated
12 L1ME3Cz 2 * 99.0 Highly correlated
13 L1MB2 1 n.s 99.0 Highly correlated
14 L1MA3 1 n.s 74.0 Weakly correlated
15 L1MB5 1 n.s 99.0 Highly correlated
16 L1MB8 1 n.s 99.0 Highly correlated
17 L2a 1 n.s 99.0 Highly correlated
18 L1ME3E 1 * 99.0 Highly correlated
19 L1MEg 1 n.s 99.0 Highly correlated
20 MLT1F 1 * 99.0 Highly correlated
21 AluSx3 1 n.s 74.0 Weakly correlated
22 MamRTE1 1 * 99.0 Highly correlated
23 MER11B 1 ** 19.6 Weakly correlated
24 L1MC 1 n.s 99.0 Highly correlated
25 MER101-int 1 ** 74.0 Weakly correlated
26 L1MD2 1 n.s 99.0 Highly correlated
27 L1MD 1 n.s 99.0 Highly correlated
28 AluSq2 1 n.s 74.0 Weakly correlated
29 MER61-int 1 * 43.0 Weakly correlated
30 LTR33B 1 ** 99.0 Highly correlated
31 MLT2B3 1 * 99.0 Highly correlated
32 MLT1B-int 1 *** 99.0 Highly correlated
33 L1ME3B 1 n.s 99.0 Highly correlated
34 AluYh9 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP