ZRdb KZFP & Repeats
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Human_ZNF665

  • Protein
    Zinc finger protein 665
  • Length
    678
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    87.0 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q9H7R5
  • NCBI_ID
    79788
Sequence:
MALPQGQLTFKDVAIEFSQEEWTCLDPAQKTLYRDVMLENYRNLVSLDISCKCVNTDLPPKGKNNMGEAFYTVKLERLESCDTVGLSFQEVQKNTYDFECQWKDDEGNYKTVLMLQKENLPGRRAQRDRRAAGNRHIENQLGVSFQSHLPELQQFQHEGKIYEYNQVEKSPNNRGKHYKCDECGKVFSQNSRLTSHKRIHTGEKPYQCNKCGKAFTVRSNLTIHQVIHTGEKPYKCNECGKVFSQPSNLAGHQRIHTGEKPYKCNECGKAFRAHSKLTTHQVIHTGEKPYKCKECGKCFTQNSHLASHRRIHTGEKPYKCNECGKAFSVRSSLTTHQTIHTGEKPYKCNECGKVFRHNSYLAKHRRIHTGEKPYKCNECGKAFSMHSNLTKHQIIHTGEKPFKCNECVKVFTQYSHLANHRRIHTGEKPYRCDECGKAFSVRSSLTTHQAIHTGEKPYKCNDCGKVFTQNSHLASHRGIHSGEKPYKCDECGKAFSQTSQLARHWRVHTGEKPYKCNECGKAFSVHSSLTIHQTIHTGQKPYKCNDCGKVFRHNSYLAIHQRIHTGEKPYKCNECGKAFSVHSNLATHQVIHTGEKPYKCNECGKVFTQNSHLANHRRIHTGEKPYRCNECGKAFSVRSTLTTHMAVHTGDKPYKCNQCGKVFTQNSNLAKHRRIHSG
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..83
2 C2h2 178..200
3 C2h2 206..228
4 C2h2 234..256
5 C2h2 262..284
6 C2h2 290..312
7 C2h2 318..340
8 C2h2 346..368
9 C2h2 374..396
10 C2h2 402..424
11 C2h2 430..452
12 C2h2 458..480
13 C2h2 486..508
14 C2h2 514..536
15 C2h2 542..564
16 C2h2 570..592
17 C2h2 598..620
18 C2h2 626..648
19 C2h2 654..676
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MA4 21 **** 87.0 Weakly correlated
2 L1M3f 19 **** 87.0 Weakly correlated
3 LTR10A 4 **** 28.9 Highly correlated
4 AluY 3 n.s 74.0 Weakly correlated
5 L1PA10 3 n.s 74.0 Weakly correlated
6 MIR3 3 n.s 99.0 Weakly correlated
7 L1MB8 3 n.s 99.0 Weakly correlated
8 MER21B 3 *** 99.0 Weakly correlated
9 AluSx 2 n.s 74.0 Weakly correlated
10 L1M1 2 n.s 74.0 Weakly correlated
11 L1M2c 2 **** 87.0 Weakly correlated
12 L1PA7 1 n.s 74.0 Weakly correlated
13 L1MEd 1 n.s 99.0 Weakly correlated
14 L2b 1 n.s 99.0 Weakly correlated
15 L2c 1 n.s 99.0 Weakly correlated
16 LTR103_Mam 1 *** 99.0 Weakly correlated
17 MER89-int 1 ** 99.0 Weakly correlated
18 MIR 1 n.s 99.0 Weakly correlated
19 MIRb 1 n.s 99.0 Weakly correlated
20 MLT1E2 1 * 99.0 Weakly correlated
21 MLT1K 1 n.s 99.0 Weakly correlated
22 MLT1L 1 n.s 99.0 Weakly correlated
23 THE1B-int 1 n.s 43.0 Moderately correlated
24 L1PA4 1 n.s 19.6 Weakly correlated
25 L1PA14 1 n.s 74.0 Weakly correlated
26 L1MEf 1 n.s 99.0 Weakly correlated
27 AluJo 1 n.s 74.0 Weakly correlated
28 L1MCb 1 * 99.0 Weakly correlated
29 L1MB7 1 n.s 99.0 Weakly correlated
30 L1M5 1 n.s 99.0 Weakly correlated
31 L1M4a2 1 * 99.0 Weakly correlated
32 L1M4 1 n.s 99.0 Weakly correlated
33 L1HS 1 n.s 8.6 Weakly correlated
34 HAL1ME 1 n.s 99.0 Weakly correlated
35 CR1-L3A_Croc 1 **** 319.0 Weakly correlated
36 AluSq2 1 n.s 74.0 Weakly correlated
37 AluSg 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MA4 2 n.s 87.0 Weakly correlated
2 L1M3f 1 ** 87.0 Weakly correlated
3 MIR3 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP