ZRdb KZFP & Repeats
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Human_ZNF699

  • Protein
    Zinc finger protein 699
  • Length
    642
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q32M78
  • NCBI_ID
    374879
Sequence:
MEEERKTAELQKNRIQDSVVFEDVAVDFTQEEWALLDLAQRNLYRDVMLENFQNLASLGYPLHTPHLISQWEQEEDLQTVKRELIQGIFMGEHREGFETQLKTNESVASQDICGEKISNEQKIVRFKRNDSWFSSLHENQESCGIDYQNKSHERHLRNHMVENIYECYEENQDGQTFSQVPNLDSLKRNTEVKSCECHECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLACFKKHMKTPTEEKPYECKECTKAFSCSSFFRAHMKIHIGKTNYECKECGKGFSCSSSLTEHKRIHSGDKPYECKECGKAFSCSSSLSKHKRIHSGDKPYECKECGKAFSSSSHLIIHIRIHTGEKPYECKECGKAFSESSKLTVHGRTHTGEKPYKCKECGKAYNCPSSLSIHMRKHTGEKPYECLECGKAFYLPTSLNTHVKNQSREKPYECKECGKAFSCPSSFRAHVRDHTGKIQYECKECGKTFSRSSSLTEHLRTHSGEKPYECKECGKAFISSSHLTVHIRTHTGEKPYECKKCGKAFIYPSALRIHMRTHTGEKPYECKECGKAFRHSSYLTVHARMHTGEKPFECLECGKAFSCPSSFRRHVRSHTGEKPYECKECGKAFVCPAYFRRHVKTHTRENI
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 19..90
2 C2h2 195..217
3 dec2h2 223..245
4 C2h2 251..273
5 C2h2 279..301
6 C2h2 307..329
7 C2h2 335..357
8 C2h2 363..385
9 C2h2 391..413
10 dec2h2 419..441
11 C2h2 447..469
12 C2h2 475..497
13 C2h2 503..525
14 C2h2 531..553
15 C2h2 559..581
16 C2h2 587..609
17 C2h2 615..637
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR41 11 **** 99.0 Highly correlated
2 L1P3 11 **** 74.0 Weakly correlated
3 SVA_F 10 **** 0.0 Weakly correlated
4 AluSc8 9 ** 74.0 Weakly correlated
5 AluJb 9 n.s 74.0 Weakly correlated
6 LTR8 8 **** 43.0 Weakly correlated
7 L2c 6 n.s 99.0 Highly correlated
8 SVA_E 6 **** 0.0 Weakly correlated
9 LTR10A 4 **** 28.9 Weakly correlated
10 L1MB8 4 n.s 99.0 Highly correlated
11 AluYj4 4 **** 0.0 Weakly correlated
12 SVA_D 4 ** 15.2 Weakly correlated
13 AluSx1 3 n.s 74.0 Weakly correlated
14 MIRc 2 n.s 99.0 Highly correlated
15 FRAM 2 * 74.0 Weakly correlated
16 AluSp 2 n.s 74.0 Weakly correlated
17 MER21B 2 * 99.0 Highly correlated
18 L1M3 2 n.s 99.0 Highly correlated
19 L1MB3 2 n.s 99.0 Highly correlated
20 MLT1E3 2 ** 99.0 Highly correlated
21 L1ME2 2 n.s 99.0 Highly correlated
22 LTR41B 2 *** 99.0 Highly correlated
23 LTR10F 2 *** 28.9 Weakly correlated
24 L1P4 2 n.s 74.0 Weakly correlated
25 LTR13 2 ** 19.6 Weakly correlated
26 L1PA13 1 n.s 74.0 Weakly correlated
27 LTR10B1 1 *** 28.9 Weakly correlated
28 LTR12E 1 ** 19.6 Weakly correlated
29 SVA_A 1 * 19.6 Weakly correlated
30 MLT1L 1 n.s 99.0 Highly correlated
31 MER52A 1 n.s 74.0 Weakly correlated
32 MIRb 1 n.s 99.0 Highly correlated
33 HAL1 1 n.s 99.0 Highly correlated
34 AluSc 1 n.s 74.0 Weakly correlated
35 AluSx 1 n.s 74.0 Weakly correlated
36 AluSz 1 n.s 74.0 Weakly correlated
37 AluSz6 1 n.s 74.0 Weakly correlated
38 AluY 1 n.s 74.0 Weakly correlated
39 AluYa8 1 *** 15.2 Weakly correlated
40 AluYh9 1 **** 15.2 Weakly correlated
41 ERV3-16A3_I-int 1 n.s 99.0 Highly correlated
42 L2b 1 n.s 99.0 Highly correlated
43 L1HS 1 n.s 8.6 Weakly correlated
44 L1MC4 1 n.s 99.0 Highly correlated
45 L1MEc 1 n.s 99.0 Highly correlated
46 L1PA2 1 n.s 15.2 Weakly correlated
47 L1PA4 1 n.s 19.6 Weakly correlated
48 L1PA5 1 n.s 19.6 Weakly correlated
49 L2a 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP