ZRdb KZFP & Repeats
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Human_ZNF675

  • Protein
    Zinc finger protein 675
  • Length
    568
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    8.6 Mya
  • Time of Changing in binding specificity
    8.6 Mya
  • Uniprot_ID
  • NCBI_ID
Sequence:
MGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPVMCSHFAQEFWPEQNIKDSFEKVTLRRYEKCGNDNFQLKGCKSVDECKLHKGGYNGLNQCLPTMQSKMFQCDKYVKVFNKFSHSDRHKIKHMENKPFKCKECGRSFCMLSHLTRHERNYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSNLTEYKKDYAREKPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLTTHKKIHTGEQPYICEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEECGKAFNRSSNLTEHRKIHTEEKPYKCKECGKAFKHSSALTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKHSSSLTTHKRIHTGEKPYKCEECGKAFSRSSKLTEHKIIHTGEKPYKCERCDKAFNQSANLTKHKKIHTGEKLQNWNV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..75
2 dec2h2 144..166
3 dec2h2 172..194
4 dec2h2 200..222
5 dec2h2 228..250
6 C2h2 256..278
7 C2h2 284..306
8 C2h2 312..334
9 C2h2 340..362
10 C2h2 368..390
11 C2h2 396..418
12 C2h2 424..446
13 C2h2 452..474
14 C2h2 480..502
15 C2h2 508..530
16 C2h2 536..558
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Cellular Component perinuclear region of cytoplasm
3 Molecular Function DNA binding
4 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Molecular Function ubiquitin protein ligase binding
7 Molecular Function zinc ion binding
8 Biological Process bone resorption
9 Biological Process cytokine-mediated signaling pathway
10 Biological Process I-kappaB kinase/NF-kappaB signaling
11 Biological Process negative regulation of interleukin-1-mediated signaling pathway
12 Biological Process negative regulation of JNK cascade
13 Biological Process negative regulation of JUN kinase activity
14 Biological Process negative regulation of NF-kappaB transcription factor activity
15 Biological Process negative regulation of osteoclast differentiation
16 Biological Process negative regulation of transcription by RNA polymerase II
17 Biological Process negative regulation of transcription regulatory region DNA binding
18 Biological Process negative regulation of tumor necrosis factor-mediated signaling pathway
19 Biological Process regulation of DNA-templated transcription
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 THE1B-int 1181 **** 43.0 Weakly correlated
2 MSTA-int 595 **** 43.0 Weakly correlated
3 THE1C-int 517 **** 43.0 Weakly correlated
4 THE1D-int 504 **** 28.9 Weakly correlated
5 THE1A-int 414 **** 43.0 Weakly correlated
6 MSTB-int 150 **** 43.0 Weakly correlated
7 AluJb 44 n.s 74.0 Weakly correlated
8 AluY 40 n.s 74.0 Weakly correlated
9 AluSx 35 n.s 74.0 Weakly correlated
10 AluSx1 33 n.s 74.0 Weakly correlated
11 MSTB1-int 30 **** 74.0 Weakly correlated
12 AluJo 27 n.s 74.0 Weakly correlated
13 THE1-int 26 **** 43.0 Weakly correlated
14 AluSz 25 n.s 74.0 Weakly correlated
15 L2a 25 n.s 99.0 Weakly correlated
16 MIRb 24 n.s 99.0 Weakly correlated
17 MST-int 20 **** 74.0 Weakly correlated
18 MSTC-int 20 **** 74.0 Weakly correlated
19 AluJr 19 n.s 74.0 Weakly correlated
20 L2b 17 n.s 99.0 Weakly correlated
21 MSTD-int 17 **** 74.0 Weakly correlated
22 AluSz6 15 n.s 74.0 Weakly correlated
23 MIR 12 n.s 99.0 Weakly correlated
24 MIR3 11 n.s 99.0 Weakly correlated
25 AluSg 10 n.s 74.0 Weakly correlated
26 L2c 10 n.s 99.0 Weakly correlated
27 MSTA 9 n.s 43.0 Weakly correlated
28 THE1B 9 n.s 43.0 Weakly correlated
29 AluSp 8 n.s 74.0 Weakly correlated
30 HERVH-int 8 n.s 28.9 Weakly correlated
31 LTR10F 8 **** 28.9 Weakly correlated
32 L2 7 n.s 99.0 Weakly correlated
33 LTR12C 7 n.s 19.6 Moderately correlated
34 MIRc 7 n.s 99.0 Weakly correlated
35 MLT1D 7 n.s 99.0 Weakly correlated
36 MSTB2-int 7 **** 74.0 Weakly correlated
37 AluSx3 6 n.s 74.0 Weakly correlated
38 FLAM_C 6 n.s 74.0 Weakly correlated
39 MLT1A 6 n.s 99.0 Weakly correlated
40 MLT1C 6 n.s 94.0 Weakly correlated
41 AluSc8 5 n.s 74.0 Weakly correlated
42 AluSg7 5 n.s 74.0 Weakly correlated
43 AluSq2 5 n.s 74.0 Weakly correlated
44 FRAM 5 * 74.0 Weakly correlated
45 LTR13_ 5 **** 28.9 Weakly correlated
46 MLT1L 5 n.s 99.0 Weakly correlated
47 AluSc 4 n.s 74.0 Weakly correlated
48 AluYm1 4 n.s 19.6 Moderately correlated
49 L1MB8 4 n.s 99.0 Weakly correlated
50 L1ME1 4 n.s 99.0 Weakly correlated
51 L1MEg 4 n.s 99.0 Weakly correlated
52 L1MEi 4 n.s 99.0 Weakly correlated
53 L1PB1 4 n.s 74.0 Weakly correlated
54 L3 4 n.s 99.0 Weakly correlated
55 LTR10A 4 **** 28.9 Weakly correlated
56 SVA_D 4 n.s 15.2 Moderately correlated
57 THE1A 4 n.s 43.0 Weakly correlated
58 THE1C 4 n.s 43.0 Weakly correlated
59 AluJr4 3 n.s 74.0 Weakly correlated
60 AluYa5 3 n.s 15.2 Moderately correlated
61 AluYc 3 n.s 74.0 Weakly correlated
62 AluYd8 3 **** 15.2 Moderately correlated
63 L1M4 3 n.s 99.0 Weakly correlated
64 L1MA7 3 n.s 87.0 Weakly correlated
65 L1ME4b 3 n.s 99.0 Weakly correlated
66 L1PA10 3 n.s 74.0 Weakly correlated
67 L1PA2 3 n.s 15.2 Moderately correlated
68 L1PA5 3 n.s 19.6 Moderately correlated
69 LTR13 3 ** 19.6 Moderately correlated
70 LTR18A 3 **** 43.0 Weakly correlated
71 LTR1A1 3 ** 43.0 Weakly correlated
72 MER52A 3 n.s 74.0 Weakly correlated
73 MLT1K 3 n.s 99.0 Weakly correlated
74 MLT1N2 3 n.s 99.0 Weakly correlated
75 MSTC 3 n.s 74.0 Weakly correlated
76 SVA_E 3 ** 0.0 Weakly correlated
77 THE1D 3 n.s 43.0 Weakly correlated
78 AluYj4 2 n.s 0.0 Weakly correlated
79 AmnSINE1 2 * 319.0 Weakly correlated
80 FLAM_A 2 n.s 74.0 Weakly correlated
81 L1MA5 2 n.s 87.0 Weakly correlated
82 L1MA5A 2 n.s 87.0 Weakly correlated
83 L1MC2 2 n.s 99.0 Weakly correlated
84 L1MC3 2 n.s 99.0 Weakly correlated
85 L1MC4 2 n.s 99.0 Weakly correlated
86 L1MC5a 2 n.s 99.0 Weakly correlated
87 L1ME3Cz 2 n.s 99.0 Weakly correlated
88 L1ME4a 2 n.s 99.0 Weakly correlated
89 L1MEc 2 n.s 99.0 Weakly correlated
90 L1PA16 2 n.s 74.0 Weakly correlated
91 LTR1A2 2 n.s 43.0 Weakly correlated
92 LTR33 2 n.s 99.0 Weakly correlated
93 LTR88a 2 ** 99.0 Weakly correlated
94 LTR8A 2 n.s 43.0 Weakly correlated
95 LTR8B 2 n.s 43.0 Weakly correlated
96 MER11A 2 n.s 28.9 Weakly correlated
97 MER39 2 n.s 74.0 Weakly correlated
98 MLT-int 2 ** 99.0 Weakly correlated
99 MLT1B 2 n.s 99.0 Weakly correlated
100 MLT1F1 2 n.s 99.0 Weakly correlated
101 MLT1G 2 n.s 99.0 Weakly correlated
102 MLT1I 2 n.s 99.0 Weakly correlated
103 MLT1J 2 n.s 99.0 Weakly correlated
104 MLT2B3 2 n.s 99.0 Weakly correlated
105 MSTA1-int 2 **** 74.0 Weakly correlated
106 MSTB 2 n.s 43.0 Weakly correlated
107 Plat_L3 2 n.s 99.0 Weakly correlated
108 SVA_B 2 n.s 15.2 Moderately correlated
109 AluSx4 1 n.s 74.0 Weakly correlated
110 AluYf1 1 n.s 19.6 Moderately correlated
111 AluYg6 1 * 15.2 Moderately correlated
112 AluYk12 1 ** 15.2 Moderately correlated
113 CR1_Mam 1 n.s 99.0 Weakly correlated
114 FAM 1 n.s 87.0 Weakly correlated
115 HAL1 1 n.s 99.0 Weakly correlated
116 HERV16-int 1 n.s 99.0 Weakly correlated
117 L1M1 1 n.s 74.0 Weakly correlated
118 L1M2 1 n.s 99.0 Weakly correlated
119 L1M4a2 1 n.s 99.0 Weakly correlated
120 L1M4b 1 n.s 99.0 Weakly correlated
121 L1M5 1 n.s 99.0 Weakly correlated
122 L1M7 1 n.s 99.0 Weakly correlated
123 L1MA1 1 n.s 74.0 Weakly correlated
124 L1MA2 1 n.s 74.0 Weakly correlated
125 L1MA4 1 n.s 87.0 Weakly correlated
126 L1MA6 1 n.s 87.0 Weakly correlated
127 L1MA8 1 n.s 87.0 Weakly correlated
128 L1MA9 1 n.s 99.0 Weakly correlated
129 L1MB7 1 n.s 99.0 Weakly correlated
130 L1MC4a 1 n.s 99.0 Weakly correlated
131 L1MD1 1 n.s 99.0 Weakly correlated
132 L1MD2 1 n.s 99.0 Weakly correlated
133 L1MD3 1 n.s 99.0 Weakly correlated
134 L1MDa 1 n.s 99.0 Weakly correlated
135 L1ME2 1 n.s 99.0 Weakly correlated
136 L1ME3 1 n.s 99.0 Weakly correlated
137 L1ME3A 1 n.s 99.0 Weakly correlated
138 L1ME3B 1 n.s 99.0 Weakly correlated
139 L1ME3C 1 n.s 99.0 Weakly correlated
140 L1ME3F 1 n.s 99.0 Weakly correlated
141 L1MEd 1 n.s 99.0 Weakly correlated
142 L1MEf 1 n.s 99.0 Weakly correlated
143 L1MEh 1 n.s 99.0 Weakly correlated
144 L1P1 1 n.s 19.6 Moderately correlated
145 L1P4 1 n.s 74.0 Weakly correlated
146 L1PA11 1 n.s 74.0 Weakly correlated
147 L1PA4 1 n.s 19.6 Moderately correlated
148 L1PA6 1 n.s 28.9 Weakly correlated
149 L1PA7 1 n.s 74.0 Weakly correlated
150 L1PA8A 1 n.s 74.0 Weakly correlated
151 L1PBa1 1 n.s 74.0 Weakly correlated
152 L1PREC2 1 n.s 43.0 Weakly correlated
153 L3b 1 n.s 99.0 Weakly correlated
154 LOR1a 1 n.s 74.0 Weakly correlated
155 LTR101_Mam 1 n.s 99.0 Weakly correlated
156 LTR102_Mam 1 * 99.0 Weakly correlated
157 LTR12D 1 n.s 19.6 Moderately correlated
158 LTR12_ 1 n.s 28.9 Weakly correlated
159 LTR13A 1 * 28.9 Weakly correlated
160 LTR16A 1 n.s 99.0 Weakly correlated
161 LTR16B2 1 n.s 99.0 Weakly correlated
162 LTR16E1 1 n.s 99.0 Weakly correlated
163 LTR1D 1 n.s 43.0 Weakly correlated
164 LTR1D1 1 n.s 43.0 Weakly correlated
165 LTR27E 1 * 43.0 Weakly correlated
166 LTR40a 1 n.s 99.0 Weakly correlated
167 LTR41 1 n.s 99.0 Weakly correlated
168 LTR41B 1 n.s 99.0 Weakly correlated
169 LTR50 1 n.s 99.0 Weakly correlated
170 LTR64 1 * 74.0 Weakly correlated
171 LTR6A 1 * 28.9 Weakly correlated
172 LTR81B 1 n.s 99.0 Weakly correlated
173 LTR82A 1 n.s 99.0 Weakly correlated
174 LTR85c 1 n.s 99.0 Weakly correlated
175 MER21B 1 n.s 99.0 Weakly correlated
176 MER21C 1 n.s 99.0 Weakly correlated
177 MER39B 1 n.s 74.0 Weakly correlated
178 MER4A 1 n.s 74.0 Weakly correlated
179 MER4D 1 n.s 74.0 Weakly correlated
180 MER50 1 n.s 43.0 Weakly correlated
181 MER51B 1 n.s 43.0 Weakly correlated
182 MER54A 1 n.s 87.0 Weakly correlated
183 MER54B 1 * 87.0 Weakly correlated
184 MER61-int 1 n.s 43.0 Weakly correlated
185 MER61C 1 * 43.0 Weakly correlated
186 MER70B 1 n.s 87.0 Weakly correlated
187 MER74C 1 ** 99.0 Weakly correlated
188 MER83C 1 ** 43.0 Weakly correlated
189 MIR1_Amn 1 n.s 319.0 Weakly correlated
190 MLT1A0 1 n.s 99.0 Weakly correlated
191 MLT1A1 1 n.s 87.0 Weakly correlated
192 MLT1B-int 1 n.s 99.0 Weakly correlated
193 MLT1E 1 n.s 99.0 Weakly correlated
194 MLT1E2 1 n.s 99.0 Weakly correlated
195 MLT1F 1 n.s 99.0 Weakly correlated
196 MLT1J2 1 n.s 99.0 Weakly correlated
197 MLT1M 1 n.s 99.0 Weakly correlated
198 MLT2A1 1 n.s 74.0 Weakly correlated
199 MLT2D 1 n.s 99.0 Weakly correlated
200 MSTA1 1 * 74.0 Weakly correlated
201 MamRTE1 1 n.s 99.0 Weakly correlated
202 MamSINE1 1 n.s 99.0 Weakly correlated
203 SVA_A 1 n.s 19.6 Moderately correlated
204 SVA_C 1 n.s 15.2 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 THE1B-int 1157 **** 43.0 Weakly correlated
2 MSTA-int 579 **** 43.0 Weakly correlated
3 THE1C-int 508 **** 43.0 Weakly correlated
4 THE1D-int 491 **** 28.9 Weakly correlated
5 THE1A-int 402 **** 43.0 Weakly correlated
6 MSTB-int 146 **** 43.0 Weakly correlated
7 MSTB1-int 29 **** 74.0 Weakly correlated
8 THE1-int 23 **** 43.0 Weakly correlated
9 MSTC-int 20 **** 74.0 Weakly correlated
10 MSTD-int 17 **** 74.0 Weakly correlated
11 MST-int 17 **** 74.0 Weakly correlated
12 AluJb 15 n.s 74.0 Weakly correlated
13 L2a 12 n.s 99.0 Weakly correlated
14 AluJo 11 n.s 74.0 Weakly correlated
15 MIRb 7 n.s 99.0 Weakly correlated
16 MSTB2-int 6 **** 74.0 Weakly correlated
17 AluSx1 6 n.s 74.0 Weakly correlated
18 AluY 6 n.s 74.0 Weakly correlated
19 AluSx 5 n.s 74.0 Weakly correlated
20 L2c 4 n.s 99.0 Weakly correlated
21 AluJr 4 n.s 74.0 Weakly correlated
22 MLT1A 4 n.s 99.0 Weakly correlated
23 MLT1D 4 n.s 99.0 Weakly correlated
24 L1ME1 4 n.s 99.0 Weakly correlated
25 L1MEg 3 n.s 99.0 Weakly correlated
26 L2b 3 n.s 99.0 Weakly correlated
27 MIR 3 n.s 99.0 Weakly correlated
28 LTR10F 3 *** 28.9 Weakly correlated
29 AluSz6 3 n.s 74.0 Weakly correlated
30 L2 3 n.s 99.0 Weakly correlated
31 FLAM_C 3 n.s 74.0 Weakly correlated
32 L1MB8 3 n.s 99.0 Weakly correlated
33 L1MA7 3 n.s 87.0 Weakly correlated
34 L1MEi 3 n.s 99.0 Weakly correlated
35 MIRc 3 n.s 99.0 Weakly correlated
36 LTR13_ 2 **** 28.9 Weakly correlated
37 MLT1J 2 n.s 99.0 Weakly correlated
38 MSTA1-int 2 **** 74.0 Weakly correlated
39 THE1B 2 n.s 43.0 Weakly correlated
40 AluSp 2 n.s 74.0 Weakly correlated
41 MLT1I 2 n.s 99.0 Weakly correlated
42 L1MEc 2 n.s 99.0 Weakly correlated
43 MLT1B 2 n.s 99.0 Weakly correlated
44 FRAM 2 n.s 74.0 Weakly correlated
45 MLT1L 2 n.s 99.0 Weakly correlated
46 L1PA10 2 n.s 74.0 Weakly correlated
47 LTR1A1 2 * 43.0 Weakly correlated
48 MLT-int 2 ** 99.0 Weakly correlated
49 AluSz 2 n.s 74.0 Weakly correlated
50 MSTA 2 n.s 43.0 Weakly correlated
51 MLT1C 2 n.s 94.0 Weakly correlated
52 HAL1 1 n.s 99.0 Weakly correlated
53 HERV16-int 1 n.s 99.0 Weakly correlated
54 L1M4b 1 n.s 99.0 Weakly correlated
55 L1ME4a 1 n.s 99.0 Weakly correlated
56 L1ME4b 1 n.s 99.0 Weakly correlated
57 MLT1F1 1 n.s 99.0 Weakly correlated
58 MLT1M 1 n.s 99.0 Weakly correlated
59 MLT2D 1 n.s 99.0 Weakly correlated
60 LTR8A 1 n.s 43.0 Weakly correlated
61 MER39 1 n.s 74.0 Weakly correlated
62 MER83C 1 ** 43.0 Weakly correlated
63 MLT1N2 1 n.s 99.0 Weakly correlated
64 L1MA5A 1 n.s 87.0 Weakly correlated
65 L1MC2 1 n.s 99.0 Weakly correlated
66 L1MDa 1 n.s 99.0 Weakly correlated
67 L1ME2 1 n.s 99.0 Weakly correlated
68 L1MEh 1 n.s 99.0 Weakly correlated
69 L1PA6 1 n.s 28.9 Weakly correlated
70 LTR40a 1 n.s 99.0 Weakly correlated
71 MLT1G 1 n.s 99.0 Weakly correlated
72 Plat_L3 1 n.s 99.0 Weakly correlated
73 THE1C 1 n.s 43.0 Weakly correlated
74 AmnSINE1 1 n.s 319.0 Weakly correlated
75 HERVH-int 1 n.s 28.9 Weakly correlated
76 L1MC4a 1 n.s 99.0 Weakly correlated
77 L1PB1 1 n.s 74.0 Weakly correlated
78 LTR33 1 n.s 99.0 Weakly correlated
79 MER52A 1 n.s 74.0 Weakly correlated
80 MLT1B-int 1 n.s 99.0 Weakly correlated
81 L1MA6 1 n.s 87.0 Weakly correlated
82 LTR41B 1 n.s 99.0 Weakly correlated
83 LTR50 1 n.s 99.0 Weakly correlated
84 MER54A 1 n.s 87.0 Weakly correlated
85 MER61-int 1 n.s 43.0 Weakly correlated
86 MIR3 1 n.s 99.0 Weakly correlated
87 L1MC5a 1 n.s 99.0 Weakly correlated
88 L3 1 n.s 99.0 Weakly correlated
89 LTR81B 1 n.s 99.0 Weakly correlated
90 AluJr4 1 n.s 74.0 Weakly correlated
91 CR1_Mam 1 n.s 99.0 Weakly correlated
92 L1M5 1 n.s 99.0 Weakly correlated
93 L1P1 1 n.s 19.6 Moderately correlated
94 L1PREC2 1 n.s 43.0 Weakly correlated
95 MER4A 1 n.s 74.0 Weakly correlated
96 MER70B 1 n.s 87.0 Weakly correlated
97 FLAM_A 1 n.s 74.0 Weakly correlated
98 L1MA5 1 n.s 87.0 Weakly correlated
99 L1MB7 1 n.s 99.0 Weakly correlated
100 L1MD1 1 n.s 99.0 Weakly correlated
101 L1ME3C 1 n.s 99.0 Weakly correlated
102 L1ME3Cz 1 n.s 99.0 Weakly correlated
103 LTR16E1 1 n.s 99.0 Weakly correlated
104 LTR1A2 1 n.s 43.0 Weakly correlated
105 MER54B 1 * 87.0 Weakly correlated
106 MSTA1 1 * 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP