ZRdb KZFP & Repeats
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Human_ZNF66

  • Protein
    Putative zinc finger protein 66
  • Length
    573
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    0.0 Mya
  • Uniprot_ID
    Q6ZN08
  • NCBI_ID
    7617
Sequence:
MGPLQFRDVAIEFSLEEWHCLDMAQRNLYRDVMLENYRNLVFLGIVVSKPDLITHLEQGKKPSTMQRHEMVANPSVLCSHFNQDLWPEQSIKDSFQKLILRRHKKCGHDNLQLKKGCESVDKCKVHKRGYNGLNQCLTTTQSKMFQCDKHGKVFHQFSNTNRHKIRHTGKNPCKFTECGKAFNRSSTFTTHKKIHTGEKPYKCIECGKAFNRSSHLTTHKIIHTGEKRYKCEDCGKAFNRSSNLTTHKKIHTGEKPYKCEECGKAFKRSSILTTHKRIHTGEKPYKCEECGKVFKYLSSLSTHKIIHTGEKPYKCEECGKAFNWSSHLTTHKRIHTGEKPYKCEECGKGFKYSSTLTKHKIIHTGEKPYKCEECGEAFKYSCSLTAHKIIHTGKKPYKCEECGKVFKHSSPLSKHKRIHTGEKPYKCEECGKAFSRSSILTTHKIIHTGEKPYECEDCGKAFNRSSNLTKHKKIHTGEKPYKCEECGKAFKCSSILTTHKRIHTADKPYKCEECGKDFKYSSTLTRHKKIHTGGKPHKCNKCGKAFISSSNLSRHEIIHMGGNPYKCENVAKP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..75
2 C2h2 145..167
3 C2h2 171..195
4 C2h2 201..223
5 C2h2 229..251
6 C2h2 257..279
7 C2h2 285..307
8 C2h2 313..335
9 C2h2 341..363
10 C2h2 369..391
11 C2h2 397..419
12 C2h2 425..447
13 C2h2 453..475
14 C2h2 481..503
15 C2h2 509..531
16 C2h2 537..559
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of DNA-templated transcription
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 21 n.s 74.0 Weakly correlated
2 L1P3 10 **** 74.0 Weakly correlated
3 AluYj4 10 **** 0.0 Highly correlated
4 AluSc8 8 * 74.0 Weakly correlated
5 SVA_F 6 **** 0.0 Highly correlated
6 L2c 6 n.s 99.0 Weakly correlated
7 LTR8 6 **** 43.0 Weakly correlated
8 SVA_D 5 ** 15.2 Weakly correlated
9 LTR10A 4 **** 28.9 Weakly correlated
10 THE1D-int 3 * 28.9 Weakly correlated
11 L1MB8 3 n.s 99.0 Weakly correlated
12 ERV3-16A3_I-int 3 n.s 99.0 Weakly correlated
13 LTR12C 3 n.s 19.6 Weakly correlated
14 MER21B 3 ** 99.0 Weakly correlated
15 AluY 3 n.s 74.0 Weakly correlated
16 AluSz 3 n.s 74.0 Weakly correlated
17 AluSx1 3 n.s 74.0 Weakly correlated
18 AluSp 3 n.s 74.0 Weakly correlated
19 MER21C 2 n.s 99.0 Weakly correlated
20 MER52A 2 n.s 74.0 Weakly correlated
21 L2b 2 n.s 99.0 Weakly correlated
22 L1PA4 2 n.s 19.6 Weakly correlated
23 L1PA2 2 n.s 15.2 Weakly correlated
24 L1P4 2 n.s 74.0 Weakly correlated
25 L1MB3 2 n.s 99.0 Weakly correlated
26 L1MA8 2 n.s 87.0 Weakly correlated
27 L1M4 2 n.s 99.0 Weakly correlated
28 MLT1H1 1 n.s 99.0 Weakly correlated
29 LTR78B 1 n.s 99.0 Weakly correlated
30 AluYh9 1 **** 15.2 Weakly correlated
31 AluYf1 1 n.s 19.6 Weakly correlated
32 AluYa8 1 *** 15.2 Weakly correlated
33 AluSz6 1 n.s 74.0 Weakly correlated
34 MER52C 1 * 74.0 Weakly correlated
35 MER52D 1 n.s 74.0 Weakly correlated
36 MIR3 1 n.s 99.0 Weakly correlated
37 MIRb 1 n.s 99.0 Weakly correlated
38 MLT1E3 1 n.s 99.0 Weakly correlated
39 LTR5_Hs 1 n.s 0.0 Highly correlated
40 MLT1K 1 n.s 99.0 Weakly correlated
41 MLT1L 1 n.s 99.0 Weakly correlated
42 MSTA 1 n.s 43.0 Weakly correlated
43 SVA_C 1 * 15.2 Weakly correlated
44 AluSx 1 n.s 74.0 Weakly correlated
45 AluSg 1 n.s 74.0 Weakly correlated
46 THE1B-int 1 n.s 43.0 Weakly correlated
47 AluJr 1 n.s 74.0 Weakly correlated
48 L1PA5 1 n.s 19.6 Weakly correlated
49 L1MA9 1 n.s 99.0 Weakly correlated
50 L1MA1 1 n.s 74.0 Weakly correlated
51 L1MC1 1 n.s 99.0 Weakly correlated
52 L1MC4 1 n.s 99.0 Weakly correlated
53 L1M3e 1 * 99.0 Weakly correlated
54 L1M3 1 n.s 99.0 Weakly correlated
55 L1PA14 1 n.s 74.0 Weakly correlated
56 L1HS 1 n.s 8.6 Moderately correlated
57 HERV1_I-int 1 ** 43.0 Weakly correlated
58 L1MA2 1 n.s 74.0 Weakly correlated
59 L1PA6 1 n.s 28.9 Weakly correlated
60 L2a 1 n.s 99.0 Weakly correlated
61 HERV15-int 1 ** 28.9 Weakly correlated
62 HAL1 1 n.s 99.0 Weakly correlated
63 FRAM 1 n.s 74.0 Weakly correlated
64 LTR10B1 1 *** 28.9 Weakly correlated
65 AluYm1 1 n.s 19.6 Weakly correlated
66 LTR13 1 * 19.6 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 4 * 74.0 Weakly correlated
2 L1M3 1 n.s 99.0 Weakly correlated
3 L1MA8 1 n.s 87.0 Weakly correlated
4 AluSx1 1 n.s 74.0 Weakly correlated
5 MIR3 1 n.s 99.0 Weakly correlated
6 L1PA2 1 n.s 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP