ZRdb KZFP & Repeats
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Human_ZNF681

  • Protein
    Zinc finger protein 681
  • Length
    645
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q96N22
  • NCBI_ID
    148213
Sequence:
MEPLKFRDVAIEFSLEEWQCLDTIQQNLYRNVMLENYRNLVFLGIVVSKPDLITCLEQEKEPWTRKRHRMVAEPPVICSHFAQDFSPEQNIKDSFQKVTPRRYGKCEHENLQLSKSVDECKVQKGGYNGLNQCLPTTQSKIFQCDKYMKIFHKFSNLNGHKVRHTRKKPFKYKEFGKSFCIFSNLTQHKIICTRVNFYKCEDCGKAFNGSSIFTKHKRIHIGEKSYICEECGKACNQFTNLTTHKIIYTRDKLYKREECSKAFNLSSHITTHTIIHTGENPYKREECDKAFNQSLTLTTHKIIHTREKLNEYKECGKAFNQSSHLTRHKIIHTGEKPYKCEECGKAFNQSSHLTRHKIIHTGEKPYRCEECGKAFRQSSHLTTHKIIHTGEKPYKCEECGKAFNKSSHLTRHKSIHTGEKPYQCEKCGKASNQSSNLTEHKNIHTEEKPYKCEECGKAFNQFSNLTTHKRIHTGEKPYKCEECGKAFNQSSILTTHKRIHTGEKSYKCEECGKAFYRSSKLTEHKKIHTGEKPYTCEECGKAFNHSSHLATHKVIHTGEKPYQCEECGKAFNQSSHLTRHKRIHTGEKPYQCEKCGKAFNQSSNLTGHKKIHTGEKLYKPKRCNSDFENTSKFSKHKRNYAGEKS
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..75
2 dec2h2 142..164
3 C2h2 198..220
4 dec2h2 226..248
5 dec2h2 254..276
6 dec2h2 282..304
7 dec2h2 310..332
8 C2h2 338..360
9 C2h2 366..388
10 C2h2 394..416
11 C2h2 422..444
12 C2h2 450..472
13 C2h2 478..500
14 C2h2 506..528
15 C2h2 534..556
16 C2h2 562..584
17 C2h2 590..612
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR9A1 66 **** 43.0 Moderately correlated
2 LTR9D 21 **** 43.0 Moderately correlated
3 MER61E 18 **** 43.0 Moderately correlated
4 LTR19C 13 **** 43.0 Moderately correlated
5 MER61F 12 **** 43.0 Moderately correlated
6 LTR25 9 **** 43.0 Moderately correlated
7 L2a 8 n.s 99.0 Weakly correlated
8 L2c 8 n.s 99.0 Weakly correlated
9 AluJb 7 n.s 74.0 Weakly correlated
10 AluJr 5 n.s 74.0 Weakly correlated
11 L2b 5 n.s 99.0 Weakly correlated
12 L2 4 n.s 99.0 Weakly correlated
13 LTR10A 4 **** 28.9 Highly correlated
14 MIR 4 n.s 99.0 Weakly correlated
15 MLT1C 3 n.s 94.0 Weakly correlated
16 MIRb 3 n.s 99.0 Weakly correlated
17 AluSx 3 n.s 74.0 Weakly correlated
18 MLT1A0 2 n.s 99.0 Weakly correlated
19 L3 2 n.s 99.0 Weakly correlated
20 MER39B 2 *** 74.0 Weakly correlated
21 L1PA5 2 n.s 19.6 Weakly correlated
22 L1MA7 2 n.s 87.0 Weakly correlated
23 L1M1 2 n.s 74.0 Weakly correlated
24 FLAM_A 2 ** 74.0 Weakly correlated
25 MLT2A2 2 ** 74.0 Weakly correlated
26 AluY 2 n.s 74.0 Weakly correlated
27 AluSc 2 n.s 74.0 Weakly correlated
28 AluSz 2 n.s 74.0 Weakly correlated
29 AluSx1 2 n.s 74.0 Weakly correlated
30 MSTB1 2 ** 74.0 Weakly correlated
31 LTR8 2 ** 43.0 Moderately correlated
32 AluSg 2 n.s 74.0 Weakly correlated
33 MER77 1 ** 99.0 Weakly correlated
34 LTR79 1 * 99.0 Weakly correlated
35 LTR82A 1 ** 99.0 Weakly correlated
36 MER21C 1 n.s 99.0 Weakly correlated
37 MER101-int 1 ** 74.0 Weakly correlated
38 LTR84b 1 ** 99.0 Weakly correlated
39 MIRc 1 n.s 99.0 Weakly correlated
40 MamRTE1 1 * 99.0 Weakly correlated
41 MSTB 1 n.s 43.0 Moderately correlated
42 MLT2B1 1 * 99.0 Weakly correlated
43 MLT1L 1 n.s 99.0 Weakly correlated
44 MLT1K 1 n.s 99.0 Weakly correlated
45 MLT1H2 1 * 99.0 Weakly correlated
46 MLT1E1A 1 * 99.0 Weakly correlated
47 MLT1D 1 n.s 99.0 Weakly correlated
48 MER4-int 1 n.s 74.0 Weakly correlated
49 MER89 1 ** 99.0 Weakly correlated
50 LTR104_Mam 1 ** 99.0 Weakly correlated
51 MER66C 1 *** 43.0 Moderately correlated
52 MER61C 1 *** 43.0 Moderately correlated
53 MER61-int 1 * 43.0 Moderately correlated
54 MER4D1 1 * 74.0 Weakly correlated
55 MER41B 1 * 74.0 Weakly correlated
56 L1M5 1 n.s 99.0 Weakly correlated
57 L1MC5a 1 n.s 99.0 Weakly correlated
58 L1MC3 1 n.s 99.0 Weakly correlated
59 L1MC1 1 n.s 99.0 Weakly correlated
60 L1MB8 1 n.s 99.0 Weakly correlated
61 L1MB5 1 n.s 99.0 Weakly correlated
62 L1MA5A 1 n.s 87.0 Weakly correlated
63 L1MA4 1 n.s 87.0 Weakly correlated
64 L1MA2 1 n.s 74.0 Weakly correlated
65 L1MD2 1 n.s 99.0 Weakly correlated
66 HAL1 1 n.s 99.0 Weakly correlated
67 AmnSINE1 1 ** 319.0 Weakly correlated
68 AluYc3 1 *** 74.0 Weakly correlated
69 AluSq2 1 n.s 74.0 Weakly correlated
70 AluSp 1 n.s 74.0 Weakly correlated
71 AluSc5 1 n.s 74.0 Weakly correlated
72 AluJo 1 n.s 74.0 Weakly correlated
73 L1PA14 1 n.s 74.0 Weakly correlated
74 LTR37A 1 ** 99.0 Weakly correlated
75 LTR29 1 ** 43.0 Moderately correlated
76 LTR16C 1 n.s 99.0 Weakly correlated
77 LTR16B2 1 ** 99.0 Weakly correlated
78 LTR13 1 ** 19.6 Weakly correlated
79 LTR12D 1 ** 19.6 Weakly correlated
80 L4_A_Mam 1 n.s 99.0 Weakly correlated
81 L1PA15 1 n.s 74.0 Weakly correlated
82 LTR48B 1 ** 74.0 Weakly correlated
83 L1PA13 1 n.s 74.0 Weakly correlated
84 L1P1 1 n.s 19.6 Weakly correlated
85 L1MEi 1 n.s 99.0 Weakly correlated
86 L1MEf 1 n.s 99.0 Weakly correlated
87 L1MEd 1 n.s 99.0 Weakly correlated
88 L1ME5 1 * 99.0 Weakly correlated
89 L1MDa 1 n.s 99.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR9A1 63 **** 43.0 Moderately correlated
2 LTR9D 20 **** 43.0 Moderately correlated
3 MER61E 18 **** 43.0 Moderately correlated
4 LTR19C 13 **** 43.0 Moderately correlated
5 MER61F 5 **** 43.0 Moderately correlated
6 L2c 2 n.s 99.0 Weakly correlated
7 LTR25 2 **** 43.0 Moderately correlated
8 L2 1 n.s 99.0 Weakly correlated
9 L4_A_Mam 1 n.s 99.0 Weakly correlated
10 MLT2A2 1 n.s 74.0 Weakly correlated
11 L1MB5 1 n.s 99.0 Weakly correlated
12 MLT1C 1 n.s 94.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP