ZRdb KZFP & Repeats
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Human_ZNF684

  • Protein
    Zinc finger protein 684
  • Length
    378
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q5T5D7
  • NCBI_ID
    127396
Sequence:
MISFQESVTFQDVAVDFTAEEWQLLDCAERTLYWDVMLENYRNLISVGCPITKTKVILKVEQGQEPWMVEGANPHESSPESDYPLVDEPGKHRESKDNFLKSVLLTFNKILTMERIHHYNMSTSLNPMRKKSYKSFEKCLPPNLDLLKYNRSYTVENAYECSECGKAFKKKFHFIRHEKNHTRKKPFECNDCGKAYSRKAHLATHQKIHNGERPFVCNDCGKAFMHKAQLVVHQRLHTGEKPYECSQCGKTFTWNSSFNQHVKSHTLEKSFECKECGKTFRYSSSLYKHSRFHTGEKPYQCIICGKAFGNTSVLVTHQRIHTGEKPYSCIECGKAFIKKSHLLRHQITHTGEKPYECNRCGKAFSQKSNLIVHQKIHT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 C2h2 159..181
3 C2h2 187..209
4 C2h2 215..237
5 C2h2 243..265
6 C2h2 271..293
7 C2h2 299..321
8 C2h2 327..349
9 C2h2 355..377
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Molecular Function sequence-specific double-stranded DNA binding
7 Biological Process negative regulation of transcription by RNA polymerase II
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 ERV3-16A3_I-int 19 **** 99.0 Highly correlated
2 MER41B 15 **** 74.0 Weakly correlated
3 LTR16E2 11 **** 99.0 Highly correlated
4 ERVL-E-int 10 **** 99.0 Highly correlated
5 LTR16 8 **** 99.0 Highly correlated
6 MIR3 8 ** 99.0 Highly correlated
7 L2a 7 n.s 99.0 Highly correlated
8 AluSx1 6 n.s 74.0 Weakly correlated
9 L2b 6 n.s 99.0 Highly correlated
10 LTR8 6 **** 43.0 Weakly correlated
11 MIR 6 n.s 99.0 Highly correlated
12 MIRc 6 n.s 99.0 Highly correlated
13 AluJo 5 n.s 74.0 Weakly correlated
14 LTR16A 5 **** 99.0 Highly correlated
15 LTR41C 5 **** 99.0 Highly correlated
16 MER11B 5 **** 19.6 Weakly correlated
17 AluSc8 4 * 74.0 Weakly correlated
18 AluSz 4 n.s 74.0 Weakly correlated
19 AluY 4 n.s 74.0 Weakly correlated
20 HAL1 4 n.s 99.0 Highly correlated
21 L2 4 n.s 99.0 Highly correlated
22 L2c 4 n.s 99.0 Highly correlated
23 L3 4 n.s 99.0 Highly correlated
24 LTR16C 4 *** 99.0 Highly correlated
25 LTR16E1 4 **** 99.0 Highly correlated
26 LTR33 4 *** 99.0 Highly correlated
27 LTR41 4 **** 99.0 Highly correlated
28 MER11C 4 **** 19.6 Weakly correlated
29 MIRb 4 n.s 99.0 Highly correlated
30 MLT1J 4 ** 99.0 Highly correlated
31 AluJr4 3 * 74.0 Weakly correlated
32 AluSg 3 n.s 74.0 Weakly correlated
33 AluSq2 3 n.s 74.0 Weakly correlated
34 ERVL-B4-int 3 ** 99.0 Highly correlated
35 HERVL-int 3 * 74.0 Weakly correlated
36 L1ME4b 3 n.s 99.0 Highly correlated
37 LTR10A 3 **** 28.9 Weakly correlated
38 LTR16B1 3 **** 99.0 Highly correlated
39 LTR18A 3 **** 43.0 Weakly correlated
40 LTR33A 3 **** 99.0 Highly correlated
41 LTR33C 3 **** 99.0 Highly correlated
42 LTR50 3 **** 99.0 Highly correlated
43 MER50 3 *** 43.0 Weakly correlated
44 MLT1A0 3 n.s 99.0 Highly correlated
45 MLT1H 3 ** 99.0 Highly correlated
46 MLT1K 3 * 99.0 Highly correlated
47 MLT1N2 3 *** 99.0 Highly correlated
48 MSTA 3 n.s 43.0 Weakly correlated
49 THE1D-int 3 ** 28.9 Weakly correlated
50 AluJb 2 n.s 74.0 Weakly correlated
51 AluJr 2 n.s 74.0 Weakly correlated
52 AluSp 2 n.s 74.0 Weakly correlated
53 AluSx 2 n.s 74.0 Weakly correlated
54 AluYa5 2 ** 15.2 Weakly correlated
55 AluYm1 2 ** 19.6 Weakly correlated
56 ERV3-16A3_LTR 2 **** 99.0 Highly correlated
57 FRAM 2 ** 74.0 Weakly correlated
58 L1MB2 2 n.s 99.0 Highly correlated
59 L1MC4 2 n.s 99.0 Highly correlated
60 L1ME3G 2 n.s 99.0 Highly correlated
61 L1PA2 2 n.s 15.2 Weakly correlated
62 L1PA4 2 n.s 19.6 Weakly correlated
63 L1PA5 2 n.s 19.6 Weakly correlated
64 LTR16A1 2 ** 99.0 Highly correlated
65 LTR16A2 2 *** 99.0 Highly correlated
66 LTR16B 2 **** 99.0 Highly correlated
67 LTR33B 2 *** 99.0 Highly correlated
68 MER21-int 2 *** 99.0 Highly correlated
69 MER41A 2 ** 74.0 Weakly correlated
70 MLT1A1 2 * 87.0 Weakly correlated
71 MLT1B 2 n.s 99.0 Highly correlated
72 MLT1D 2 n.s 99.0 Highly correlated
73 MLT1G 2 ** 99.0 Highly correlated
74 MLT1I 2 * 99.0 Highly correlated
75 MLT1L 2 * 99.0 Highly correlated
76 MLT1O 2 ** 99.0 Highly correlated
77 MLT2C1 2 *** 99.0 Highly correlated
78 MLT2F 2 *** 99.0 Highly correlated
79 MSTB-int 2 ** 43.0 Weakly correlated
80 THE1B 2 n.s 43.0 Weakly correlated
81 THE1B-int 2 n.s 43.0 Weakly correlated
82 AluSx3 1 n.s 74.0 Weakly correlated
83 AluSz6 1 n.s 74.0 Weakly correlated
84 AluYh3 1 * 15.2 Weakly correlated
85 AluYh9 1 **** 15.2 Weakly correlated
86 ERVL-int 1 ** 99.0 Highly correlated
87 HAL1ME 1 n.s 99.0 Highly correlated
88 HUERS-P3-int 1 * 43.0 Weakly correlated
89 L1M4a2 1 * 99.0 Highly correlated
90 L1MA3 1 n.s 74.0 Weakly correlated
91 L1MA7 1 n.s 87.0 Weakly correlated
92 L1MB7 1 n.s 99.0 Highly correlated
93 L1MC5a 1 n.s 99.0 Highly correlated
94 L1MD1 1 n.s 99.0 Highly correlated
95 L1MDa 1 n.s 99.0 Highly correlated
96 L1ME1 1 n.s 99.0 Highly correlated
97 L1ME2z 1 n.s 99.0 Highly correlated
98 L1ME3 1 n.s 99.0 Highly correlated
99 L1ME3B 1 n.s 99.0 Highly correlated
100 L1ME3D 1 n.s 99.0 Highly correlated
101 L1ME4a 1 n.s 99.0 Highly correlated
102 L1MEd 1 n.s 99.0 Highly correlated
103 L1P1 1 n.s 19.6 Weakly correlated
104 L4_B_Mam 1 * 99.0 Highly correlated
105 LOR1-int 1 * 74.0 Weakly correlated
106 LTR13 1 ** 19.6 Weakly correlated
107 LTR16D 1 ** 99.0 Highly correlated
108 LTR16D1 1 *** 99.0 Highly correlated
109 LTR16D2 1 *** 99.0 Highly correlated
110 LTR25-int 1 * 43.0 Weakly correlated
111 LTR47A2 1 *** 74.0 Weakly correlated
112 LTR56 1 ** 74.0 Weakly correlated
113 LTR67B 1 * 99.0 Highly correlated
114 LTR78B 1 * 99.0 Highly correlated
115 LTR7B 1 ** 28.9 Weakly correlated
116 LTR81A 1 ** 99.0 Highly correlated
117 LTR86A1 1 *** 99.0 Highly correlated
118 MER11A 1 * 28.9 Weakly correlated
119 MER21C 1 n.s 99.0 Highly correlated
120 MER41C 1 ** 74.0 Weakly correlated
121 MER4A 1 ** 74.0 Weakly correlated
122 MER50-int 1 ** 43.0 Weakly correlated
123 MER51A 1 ** 43.0 Weakly correlated
124 MER52A 1 n.s 74.0 Weakly correlated
125 MER66-int 1 ** 43.0 Weakly correlated
126 MER76 1 ** 99.0 Highly correlated
127 MER9a3 1 ** 28.9 Weakly correlated
128 MIR1_Amn 1 * 319.0 Weakly correlated
129 MLT-int 1 *** 99.0 Highly correlated
130 MLT1D-int 1 ** 99.0 Highly correlated
131 MLT1E1A 1 * 99.0 Highly correlated
132 MLT1F1 1 * 99.0 Highly correlated
133 MLT1F1-int 1 *** 99.0 Highly correlated
134 MLT1G1 1 * 99.0 Highly correlated
135 MLT1J-int 1 ** 99.0 Highly correlated
136 MLT1L-int 1 **** 99.0 Highly correlated
137 MLT1M 1 ** 99.0 Highly correlated
138 MLT2B4 1 n.s 99.0 Highly correlated
139 MLT2D 1 * 99.0 Highly correlated
140 MSTA-int 1 n.s 43.0 Weakly correlated
141 MSTB1 1 n.s 74.0 Weakly correlated
142 MSTC 1 * 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 ERV3-16A3_I-int 17 **** 99.0 Highly correlated
2 MER41B 15 **** 74.0 Weakly correlated
3 ERVL-E-int 10 **** 99.0 Highly correlated
4 LTR16E2 8 **** 99.0 Highly correlated
5 LTR16 6 **** 99.0 Highly correlated
6 L2b 5 n.s 99.0 Highly correlated
7 MIR3 4 n.s 99.0 Highly correlated
8 LTR41C 4 **** 99.0 Highly correlated
9 LTR16A 4 **** 99.0 Highly correlated
10 LTR41 4 **** 99.0 Highly correlated
11 L2a 4 n.s 99.0 Highly correlated
12 MLT1J 4 ** 99.0 Highly correlated
13 L3 3 n.s 99.0 Highly correlated
14 MIRc 3 n.s 99.0 Highly correlated
15 LTR16E1 3 **** 99.0 Highly correlated
16 LTR33 3 ** 99.0 Highly correlated
17 HERVL-int 3 * 74.0 Weakly correlated
18 L2 3 n.s 99.0 Highly correlated
19 MER50 3 *** 43.0 Weakly correlated
20 MLT1H 3 ** 99.0 Highly correlated
21 ERVL-B4-int 3 ** 99.0 Highly correlated
22 L1PA4 2 n.s 19.6 Weakly correlated
23 LTR16B1 2 *** 99.0 Highly correlated
24 MLT1N2 2 ** 99.0 Highly correlated
25 AluSg 2 n.s 74.0 Weakly correlated
26 MLT2C1 2 *** 99.0 Highly correlated
27 MSTA 2 n.s 43.0 Weakly correlated
28 L2c 2 n.s 99.0 Highly correlated
29 MIRb 2 n.s 99.0 Highly correlated
30 AluJr4 2 n.s 74.0 Weakly correlated
31 L1MC4 2 n.s 99.0 Highly correlated
32 MLT1A1 2 * 87.0 Weakly correlated
33 MER21-int 2 *** 99.0 Highly correlated
34 MER11B 2 *** 19.6 Weakly correlated
35 MLT1I 2 * 99.0 Highly correlated
36 MLT1L 2 * 99.0 Highly correlated
37 AluSq2 1 n.s 74.0 Weakly correlated
38 HAL1ME 1 n.s 99.0 Highly correlated
39 L1MA3 1 n.s 74.0 Weakly correlated
40 L1ME4a 1 n.s 99.0 Highly correlated
41 L1ME4b 1 n.s 99.0 Highly correlated
42 LTR16A1 1 * 99.0 Highly correlated
43 LTR16A2 1 ** 99.0 Highly correlated
44 LTR16C 1 n.s 99.0 Highly correlated
45 LTR33C 1 ** 99.0 Highly correlated
46 LTR56 1 ** 74.0 Weakly correlated
47 LTR78B 1 * 99.0 Highly correlated
48 MER21C 1 n.s 99.0 Highly correlated
49 MLT1D-int 1 ** 99.0 Highly correlated
50 L1MA7 1 n.s 87.0 Weakly correlated
51 L1PA5 1 n.s 19.6 Weakly correlated
52 MER51A 1 ** 43.0 Weakly correlated
53 MLT1F1-int 1 *** 99.0 Highly correlated
54 MLT1G 1 * 99.0 Highly correlated
55 AluSz 1 n.s 74.0 Weakly correlated
56 L1MDa 1 n.s 99.0 Highly correlated
57 MER41A 1 * 74.0 Weakly correlated
58 MLT1J-int 1 ** 99.0 Highly correlated
59 MLT1O 1 * 99.0 Highly correlated
60 AluYa5 1 * 15.2 Weakly correlated
61 L1ME3 1 n.s 99.0 Highly correlated
62 L1ME3G 1 n.s 99.0 Highly correlated
63 LTR16D 1 ** 99.0 Highly correlated
64 LTR16D1 1 *** 99.0 Highly correlated
65 MER76 1 ** 99.0 Highly correlated
66 MLT2B4 1 n.s 99.0 Highly correlated
67 MLT2F 1 * 99.0 Highly correlated
68 MSTB-int 1 * 43.0 Weakly correlated
69 AluSx1 1 n.s 74.0 Weakly correlated
70 ERV3-16A3_LTR 1 ** 99.0 Highly correlated
71 L1ME3D 1 n.s 99.0 Highly correlated
72 L1MEd 1 n.s 99.0 Highly correlated
73 LTR50 1 * 99.0 Highly correlated
74 LTR7B 1 ** 28.9 Weakly correlated
75 MER41C 1 ** 74.0 Weakly correlated
76 MER52A 1 n.s 74.0 Weakly correlated
77 MLT1G1 1 * 99.0 Highly correlated
78 HAL1 1 n.s 99.0 Highly correlated
79 L1MC5a 1 n.s 99.0 Highly correlated
80 L1ME2z 1 n.s 99.0 Highly correlated
81 L1P1 1 n.s 19.6 Weakly correlated
82 LTR16D2 1 *** 99.0 Highly correlated
83 MLT1D 1 n.s 99.0 Highly correlated
84 MSTA-int 1 n.s 43.0 Weakly correlated
85 MSTC 1 * 74.0 Weakly correlated
86 ERVL-int 1 ** 99.0 Highly correlated
87 L1MB2 1 n.s 99.0 Highly correlated
88 L1ME1 1 n.s 99.0 Highly correlated
89 LTR16B 1 ** 99.0 Highly correlated
90 LTR18A 1 *** 43.0 Weakly correlated
91 LTR33A 1 ** 99.0 Highly correlated
92 MIR 1 n.s 99.0 Highly correlated
93 MLT1M 1 ** 99.0 Highly correlated
94 L1MD1 1 n.s 99.0 Highly correlated
95 L4_B_Mam 1 * 99.0 Highly correlated
96 LOR1-int 1 * 74.0 Weakly correlated
97 LTR86A1 1 *** 99.0 Highly correlated
98 MER66-int 1 ** 43.0 Weakly correlated
99 MLT1A0 1 n.s 99.0 Highly correlated
100 MLT1E1A 1 * 99.0 Highly correlated
101 MLT1L-int 1 **** 99.0 Highly correlated
102 THE1D-int 1 n.s 28.9 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 ERVL-E-INT 99.0 Highly correlated
2 MER41B 74.0 Weakly correlated