ZRdb KZFP & Repeats
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Human_ZNF667

  • Protein
    Zinc finger protein 667
  • Length
    610
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q5HYK9
  • NCBI_ID
    63934
Sequence:
MPSARGKSKSKAPITFGDLAIYFSQEEWEWLSPIQKDLYEDVMLENYRNLVSLGLSFRRPNVITLLEKGKAPWMVEPVRRRRAPDSGSKCETKKLPPNQCNKSGQSICQKLVSAQQKAPTRKSGCNKNSVLVKPKKGHSGKKPLKCNDCGKTFSRSFSLKLHQNIHTGEKPFECSNCRKAFRQISSILLHQRIHSGKKSHECNKCGESFNQRTTLILHMRIHDGKEILDCGKALSQCQSFNIHQKIHVVGNVCQCRKCGKAFNQMSSLLLHKKIHNGKKTHKYNKCGRGFKKKSVFVVHKRIHAGEKIPENAKALSQSLQQRSHHLENPFKCRKCGKLFNRISPLMLHQRIHTSEKPYKCDKCDKFFRRLSTLILHLRIHNGEKLYRCNKCEKVCNRHSSLIQHQKVHTKKKKLFECKECGKMFSGTANLKIHQNIHSEEKPFKCNKCSKVFGRQSFLIEHQRIHTGEKPYQCEECGKAFSHRISLTRHKRIHTEDRPYECDQCGKAFSQSAHLAQHERIHTGEKPYTCKTCGKAFSQRTSLILHERSHTGEKPYECNECGKAFSSGSDLIRHQRSHSSEKPYECSKCGKAYSRSSSLIRHQNTHSEEKA
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..85
2 C2h2 144..166
3 C2h2 172..194
4 C2h2 200..222
5 C2h2 253..275
6 dec2h2 281..303
7 C2h2 330..352
8 C2h2 358..380
9 C2h2 386..408
10 C2h2 415..437
11 C2h2 443..465
12 C2h2 471..493
13 C2h2 499..521
14 C2h2 527..549
15 C2h2 555..577
16 C2h2 583..605
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2b 16 **** 99.0 Highly correlated
2 L2c 15 *** 99.0 Highly correlated
3 MIR3 8 *** 99.0 Highly correlated
4 AluY 8 n.s 74.0 Weakly correlated
5 MIRc 7 * 99.0 Highly correlated
6 MIR 6 n.s 99.0 Highly correlated
7 L2a 5 n.s 99.0 Highly correlated
8 AluJr4 4 ** 74.0 Weakly correlated
9 L1P3 4 *** 74.0 Weakly correlated
10 AluJb 4 n.s 74.0 Weakly correlated
11 FRAM 4 **** 74.0 Weakly correlated
12 FLAM_C 3 ** 74.0 Weakly correlated
13 L1MEc 3 n.s 99.0 Highly correlated
14 L1PA5 3 n.s 19.6 Weakly correlated
15 MER21A 3 **** 74.0 Weakly correlated
16 AluSz 3 n.s 74.0 Weakly correlated
17 LTR10A 3 **** 28.9 Weakly correlated
18 AluSp 3 n.s 74.0 Weakly correlated
19 LTR78 2 ** 99.0 Highly correlated
20 L3 2 n.s 99.0 Highly correlated
21 L3b 2 ** 99.0 Highly correlated
22 L4_A_Mam 2 ** 99.0 Highly correlated
23 L1P1 2 * 19.6 Weakly correlated
24 L1ME4b 2 n.s 99.0 Highly correlated
25 LTR10F 2 **** 28.9 Weakly correlated
26 LTR16C 2 ** 99.0 Highly correlated
27 L1ME1 2 n.s 99.0 Highly correlated
28 MIRb 2 n.s 99.0 Highly correlated
29 L1ME3A 2 n.s 99.0 Highly correlated
30 MLT1C 2 n.s 94.0 Weakly correlated
31 AluJr 2 n.s 74.0 Weakly correlated
32 HUERS-P1-int 2 *** 43.0 Weakly correlated
33 MamGypLTR3 2 **** 99.0 Highly correlated
34 ERVL-E-int 2 n.s 99.0 Highly correlated
35 AluYj4 2 *** 0.0 Weakly correlated
36 MLT1O 2 ** 99.0 Highly correlated
37 L1PA14 1 n.s 74.0 Weakly correlated
38 Penelope1_Vert 1 *** 319.0 Weakly correlated
39 LTR79 1 * 99.0 Highly correlated
40 MamRep605 1 * 99.0 Highly correlated
41 MLT2B4 1 * 99.0 Highly correlated
42 MLT1N2-int 1 **** 99.0 Highly correlated
43 MLT1J 1 n.s 99.0 Highly correlated
44 MLT1H2 1 * 99.0 Highly correlated
45 MER57C2 1 *** 87.0 Weakly correlated
46 MLT1E1A 1 * 99.0 Highly correlated
47 MER61F 1 *** 43.0 Weakly correlated
48 MLT1A 1 n.s 99.0 Highly correlated
49 L1MA6 1 n.s 87.0 Weakly correlated
50 AluJo 1 n.s 74.0 Weakly correlated
51 AluSx1 1 n.s 74.0 Weakly correlated
52 AluSx3 1 n.s 74.0 Weakly correlated
53 AluSz6 1 n.s 74.0 Weakly correlated
54 AluYh9 1 **** 15.2 Weakly correlated
55 HAL1 1 n.s 99.0 Highly correlated
56 HERVL40-int 1 ** 99.0 Highly correlated
57 L1M1 1 n.s 74.0 Weakly correlated
58 L1M4a1 1 * 99.0 Highly correlated
59 LTR48 1 ** 74.0 Weakly correlated
60 L1MA8 1 n.s 87.0 Weakly correlated
61 L1MC3 1 n.s 99.0 Highly correlated
62 L1MC5a 1 n.s 99.0 Highly correlated
63 L1MDa 1 n.s 99.0 Highly correlated
64 L1ME4a 1 n.s 99.0 Highly correlated
65 L1MEi 1 n.s 99.0 Highly correlated
66 L1P4 1 n.s 74.0 Weakly correlated
67 L2 1 n.s 99.0 Highly correlated
68 LTR13 1 ** 19.6 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2b 6 n.s 99.0 Highly correlated
2 L2c 5 n.s 99.0 Highly correlated
3 L2a 4 n.s 99.0 Highly correlated
4 MIR3 3 n.s 99.0 Highly correlated
5 L1MEc 3 n.s 99.0 Highly correlated
6 MIR 2 n.s 99.0 Highly correlated
7 MIRc 2 n.s 99.0 Highly correlated
8 HUERS-P1-int 2 *** 43.0 Weakly correlated
9 MIRb 1 n.s 99.0 Highly correlated
10 L1M4a1 1 * 99.0 Highly correlated
11 MLT1N2-int 1 **** 99.0 Highly correlated
12 MER21A 1 * 74.0 Weakly correlated
13 LTR48 1 ** 74.0 Weakly correlated
14 LTR78 1 * 99.0 Highly correlated
15 L1ME4a 1 n.s 99.0 Highly correlated
16 MLT1O 1 * 99.0 Highly correlated
17 MLT1H2 1 * 99.0 Highly correlated
18 L2 1 n.s 99.0 Highly correlated
19 AluJr4 1 n.s 74.0 Weakly correlated
20 L4_A_Mam 1 n.s 99.0 Highly correlated
21 L1ME1 1 n.s 99.0 Highly correlated
22 ERVL-E-int 1 n.s 99.0 Highly correlated
23 AluY 1 n.s 74.0 Weakly correlated
24 MLT1E1A 1 * 99.0 Highly correlated
25 L3 1 n.s 99.0 Highly correlated
26 LTR16C 1 n.s 99.0 Highly correlated
27 L3b 1 * 99.0 Highly correlated
28 L1MDa 1 n.s 99.0 Highly correlated
29 L1M1 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP