ZRdb KZFP & Repeats
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Human_ZNF669

  • Protein
    Zinc finger protein 669
  • Length
    464
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q96BR6
  • NCBI_ID
    79862
Sequence:
MVSGLRLASRSGEEGWLKPAVARLGPPRHRLRNLRTESPWRSRGSVLFCSGPGRAGRAAEPLHPVCTCGRHFRRPEPCREPLASPIQDSVAFEDVAVNFTQEEWALLDSSQKNLYREVMQETCRNLASVGSQWKDQNIEDHFEKPGKDIRNHIVQRLCESKEDGQYGEVVSQIPNLDLNENISTGLKPCECSICGKVFVRHSLLNRHILAHSGYKPYGEKQYKCEQCGKFFVSVPGVRRHMIMHSGNPAYKCTICGKAFYFLNSVERHQRTHTGEKPYKCKQCGKAFTVSGSCLIHERTHTGEKPYECKECGKTFRFSCSFKTHERTHTGERPYKCTKCDKAFSCSTSLRYHGSIHTGERPYECKQCGKAFSRLSSLCNHRSTHTGEKPYECKQCDQAFSRLSSLHLHERIHTGEKPYECKKCGKAYTRSSHLTRHERSHDIEAGCSDSAYNPSTLGGQGVWIA
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 90..176
2 C2h2 189..211
3 C2h2 222..244
4 C2h2 250..272
5 C2h2 278..300
6 C2h2 306..328
7 C2h2 334..356
8 C2h2 362..384
9 C2h2 390..412
10 C2h2 418..440
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HERV17-int 100 **** 28.9 Weakly correlated
2 HERV9-int 90 **** 28.9 Weakly correlated
3 LTR17 81 **** 28.9 Weakly correlated
4 HERV9NC-int 66 **** 19.6 Weakly correlated
5 LTR12 45 **** 28.9 Weakly correlated
6 LTR12C 36 **** 19.6 Weakly correlated
7 HERV9N-int 30 **** 19.6 Weakly correlated
8 LTR12F 27 **** 28.9 Weakly correlated
9 LTR12D 26 **** 19.6 Weakly correlated
10 LTR12_ 26 **** 28.9 Weakly correlated
11 LTR12B 14 **** 28.9 Weakly correlated
12 HUERS-P2-int 11 **** 43.0 Highly correlated
13 LTR76 10 **** 74.0 Weakly correlated
14 AluSx1 9 n.s 74.0 Weakly correlated
15 MIRc 7 n.s 99.0 Weakly correlated
16 LTR10A 6 **** 28.9 Weakly correlated
17 LTR25-int 6 **** 43.0 Highly correlated
18 LTR8 6 **** 43.0 Highly correlated
19 L2c 5 n.s 99.0 Weakly correlated
20 LTR9B 5 **** 43.0 Highly correlated
21 HERV30-int 4 **** 28.9 Weakly correlated
22 HUERS-P1-int 4 **** 43.0 Highly correlated
23 HUERS-P3b-int 4 **** 43.0 Highly correlated
24 L1MEd 4 n.s 99.0 Weakly correlated
25 LTR12E 4 **** 19.6 Weakly correlated
26 MER51A 4 **** 43.0 Highly correlated
27 MER52D 4 **** 74.0 Weakly correlated
28 MER61-int 4 **** 43.0 Highly correlated
29 AluJo 3 n.s 74.0 Weakly correlated
30 AluSc8 3 n.s 74.0 Weakly correlated
31 AluY 3 n.s 74.0 Weakly correlated
32 HUERS-P3-int 3 **** 43.0 Highly correlated
33 L1M1 3 n.s 74.0 Weakly correlated
34 L1M4b 3 * 99.0 Weakly correlated
35 L1MEf 3 n.s 99.0 Weakly correlated
36 L1P3 3 * 74.0 Weakly correlated
37 L2a 3 n.s 99.0 Weakly correlated
38 LTR19A 3 **** 43.0 Highly correlated
39 LTR4 3 **** 28.9 Weakly correlated
40 LTR50 3 *** 99.0 Weakly correlated
41 LTR8B 3 *** 43.0 Highly correlated
42 MER11A 3 *** 28.9 Weakly correlated
43 MER11B 3 **** 19.6 Weakly correlated
44 MER41D 3 **** 74.0 Weakly correlated
45 MER52-int 3 **** 99.0 Weakly correlated
46 MER57-int 3 *** 87.0 Weakly correlated
47 MIRb 3 n.s 99.0 Weakly correlated
48 AluJr 2 n.s 74.0 Weakly correlated
49 HAL1M8 2 ** 99.0 Weakly correlated
50 L1M4 2 n.s 99.0 Weakly correlated
51 L1M4a1 2 ** 99.0 Weakly correlated
52 L1M5 2 n.s 99.0 Weakly correlated
53 L1MA4 2 n.s 87.0 Weakly correlated
54 L1MB5 2 n.s 99.0 Weakly correlated
55 L1MC4 2 n.s 99.0 Weakly correlated
56 L1MC5 2 n.s 99.0 Weakly correlated
57 L1MEc 2 n.s 99.0 Weakly correlated
58 L1PA10 2 n.s 74.0 Weakly correlated
59 L1PA2 2 n.s 15.2 Weakly correlated
60 L1PA8 2 n.s 74.0 Weakly correlated
61 L2 2 n.s 99.0 Weakly correlated
62 L2b 2 n.s 99.0 Weakly correlated
63 L3 2 n.s 99.0 Weakly correlated
64 LTR16C 2 * 99.0 Weakly correlated
65 LTR18B 2 **** 43.0 Highly correlated
66 LTR1A1 2 **** 43.0 Highly correlated
67 LTR1A2 2 *** 43.0 Highly correlated
68 LTR28C 2 **** 43.0 Highly correlated
69 LTR30 2 **** 28.9 Weakly correlated
70 LTR45B 2 **** 74.0 Weakly correlated
71 LTR49-int 2 ** 74.0 Weakly correlated
72 LTR83 2 **** 99.0 Weakly correlated
73 LTR86A1 2 **** 99.0 Weakly correlated
74 MER101 2 **** 74.0 Weakly correlated
75 MER11C 2 ** 19.6 Weakly correlated
76 MER61D 2 **** 43.0 Highly correlated
77 MER66-int 2 *** 43.0 Highly correlated
78 MIR 2 n.s 99.0 Weakly correlated
79 MLT1B 2 n.s 99.0 Weakly correlated
80 MLT1G3 2 ** 99.0 Weakly correlated
81 Alu 1 ** 74.0 Weakly correlated
82 AluJb 1 n.s 74.0 Weakly correlated
83 AluSp 1 n.s 74.0 Weakly correlated
84 AluYh9 1 **** 15.2 Weakly correlated
85 AluYj4 1 * 0.0 Weakly correlated
86 HAL1 1 n.s 99.0 Weakly correlated
87 HERV3-int 1 * 28.9 Weakly correlated
88 L1M2 1 n.s 99.0 Weakly correlated
89 L1M3f 1 * 87.0 Weakly correlated
90 L1M4a2 1 * 99.0 Weakly correlated
91 L1MB7 1 n.s 99.0 Weakly correlated
92 L1MB8 1 n.s 99.0 Weakly correlated
93 L1MC 1 n.s 99.0 Weakly correlated
94 L1MC2 1 n.s 99.0 Weakly correlated
95 L1MC5a 1 n.s 99.0 Weakly correlated
96 L1MCc 1 n.s 99.0 Weakly correlated
97 L1ME3Cz 1 n.s 99.0 Weakly correlated
98 L1MEg 1 n.s 99.0 Weakly correlated
99 L1P2 1 n.s 28.9 Weakly correlated
100 L1P4 1 n.s 74.0 Weakly correlated
101 L1PA3 1 n.s 19.6 Weakly correlated
102 L1PA5 1 n.s 19.6 Weakly correlated
103 L1PB1 1 n.s 74.0 Weakly correlated
104 L1PREC2 1 n.s 43.0 Highly correlated
105 L2-1_AMi 1 ** 319.0 Weakly correlated
106 LOR1-int 1 * 74.0 Weakly correlated
107 LTR13 1 * 19.6 Weakly correlated
108 LTR18A 1 *** 43.0 Highly correlated
109 LTR1F1 1 ** 43.0 Highly correlated
110 LTR1F2 1 *** 43.0 Highly correlated
111 LTR23 1 ** 74.0 Weakly correlated
112 LTR27E 1 ** 43.0 Highly correlated
113 LTR33 1 n.s 99.0 Weakly correlated
114 LTR41B 1 ** 99.0 Weakly correlated
115 LTR57 1 *** 74.0 Weakly correlated
116 MER21C 1 n.s 99.0 Weakly correlated
117 MER4-int 1 n.s 74.0 Weakly correlated
118 MER41-int 1 n.s 74.0 Weakly correlated
119 MER4B-int 1 * 99.0 Weakly correlated
120 MER50-int 1 ** 43.0 Highly correlated
121 MER52A 1 n.s 74.0 Weakly correlated
122 MER65-int 1 * 87.0 Weakly correlated
123 MER65C 1 ** 74.0 Weakly correlated
124 MER72 1 ** 43.0 Highly correlated
125 MER76 1 ** 99.0 Weakly correlated
126 MLT1F2 1 n.s 99.0 Weakly correlated
127 MLT1J 1 n.s 99.0 Weakly correlated
128 MLT1K 1 n.s 99.0 Weakly correlated
129 MLT1O 1 * 99.0 Weakly correlated
130 MamGypLTR3a 1 ** 99.0 Weakly correlated
131 PABL_A-int 1 ** 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HERV17-int 62 **** 28.9 Weakly correlated
2 HERV9-int 55 **** 28.9 Weakly correlated
3 HERV9NC-int 43 **** 19.6 Weakly correlated
4 HERV9N-int 18 **** 19.6 Weakly correlated
5 HUERS-P2-int 6 **** 43.0 Highly correlated
6 HUERS-P1-int 3 **** 43.0 Highly correlated
7 HUERS-P3b-int 3 **** 43.0 Highly correlated
8 LTR25-int 2 ** 43.0 Highly correlated
9 MER61-int 2 ** 43.0 Highly correlated
10 HERV30-int 2 **** 28.9 Weakly correlated
11 HUERS-P3-int 2 ** 43.0 Highly correlated
12 PABL_A-int 1 ** 74.0 Weakly correlated
13 L1MEg 1 n.s 99.0 Weakly correlated
14 AluSc8 1 n.s 74.0 Weakly correlated
15 MLT1J 1 n.s 99.0 Weakly correlated
16 L1MA4 1 n.s 87.0 Weakly correlated
17 MER65C 1 ** 74.0 Weakly correlated
18 LTR50 1 * 99.0 Weakly correlated
19 MLT1K 1 n.s 99.0 Weakly correlated
20 LTR83 1 ** 99.0 Weakly correlated
21 L1MC4 1 n.s 99.0 Weakly correlated
22 LTR28C 1 ** 43.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP