ZRdb KZFP & Repeats
...

Human_ZNF69

  • Protein
    Zinc finger protein 69
  • Length
    566
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q9UC07
  • NCBI_ID
    7620
Sequence:
MPCCSHRRCREDPGTSESQEMDPVAFDDVAVNFTQEEWALLDISQRKLYKEVMLETFRNLTSVGKSWKDQNIEYEYQNPRRNFRSLIEKKVNEIKDDSHCGETFTQVPDDRLNFQEKKASPEIKSCDSFVCGEVGLGNSSFNMNIRGDIGHKAYEYQEYGPKPCKCQQPKKAFRYHPSFRTPQRDHTGEKPYACKECGKTFISHSSIQRHVVMHSGDGPYKCKFCGKAFHCLSLYLIHERIHTGEKPYECKQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHERIHTGEKAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQCGKALSSLTSFQTHIRMHSGERPYECKICGKGFCSANSFQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQSHERTQTHVRIHSGERPYKCKLCGKGFYCPKSLQRHEKTHTGEKLYECKQCGEAFSSSSSFRYHERTHTGEKPYKCKQCGKAFRAASVLRMHGRTHPEDKPYECKQ
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 24..106
2 dec2h2 164..186
3 C2h2 192..214
4 C2h2 220..242
5 C2h2 248..270
6 C2h2 276..298
7 C2h2 304..326
8 C2h2 332..354
9 C2h2 360..382
10 C2h2 388..410
11 C2h2 416..438
12 C2h2 444..472
13 C2h2 478..500
14 C2h2 506..528
15 C2h2 534..556
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function identical protein binding
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
7 Biological Process negative regulation of transcription by RNA polymerase II
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR5_Hs 32 **** 0.0 Weakly correlated
2 LTR5B 6 **** 28.9 Highly correlated
3 AluJb 4 n.s 74.0 Weakly correlated
4 AluY 3 n.s 74.0 Weakly correlated
5 LTR10A 3 **** 28.9 Highly correlated
6 LTR13 2 **** 19.6 Weakly correlated
7 LTR10F 2 **** 28.9 Highly correlated
8 L1PA5 2 n.s 19.6 Weakly correlated
9 L1P1 1 * 19.6 Weakly correlated
10 MLT1G3 1 ** 99.0 Weakly correlated
11 MIRc 1 n.s 99.0 Weakly correlated
12 MER50 1 ** 43.0 Moderately correlated
13 MER39B 1 ** 74.0 Weakly correlated
14 L1ME4b 1 n.s 99.0 Weakly correlated
15 L1MDa 1 n.s 99.0 Weakly correlated
16 FRAM 1 ** 74.0 Weakly correlated
17 AluYm1 1 * 19.6 Weakly correlated
18 AluYh9 1 **** 15.2 Weakly correlated
19 AluSq2 1 n.s 74.0 Weakly correlated
20 AluSc8 1 n.s 74.0 Weakly correlated
21 AluJr 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR5_Hs 27 **** 0.0 Weakly correlated
2 LTR5B 4 **** 28.9 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP